메뉴 건너뛰기




Volumn 941, Issue , 2016, Pages 89-116

Regulation of interleukin-10 expression

Author keywords

Blimp 1; C Maf; Immune suppression; Infl ammation; Interleukin 10; Myeloid cell; T cell; Tolerance; Transcriptional regulation

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 27; NOTCH RECEPTOR; PATTERN RECOGNITION RECEPTOR; SMAD PROTEIN; STAT PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR C MAF; TRANSFORMING GROWTH FACTOR BETA; TRISTETRAPROLIN; IL10 PROTEIN, HUMAN;

EID: 84991643976     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-94-024-0921-5_5     Document Type: Chapter
Times cited : (117)

References (203)
  • 1
    • 79953892799 scopus 로고    scopus 로고
    • TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors
    • Agrawal S, Gupta S. TLR1/2, TLR7, and TLR9 signals directly activate human peripheral blood naive and memory B cell subsets to produce cytokines, chemokines, and hematopoietic growth factors. J Clin Immunol. 2011;31(1):89-98.
    • (2011) J Clin Immunol , vol.31 , Issue.1 , pp. 89-98
    • Agrawal, S.1    Gupta, S.2
  • 2
    • 0242580118 scopus 로고    scopus 로고
    • Cutting edge: Different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos
    • Agrawal S, et al. Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol. 2003;171(10):4984-9.
    • (2003) J Immunol , vol.171 , Issue.10 , pp. 4984-4989
    • Agrawal, S.1
  • 3
    • 68149125188 scopus 로고    scopus 로고
    • IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines
    • Ahyi A-NN, et al. IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol. 2009;183(3):1598-606.
    • (2009) J Immunol , vol.183 , Issue.3 , pp. 1598-1606
    • Ahyi, A.-N.1
  • 4
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4(7):499-511.
    • (2004) Nat Rev Immunol , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 5
    • 9344260280 scopus 로고    scopus 로고
    • Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes
    • Aman MJ, et al. Interferon-alpha stimulates production of interleukin-10 in activated CD4+ T cells and monocytes. Blood. 1996;87(11):4731-6.
    • (1996) Blood , vol.87 , Issue.11 , pp. 4731-4736
    • Aman, M.J.1
  • 6
    • 58849099058 scopus 로고    scopus 로고
    • The different faces of Notch in T-helper-cell differentiation
    • Amsen D, Antov A, Flavell RA. The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol. 2009;9(2):116-24.
    • (2009) Nat Rev Immunol , vol.9 , Issue.2 , pp. 116-124
    • Amsen, D.1    Antov, A.2    Flavell, R.A.3
  • 7
    • 50049086910 scopus 로고    scopus 로고
    • The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
    • Ananieva O, et al. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol. 2008;9(9):1028-36.
    • (2008) Nat Immunol , vol.9 , Issue.9 , pp. 1028-1036
    • Ananieva, O.1
  • 8
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • Anderson CF, et al. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med. 2007;204(2):285-97.
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 285-297
    • Anderson, C.F.1
  • 9
    • 70449732757 scopus 로고    scopus 로고
    • IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection
    • Anderson CF, et al. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J Immunol. 2009;183(7):4619-27.
    • (2009) J Immunol , vol.183 , Issue.7 , pp. 4619-4627
    • Anderson, C.F.1
  • 10
    • 77955903212 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    • Apetoh L, et al. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010;11(9):854-61.
    • (2010) Nat Immunol , vol.11 , Issue.9 , pp. 854-861
    • Apetoh, L.1
  • 11
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-infl ammatory T cells
    • Awasthi A, et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-infl ammatory T cells. Nat Immunol. 2007;8(12):1380-9.
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1380-1389
    • Awasthi, A.1
  • 12
    • 33644761875 scopus 로고    scopus 로고
    • Diverse Toll-like receptors utilize Tpl2 to activate extracellular signalregulated kinase (ERK) in hemopoietic cells
    • Banerjee A, et al. Diverse Toll-like receptors utilize Tpl2 to activate extracellular signalregulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci U S A. 2006;103(9):3274-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.9 , pp. 3274-3279
    • Banerjee, A.1
  • 13
    • 14944386649 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production
    • Barthlott T, et al. CD25+ CD4+ T cells compete with naive CD4+ T cells for IL-2 and exploit it for the induction of IL-10 production. Int Immunol. 2005;17(3):279-88.
    • (2005) Int Immunol , vol.17 , Issue.3 , pp. 279-288
    • Barthlott, T.1
  • 14
    • 49149119535 scopus 로고    scopus 로고
    • Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells
    • Batten M, et al. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol. 2008;180(5):2752-6.
    • (2008) J Immunol , vol.180 , Issue.5 , pp. 2752-2756
    • Batten, M.1
  • 15
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009;10(2):167-75.
    • (2009) Nat Immunol , vol.10 , Issue.2 , pp. 167-175
    • Bauquet, A.T.1
  • 16
    • 0028815553 scopus 로고
    • Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
    • Berg DJ, et al. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest. 1995;96(5):2339-47.
    • (1995) J Clin Invest , vol.96 , Issue.5 , pp. 2339-2347
    • Berg, D.J.1
  • 17
    • 0037039160 scopus 로고    scopus 로고
    • Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes
    • Blokzijl A, Dijke Ten P, Ibáñez CF. Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes. Curr Biol. 2002;12(1):35-45.
    • (2002) Curr Biol , vol.12 , Issue.1 , pp. 35-45
    • Blokzijl, A.1    Dijke Ten, P.2    Ibáñez, C.F.3
  • 18
    • 33751563152 scopus 로고    scopus 로고
    • Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88-and TRIF-dependent TLR signals, and TLRindependent signals
    • Boonstra A, et al. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88-and TRIF-dependent TLR signals, and TLRindependent signals. J Immunol. 2006;177(11):7551-8.
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 7551-7558
    • Boonstra, A.1
  • 19
    • 0142249421 scopus 로고    scopus 로고
    • Increased interleukin-10 mRNA stability in melanoma cells is associated with decreased levels of A + U-rich element binding factor AUF1
    • Brewer G, et al. Increased interleukin-10 mRNA stability in melanoma cells is associated with decreased levels of A + U-rich element binding factor AUF1. J Interf Cytokine Res. 2003;23(10):553-64.
    • (2003) J Interf Cytokine Res , vol.23 , Issue.10 , pp. 553-564
    • Brewer, G.1
  • 20
    • 0034651850 scopus 로고    scopus 로고
    • A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages
    • Brightbill HD, et al. A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J Immunol. 2000;164(4):1940-51.
    • (2000) J Immunol , vol.164 , Issue.4 , pp. 1940-1951
    • Brightbill, H.D.1
  • 21
    • 0029786910 scopus 로고    scopus 로고
    • Differential regulation of the stability of cytokine mRNAs in lipopolysaccharide-activated blood monocytes in response to interleukin-10
    • Brown CY, et al. Differential regulation of the stability of cytokine mRNAs in lipopolysaccharide-activated blood monocytes in response to interleukin-10. J Biol Chem. 1996;271(33):20108-12.
    • (1996) J Biol Chem , vol.271 , Issue.33 , pp. 20108-20112
    • Brown, C.Y.1
  • 22
    • 33748756806 scopus 로고    scopus 로고
    • NF-kappaB1 (P50) homodimers differentially regulate pro-and anti-inflammatory cytokines in macrophages
    • Cao S, et al. NF-kappaB1 (p50) homodimers differentially regulate pro-and anti-inflammatory cytokines in macrophages. J Biol Chem. 2006;281(36):26041-50.
    • (2006) J Biol Chem , vol.281 , Issue.36 , pp. 26041-26050
    • Cao, S.1
  • 23
    • 14844340837 scopus 로고    scopus 로고
    • The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages
    • Cao S, et al. The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J Immunol. 2005;174(6):3484-92.
