Inhibitory and stimulatory effects of IL-10 on Human CD8+ T cells

Journal of Immunology

Volumn 160, Issue 7, 1998, Pages 3188-3193

  Groux, Hervé ^a   Bigler, Mike ^a   De Vries, Jan E ^a,b   Roncarolo, Maria Grazia ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVARTIS RESEARCH INSTITUTE   (Austria)

^c UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; HLA ANTIGEN CLASS 1; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RECOMBINANT INTERLEUKIN 10; RECOMBINANT INTERLEUKIN 2;

ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, CD86; CD8-POSITIVE T-LYMPHOCYTES; CLONAL ANERGY; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; EPITOPES; GROWTH INHIBITORS; GROWTH SUBSTANCES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-10; INTERLEUKIN-2; ISOANTIGENS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MEMBRANE GLYCOPROTEINS; MONOCYTES;

EID: 0032055224     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. + T cell clones and peripheral blood T cells. J. Immunol. 149:2378.
2. de Waal Malefyt, R., J. Haanen, H. Spits, M. G. Roncarolo, A. te Velde, C. Figdor, K. Johnson, R. Kastelein, H. Yssel, and J. E. de Vries. 1991. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med. 174:915.
3. de Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
4. Florentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815.
5. Ding, L., P. S. Linsley, L. Y. Huang, R. N. Germain, and E. M. Shevach. 1993. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151:1224.
6. Willems, F., A. Marchant, J. P. Delville, C. Gerard, A. Delvaux, T. Velu, M. de Boer, and M. Goldman. 1994. Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes. Eur. J. Immunol. 24:1007.
7. Chang, C. H., M. Furue, and K. Tamaki. 1995. B7-1 expression of Langerhans cells is up-regulated by proinflammatory cytokines, and is down-regulated by interferon-gamma or by interleukin-10. Eur. J. Immunol. 25:394.
8. Peguet-Navarro, J., C. Moulon, C. Caux, C. Dalbiez-Gauthier, J. Banchereau, and D. Schmitt. 1994. Interleukin-10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells. Eur. J. Immunol. 24:884.
9. Caux, C., C. Massacrier, B. Vanbervliet, C. Barthelemy, Y. J. Liu, and J. Banchereau. 1994. Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells. Int. Immunol. 6:1177.
10. de Waal Malefyt, R., H. Yssel, and J. E. de Vries. 1993. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells: specific inhibition of IL-2 production and proliferation. J. Immunol. 150:4754.
11. Taga, K., H. Mostowski, and G. Tosato. 1993. Human interleukin-10 can directly inhibit T-cell growth. Blood 81:2964.
12. Bejarano, M. T., R. de Waal Malefyt, J. S. Abrams, M. Bigler, R. Bacchetta, J. E. de Vries, and M. G. Roncarolo. 1992. Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures. Int. Immunol. 4:1389.
13. + T cells. J. Exp. Med. 184:19.
14. Roussel, F., E. Garcia, T. Defrance, C. Peronne, N. Vezzio, D. H. Hsu, R. Kastelein, K. W. Moore, and J. Banchereau. 1992. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA 89:1890.
15. Defrance, T., B. Vanbervliet, F. Briere, I. Durand, F. Rousset, and J. Banchereau. 1992. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:671.
16. Taga, K., B. Cherney, and G. Tosato. 1993. IL-10 inhibits apoptotic cell death in human T cells starved of IL-2. Int. Immunol. 5:1599.
17. MacNeil, I. A., T. Suda, K. W. Moore, T. R. Mosmann, and A. Zlotnik. 1990. IL-10, a novel growth cofactor for mature and immature T cells. J. Immunol. 145:4167.
18. Chen, W. F., and A. Zlotnik. 1991. IL-10: a novel cytotoxic T cell differentiation factor. J. Immunol. 147:528.
19. Blazar, B. R., P. A. Taylor, S. Smith, and D. A. Vallera. 1995. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blood 85:842.
20. Wogensen, L., X. Huang, and N. Sarvetnick. 1993. Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J. Exp. Med. 178:175.
