메뉴 건너뛰기




Volumn 8, Issue FEB, 2017, Pages

TNF blockade maintains an IL-10+ phenotype in human effector CD4+ and CD8+ T cells

Author keywords

Adalimumab; Anti TNF; CD4+ T cell polarization; CD8+ T cell polarization; IL 10 regulation; Interleukin 10; TNF inhibitors; Tumor necrosis factor

Indexed keywords

ADALIMUMAB; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; TUMOR NECROSIS FACTOR INHIBITOR;

EID: 85014363690     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00157     Document Type: Article
Times cited : (22)

References (53)
  • 1
    • 0036584028 scopus 로고    scopus 로고
    • Development of anti-TNF therapy for rheumatoid arthritis
    • Feldmann M. Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol (2002) 2:364-71. doi: 10.1038/nri802
    • (2002) Nat Rev Immunol , vol.2 , pp. 364-371
    • Feldmann, M.1
  • 2
    • 70349967965 scopus 로고    scopus 로고
    • Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
    • Taylor PC, Feldmann M. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol (2009) 5(10):578-82. doi:10.1038/nrrheum.2009.181
    • (2009) Nat Rev Rheumatol , vol.5 , Issue.10 , pp. 578-582
    • Taylor, P.C.1    Feldmann, M.2
  • 3
    • 74849094402 scopus 로고    scopus 로고
    • Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish DANBIO registry
    • Hetland ML, Christensen IJ, Tarp U, Dreyer L, Hansen A, Hansen IT, et al. Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish DANBIO registry. Arthritis Rheum (2010) 62(1):22-32. doi:10.1002/art.27227
    • (2010) Arthritis Rheum , vol.62 , Issue.1 , pp. 22-32
    • Hetland, M.L.1    Christensen, I.J.2    Tarp, U.3    Dreyer, L.4    Hansen, A.5    Hansen, I.T.6
  • 4
    • 11144355974 scopus 로고    scopus 로고
    • Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled trial of remicade in primary Sjögren's syndrome (TRIPSS)
    • Mariette X, Ravaud P, Steinfeld S, Baron G, Goetz J, Hachulla E, et al. Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled trial of remicade in primary Sjögren's syndrome (TRIPSS). Arthritis Rheum (2004) 50(4):1270-6. doi:10.1002/art.20146
    • (2004) Arthritis Rheum , vol.50 , Issue.4 , pp. 1270-1276
    • Mariette, X.1    Ravaud, P.2    Steinfeld, S.3    Baron, G.4    Goetz, J.5    Hachulla, E.6
  • 5
    • 53149096567 scopus 로고    scopus 로고
    • Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor a and systemic immune activation
    • Moutsopoulos NM, Katsifis GE, Angelov N, Leakan RA, Sankar V, Pillemer S, et al. Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor a and systemic immune activation. Ann Rheum Dis (2008) 67(10):1437-43. doi:10.1136/ard.2007.077891
    • (2008) Ann Rheum Dis , vol.67 , Issue.10 , pp. 1437-1443
    • Moutsopoulos, N.M.1    Katsifis, G.E.2    Angelov, N.3    Leakan, R.A.4    Sankar, V.5    Pillemer, S.6
  • 6
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group, The University of British Columbia MS/MRI Analysis Group. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology (1999) 53:457-65. doi:10.1212/WNL.53.3.457
    • (1999) Neurology , vol.53 , pp. 457-465
  • 8
    • 59249096762 scopus 로고    scopus 로고
    • Differences in binding and effector functions between classes of TNF antagonists
    • Arora T, Padaki R, Liu L, Hamburger AE, Ellison AR, Stevens SR, et al. Differences in binding and effector functions between classes of TNF antagonists. Cytokine (2009) 45(2):124-31. doi:10.1016/j.cyto.2008.11.008
    • (2009) Cytokine , vol.45 , Issue.2 , pp. 124-131
    • Arora, T.1    Padaki, R.2    Liu, L.3    Hamburger, A.E.4    Ellison, A.R.5    Stevens, S.R.6
  • 9
    • 63749093322 scopus 로고    scopus 로고
    • Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor
    • Kaymakcalan Z, Sakorafas P, Bose S, Scesney S, Xiong L, Hanzatian DK, et al. Comparisons of affinities, avidities, and complement activation of adalimumab, infliximab, and etanercept in binding to soluble and membrane tumor necrosis factor. Clin Immunol (2009) 131(2):308-16. doi:10.1016/j.clim.2009.01.002
    • (2009) Clin Immunol , vol.131 , Issue.2 , pp. 308-316