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3484-3492
    • Cao, S.1
  • 24
    • 0034653560 scopus 로고    scopus 로고
    • Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
    • Carballo E, Lai WS, Blackshear PJ. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood. 2000;95(6):1891-9.
    • (2000) Blood , vol.95 , Issue.6 , pp. 1891-1899
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 25
    • 0032516626 scopus 로고    scopus 로고
    • Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
    • Carballo E, Lai WS, Blackshear PJ. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science. 1998;281(5379):1001-5.
    • (1998) Science , vol.281 , Issue.5379 , pp. 1001-1005
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 26
    • 54449092414 scopus 로고    scopus 로고
    • Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA
    • Chakrabarti A, et al. Protein kinase R-dependent regulation of interleukin-10 in response to double-stranded RNA. J Biol Chem. 2008;283(37):25132-9.
    • (2008) J Biol Chem , vol.283 , Issue.37 , pp. 25132-25139
    • Chakrabarti, A.1
  • 27
    • 34249826961 scopus 로고    scopus 로고
    • Cutting edge: Involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production
    • Chang EY, et al. Cutting edge: involvement of the type I IFN production and signaling pathway in lipopolysaccharide-induced IL-10 production. J Immunol. 2007;178(11):6705-9.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 6705-6709
    • Chang, E.Y.1
  • 28
    • 34147163337 scopus 로고    scopus 로고
    • Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3
    • Chang H-D, et al. Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3. Eur J Immunol. 2007;37(3):807-17.
    • (2007) Eur J Immunol , vol.37 , Issue.3 , pp. 807-817
    • Chang, H.-D.1
  • 29
    • 79954608612 scopus 로고    scopus 로고
    • Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated infl ammation
    • Chaudhry A, et al. Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated infl ammation. Immunity. 2011;34(4):566-78.
    • (2011) Immunity , vol.34 , Issue.4 , pp. 566-578
    • Chaudhry, A.1
  • 30
    • 33144460185 scopus 로고    scopus 로고
    • Dynamic regulation of pro-and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    • Chi H, et al. Dynamic regulation of pro-and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proc Natl Acad Sci U S A. 2006;103(7):2274-9.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.7 , pp. 2274-2279
    • Chi, H.1
  • 31
    • 84867581744 scopus 로고    scopus 로고
    • A validated regulatory network for Th17 cell specification
    • Ciofani M, et al. A validated regulatory network for Th17 cell specification. Cell. 2012;151(2):289-303.
    • (2012) Cell , vol.151 , Issue.2 , pp. 289-303
    • Ciofani, M.1
  • 32
    • 84885783510 scopus 로고    scopus 로고
    • Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4 + T cells
    • Corre B, et al. Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4 + T cells. Eur J Immunol. 2013;43(10):2730-40.
    • (2013) Eur J Immunol , vol.43 , Issue.10 , pp. 2730-2740
    • Corre, B.1
  • 33
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol. 2008;180(9):5771-7.
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 34
    • 0030048535 scopus 로고    scopus 로고
    • Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which infl uence the development of T helper cell phenotype
    • Creery WD, et al. Differential modulation of B7-1 and B7-2 isoform expression on human monocytes by cytokines which infl uence the development of T helper cell phenotype. Eur J Immunol. 1996;26(6):1273-7.
    • (1996) Eur J Immunol , vol.26 , Issue.6 , pp. 1273-1277
    • Creery, W.D.1
  • 35
    • 79952955744 scopus 로고    scopus 로고
    • The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
    • Cretney, E. et al. The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol. 2011;12(4):304-11.
    • (2011) Nat Immunol , vol.12 , Issue.4 , pp. 304-311
    • Cretney, E.1
  • 36
    • 84873160951 scopus 로고    scopus 로고
    • Differentiation and function of Foxp3(+) effector regulatory T cells
    • Cretney E, Kallies A, Nutt SL. Differentiation and function of Foxp3(+) effector regulatory T cells. Trends Immunol. 2012;34(2):74-80.
    • (2012) Trends Immunol , vol.34 , Issue.2 , pp. 74-80
    • Cretney, E.1    Kallies, A.2    Nutt, S.L.3
  • 37
    • 33747343219 scopus 로고    scopus 로고
    • Role of p38 in stress activation of Sp1
    • D’Addario M, Arora PD, McCulloch CA. Role of p38 in stress activation of Sp1. Gene. 2006;379:51-61.
    • (2006) Gene , vol.379 , pp. 51-61
    • D’Addario, M.1    Arora, P.D.2    McCulloch, C.A.3
  • 38
    • 0027240219 scopus 로고
    • Interleukin 10 (IL-10) inhibits human lymphocyte interferon gammaproduction by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells
    • D’Andrea A, et al. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gammaproduction by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med. 1993;178(3):1041-8.
    • (1993) J Exp Med , vol.178 , Issue.3 , pp. 1041-1048
    • D’Andrea, A.1
  • 39
    • 56349093347 scopus 로고    scopus 로고
    • IL-4 inhibits TGF-beta-induced Foxp3+ T cells, and together with TGFbeta, generates IL-9+ IL-10+ Foxp3(-) effector T cells
    • Dardalhon V, et al. IL-4 inhibits TGF-beta-induced Foxp3+ T cells, and together with TGFbeta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008;9(12):1347-55.
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1347-1355
    • Dardalhon, V.1
  • 40
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal-Malefyt R, Abrams J, et al. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991;174(5):1209-20.
    • (1991) J Exp Med , vol.174 , Issue.5 , pp. 1209-1220
    • De Waal-Malefyt, R.1    Abrams, J.2
  • 41
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
    • de Waal-Malefyt R, Haanen J, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med. 1991;174(4):915-24.
    • (1991) J Exp Med , vol.174 , Issue.4 , pp. 915-924
    • De Waal-Malefyt, R.1    Haanen, J.2
  • 42
    • 67649950931 scopus 로고    scopus 로고
    • Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways
    • Dennehy KM, et al. Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways. Eur J Immunol. 2009;39(5):1379-86.
    • (2009) Eur J Immunol , vol.39 , Issue.5 , pp. 1379-1386
    • Dennehy, K.M.1
  • 43
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • Denning TL, et al. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol. 2007;8(10):1086-94.
    • (2007) Nat Immunol , vol.8 , Issue.10 , pp. 1086-1094
    • Denning, T.L.1
  • 44
    • 1842477227 scopus 로고    scopus 로고
    • A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells
    • Dillon S, et al. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol. 2004;172(8):4733-43.
    • (2004) J Immunol , vol.172 , Issue.8 , pp. 4733-4743
    • Dillon, S.1
  • 45
    • 32944463876 scopus 로고    scopus 로고
    • Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigenpresenting cells and immunological tolerance
    • Dillon S, et al. Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigenpresenting cells and immunological tolerance. J Clin Invest. 2006;116(4):916-28.
    • (2006) J Clin Invest , vol.116 , Issue.4 , pp. 916-928
    • Dillon, S.1
  • 47
    • 0036786447 scopus 로고    scopus 로고
    • Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering
    • Edwards AD, et al. Microbial recognition via Toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J Immunol. 2002;169(7):3652-60.
    • (2002) J Immunol , vol.169 , Issue.7 , pp. 3652-3660
    • Edwards, A.D.1
  • 48
    • 84958544987 scopus 로고    scopus 로고
    • Role of IL-22 in microbial host defense
    • (Chapter 10)
    • Eidenschenk C, et al. Role of IL-22 in microbial host defense. Curr Top Microbiol Immunol. 2014;380(Chapter 10):213-36.
    • (2014) Curr Top Microbiol Immunol , vol.380 , pp. 213-236
    • Eidenschenk, C.1
  • 49
    • 84875323963 scopus 로고    scopus 로고
    • Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers
    • R. Lang, ed
    • Elcombe SE, et al. Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers. R. Lang, ed. PLoS One. 2013;8(3):e60086.
    • (2013) Plos One , vol.8 , Issue.3
    • Elcombe, S.E.1
  • 50
    • 0029118395 scopus 로고
    • IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes
    • Finbloom DS, Winestock KD. IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes. J Immunol. 1995;155(3):1079-90.
