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Volumn 13, Issue 5, 2019, Pages 648-658

A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn's Disease in Japanese Individuals

(36)  Kakuta, Yoichi a   Kawai, Yosuke b   Naito, Takeo a   Hirano, Atsushi c   Umeno, Junji c   Fuyuno, Yuta c   Liu, Zhenqiu d   Li, Dalin d   Nakano, Takeru a   Izumiyama, Yasuhiro a   Ichikawa, Ryo a   Okamoto, Daisuke a   Nagai, Hiroshi a   Matsumoto, Shin a   Yamamoto, Katsutoshi a   Yokoyama, Naonobu a   Chiba, Hirofumi a   Shimoyama, Yusuke a   Onodera, Motoyuki a   Moroi, Rintaro a   more..


Author keywords

Crohn's disease; RAP1A; susceptibility gene

Indexed keywords

HLA DQB1 ANTIGEN; VASCULAR ENDOTHELIAL GROWTH INHIBITOR; RAP1 PROTEIN; RAP1A PROTEIN, HUMAN;

EID: 85068490457     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjy197     Document Type: Article
Times cited : (27)

References (52)
  • 1
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-25.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3
  • 2
    • 84868336049 scopus 로고    scopus 로고
    • International ibd genetics consortium [IIBDGC]. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, et al.; International IBD Genetics Consortium [IIBDGC]. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012;491:119-24.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3
  • 3
    • 84940771118 scopus 로고    scopus 로고
    • International multiple sclerosis genetics consortium; international IBD genetics consortium. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
    • Liu JZ, van Sommeren S, Huang H, et al.; International Multiple Sclerosis Genetics Consortium; International IBD Genetics Consortium. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet 2015;47:979-86.
    • (2015) Nat Genet , vol.47 , pp. 979-986
    • Liu, J.Z.1    Van Sommeren, S.2    Huang, H.3
  • 4
    • 79960279940 scopus 로고    scopus 로고
    • Promise and pitfalls of the Immunochip
    • Cortes A, Brown MA. Promise and pitfalls of the Immunochip. Arthritis Res Ther 2011;13:101.
    • (2011) Arthritis Res Ther , vol.13 , pp. 101
    • Cortes, A.1    Brown, M.A.2
  • 5
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine- rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine- rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 6
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 7
    • 0036306951 scopus 로고    scopus 로고
    • Lack of common NOD2 variants in Japanese patients with Crohn's disease
    • Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002;123:86-91.
    • (2002) Gastroenterology , vol.123 , pp. 86-91
    • Inoue, N.1    Tamura, K.2    Kinouchi, Y.3
  • 8
    • 0036373539 scopus 로고    scopus 로고
    • Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease
    • Yamazaki K, Takazoe M, Tanaka T, Kazumori T, Nakamura Y. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet 2002;47:469-72.
    • (2002) J Hum Genet , vol.47 , pp. 469-472
    • Yamazaki, K.1    Takazoe, M.2    Tanaka, T.3    Kazumori, T.4    Nakamura, Y.5
  • 9
    • 34347357508 scopus 로고    scopus 로고
    • Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    • Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet 2007;52:575-83.
    • (2007) J Hum Genet , vol.52 , pp. 575-583
    • Yamazaki, K.1    Onouchi, Y.2    Takazoe, M.3    Kubo, M.4    Nakamura, Y.5    Hata, A.6
  • 10
    • 84876373775 scopus 로고    scopus 로고
    • Association study of 71 European Crohn's disease susceptibility loci in a Japanese population
    • Hirano A, Yamazaki K, Umeno J, et al. Association study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflamm Bowel Dis 2013;19:526-33.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 526-533
    • Hirano, A.1    Yamazaki, K.2    Umeno, J.3
  • 11
    • 27944464550 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease
    • Yamazaki K, McGovern D, Ragoussis J, et al. Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Hum Mol Genet 2005;14:3499-506.
    • (2005) Hum Mol Genet , vol.14 , pp. 3499-3506
    • Yamazaki, K.1    McGovern, D.2    Ragoussis, J.3
  • 12
    • 33749182955 scopus 로고    scopus 로고
    • Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease
    • Kakuta Y, Kinouchi Y, Negoro K, Takahashi S, Shimosegawa T. Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease. Gut 2006;55:1527-8.
    • (2006) Gut , vol.55 , pp. 1527-1528
    • Kakuta, Y.1    Kinouchi, Y.2    Negoro, K.3    Takahashi, S.4    Shimosegawa, T.5
