Etv5 regulates il-10 production in th cells

Journal of Immunology

Volumn 198, Issue 5, 2017, Pages 2165-2171

  Koh, Byunghee ^a,b   Hufford, Matthew M ^a   Sun, Xin ^c   Kaplan, Mark H ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON REGULATORY FACTOR 4; INTERLEUKIN 10; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E4BP4; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR ETV5; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG; ALLERGEN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; ETV5 PROTEIN, MOUSE; FUNGUS ANTIGEN; NFIL3 PROTEIN, MOUSE; PROTEIN BINDING;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS FUMIGATUS; BRONCHOALVEOLAR LAVAGE FLUID; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE LOCUS; HELPER CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROMOTER REGION; TH1 CELL; TH2 CELL; ANIMAL; CELL CULTURE; CELL DIFFERENTIATION; GENETICS; HYPERSENSITIVITY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY;

ALLERGENS; ANIMALS; ANTIGENS, FUNGAL; ASPERGILLUS FUMIGATUS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; HYPERSENSITIVITY; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; PROTEIN BINDING; TH2 CELLS; TRANSCRIPTION FACTORS;

EID: 85014914802     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1600801     Document Type: Article

References (25)

1. Wilson, C. B., E. Rowell, and M. Sekimata. 2009. Epigenetic control of Thelper-cell differentiation. Nat. Rev. Immunol. 9: 91-105.
2. Chaudhry, A., and A. Y. Rudensky. 2013. Control of inflammation by integration of environmental cues by regulatory T cells. J. Clin. Invest. 123: 939-944.
3. Zheng, W., and R. A. Flavell. 1997. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
4. Zhu, J., B. Min, J. Hu-Li, C. J. Watson, A. Grinberg, Q. Wang, N. Killeen, J. F. Urban, Jr., L. Guo, and W. E. Paul. 2004. Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses. Nat. Immunol. 5: 1157-1165.
5. Shoemaker, J., M. Saraiva, and A. O'Garra. 2006. GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells. J. Immunol. 176: 3470-3479.
6. Groux, H., and F. Cottrez. 2003. The complex role of interleukin-10 in autoimmunity. J. Autoimmun. 20: 281-285.
7. Saraiva, M., and A. O'Garra. 2010. The regulation of IL-10 production by immune cells. Nat. Rev. Immunol. 10: 170-181.
8. Ahyi, A. N., H. C. Chang, A. L. Dent, S. L. Nutt, and M. H. Kaplan. 2009. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J. Immunol. 183: 1598-1606.
9. Motomura, Y., H. Kitamura, A. Hijikata, Y. Matsunaga, K. Matsumoto, H. Inoue, K. Atarashi, S. Hori, H. Watarai, J. Zhu, et al. 2011. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12: 450-459.
10. Wang, Z. Y., H. Sato, S. Kusam, S. Sehra, L. M. Toney, and A. L. Dent. 2005. Regulation of IL-10 gene expression in Th2 cells by Jun proteins. J. Immunol. 174: 2098-2105.
11. Oh, S., S. Shin, and R. Janknecht. 2012. ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. Biochim. Biophys. Acta 1826: 1-12.
12. Zhang, Z., J. M. Verheyden, J. A. Hassell, and X. Sun. 2009. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev. Cell 16: 607-613.
13. Zhang, Z., P. Sui, A. Dong, J. Hassell, P. Cserjesi, Y. T. Chen, R. R. Behringer, and X. Sun. 2010. Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development 137: 3417-3426.
14. Wu, X., S. M. Goodyear, J. W. Tobias, M. R. Avarbock, and R. L. Brinster. 2011. Spermatogonial stem cell self-renewal requires ETV5-mediated downstream activation of Brachyury in mice. Biol. Reprod. 85: 1114-1123.
15. Ouyang, W., N. G. Jacobson, D. Bhattacharya, J. D. Gorham, D. Fenoglio, W. C. Sha, T. L. Murphy, and K. M. Murphy. 1999. The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. Proc. Natl. Acad. Sci. USA 96: 3888-3893.
16. Pham, D., S. Sehra, X. Sun, and M. H. Kaplan. 2014. The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation. J. Allergy Clin. Immunol. 134: 204-214.
17. Koh, B., M. M. Hufford, D. Pham, M. R. Olson, T. Wu, R. Jabeen, X. Sun, and M. H. Kaplan. 2016. The ETS family transcription factors Etv5 and PU.1 function in parallel to promote Th9 cell development. J. Immunol. 197: 2465-2472.
18. Neumann, C., F. Heinrich, K. Neumann, V. Junghans, M. F. Mashreghi, J. Ahlers, M. Janke, C. Rudolph, N. Mockel-Tenbrinck, A. A. Kuhl, et al. 2014. Role of Blimp-1 in programing Th effector cells into IL-10 producers. J. Exp. Med. 211: 1807-1819.
19. Stritesky, G. L., R. Muthukrishnan, S. Sehra, R. Goswami, D. Pham, J. Travers, E. T. Nguyen, D. E. Levy, and M. H. Kaplan. 2011. The transcription factor STAT3 is required for T helper 2 cell development. Immunity 34: 39-49.
20. Yu, Q., V. T. Thieu, and M. H. Kaplan. 2007. Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ra gene during Th1 differentiation. EMBO J. 26: 2052-2060.
21. Lee, C. G., H. K. Kwon, A. Sahoo, W. Hwang, J. S. So, J. S. Hwang, C. S. Chae, G. C. Kim, J. E. Kim, H. S. So, et al. 2012. Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells. J. Immunol. 188: 2244-2253.
22. Grunig, G., D. B. Corry, M. W. Leach, B. W. Seymour, V. P. Kurup, and D. M. Rennick. 1997. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J. Exp. Med. 185: 1089-1099.
23. Kuhn, R., J. Löhler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75: 263-274.
24. Sakurai, D., J. Zhao, Y. Deng, J. A. Kelly, E. E. Brown, J. B. Harley, S. C. Bae, M. E. Alarc?n-Riquelme,, BIOLUPUS and GENLES networks, J. C. Edberg, et al. 2013. Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS Genet. 9: e1003870.
25. Chang, H. C., S. Zhang, V. T. Thieu, R. B. Slee, H. A. Bruns, R. N. Laribee, M. J. Klemsz, and M. H. Kaplan. 2005. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 22: 693-703.