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1079-1090
    • Finbloom, D.S.1    Winestock, K.D.2
  • 51
    • 0025889028 scopus 로고
    • IL-10 inhibits cytokine production by activated macrophages
    • Fiorentino DF, et al. IL-10 inhibits cytokine production by activated macrophages. J Immunol. 1991;147(11):3815-22.
    • (1991) J Immunol , vol.147 , Issue.11 , pp. 3815-3822
    • Fiorentino, D.F.1
  • 52
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989;170(6):2081-95.
    • (1989) J Exp Med , vol.170 , Issue.6 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 53
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune infl ammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald DC, et al. Suppression of autoimmune infl ammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol. 2007;8(12):1372-9.
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1372-1379
    • Fitzgerald, D.C.1
  • 54
    • 0031985903 scopus 로고    scopus 로고
    • Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: Role of the p38 and p42/44 mitogen-activated protein kinases
    • Foey AD, et al. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases. J Immunol. 1998;160(2):920-8.
    • (1998) J Immunol , vol.160 , Issue.2 , pp. 920-928
    • Foey, A.D.1
  • 55
    • 84856567798 scopus 로고    scopus 로고
    • IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: A critical mechanism for protection from severe immunopathology during malaria infection
    • Freitas do Rosário AP, et al. IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection. J Immunol. 2012;188(3):1178-90.
    • (2012) J Immunol , vol.188 , Issue.3 , pp. 1178-1190
    • Freitas Do Rosário, A.P.1
  • 56
    • 33646408493 scopus 로고    scopus 로고
    • Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response
    • Fujita S, et al. Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response. Blood. 2006;107(9):3656-64.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3656-3664
    • Fujita, S.1
  • 57
    • 84865417805 scopus 로고    scopus 로고
    • Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production
    • Gaba A, et al. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. J Immunol. 2012;189(5):2089-93.
    • (2012) J Immunol , vol.189 , Issue.5 , pp. 2089-2093
    • Gaba, A.1
  • 58
    • 77955859470 scopus 로고    scopus 로고
    • Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    • Gandhi R, et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010;11(9):846-53.
    • (2010) Nat Immunol , vol.11 , Issue.9 , pp. 846-853
    • Gandhi, R.1
  • 59
    • 0037237593 scopus 로고    scopus 로고
    • Mycobacteria target DC-SIGN to suppress dendritic cell function
    • Geijtenbeek TBH, et al. Mycobacteria target DC-SIGN to suppress dendritic cell function. J Exp Med. 2003;197(1):7-17.
    • (2003) J Exp Med , vol.197 , Issue.1 , pp. 7-17
    • Geijtenbeek, T.1
  • 60
    • 0029984051 scopus 로고    scopus 로고
    • Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10
    • Gerosa F, et al. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10. J Exp Med. 1996;183(6):2559-69.
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2559-2569
    • Gerosa, F.1
  • 61
    • 77958584113 scopus 로고    scopus 로고
    • Generation of pathogenic T(H) 17 cells in the absence of TGF-β signalling
    • Ghoreschi K, et al. Generation of pathogenic T(H) 17 cells in the absence of TGF-β signalling. Nature. 2010;467(7318):967-71.
    • (2010) Nature , vol.467 , Issue.7318 , pp. 967-971
    • Ghoreschi, K.1
  • 62
    • 69449089454 scopus 로고    scopus 로고
    • IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig production
    • Giordani L, et al. IFN-alpha amplifies human naive B cell TLR-9-mediated activation and Ig production. J Leukoc Biol. 2009;86(2):261-71.
    • (2009) J Leukoc Biol , vol.86 , Issue.2 , pp. 261-271
    • Giordani, L.1
  • 63
    • 84869116884 scopus 로고    scopus 로고
    • A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes
    • Glasmacher E, et al. A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012;338(6109):975-80.
    • (2012) Science , vol.338 , Issue.6109 , pp. 975-980
    • Glasmacher, E.1
  • 64
    • 84855318412 scopus 로고    scopus 로고
    • IL-10 and IL-10 receptor defects in humans
    • Glocker E-O, et al. IL-10 and IL-10 receptor defects in humans. Ann N Y Acad Sci. 2011;1246:102-7.
    • (2011) Ann N Y Acad Sci , vol.1246 , pp. 102-107
    • Glocker, E.-O.1
  • 65
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
    • Groux H, et al. Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells. J Exp Med. 1996;184(1):19-29.
    • (1996) J Exp Med , vol.184 , Issue.1 , pp. 19-29
    • Groux, H.1
  • 66
    • 79951740151 scopus 로고    scopus 로고
    • Type I interferon inhibits interleukin-1 production and infl ammasome activation
    • Guarda G, et al. Type I interferon inhibits interleukin-1 production and infl ammasome activation. Immunity. 2011;34(2):213-23.
    • (2011) Immunity , vol.34 , Issue.2 , pp. 213-223
    • Guarda, G.1
  • 67
    • 79951772860 scopus 로고    scopus 로고
    • Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    • Hadis U, et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity. 2011;34(2):237-46.
    • (2011) Immunity , vol.34 , Issue.2 , pp. 237-246
    • Hadis, U.1
  • 68
    • 30544451546 scopus 로고    scopus 로고
    • Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    • Häcker H, et al. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 2006;439(7073):204-7.
    • (2006) Nature , vol.439 , Issue.7073 , pp. 204-207
    • Häcker, H.1
  • 69
    • 0042333419 scopus 로고    scopus 로고
    • Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology
    • Higgins SC, et al. Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J Immunol. 2003;171(6):3119-27.
    • (2003) J Immunol , vol.171 , Issue.6 , pp. 3119-3127
    • Higgins, S.C.1
  • 70
    • 0029148046 scopus 로고
    • Functional regions of the mouse interleukin-10 receptor cytoplasmic domain
    • Ho AS, et al. Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol Cell Biol. 1995;15(9):5043-53.
    • (1995) Mol Cell Biol , vol.15 , Issue.9 , pp. 5043-5053
    • Ho, A.S.1
  • 71
    • 84869455238 scopus 로고    scopus 로고
    • MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
    • Hoshi N, et al. MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun. 2012;3:1120.
    • (2012) Nat Commun , vol.3 , pp. 1120
    • Hoshi, N.1
  • 72
    • 33646595287 scopus 로고    scopus 로고
    • IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins
    • Hu X, et al. IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins. Immunity. 2006;24(5):563-74.
    • (2006) Immunity , vol.24 , Issue.5 , pp. 563-574
    • Hu, X.1
  • 73
    • 84870873399 scopus 로고    scopus 로고
    • Interleukin-27: Balancing protective and pathological immunity
    • Hunter CA, Kastelein R. Interleukin-27: balancing protective and pathological immunity. Immunity. 2012;37(6):960-9.
    • (2012) Immunity , vol.37 , Issue.6 , pp. 960-969
    • Hunter, C.A.1    Kastelein, R.2
  • 74
    • 8744258956 scopus 로고    scopus 로고
    • Chromatin-level regulation of the IL10 gene in T cells
    • Im S-H, et al. Chromatin-level regulation of the IL10 gene in T cells. J Biol Chem. 2004;279(45):46818-25.
    • (2004) J Biol Chem , vol.279 , Issue.45 , pp. 46818-46825
    • Im, S.-H.1
  • 75
    • 84875781795 scopus 로고    scopus 로고
    • Post-transcriptional regulatory networks in immunity
    • Ivanov P, Anderson P. Post-transcriptional regulatory networks in immunity. Immunol Rev. 2013;253(1):253-72.
    • (2013) Immunol Rev , vol.253 , Issue.1 , pp. 253-272
    • Ivanov, P.1    Erson, P.2
  • 76
    • 84876436991 scopus 로고    scopus 로고
    • Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells
    • Iwasaki Y, et al. Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells. Eur J Immunol. 2013;43(4):1063-73.