  • 13
    • 84939857070 scopus 로고    scopus 로고
    • ToMMo Japanese reference panel project. Rare variant discovery by deep whole-genome sequencing of 1070 Japanese individuals
    • Nagasaki M, Yasuda J, Katsuoka F, et al.; ToMMo Japanese Reference Panel Project. Rare variant discovery by deep whole-genome sequencing of 1070 Japanese individuals. Nat Commun 2015;6:8018.
    • (2015) Nat Commun , vol.6 , pp. 8018
    • Nagasaki, M.1    Yasuda, J.2    Katsuoka, F.3
  • 14
    • 84939842504 scopus 로고    scopus 로고
    • Japonica array: Improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals
    • Kawai Y, Mimori T, Kojima K, et al. Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals. J Hum Genet 2015;60:581-7.
    • (2015) J Hum Genet , vol.60 , pp. 581-587
    • Kawai, Y.1    Mimori, T.2    Kojima, K.3
  • 15
    • 84991070369 scopus 로고    scopus 로고
    • The Tohoku medical megabank project: Design and mission
    • Kuriyama S, Yaegashi N, Nagami F, et al. The Tohoku medical megabank project: design and mission. J Epidemiol 2016;26:493-511.
    • (2016) J Epidemiol , vol.26 , pp. 493-511
    • Kuriyama, S.1    Yaegashi, N.2    Nagami, F.3
  • 16
    • 85048774174 scopus 로고    scopus 로고
    • NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: A multicenter study
    • Jun 19. [Epub ahead of print]
    • Kakuta Y, Kawai Y, Okamoto D, et al. NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study. J Gastroenterol 2018, Jun 19. doi: 10.1007/s00535-018-1486-7. [Epub ahead of print.]
    • (2018) J Gastroenterol
    • Kakuta, Y.1    Kawai, Y.2    Okamoto, D.3
  • 17
    • 84872496272 scopus 로고    scopus 로고
    • Annual reports of the research group of intractable inflammatory bowel disease granted by the Ministry of Health, Labour, and Welfare of Japan
    • Matsui T, Hirai F, Hisabe T. Proposed diagnostic criteria for Crohn's disease. Annual reports of the research group of intractable inflammatory bowel disease granted by the Ministry of Health, Labour, and Welfare of Japan. 2011; 52-4.
    • (2011) Proposed Diagnostic Criteria for Crohn's Disease , pp. 52-54
    • Matsui, T.1    Hirai, F.2    Hisabe, T.3
  • 18
    • 33646778482 scopus 로고    scopus 로고
    • The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications
    • Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006;55:749-53.
    • (2006) Gut , vol.55 , pp. 749-753
    • Satsangi, J.1    Silverberg, M.S.2    Vermeire, S.3    Colombel, J.F.4
  • 20
    • 84872425214 scopus 로고    scopus 로고
    • Utilizing graph theory to select the largest set of unrelated individuals for genetic analysis
    • Staples J, Nickerson DA, Below JE. Utilizing graph theory to select the largest set of unrelated individuals for genetic analysis. Genet Epidemiol 2013;37:136-41.
    • (2013) Genet Epidemiol , vol.37 , pp. 136-141
    • Staples, J.1    Nickerson, D.A.2    Below, J.E.3
  • 21
    • 67651222400 scopus 로고    scopus 로고
    • A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
    • Howie BN, Donnelly P, Marchini J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet 2009;5:e1000529.
    • (2009) PLoS Genet , vol.5
    • Howie, B.N.1    Donnelly, P.2    Marchini, J.3
  • 22
    • 84856478855 scopus 로고    scopus 로고
    • A linear complexity phasing method for thousands of genomes
    • Delaneau O, Marchini J, Zagury JF. A linear complexity phasing method for thousands of genomes. Nat Methods 2011;9:179-81.
    • (2011) Nat Methods , vol.9 , pp. 179-181
    • Delaneau, O.1    Marchini, J.2    Zagury, J.F.3
  • 23
    • 52649106543 scopus 로고    scopus 로고
    • Isolation of human intestinal mucosal mononuclear cells
    • Chapter 7:Unit 7.30
    • Fiocchi C, Youngman KR. Isolation of human intestinal mucosal mononuclear cells. Curr Protoc Immunol 2001;Chapter 7:Unit 7.30.
    • (2001) Curr Protoc Immunol
    • Fiocchi, C.1    Youngman, K.R.2
  • 24
    • 80255127234 scopus 로고    scopus 로고
    • Cutadapt removes adapter sequences from high-throughput sequencing reads
    • Martin, M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet.journal 2011;17:10-2.
    • (2011) EMBnet.journal , vol.17 , pp. 10-12
    • Martin, M.1
  • 25
    • 79952422304 scopus 로고    scopus 로고
    • Quality control and preprocessing of metagenomic datasets
    • Schmieder R, Edwards R. Quality control and preprocessing of metagenomic datasets. Bioinformatics 2011;27:863-4.
    • (2011) Bioinformatics , vol.27 , pp. 863-864
