Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis

Journal of Immunology

Volumn 184, Issue 2, 2010, Pages 550-554

  Kassner, Nadine ^a   Krueger, Manuela ^a   Yagita, Hideo ^b   Dzionek, Andrzej ^c   Hutloff, Andreas ^a,d   Kroczek, Richard ^d   Scheffold, Alexander ^a,c   Rutz, Sascha ^a,e  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c MILTENYI BIOTEC GMBH   (Germany)

^d ROBERT KOCH INSTITUTE   (Germany)

^e GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; JAGGED1; NOTCH4 RECEPTOR; AUTACOID; DLL4 PROTEIN, MOUSE; LIGAND; MEMBRANE PROTEIN; NOTCH RECEPTOR; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 CELL; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; DENDRITIC CELL; IMMUNOLOGY; INFLAMMATION; METABOLISM;

ANIMALS; DENDRITIC CELLS; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; RECEPTORS, NOTCH; T-LYMPHOCYTES;

EID: 76249101454     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903152     Document Type: Article

References (18)

1. Moore, K. W., R. de Waal Malefyt, R. L. Coffman, and A. O'Garra. 2001. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19: 683-765.
2. Assenmacher, M., J. Schmitz, and A. Radbruch. 1994. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-g and in interleukin-4-expressing cells. Eur. J. Immunol. 24: 1097-1101.
3. Gerosa, F., C. Nisii, S. Righetti, R. Micciolo, M. Marchesini, A. Cazzadori, and G. Trinchieri. 1999. CD4(+) T cell clones producing both interferon-γ and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients. Clin. Immunol. 92: 224-234.
4. Jankovic, D., M. C. Kullberg, C. G. Feng, R. S. Goldszmid, C. M. Collazo, M. Wilson, T. A. Wynn, M. Kamanaka, R. A. Flavell, and A. Sher. 2007. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 204: 273-283.
5. Anderson, C. F., M. Oukka, V. J. Kuchroo, and D. Sacks. 2007. CD4(+)CD25(-) Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 204: 285-297.
6. Rutz, S., M. Janke, N. Kassner, T. Hohnstein, M. Krueger, and A. Scheffold. 2008. Notch regulates IL-10 production by T helper 1 cells. Proc. Natl. Acad. Sci. USA 105: 3497-3502.
7. Chang, H. D., C. Helbig, L. Tykocinski, S. Kreher, J. Koeck, U. Niesner, and A. Radbruch. 2007. Expression of IL-10 in Th memory lymphocytes is conditional on IL-12 or IL-4, unless the IL-10 gene is imprinted by GATA-3. Eur. J. Immunol. 37: 807-817.
8. Gerosa, F., C. Paganin, D. Peritt, F. Paiola, M. T. Scupoli, M. Aste-Amezaga, I. Frank, and G. Trinchieri. 1996. Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-γ and interleukin-10. J. Exp. Med. 183: 2559-2569.
9. Stumhofer, J. S., J. S. Silver, A. Laurence, P. M. Porrett, T. H. Harris, L. A. Turka, M. Ernst, C. J. Saris, J. J. O'Shea, and C. A. Hunter. 2007. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8: 1363-1371.
10. Awasthi, A., Y. Carrier, J. P. Peron, E. Bettelli, M. Kamanaka, R. A. Flavell, V. K. Kuchroo, M. Oukka, and H. L. Weiner. 2007. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8: 1380-1389.
11. Yamaguchi, E., S. Chiba, K. Kumano, A. Kunisato, T. Takahashi, T. Takahashi, and H. Hirai. 2002. Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice. Immunol. Lett. 81: 59-64.
12. Elyaman, W., E. M. Bradshaw, Y. Wang, M. Oukka, P. Kivisäkk, S. Chiba, H. Yagita, and S. J. Khoury. 2007. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179: 5990-5998.
13. Kijima, M., T. Yamaguchi, C. Ishifune, Y. Maekawa, A. Koyanagi, H. Yagita, S. Chiba, K. Kishihara, M. Shimada, and K. Yasutomo. 2008. Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction. Proc. Natl. Acad. Sci. USA 105: 7010-7015.
14. Ridgway, J., G. Zhang, Y. Wu, S. Stawicki, W. C. Liang, Y. Chanthery, J. Kowalski, R. J. Watts, C. Callahan, I. Kasman, et al. 2006. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444: 1083-1087.
15. Besseyrias, V., E. Fiorini, L. J. Strobl, U. Zimber-Strobl, A. Dumortier, U. Koch, M. L. Arcangeli, S. Ezine, H. R. Macdonald, and F. Radtke. 2007. Hierarchy of Notch-Δ interactions promoting T cell lineage commitment and maturation. J. Exp. Med. 204: 331-343.
16. Ito, T., M. Yang, Y. H. Wang, R. Lande, J. Gregorio, O. A. Perng, X. F. Qin, Y. J. Liu, and M. Gilliet. 2007. Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand. J. Exp. Med. 204: 105-115.
17. Janke, M., E. J. Witsch, H. W. Mages, A. Hutloff, and R. A. Kroczek. 2006. Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells. Immunology 118: 353-360.
18. Benedito, R., C. Roca, I. Sörensen, S. Adams, A. Gossler, M. Fruttiger, and R. H. Adams. 2009. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137: 1124-1135.