    • (2013) Eur J Immunol , vol.43 , Issue.4 , pp. 1063-1073
    • Iwasaki, Y.1
  • 77
    • 33847144180 scopus 로고    scopus 로고
    • Conventional T-bet(+)Foxp3(−) Th1 cells are the major source of hostprotective regulatory IL-10 during intracellular protozoan infection
    • Jankovic D, et al. Conventional T-bet(+)Foxp3(−) Th1 cells are the major source of hostprotective regulatory IL-10 during intracellular protozoan infection. J Exp Med. 2007;204(2):273-83.
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 273-283
    • Jankovic, D.1
  • 78
    • 44749088349 scopus 로고    scopus 로고
    • Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics
    • Jarnicki AG, et al. Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J Immunol. 2008;180(6):3797-806.
    • (2008) J Immunol , vol.180 , Issue.6 , pp. 3797-3806
    • Jarnicki, A.G.1
  • 79
    • 28244474539 scopus 로고    scopus 로고
    • Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster
    • Jones EA, Flavell RA. Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster. J Immunol. 2005;175(11):7437-46.
    • (2005) J Immunol , vol.175 , Issue.11 , pp. 7437-7446
    • Jones, E.A.1    Flavell, R.A.2
  • 80
    • 69549129472 scopus 로고    scopus 로고
    • TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells
    • Kaiser F, et al. TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells. J Exp Med. 2009;206(9):1863-71.
    • (2009) J Exp Med , vol.206 , Issue.9 , pp. 1863-1871
    • Kaiser, F.1
  • 82
    • 0346727295 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice
    • Kanters E, et al. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003;112(8):1176-85.
    • (2003) J Clin Invest , vol.112 , Issue.8 , pp. 1176-1185
    • Kanters, E.1
  • 83
    • 76249101454 scopus 로고    scopus 로고
    • Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the delta-like-4/Notch axis
    • Kassner N, et al. Cutting edge: plasmacytoid dendritic cells induce IL-10 production in T cells via the delta-like-4/Notch axis. J Immunol. 2010;184(2):550-4.
    • (2010) J Immunol , vol.184 , Issue.2 , pp. 550-554
    • Kassner, N.1
  • 84
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: Related but functionally distinct regulators of infl ammation
    • Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of infl ammation. Annu Rev Immunol. 2007;25:221-42.
    • (2007) Annu Rev Immunol , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 85
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol. 2010;11(5):373-84.
    • (2010) Nat Immunol , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 86
    • 50049122380 scopus 로고    scopus 로고
    • The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro-and anti-inflammatory gene expression
    • Kim C, et al. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro-and anti-inflammatory gene expression. Nat Immunol. 2008;9(9):1019-27.
    • (2008) Nat Immunol , vol.9 , Issue.9 , pp. 1019-1027
    • Kim, C.1
  • 87
    • 0033152267 scopus 로고    scopus 로고
    • The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines
    • Kim JI, et al. The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity. 1999;10(6):745-51.
    • (1999) Immunity , vol.10 , Issue.6 , pp. 745-751
    • Kim, J.I.1
  • 88
    • 0026549323 scopus 로고
    • Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
    • Kim JM, et al. Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes. J Immunol. 1992;148(11):3618-23.
    • (1992) J Immunol , vol.148 , Issue.11 , pp. 3618-3623
    • Kim, J.M.1
  • 89
    • 15444367812 scopus 로고    scopus 로고
    • P38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection
    • Kim L, et al. p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection. J Immunol. 2005;174(7):4178-84.
    • (2005) J Immunol , vol.174 , Issue.7 , pp. 4178-4184
    • Kim, L.1
  • 90
    • 69549126213 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced infl ammatory responses
    • Kimura A, et al. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced infl ammatory responses. J Exp Med. 2009;206(9):2027-35.
    • (2009) J Exp Med , vol.206 , Issue.9 , pp. 2027-2035
    • Kimura, A.1
  • 91
    • 0142219250 scopus 로고    scopus 로고
    • Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis
    • Kitani A, et al. Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis. J Exp Med. 2003;198(8):1179-88.
    • (2003) J Exp Med , vol.198 , Issue.8 , pp. 1179-1188
    • Kitani, A.1
  • 92
    • 0030799157 scopus 로고    scopus 로고
    • Identification and functional characterization of a second chain of the interleukin-10 receptor complex
    • Kotenko SV, et al. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J. 1997;16(19):5894-903.
    • (1997) EMBO J , vol.16 , Issue.19 , pp. 5894-5903
    • Kotenko, S.V.1
  • 93
    • 84865179916 scopus 로고    scopus 로고
    • Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in infl ammation
    • Kratochvill F, et al. Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in infl ammation. Mol Syst Biol. 2011;7(1):560.
    • (2011) Mol Syst Biol , vol.7 , Issue.1 , pp. 560
    • Kratochvill, F.1
  • 94
    • 79951671510 scopus 로고    scopus 로고
    • IRF5 promotes infl ammatory macrophage polarization and TH1-TH17 responses
    • Krausgruber T, et al. IRF5 promotes infl ammatory macrophage polarization and TH1-TH17 responses. Nat Immunol. 2011;12(3):231-8.
    • (2011) Nat Immunol , vol.12 , Issue.3 , pp. 231-238
    • Krausgruber, T.1
  • 95
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kühn R, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75(2):263-74.
    • (1993) Cell , vol.75 , Issue.2 , pp. 263-274
    • Kühn, R.1
  • 96
    • 4644369302 scopus 로고    scopus 로고
    • Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
    • de La Rosa M, et al. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. European J Immunol. 2004;34(9):2480-8.
    • (2004) European J Immunol , vol.34 , Issue.9 , pp. 2480-2488
    • De La Rosa, M.1
  • 97
    • 42649111367 scopus 로고    scopus 로고
    • TLR-activated B cells suppress T cell-mediated autoimmunity
    • Lampropoulou V, et al. TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol. 2008;180(7):4763-73.
    • (2008) J Immunol , vol.180 , Issue.7 , pp. 4763-4773
    • Lampropoulou, V.1
  • 98
    • 58249109466 scopus 로고    scopus 로고
    • A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells
    • Lee C-G, et al. A distal cis-regulatory element, CNS-9, controls NFAT1 and IRF4-mediated IL-10 gene activation in T helper cells. Mol Immunol. 2009;46(4):613-21.
    • (2009) Mol Immunol , vol.46 , Issue.4 , pp. 613-621
    • Lee, C.-G.1
  • 99
    • 84863184174 scopus 로고    scopus 로고
    • Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells
    • Lee C-G, et al. Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells. J Immunol. 2012;188(5):2244-53.
    • (2012) J Immunol , vol.188 , Issue.5 , pp. 2244-2253
    • Lee, C.-G.1
  • 100
    • 0035339884 scopus 로고    scopus 로고
    • IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells
    • Levings MK, et al. IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells. J Immunol. 2001;166(9):5530-9.
    • (2001) J Immunol , vol.166 , Issue.9 , pp. 5530-5539
    • Levings, M.K.1
  • 101
    • 41549169557 scopus 로고    scopus 로고
    • Contextual regulation of infl ammation: A duet by transforming growth factor-beta and interleukin-10
    • Li MO, Flavell RA. Contextual regulation of infl ammation: a duet by transforming growth factor-beta and interleukin-10. Immunity. 2008;28(4):468-76.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 468-476
    • Li, M.O.1    Flavell, R.A.2
  • 102
    • 84867861268 scopus 로고    scopus 로고
    • BATF-JUN is critical for IRF4-mediated transcription in T cells
    • Li P, et al. BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012;490(7421):543-6.
    • (2012) Nature , vol.490 , Issue.7421 , pp. 543-546
    • Li, P.1
  • 103
    • 33744783446 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPKand NF-kappaB-induced CCAAT/enhancer-binding protein delta in mouse macrophages
    • Liu Y-W, et al. Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPKand NF-kappaB-induced CCAAT/enhancer-binding protein delta in mouse macrophages. Cell Signal. 2006;18(9):1492-500.