21. Wogensen, L., M. S. Lee, and N. Sarvetnick. 1994. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice. J. Exp. Med. 179:1379.
22. Spits, H., G. Keizer, J. Borst, C. Terhorst, A. Hekman, and J. E. de Vries. 1983. Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma 2:423.
23. Herve, P., J. Wijdenes, J. P. Bergerat, P. Bordigoni, N. Milpied, J. Y. Cahn, C. Clement, R. Beliard, B. Morel-Fourrier, E. Racadot, X. Troussard, E. Benz-Lemoine, C. Gaud, M. Legros, M. Attal, M. Kloft, and A. Peters. 1990. Treatment of corticostcroid resistant acute graft-versus-host disease by in vivo administration of anti-interleukin-2 receptor monoclonal antibody (B-B10). Blood 75:1017.
24. Yssel, H., J. E. De Vries, M. Koken, W. Van Blitterswijk, and H. Spits. 1984. Serum-free medium for generation and propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Methods 72:219.
25. Bacchetta, R., M. Bigler, J. L. Touraine, R. Parkman, P. A. Tovo, J. Abrams, R. de Waal Malefyt, J. E. de Vries, and M. G. Roncarolo. 1994. High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells. J. Exp. Med. 179: 493.
26. de Waal Malefyt, R., C. G. Figdor, and J. E. de Vries. 1994. Regulation of human monocyte functions by interleukin-10. In Interieukin-10. J. E. de Vries, and R. de Waal Malefyt, eds. R. G. Landes Company, Austin, TX, pp. 37-52.
27. de Waal Malefyt, R., H. Yssel, M. G. Roncarolo, H. Spits, and J. E. de Vries. 1992. Interleukin-10. Curr. Opin. Immunol. 4:314.
28. Fiorentino, D. F., A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. W. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444.
29. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
30. Bean, A. G. D., R. A. Freiberg, S. Andrade, S. Menon, and A. Zlotnik. 1993. Interleukin 10 protects mice against staphylecoccal enterotoxin B-induced lethal shock. Infect. Immun. 61:4337.
31. Chernoff, A. E., E. V. Granowitz, L. Shapiro, E. Vannier, G. Lonnemann, J. B. Angel, J. S. Kennedy, A. R. Rabson, S. M. Wolff, and C. A. Dinarello. 1995. A randomized, controlled trial of IL-10 in humans: inhibition of inflammatory cytokine production and immune responses. J. Immunol. 154:5492.
32. Holler, E., M. G. Roncarolo, and R. Hintermeier-Knable. 1994. Low incidence of transplant-related complications in patients with high spontaneous cellular IL-10 production prior to conditioning: evidence for a protective role of IL-10 in allogeneic BMT. In Annual Meeting of the EBMT.
33. Krenger, W., K. Snyder, S. Smith, and J. L. Ferrara. 1994. Effects of exogenous interleukin-10 in a murine model of graft-versus-host disease to minor histocompatibility antigens. Transplantation 58:1251.
34. Lee, M.-S., L. Wogensen, J. Shizuru, M. B. A. Oldstone, and N. Sarvetnick. 1994. Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J. Clin. Invest. 93:1332.
35. Jenkins, M. K., and R. H. Schwartz. 1987. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165:302.
36. + T cell: receptor dependent cytolysis in the absence of interleukin-2 production. Science 251:1228.
37. Boussiotis, V. A., J. G. Gribben, G. J. Freeman, and L. M. Nadler. 1994. Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance. Curr. Opin. Immunol. 6:797.
38. Jendrisak, G., J. Gamero, T. Mohanakumar, and M. Jendrisak. 1993. Clonal anergy induction by monoclonal antibodies to CD4. LFA-1, and ICAM-1. Transplant. Proc. 25:828.
39. Boussiotis, V. A., G. J. Freeman, J. D. Griffin, G. S. Gray, J. G. Gribben, and L. M. Nadler. 1994. CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy. J. Exp. Med. 180:1665.
40. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
41. Rohrer, J. W., and J. H. Coggin, Jr. 1995. CD8 T cell clones inhibit antitumor T cell function by secreting IL-10. J. Immunol. 155:5719.
42. Cohen, S. B., P. D. Katsikis, M. Feldmann, and M. Londei. 1994. IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. Immunology 83:329.