    • Schmieder, R.1    Edwards, R.2
  • 26
    • 65449136284 scopus 로고    scopus 로고
    • TopHat: Discovering splice junctions with RNA-Seq
    • Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 2009;25:1105-11.
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 27
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell C, Williams BA, Pertea G, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010;28:511-5.
    • (2010) Nat Biotechnol , vol.28 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3
  • 29
    • 77956586071 scopus 로고    scopus 로고
    • LocusZoom: Regional visualization of genome-wide association scan results
    • Pruim RJ, Welch RP, Sanna S, et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 2010;26:2336-7.
    • (2010) Bioinformatics , vol.26 , pp. 2336-2337
    • Pruim, R.J.1    Welch, R.P.2    Sanna, S.3
  • 30
    • 85021857514 scopus 로고    scopus 로고
    • The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible
    • Szklarczyk D, Morris JH, Cook H, et al. The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res 2017;45:D362-8.
    • (2017) Nucleic Acids Res , vol.45 , pp. D362-D368
    • Szklarczyk, D.1    Morris, J.H.2    Cook, H.3
  • 31
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: A software environment for integrated models of biomolecular interaction networks
    • Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 2003;13:2498-504.
    • (2003) Genome Res , vol.13 , pp. 2498-2504
    • Shannon, P.1    Markiel, A.2    Ozier, O.3
  • 33
    • 0032733665 scopus 로고    scopus 로고
    • HLA class II alleles in Japanese patients with inflammatory bowel disease
    • Yoshitake S, Kimura A, Okada M, Yao T, Sasazuki T. HLA class II alleles in Japanese patients with inflammatory bowel disease. Tissue Antigens 1999;53:350-8.
    • (1999) Tissue Antigens , vol.53 , pp. 350-358
    • Yoshitake, S.1    Kimura, A.2    Okada, M.3    Yao, T.4    Sasazuki, T.5
  • 34
    • 84889680996 scopus 로고    scopus 로고
    • Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations
    • Yang SK, Hong M, Zhao W, et al. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. Gut 2014;63:80-7.
    • (2014) Gut , vol.63 , pp. 80-87
    • Yang, S.K.1    Hong, M.2    Zhao, W.3
  • 35
    • 58849111798 scopus 로고    scopus 로고
    • Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients
    • Yamazaki K, Takahashi A, Takazoe M, et al. Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients. Gut 2009;58:228-32.
    • (2009) Gut , vol.58 , pp. 228-232
    • Yamazaki, K.1    Takahashi, A.2    Takazoe, M.3
  • 36
    • 85013466894 scopus 로고    scopus 로고
    • Increased expression of IL12b mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients
    • Kakuta Y, Kimura T, Negoro K, et al. Increased expression of IL12b mRNA transcribed from the risk haplotype for Crohn's disease is a risk factor for disease relapse in Japanese patients. J Gastroenterol 2017;52(12):1230-9.
    • (2017) J Gastroenterol , vol.52 , Issue.12 , pp. 1230-1239
    • Kakuta, Y.1    Kimura, T.2    Negoro, K.3
  • 37
    • 80053568626 scopus 로고    scopus 로고
    • Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease
    • Kim SW, Kim ES, Moon CM, et al. Genetic polymorphisms of IL-23R and IL-17A and novel insights into their associations with inflammatory bowel disease. Gut 2011;60:1527-36.
    • (2011) Gut , vol.60 , pp. 1527-1536
    • Kim, S.W.1    Kim, E.S.2    Moon, C.M.3
  • 38
    • 84945539282 scopus 로고    scopus 로고
    • Low-frequency IL23R coding variant associated with Crohn's disease susceptibility in Japanese subjects identified by personal genomics analysis
    • Onodera K, Arimura Y, Isshiki H, et al. Low-frequency IL23R coding variant associated with Crohn's disease susceptibility in Japanese subjects identified by personal genomics analysis. PLoS One 2015;10:e0137801.
    • (2015) PLoS One , vol.10
    • Onodera, K.1    Arimura, Y.2    Isshiki, H.3
  • 39
    • 84929589668 scopus 로고    scopus 로고
    • IBD study group of the Korean association for the study of intestinal diseases [KASID]. Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants
    • Hong SN, Park C, Park SJ, et al.; IBD Study Group of the Korean Association for the Study of Intestinal Diseases [KASID]. Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants. Gut 2016;65:788-96.
    • (2016) Gut , vol.65 , pp. 788-796
    • Hong, S.N.1    Park, C.2    Park, S.J.3
  • 40
    • 48349136889 scopus 로고    scopus 로고