    • (2006) Cell Signal , vol.18 , Issue.9 , pp. 1492-1500
    • Liu, Y.-W.1
  • 104
    • 21244502077 scopus 로고    scopus 로고
    • ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus
    • Lucas M, et al. ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus. J Immunol. 2005;175(1):469-77.
    • (2005) J Immunol , vol.175 , Issue.1 , pp. 469-477
    • Lucas, M.1
  • 105
    • 77953411618 scopus 로고    scopus 로고
    • MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation
    • Ma F, et al. MicroRNA-466l upregulates IL-10 expression in TLR-triggered macrophages by antagonizing RNA-binding protein tristetraprolin-mediated IL-10 mRNA degradation. J Immunol. 2010;184(11):6053-9.
    • (2010) J Immunol , vol.184 , Issue.11 , pp. 6053-6059
    • Ma, F.1
  • 106
    • 0035958007 scopus 로고    scopus 로고
    • The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages
    • Ma W, et al. The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J Biol Chem. 2001;276(17):13664-74.
    • (2001) J Biol Chem , vol.276 , Issue.17 , pp. 13664-13674
    • Ma, W.1
  • 107
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005;5(6):472-84.
    • (2005) Nat Rev Immunol , vol.5 , Issue.6 , pp. 472-484
    • Macian, F.1
  • 108
    • 70149098555 scopus 로고    scopus 로고
    • Nonredundant roles for B cell-derived IL-10 in immune counter-regulation
    • Madan R, et al. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol. 2009;183(4):2312-20.
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2312-2320
    • Madan, R.1
  • 109
    • 0038446051 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
    • Martin M, et al. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol. 2003;171(2):717-25.
    • (2003) J Immunol , vol.171 , Issue.2 , pp. 717-725
    • Martin, M.1
  • 110
    • 42649120075 scopus 로고    scopus 로고
    • Regulation and functions of Blimp-1 in T and B lymphocytes. How TCRS bind MHCS, peptides, and coreceptors
    • Martins G, Calame K. Regulation and functions of Blimp-1 in T and B lymphocytes. How TCRS bind MHCS, peptides, and coreceptors. Annu Rev Immunol. 2008;26:133-169.
    • (2008) Annu Rev Immunol , vol.26 , pp. 133-169
    • Martins, G.1    Calame, K.2
  • 111
    • 33646010346 scopus 로고    scopus 로고
    • Transcriptional repressor Blimp-1 regulates T cell homeostasis and function
    • Martins GA, et al. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol. 2006;7(5):457-65.
    • (2006) Nat Immunol , vol.7 , Issue.5 , pp. 457-465
    • Martins, G.A.1
  • 112
    • 84255162073 scopus 로고    scopus 로고
    • Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection
    • Mayer-Barber KD, et al. Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection. Immunity. 2011;35(6):1023-34.
    • (2011) Immunity , vol.35 , Issue.6 , pp. 1023-1034
    • Mayer-Barber, K.D.1
  • 113
    • 55149111143 scopus 로고    scopus 로고
    • Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation
    • Maynard C, Weaver C. Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev. 2008;226:219-33.
    • (2008) Immunol Rev , vol.226 , pp. 219-233
    • Maynard, C.1    Weaver, C.2
  • 114
    • 34548131112 scopus 로고    scopus 로고
    • Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3-precursor cells in the absence of interleukin 10
    • Maynard CL, et al. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3-precursor cells in the absence of interleukin 10. Nat Immunol. 2007;8(9):931-41.
    • (2007) Nat Immunol , vol.8 , Issue.9 , pp. 931-941
    • Maynard, C.L.1
  • 115
    • 36248965294 scopus 로고    scopus 로고
    • TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
    • McGeachy MJ, et al. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat Immunol. 2007;8(12):1390-7.
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1390-1397
    • McGeachy, M.J.1
  • 116
    • 84881454396 scopus 로고    scopus 로고
    • TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production
    • McNab FW, et al. TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production. J Immunol. 2013;191(4):1732-43.
    • (2013) J Immunol , vol.191 , Issue.4 , pp. 1732-1743
    • McNab, F.W.1
  • 117
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz MA, et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996;84(3):431-42.
    • (1996) Cell , vol.84 , Issue.3 , pp. 431-442
    • Meraz, M.A.1
  • 118
    • 0030584733 scopus 로고    scopus 로고
    • IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
    • Meyaard L, et al. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses. J Immunol. 1996;156(8):2776-82.
    • (1996) J Immunol , vol.156 , Issue.8 , pp. 2776-2782
    • Meyaard, L.1
  • 119
    • 0035062021 scopus 로고    scopus 로고
    • Interleukin-10 and the interleukin-10 receptor
    • Moore K et al. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001;19:683-765.
    • (2001) Annu Rev Immunol , vol.19 , pp. 683-765
    • Moore, K.1
  • 120
    • 0025335354 scopus 로고
    • Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
    • Moore KW, et al. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI. Science. 1990;248(4960):1230-4.
    • (1990) Science , vol.248 , Issue.4960 , pp. 1230-1234
    • Moore, K.W.1
  • 121
    • 79954992071 scopus 로고    scopus 로고
    • The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
    • Motomura Y, et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol. 2011;12(5):450-9.
    • (2011) Nat Immunol , vol.12 , Issue.5 , pp. 450-459
    • Motomura, Y.1
  • 122
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai M, et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol. 2009;10(11):1178-84.
    • (2009) Nat Immunol , vol.10 , Issue.11 , pp. 1178-1184
    • Murai, M.1
  • 123
    • 84879689439 scopus 로고    scopus 로고
    • Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks
    • Murphy TL, Tussiwand R, Murphy KM. Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat Rev Immunol. 2013;13(7):499-509.
    • (2013) Nat Rev Immunol , vol.13 , Issue.7 , pp. 499-509
    • Murphy, T.L.1    Tussiwand, R.2    Murphy, K.M.3
  • 124
    • 70149105112 scopus 로고    scopus 로고
    • IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
    • Murugaiyan G, et al. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol. 2009;183(4):2435-43.
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2435-2443
    • Murugaiyan, G.1
  • 125
    • 84855387052 scopus 로고    scopus 로고
    • Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase
    • Nandan D, et al. Myeloid cell IL-10 production in response to leishmania involves inactivation of glycogen synthase kinase-3β downstream of phosphatidylinositol-3 kinase. J Immunol. 2012;188(1):367-78.
    • (2012) J Immunol , vol.188 , Issue.1 , pp. 367-378
    • Nandan, D.1
  • 126
    • 0036479125 scopus 로고    scopus 로고
    • MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
    • Neininger A, et al. MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem. 2002;277(5):3065-8.
    • (2002) J Biol Chem , vol.277 , Issue.5 , pp. 3065-3068
    • Neininger, A.1
  • 127
    • 1542409922 scopus 로고    scopus 로고
    • Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells
    • Netea MG, et al. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J Immunol. 2004;172(6):3712-8.
    • (2004) J Immunol , vol.172 , Issue.6 , pp. 3712-3718
    • Netea, M.G.1
  • 128
    • 84991599250 scopus 로고    scopus 로고
    • Role of Blimp-1 in programing Th effector cells into IL-10 producers
    • Neumann C, et al. Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med. 2014;204(2):285.
    • (2014) J Exp Med , vol.204 , Issue.2 , pp. 285
    • Neumann, C.1
  • 129
    • 34249678457 scopus 로고    scopus 로고
    • T(H)1 cells control themselves by producing interleukin-10
    • O’Garra A, Vieira P. T(H)1 cells control themselves by producing interleukin-10. Nat Rev Immunol. 2007;7(6):425-8.
    • (2007) Nat Rev Immunol , vol.7 , Issue.6 , pp. 425-428
    • O’Garra, A.1    Vieira, P.2
  • 130
    • 50949130076 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
    • Ohtani M, et al. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood. 2008;112(3):635-43.