    • Kaymakcalan, Z.1    Sakorafas, P.2    Bose, S.3    Scesney, S.4    Xiong, L.5    Hanzatian, D.K.6
  • 10
    • 43949126520 scopus 로고    scopus 로고
    • Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor a-expressing cells: comparison among infliximab, etanercept, and adalimumab
    • Mitoma H, Horiuchi T, Tsukamoto H, Tamimoto Y, Kimoto Y, Uchino A, et al. Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor a-expressing cells: comparison among infliximab, etanercept, and adalimumab. Arthritis Rheum (2008) 58(5):1248-57. doi:10.1002/art.23447
    • (2008) Arthritis Rheum , vol.58 , Issue.5 , pp. 1248-1257
    • Mitoma, H.1    Horiuchi, T.2    Tsukamoto, H.3    Tamimoto, Y.4    Kimoto, Y.5    Uchino, A.6
  • 11
    • 36749070996 scopus 로고    scopus 로고
    • Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents
    • Nesbitt A, Fossati G, Bergin M, Stephens P, Stephens S, Foulkes R, et al. Mechanism of action of certolizumab pegol (CDP870): in vitro comparison with other anti-tumor necrosis factor alpha agents. Inflamm Bowel Dis (2007) 13(11):1323-32. doi:10.1002/ibd.20225
    • (2007) Inflamm Bowel Dis , vol.13 , Issue.11 , pp. 1323-1332
    • Nesbitt, A.1    Fossati, G.2    Bergin, M.3    Stephens, P.4    Stephens, S.5    Foulkes, R.6
  • 12
    • 77953701042 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis
    • Baldwin HM, Ito-Ihara T, Isaacs JD, Hilkens CM. Tumour necrosis factor alpha blockade impairs dendritic cell survival and function in rheumatoid arthritis. Ann Rheum Dis (2010) 69(6):1200-7. doi:10.1136/ard.2009.110502
    • (2010) Ann Rheum Dis , vol.69 , Issue.6 , pp. 1200-1207
    • Baldwin, H.M.1    Ito-Ihara, T.2    Isaacs, J.D.3    Hilkens, C.M.4
  • 13
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta
    • Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med (2007) 204(1):33-9. doi:10.1084/jem.20061531
    • (2007) J Exp Med , vol.204 , Issue.1 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 14
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFa therapy
    • Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFa therapy. J Exp Med (2004) 200(3):277-85. doi:10.1084/jem.20040165
    • (2004) J Exp Med , vol.200 , Issue.3 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 15
    • 84977632681 scopus 로고    scopus 로고
    • Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis
    • Nguyen DX, Ehrenstein MR. Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis. J Exp Med (2016) 213(7):1241-53. doi:10.1084/jem.20151255
    • (2016) J Exp Med , vol.213 , Issue.7 , pp. 1241-1253
    • Nguyen, D.X.1    Ehrenstein, M.R.2
  • 16
    • 80053140303 scopus 로고    scopus 로고
    • Number and phenotype of rheumatoid arthritis patients' CD4+CD25hi regulatory T cells are not affected by adalimumab or etanercept
    • Blache C, Lequerre T, Roucheux A, Beutheu S, Dedreux I, Jacquot S, et al. Number and phenotype of rheumatoid arthritis patients' CD4+CD25hi regulatory T cells are not affected by adalimumab or etanercept. Rheumatology (Oxford) (2011) 50(10):1814-22. doi:10.1093/rheumatology/ker183
    • (2011) Rheumatology (Oxford) , vol.50 , Issue.10 , pp. 1814-1822
    • Blache, C.1    Lequerre, T.2    Roucheux, A.3    Beutheu, S.4    Dedreux, I.5    Jacquot, S.6
  • 17
    • 33645059178 scopus 로고    scopus 로고
    • Influence of anti-tumor necrosis factor therapy (Adalimumab) on regulatory T cells and dendritic cells in rheumatoid arthritis
    • Dombrecht EJ, Aerts NE, Schuerwegh AJ, Hagendorens MM, Ebo DG, Van Offel JF, et al. Influence of anti-tumor necrosis factor therapy (Adalimumab) on regulatory T cells and dendritic cells in rheumatoid arthritis. Clin Exp Rheumatol (2006) 24:31-7.
    • (2006) Clin Exp Rheumatol , vol.24 , pp. 31-37
    • Dombrecht, E.J.1    Aerts, N.E.2    Schuerwegh, A.J.3    Hagendorens, M.M.4    Ebo, D.G.5    Van Offel, J.F.6
  • 18
    • 77956395771 scopus 로고    scopus 로고
    • Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells
    • Kleijwegt FS, Laban S, Duinkerken G, Joosten AM, Zaldumbide A, Nikolic T, et al. Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells. J Immunol (2010) 185(3):1412-8. doi:10.4049/jimmunol.1000560