    • NIDDK IBD genetics consortium; Belgian-French IBD consortium; wellcome trust case control consortium. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, et al.; NIDDK IBD Genetics Consortium; Belgian-French IBD Consortium; Wellcome Trust Case Control Consortium. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3
  • 41
    • 84875234775 scopus 로고    scopus 로고
    • A genome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population
    • Yamazaki K, Umeno J, Takahashi A, et al. A genome-wide association study identifies 2 susceptibility loci for Crohn's disease in a Japanese population. Gastroenterology 2013;144:781-8.
    • (2013) Gastroenterology , vol.144 , pp. 781-788
    • Yamazaki, K.1    Umeno, J.2    Takahashi, A.3
  • 42
    • 84925779171 scopus 로고    scopus 로고
    • Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans
    • Yang SK, Hong M, Choi H, et al. Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. Inflamm Bowel Dis 2015;21:1-7.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 1-7
    • Yang, S.K.1    Hong, M.2    Choi, H.3
  • 43
    • 84975742565 scopus 로고    scopus 로고
    • 1000 genomes project consortium. A map of human genome variation from population-scale sequencing
    • Abecasis GR, Altshuler D, Auton A, et al.; 1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 2010;467:1061-73.
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Abecasis, G.R.1    Altshuler, D.2    Auton, A.3
  • 44
    • 84943171338 scopus 로고    scopus 로고
    • 1000 genomes project consortium. A global reference for human genetic variation
    • Auton A, Brooks LD, Durbin RM, et al.; 1000 Genomes Project Consortium. A global reference for human genetic variation. Nature 2015;526:68-74.
    • (2015) Nature , vol.526 , pp. 68-74
    • Auton, A.1    Brooks, L.D.2    Durbin, R.M.3
  • 45
    • 84949257659 scopus 로고    scopus 로고
    • Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis
    • Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K. Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis. Nat Commun 2015;6:8982.
    • (2015) Nat Commun , vol.6 , pp. 8982
    • Ishihara, S.1    Nishikimi, A.2    Umemoto, E.3    Miyasaka, M.4    Saegusa, M.5    Katagiri, K.6
  • 46
    • 84930817087 scopus 로고    scopus 로고
    • Cell specific eQTL analysis without sorting cells
    • Westra HJ, Arends D, Esko T, et al. Cell specific eQTL analysis without sorting cells. PLoS Genet 2015;11:e1005223.
    • (2015) PLoS Genet , vol.11
    • Westra, H.J.1    Arends, D.2    Esko, T.3
  • 48
    • 79956042376 scopus 로고    scopus 로고
    • Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions
    • Wittchen ES, Aghajanian A, Burridge K. Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions. Small GTPases 2011;2:65-76.
    • (2011) Small GTPases , vol.2 , pp. 65-76
    • Wittchen, E.S.1    Aghajanian, A.2    Burridge, K.3
  • 49
    • 84882749768 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med 2013;369:711-21.
    • (2013) N Engl J Med , vol.369 , pp. 711-721
    • Sandborn, W.J.1    Feagan, B.G.2    Rutgeerts, P.3
  • 50
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Natalizumab Pan-European Study Group
    • Ghosh S, Goldin E, Gordon FH, et al.; Natalizumab Pan-European Study Group. Natalizumab for active Crohn's disease. N Engl J Med 2003;348:24-32.
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.H.3
  • 51
    • 84929279522 scopus 로고    scopus 로고
    • Systematic review and meta-analysis: Opportunistic infections and malignancies during treatment with antiintegrin antibodies in inflammatory bowel disease
    • Luthra P, Peyrin-Biroulet L, Ford AC. Systematic review and meta-analysis: opportunistic infections and malignancies during treatment with antiintegrin antibodies in inflammatory bowel disease. Aliment Pharmacol Ther 2015;41:1227-36.
    • (2015) Aliment Pharmacol Ther , vol.41 , pp. 1227-1236
    • Luthra, P.1    Peyrin-Biroulet, L.2    Ford, A.C.3
  • 52
    • 85024387670 scopus 로고    scopus 로고
    • International inflammatory bowel disease genetics consortium. Fine-mapping inflammatory bowel disease loci to single-variant resolution
    • Huang H, Fang M, Jostins L, et al.; International Inflammatory Bowel Disease Genetics Consortium. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature 2017;547:173-8.
    • (2017) Nature , vol.547 , pp. 173-178
    • Huang, H.1    Fang, M.2    Jostins, L.3


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