Type i IFN induces IL-10 production in an IL-27-Independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in mycobacterium tuberculosis-infected macrophages

Journal of Immunology

Volumn 193, Issue 7, 2014, Pages 3600-3612

  McNab, Finlay W ^a,d   Ewbank, John ^a   Howes, Ashleigh ^a   Moreira Teixeira, Lucia ^a,b   Martirosyan, Anna ^a   Ghilardi, Nico ^c   Saraiva, Margarida ^a,b   O'Garra, Anne ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^b UNIVERSITY OF MINHO   (Portugal)

^c GENENTECH INC   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 27; STAT1 PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; IL10 PROTEIN, MOUSE; IL1B PROTEIN, MOUSE; IL27 PROTEIN, MOUSE; INTERLEUKIN DERIVATIVE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOREGULATION; LYMPHOID TISSUE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WILD TYPE; ANIMAL; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; MICROBIOLOGY; PATHOLOGY; TUBERCULOSIS;

ANIMALS; INTERFERON TYPE I; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-1BETA; INTERLEUKINS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MICE, KNOCKOUT; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84907215689     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401088     Document Type: Article

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