    • (2008) Blood , vol.112 , Issue.3 , pp. 635-643
    • Ohtani, M.1
  • 131
    • 79953048089 scopus 로고    scopus 로고
    • Regulation and functions of the IL-10 family of cytokines in infl ammation and disease
    • Ouyang W, et al. Regulation and functions of the IL-10 family of cytokines in infl ammation and disease. Annu Rev Immunol. 2011;29(1):71-109.
    • (2011) Annu Rev Immunol , vol.29 , Issue.1 , pp. 71-109
    • Ouyang, W.1
  • 132
    • 84866166941 scopus 로고    scopus 로고
    • Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback
    • Pattison MJ, MacKenzie KF, Arthur JSC. Inhibition of JAKs in macrophages increases lipopolysaccharide-induced cytokine production by blocking IL-10-mediated feedback. J Immunol. 2012;189(6):2784-92.
    • (2012) J Immunol , vol.189 , Issue.6 , pp. 2784-2792
    • Pattison, M.J.1    Mackenzie, K.F.2    Arthur, J.S.C.3
  • 133
    • 0032858430 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells
    • Platzer C, et al. Cyclic adenosine monophosphate-responsive elements are involved in the transcriptional activation of the human IL-10 gene in monocytic cells. Eur J Immunol. 1999;29(10):3098-104.
    • (1999) Eur J Immunol , vol.29 , Issue.10 , pp. 3098-3104
    • Platzer, C.1
  • 134
    • 69249083836 scopus 로고    scopus 로고
    • Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
    • Pot C, et al. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009;183(2):797-801.
    • (2009) J Immunol , vol.183 , Issue.2 , pp. 797-801
    • Pot, C.1
  • 135
    • 82755160805 scopus 로고    scopus 로고
    • Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27
    • Pot C, et al. Induction of regulatory Tr1 cells and inhibition of T(H)17 cells by IL-27. Semin Immunol. 2011;23(6):438-45.
    • (2011) Semin Immunol , vol.23 , Issue.6 , pp. 438-445
    • Pot, C.1
  • 136
    • 0034235224 scopus 로고    scopus 로고
    • Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region
    • Powell MJ, et al. Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′-untranslated region. J Immunol. 2000;165(1):292-6.
    • (2000) J Immunol , vol.165 , Issue.1 , pp. 292-296
    • Powell, M.J.1
  • 137
    • 74949116731 scopus 로고    scopus 로고
    • Pivotal advance: Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes
    • Qin Z, et al. Pivotal advance: Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded microRNA specifically induce IL-6 and IL-10 secretion by macrophages and monocytes. J Leukoc Biol. 2010;87(1):25-34.
    • (2010) J Leukoc Biol , vol.87 , Issue.1 , pp. 25-34
    • Qin, Z.1
  • 138
    • 84958545552 scopus 로고    scopus 로고
    • The role of microRNAs in the control and mechanism of action of IL-10
    • (Chapter 7)
    • Quinn SR, O’Neill LA. The role of microRNAs in the control and mechanism of action of IL-10. Curr Top Microbiol Immunol. 2014;380(Chapter 7):145-55.
    • (2014) Curr Top Microbiol Immunol , vol.380 , pp. 145-155
    • Quinn, S.R.1    O’Neill, L.A.2
  • 139
  • 140
    • 33747114270 scopus 로고    scopus 로고
    • Role of toll-like receptors in spontaneous commensal-dependent colitis
    • Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity. 2006;25(2):319-29.
    • (2006) Immunity , vol.25 , Issue.2 , pp. 319-329
    • Rakoff-Nahoum, S.1    Hao, L.2    Medzhitov, R.3
  • 141
    • 84863936555 scopus 로고    scopus 로고
    • P38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation
    • Risco A, et al. p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation. Proc Natl Acad Sci U S A. 2012;109(28):11200-5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.28 , pp. 11200-11205
    • Risco, A.1
  • 142
    • 9244237038 scopus 로고    scopus 로고
    • T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    • Roers A, et al. T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. J Exp Med. 2004;200(10):1289-97.
    • (2004) J Exp Med , vol.200 , Issue.10 , pp. 1289-1297
    • Roers, A.1
  • 143
    • 20244363662 scopus 로고    scopus 로고
    • Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
    • Rogers NC, et al. Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins. Immunity. 2005;22(4):507-17.
    • (2005) Immunity , vol.22 , Issue.4 , pp. 507-517
    • Rogers, N.C.1
  • 144
    • 33746338535 scopus 로고    scopus 로고
    • Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
    • Roncarolo MG, et al. Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev. 2006;212:28-50.
    • (2006) Immunol Rev , vol.212 , pp. 28-50
    • Roncarolo, M.G.1
  • 145
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits infl ammation at environmental interfaces
    • Rubtsov YP, et al. Regulatory T cell-derived interleukin-10 limits infl ammation at environmental interfaces. Immunity. 2008;28(4):546-58.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 546-558
    • Rubtsov, Y.P.1
  • 146
    • 80053614883 scopus 로고    scopus 로고
    • Regulation of interleukin-10 and interleukin-22 expression in T helper cells
    • Rutz S, Ouyang W. Regulation of interleukin-10 and interleukin-22 expression in T helper cells. Curr Opin Immunol. 2011;23(5):605-12.
    • (2011) Curr Opin Immunol , vol.23 , Issue.5 , pp. 605-612
    • Rutz, S.1    Ouyang, W.2
  • 147
    • 42149162217 scopus 로고    scopus 로고
    • Notch regulates IL-10 production by T helper 1 cells
    • Rutz S, et al. Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci U S A. 2008;105(9):3497-502.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.9 , pp. 3497-3502
    • Rutz, S.1
  • 148
    • 81255136238 scopus 로고    scopus 로고
    • Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells
    • Rutz S, et al. Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 2011;12(12):1238-45.
    • (2011) Nat Immunol , vol.12 , Issue.12 , pp. 1238-1245
    • Rutz, S.1
  • 149
    • 84922479625 scopus 로고    scopus 로고
    • The IL-20 subfamily of cytokines - From host defence to tissue homeostasis
    • Rutz S, Wang X, Ouyang W. The IL-20 subfamily of cytokines - from host defence to tissue homeostasis. Nat Rev Immunol. 2014;14(12):783-95.
    • (2014) Nat Rev Immunol , vol.14 , Issue.12 , pp. 783-795
    • Rutz, S.1    Wang, X.2    Ouyang, W.3
  • 150
    • 84871168621 scopus 로고    scopus 로고
    • B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells
    • Salehi S, et al. B lymphocyte-induced maturation protein-1 contributes to intestinal mucosa homeostasis by limiting the number of IL-17-producing CD4+ T cells. J Immunol. 2012;189(12):5682-93.
    • (2012) J Immunol , vol.189 , Issue.12 , pp. 5682-5693
    • Salehi, S.1
  • 151
    • 31144452241 scopus 로고    scopus 로고
    • Essential role of MAPK phosphatase-1 in the negative control of innate immune responses
    • Salojin KV, et al. Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol. 2006;176(3):1899-907.
    • (2006) J Immunol , vol.176 , Issue.3 , pp. 1899-1907
    • Salojin, K.V.1
  • 152
    • 45249098952 scopus 로고    scopus 로고
    • Control of mRNA decay by phosphorylation of tristetraprolin
    • Sandler H, Stoecklin G. Control of mRNA decay by phosphorylation of tristetraprolin. Biochem Soc Trans. 2008;36(Pt 3):491-6.
    • (2008) Biochem Soc Trans , vol.36 , pp. 491-496
    • Sandler, H.1    Stoecklin, G.2
  • 153
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M, O’Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010;10(3):170-81.
    • (2010) Nat Rev Immunol , vol.10 , Issue.3 , pp. 170-181
    • Saraiva, M.1    O’Garra, A.2
  • 154
    • 23244441280 scopus 로고    scopus 로고
    • Identification of a macrophage-specific chromatin signature in the IL-10 locus
    • Saraiva M, et al. Identification of a macrophage-specific chromatin signature in the IL-10 locus. J Immunol. 2005;175(2):1041-6.
