Glycogen synthase kinase-3 controls IL-10 expression in CD4+ effector T-cell subsets through epigenetic modification of the IL-10 promoter

European Journal of Immunology

Volumn 45, Issue 4, 2015, Pages 1103-1115

  Hill, Elaine V ^a   Ng, T H Sky ^a   Burton, Bronwen R ^a   Oakley, Charly M ^a   Malik, Karim ^a   Wraith, David C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

CD4+ T cells; Epigenetic; Glycogen synthase kinase 3; IL 10

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; HISTONE H3; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; MESSENGER RNA; STAT6 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR C MAF; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR NFIL3; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; GATA3 PROTEIN, MOUSE; HISTONE; IL10 PROTEIN, MOUSE; MAF PROTEIN, MOUSE; NFIL3 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA MODIFICATION; EFFECTOR CELL; ENZYME INHIBITION; EPIGENETICS; HISTONE ACETYLATION; HISTONE METHYLATION; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL; UPREGULATION; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE; DENDRITIC CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENETICS; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; METHYLATION; TRANSPLANTATION;

ACETYLATION; ADOPTIVE TRANSFER; ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELLS, CULTURED; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GATA3 TRANSCRIPTION FACTOR; GLYCOGEN SYNTHASE KINASE 3; HISTONES; HUMANS; INFLAMMATION; INTERLEUKIN-10; METHYLATION; MICE; MICE, KNOCKOUT; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MAF; TH1 CELLS; TH17 CELLS; TH2 CELLS;

EID: 84927103576     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444661     Document Type: Article

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