    • (2005) J Immunol , vol.175 , Issue.2 , pp. 1041-1046
    • Saraiva, M.1
  • 155
    • 68649116551 scopus 로고    scopus 로고
    • Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
    • Saraiva M, et al. Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose. Immunity. 2009;31(2):209-19.
    • (2009) Immunity , vol.31 , Issue.2 , pp. 209-219
    • Saraiva, M.1
  • 156
    • 79251553145 scopus 로고    scopus 로고
    • TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells
    • Sayi A, et al. TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells. J Immunol. 2011;186(2):878-90.
    • (2011) J Immunol , vol.186 , Issue.2 , pp. 878-890
    • Sayi, A.1
  • 157
    • 70249145543 scopus 로고    scopus 로고
    • Tristetraprolin is required for full anti-infl ammatory response of murine macrophages to IL-10
    • Schaljo B, et al. Tristetraprolin is required for full anti-infl ammatory response of murine macrophages to IL-10. J Immunol. 2009;183(2):1197-206.
    • (2009) J Immunol , vol.183 , Issue.2 , pp. 1197-1206
    • Schaljo, B.1
  • 158
    • 25444492676 scopus 로고    scopus 로고
    • IL-12 family members: Differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages
    • Schuetze N, et al. IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages. Int Immunol. 2005;17(5):649-59.
    • (2005) Int Immunol , vol.17 , Issue.5 , pp. 649-659
    • Schuetze, N.1
  • 159
    • 65549118531 scopus 로고    scopus 로고
    • Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12
    • Schulz EG, et al. Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity. 2009;30(5):673-83.
    • (2009) Immunity , vol.30 , Issue.5 , pp. 673-683
    • Schulz, E.G.1
  • 160
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • Sellon RK, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 1998;66(11):5224-31.
    • (1998) Infect Immun , vol.66 , Issue.11 , pp. 5224-5231
    • Sellon, R.K.1
  • 161
    • 65249155995 scopus 로고    scopus 로고
    • Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a
    • Sharma A, et al. Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc Natl Acad Sci U S A. 2009;106(14):5761-6.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.14 , pp. 5761-5766
    • Sharma, A.1
  • 162
    • 33744907022 scopus 로고    scopus 로고
    • Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation
    • Shaw MH, et al. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. J Immunol. 2006;176(12):7263-71.
    • (2006) J Immunol , vol.176 , Issue.12 , pp. 7263-7271
    • Shaw, M.H.1
  • 163
    • 75649113377 scopus 로고    scopus 로고
    • Negative regulation of TLR4 via targeting of the proinfl ammatory tumor suppressor PDCD4 by the microRNA miR-21
    • Sheedy FJ, et al. Negative regulation of TLR4 via targeting of the proinfl ammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol. 2010;11(2):141-7.
    • (2010) Nat Immunol , vol.11 , Issue.2 , pp. 141-147
    • Sheedy, F.J.1
  • 164
    • 33644843538 scopus 로고    scopus 로고
    • GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells
    • Shoemaker J, Saraiva M, O’Garra A. GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells. J Immunol. 2006;176(6):3470-9.
    • (2006) J Immunol , vol.176 , Issue.6 , pp. 3470-3479
    • Shoemaker, J.1    Saraiva, M.2    O’Garra, A.3
  • 165
    • 84900428511 scopus 로고    scopus 로고
    • Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-infl ammatory macrophage function
    • Shouval DS, et al. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-infl ammatory macrophage function. Immunity. 2014;40(5):706-19.
    • (2014) Immunity , vol.40 , Issue.5 , pp. 706-719
    • Shouval, D.S.1
  • 166
    • 33845574337 scopus 로고    scopus 로고
    • Interleukin-10 derived from macrophages and/or neutrophils regulates the infl ammatory response to LPS but not the response to CpG DNA
    • Siewe L, et al. Interleukin-10 derived from macrophages and/or neutrophils regulates the infl ammatory response to LPS but not the response to CpG DNA. Eur J Immunol. 2006;36(12):3248-55.
    • (2006) Eur J Immunol , vol.36 , Issue.12 , pp. 3248-3255
    • Siewe, L.1
  • 167
    • 0032853304 scopus 로고    scopus 로고
    • Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: A feedback regulation of Th1 development
    • Skok J, Poudrier J, Gray D. Dendritic cell-derived IL-12 promotes B cell induction of Th2 differentiation: a feedback regulation of Th1 development. J Immunol. 1999;163(8):4284-91.
    • (1999) J Immunol , vol.163 , Issue.8 , pp. 4284-4291
    • Skok, J.1    Poudrier, J.2    Gray, D.3
  • 168
    • 34250659752 scopus 로고    scopus 로고
    • Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan
    • Slack EC, et al. Syk-dependent ERK activation regulates IL-2 and IL-10 production by DC stimulated with zymosan. Eur J Immunol. 2007;37(6):1600-12.
    • (2007) Eur J Immunol , vol.37 , Issue.6 , pp. 1600-1612
    • Slack, E.C.1
  • 169
    • 64849083153 scopus 로고    scopus 로고
    • IL-21 mediates suppressive effects via its induction of IL-10
    • Spolski R, et al. IL-21 mediates suppressive effects via its induction of IL-10. J Immunol. 2009;182(5):2859-67.
    • (2009) J Immunol , vol.182 , Issue.5 , pp. 2859-2867
    • Spolski, R.1
  • 170
    • 34247113857 scopus 로고    scopus 로고
    • IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3
    • Staples KJ, et al. IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3. J Immunol. 2007;178(8):4779-85.
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 4779-4785
    • Staples, K.J.1
  • 171
    • 45249099847 scopus 로고    scopus 로고
    • Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin
    • Stoecklin G, et al. Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem. 2008;283(17):11689-99.
    • (2008) J Biol Chem , vol.283 , Issue.17 , pp. 11689-11699
    • Stoecklin, G.1
  • 172
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic infl ammation of the central nervous system
    • Stumhofer JS, et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic infl ammation of the central nervous system. Nat Immunol. 2006;7(9):937-45.
    • (2006) Nat Immunol , vol.7 , Issue.9 , pp. 937-945
    • Stumhofer, J.S.1
  • 173
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer JS, et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol. 2007;8(12):1363-71.
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1363-1371
    • Stumhofer, J.S.1
  • 174
    • 79952994082 scopus 로고    scopus 로고
    • CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs
    • Sun J, et al. CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat Immunol. 2011;12(4):327-34.
    • (2011) Nat Immunol , vol.12 , Issue.4 , pp. 327-334
    • Sun, J.1
  • 175
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity. 1999;10(1):39-49.
    • (1999) Immunity , vol.10 , Issue.1 , pp. 39-49
    • Takeda, K.1
  • 176
    • 0027441138 scopus 로고
    • Characterization of interleukin-10 receptors on human and mouse cells
    • Tan JC, et al. Characterization of interleukin-10 receptors on human and mouse cells. J Biol Chem. 1993;268(28):21053-9.
    • (1993) J Biol Chem , vol.268 , Issue.28 , pp. 21053-21059
    • Tan, J.C.1
  • 177
    • 66349099956 scopus 로고    scopus 로고
    • Sp1 phosphorylation and its regulation of gene transcription
    • Tan NY, Khachigian LM. Sp1 phosphorylation and its regulation of gene transcription. Mol Cell Biol. 2009;29(10):2483-8.
    • (2009) Mol Cell Biol , vol.29 , Issue.10 , pp. 2483-2488
    • Tan, N.Y.1    Khachigian, L.M.2
  • 178
    • 0034234573 scopus 로고    scopus 로고
    • IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3
    • Tone M, et al. IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3. J Immunol. 2000;165(1):286-91.
    • (2000) J Immunol , vol.165 , Issue.1 , pp. 286-291
    • Tone, M.1
  • 179
    • 79953222926 scopus 로고    scopus 로고
    • Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis
    • Trandem K, et al. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol. 2011;186(6):3642-52.
    • (2011) J Immunol , vol.186 , Issue.6 , pp. 3642-3652
    • Trandem, K.1
  • 180
    • 33847165817 scopus 로고    scopus 로고
    • Interleukin-10 production by effector T cells: Th1 cells show self control
    • Trinchieri G. Interleukin-10 production by effector T cells: Th1 cells show self control. J Exp Med. 2007;204(2):239-43.
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 239-243
    • Trinchieri, G.1
  • 181
    • 67349227471 scopus 로고    scopus 로고
    • The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-infl ammatory mediator mRNAs in murine macrophages
    • Tudor C, et al. The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-infl ammatory mediator mRNAs in murine macrophages. FEBS Lett. 2009;583(12):1933-8.
    • (2009) FEBS Lett , vol.583 , Issue.12 , pp. 1933-1938
    • Tudor, C.1
  • 182
    • 84867884822 scopus 로고    scopus 로고
    • Compensatory dendritic cell development mediated by BATF-IRF interactions
    • Tussiwand R, et al. Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012;490(7421):502-7.
    • (2012) Nature , vol.490 , Issue.7421 , pp. 502-507
    • Tussiwand, R.1
  • 183
    • 33750375612 scopus 로고    scopus 로고
    • Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis
    • Uhlig HH, et al. Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis. J Immunol. 2006;177(9):5852-60.
    • (2006) J Immunol , vol.177 , Issue.9 , pp. 5852-5860
    • Uhlig, H.H.1
  • 184
    • 43449100316 scopus 로고    scopus 로고
    • Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene
    • Unterberger C, et al. Role of STAT3 in glucocorticoid-induced expression of the human IL-10 gene. Mol Immunol. 2008;45(11):3230-7.
    • (2008) Mol Immunol , vol.45 , Issue.11 , pp. 3230-3237
    • Unterberger, C.1
  • 185
    • 84870027825 scopus 로고    scopus 로고
    • STATs shape the active enhancer landscape of T cell populations
    • Vahedi G, et al. STATs shape the active enhancer landscape of T cell populations. Cell. 2012;151(5):981-93.
    • (2012) Cell , vol.151 , Issue.5 , pp. 981-993
    • Vahedi, G.1
  • 186
    • 84876437530 scopus 로고    scopus 로고
    • IL-27 paves different roads to Tr1
    • Vasanthakumar A, Kallies A. IL-27 paves different roads to Tr1. Eur J Immunol. 2013;43(4):882-5.
    • (2013) Eur J Immunol , vol.43 , Issue.4 , pp. 882-885
    • Vasanthakumar, A.1    Kallies, A.2
  • 187
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, et al. Transforming growth factor-beta “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol. 2008;9(12):1341-6.
    • (2008) Nat Immunol , vol.9 , Issue.12 , pp. 1341-1346
    • Veldhoen, M.1
  • 188
    • 57849096553 scopus 로고    scopus 로고
    • The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance
    • Villagra A, et al. The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. Nat Immunol. 2009;10(1):92-100.
    • (2009) Nat Immunol , vol.10 , Issue.1 , pp. 92-100
    • Villagra, A.1
  • 189
    • 0345570521 scopus 로고    scopus 로고
    • The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection
    • Villarino A, et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity. 2003;19(5):645-55.
    • (2003) Immunity , vol.19 , Issue.5 , pp. 645-655
    • Villarino, A.1
  • 190
    • 0031454570 scopus 로고    scopus 로고
    • Immunosuppressive effects of apoptotic cells
    • Voll RE, et al. Immunosuppressive effects of apoptotic cells. Nature. 1997;390(6658):350-1.
    • (1997) Nature , vol.390 , Issue.6658 , pp. 350-351
    • Voll, R.E.1
  • 191
    • 13544254619 scopus 로고    scopus 로고
    • Regulation of IL-10 gene expression in Th2 cells by Jun proteins
    • Wang Z-Y, et al. Regulation of IL-10 gene expression in Th2 cells by Jun proteins. J Immunol. 2005;174(4):2098-105.
    • (2005) J Immunol , vol.174 , Issue.4 , pp. 2098-2105
    • Wang, Z.-Y.1
  • 192
    • 77953917067 scopus 로고    scopus 로고
    • Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation
    • Wei L, et al. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity. 2010;32(6):840-51.
    • (2010) Immunity , vol.32 , Issue.6 , pp. 840-851
    • Wei, L.1
  • 193
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate infl ammatory response
    • Weichhart T, et al. The TSC-mTOR signaling pathway regulates the innate infl ammatory response. Immunity. 2008;29(4):565-77.
    • (2008) Immunity , vol.29 , Issue.4 , pp. 565-577
    • Weichhart, T.1
  • 194
    • 0028299069 scopus 로고
    • Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes
    • Willems F, et al. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur J Immunol. 1994;24(4):1007-9.
    • (1994) Eur J Immunol , vol.24 , Issue.4 , pp. 1007-1009
    • Willems, F.1
  • 195
    • 73249149628 scopus 로고    scopus 로고
    • C-Maf regulates IL-10 expression during Th17 polarization
    • Xu J, et al. c-Maf regulates IL-10 expression during Th17 polarization. J Immunol. 2009;182(10):6226-36.
    • (2009) J Immunol , vol.182 , Issue.10 , pp. 6226-6236
    • Xu, J.1
  • 196
    • 0036569711 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: Central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response
    • Yi A-K, et al. Role of mitogen-activated protein kinases in CpG DNA-mediated IL-10 and IL-12 production: central role of extracellular signal-regulated kinase in the negative feedback loop of the CpG DNA-mediated Th1 response. J Immunol. 2002;168(9):4711-20.
    • (2002) J Immunol , vol.168 , Issue.9 , pp. 4711-4720
    • Yi, A.-K.1
  • 197
    • 80053317358 scopus 로고    scopus 로고
    • MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1
    • Yu H, et al. MKP-1 regulates cytokine mRNA stability through selectively modulation subcellular translocation of AUF1. Cytokine. 2011;56(2):245-55.
    • (2011) Cytokine , vol.56 , Issue.2 , pp. 245-255
    • Yu, H.1
  • 198
    • 34249039859 scopus 로고    scopus 로고
    • Type I interferons protect neonates from acute infl ammation through interleukin 10-producing B cells
    • Zhang X, et al. Type I interferons protect neonates from acute infl ammation through interleukin 10-producing B cells. J Exp Med. 2007;204(5):1107-18.
    • (2007) J Exp Med , vol.204 , Issue.5 , pp. 1107-1118
    • Zhang, X.1
  • 199
    • 33745815324 scopus 로고    scopus 로고
    • Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription
    • Zhang X, Edwards J, Mosser D. Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J Immunol. 2006;177(2):1282-8.
    • (2006) J Immunol , vol.177 , Issue.2 , pp. 1282-1288
    • Zhang, X.1    Edwards, J.2    Mosser, D.3
  • 200
    • 9244263631 scopus 로고    scopus 로고
    • Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
    • Zhu J et al. Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol. 2004;5(11):1157-65.
    • (2004) Nat Immunol , vol.5 , Issue.11 , pp. 1157-1165
    • Zhu, J.1
  • 201
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol. 2010;28:445-89.
    • (2010) Annu Rev Immunol , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 202
    • 0038544646 scopus 로고    scopus 로고
    • IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3
    • Ziegler-Heitbrock L, et al. IFN-alpha induces the human IL-10 gene by recruiting both IFN regulatory factor 1 and Stat3. J Immunol. 2003;171(1):285-90.
    • (2003) J Immunol , vol.171 , Issue.1 , pp. 285-290
    • Ziegler-Heitbrock, L.1
  • 203
    • 84900448316 scopus 로고    scopus 로고
    • Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis
    • Zigmond E, et al. Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity. 2014;40(5):720-33.
    • (2014) Immunity , vol.40 , Issue.5 , pp. 720-733
    • Zigmond, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.