    • (2010) J Immunol , vol.185 , Issue.3 , pp. 1412-1418
    • Kleijwegt, F.S.1    Laban, S.2    Duinkerken, G.3    Joosten, A.M.4    Zaldumbide, A.5    Nikolic, T.6
  • 19
    • 78649900433 scopus 로고    scopus 로고
    • Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs
    • Grinberg-Bleyer Y, Saadoun D, Baeyens A, Billiard F, Goldstein JD, Gregoire S, et al. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs. J Clin Invest (2011) 120(12):4558-68. doi:10.1172/JCI42945
    • (2011) J Clin Invest , vol.120 , Issue.12 , pp. 4558-4568
    • Grinberg-Bleyer, Y.1    Saadoun, D.2    Baeyens, A.3    Billiard, F.4    Goldstein, J.D.5    Gregoire, S.6
  • 21
    • 84949553657 scopus 로고    scopus 로고
    • The interplay between monocytes/macrophages and CD4+ T cell subsets in rheumatoid arthritis
    • Roberts CA, Dickinson AK, Taams LS. The interplay between monocytes/macrophages and CD4+ T cell subsets in rheumatoid arthritis. Front Immunol (2015) 6:571. doi:10.3389/fimmu.2015.00571
    • (2015) Front Immunol , vol.6 , pp. 571
    • Roberts, C.A.1    Dickinson, A.K.2    Taams, L.S.3
  • 22
    • 84896542936 scopus 로고    scopus 로고
    • Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
    • Noack M, Miossec P. Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev (2014) 13(6):668-77. doi:10.1016/j.autrev.2013.12.004
    • (2014) Autoimmun Rev , vol.13 , Issue.6 , pp. 668-677
    • Noack, M.1    Miossec, P.2
  • 23
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology (2011) 140(6):1756-67. doi:10.1053/j.gastro.2011.02.016
    • (2011) Gastroenterology , vol.140 , Issue.6 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 24
    • 77956536780 scopus 로고    scopus 로고
    • T cells in multiple sclerosis and experimental autoimmune encephalomyelitis
    • Fletcher JM, Lalor SJ, Sweeney CM, Tubridy N, Mills KH. T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Exp Immunol (2010) 162(1):1-11. doi:10.1111/j.1365-2249.2010.04143.x
    • (2010) Clin Exp Immunol , vol.162 , Issue.1 , pp. 1-11
    • Fletcher, J.M.1    Lalor, S.J.2    Sweeney, C.M.3    Tubridy, N.4    Mills, K.H.5
  • 25
    • 84971596825 scopus 로고    scopus 로고
    • IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease
    • Srenathan U, Steel K, Taams LS. IL-17+ CD8+ T cells: differentiation, phenotype and role in inflammatory disease. Immunol Lett (2016) 178:20-6. doi:10.1016/j.imlet.2016.05.001
    • (2016) Immunol Lett , vol.178 , pp. 20-26
    • Srenathan, U.1    Steel, K.2    Taams, L.S.3
  • 26
    • 84975849745 scopus 로고    scopus 로고
    • CD8(+) T cells in human autoimmune arthritis: the unusual suspects
    • Petrelli A, van Wijk F. CD8(+) T cells in human autoimmune arthritis: the unusual suspects. Nat Rev Rheumatol (2016) 12(7):421-8. doi:10.1038/nrrheum.2016.74
    • (2016) Nat Rev Rheumatol , vol.12 , Issue.7 , pp. 421-428
    • Petrelli, A.1    van Wijk, F.2
  • 27
    • 84899717815 scopus 로고    scopus 로고
    • IL-17+CD8+ T-cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression
    • Menon B, Gullick NJ, Walter GJ, Rajasekhar M, Garrood T, Evans HG, et al. IL-17+CD8+ T-cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression. Arthritis Rheumatol (2014) 66:1272-81. doi:10.1002/art.38376
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1272-1281
    • Menon, B.1    Gullick, N.J.2    Walter, G.J.3    Rajasekhar, M.4    Garrood, T.5    Evans, H.G.6
  • 28
    • 84875216274 scopus 로고    scopus 로고
    • CD8+ T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22
    • Hijnen D, Knol EF, Gent YY, Giovannone B, Beijn SJ, Kupper TS, et al. CD8+ T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. J Invest Dermatol (2013) 133(4):973-9. doi:10.1038/jid.2012.456
    • (2013) J Invest Dermatol , vol.133 , Issue.4 , pp. 973-979
    • Hijnen, D.1    Knol, E.F.2    Gent, Y.Y.3    Giovannone, B.4    Beijn, S.J.5    Kupper, T.S.6
  • 29
    • 78649666553 scopus 로고    scopus 로고
    • Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis
    • Res PC, Piskin G, de Boer OJ, van der Loos CM, Teeling P, Bos JD, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS One (2010) 5(11):e14108. doi:10.1371/journal.pone.0014108
    • (2010) PLoS One , vol.5 , Issue.11
    • Res, P.C.1    Piskin, G.2    de Boer, O.J.3    van der Loos, C.M.4    Teeling, P.5    Bos, J.D.6
  • 30
    • 38549176118 scopus 로고    scopus 로고
    • Tumor necrosis factor antagonist mechanisms of action: a comprehensive review
    • Tracey D, Klareskog L, Sasso EH, Salfeld JG, Tak PP. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol Ther (2008) 117(2):244-79. doi:10.1016/j.pharmthera.2007.10.001
    • (2008) Pharmacol Ther , vol.117 , Issue.2 , pp. 244-279
    • Tracey, D.1    Klareskog, L.2    Sasso, E.H.3    Salfeld, J.G.4    Tak, P.P.5
  • 31
    • 84928111749 scopus 로고    scopus 로고
    • Significant associations of antidrug antibody levels with serum drug trough levels and therapeutic response of adalimumab and etanercept treatment in rheumatoid arthritis
    • Chen DY, Chen YM, Tsai WC, Tseng JC, Chen YH, Hsieh CW, et al. Significant associations of antidrug antibody levels with serum drug trough levels and therapeutic response of adalimumab and etanercept treatment in rheumatoid arthritis. Ann Rheum Dis (2015) 74(3):e16. doi:10.1136/annrheumdis-2013-203893
    • (2015) Ann Rheum Dis , vol.74 , Issue.3
    • Chen, D.Y.1    Chen, Y.M.2    Tsai, W.C.3    Tseng, J.C.4    Chen, Y.H.5    Hsieh, C.W.6
  • 32
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 8(12):1363-71. doi:10.1038/ni1537
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1363-1371
    • Stumhofer, J.S.1    Silver, J.S.2    Laurence, A.3    Porrett, P.M.4    Harris, T.H.5    Turka, L.A.6
  • 33
    • 0026000892 scopus 로고
    • Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression
    • de Waal Malefyt R, Haanen J, Spits H, Roncarolo MG, te Velde A, Figdor C, et al. Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J Exp Med (1991) 174:915-24. doi:10.1084/jem.174.4.915
    • (1991) J Exp Med , vol.174 , pp. 915-924
    • de Waal Malefyt, R.1    Haanen, J.2    Spits, H.3    Roncarolo, M.G.4    te Velde, A.5    Figdor, C.6
  • 34
    • 0033802512 scopus 로고    scopus 로고
    • Human monocytes express CD163, which is upregulated by IL-10 and identical to p155
    • Sulahian TH, Hogger P, Wahner AE, Wardwell K, Goulding NJ, Sorg C, et al. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine (2000) 12(9):1312-21. doi:10.1006/cyto.2000.0720
    • (2000) Cytokine , vol.12 , Issue.9 , pp. 1312-1321
    • Sulahian, T.H.1    Hogger, P.2    Wahner, A.E.3    Wardwell, K.4    Goulding, N.J.5    Sorg, C.6
  • 35
    • 65349138972 scopus 로고    scopus 로고
    • Infliximab and the TNF-a system
    • Ebert EC. Infliximab and the TNF-a system. Am J Physiol Gastrointest Liver Physiol (2009) 296(3):G612-20. doi:10.1152/ajpgi.90576.2008
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , Issue.3 , pp. G612-G620
    • Ebert, E.C.1
  • 36
    • 84873823762 scopus 로고    scopus 로고
    • Etanercept downregulates the Th17 pathway and decreases the IL-17+/IL-10+ cell ratio in patients with psoriasis vulgaris
    • Antiga E, Volpi W, Cardilicchia E, Maggi L, Filì L, Manuelli C, et al. Etanercept downregulates the Th17 pathway and decreases the IL-17+/IL-10+ cell ratio in patients with psoriasis vulgaris. J Clin Immunol (2012) 32:1221-32. doi:10.1007/s10875-012-9716-x
    • (2012) J Clin Immunol , vol.32 , pp. 1221-1232
    • Antiga, E.1    Volpi, W.2    Cardilicchia, E.3    Maggi, L.4    Filì, L.5    Manuelli, C.6
  • 37
    • 0347988275 scopus 로고    scopus 로고
    • Anti-TNFa therapy modulates the phenotype of peripheral blood CD4+ T cells in patients with posterior segment intraocular inflammation
    • Greiner K, Murphy CC, Willermain F, Duncan L, Plskova J, Hale G, et al. Anti-TNFa therapy modulates the phenotype of peripheral blood CD4+ T cells in patients with posterior segment intraocular inflammation. Invest Ophthalmol Vis Sci (2004) 45(1):170-6. doi:10.1167/iovs.03-0659
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , Issue.1 , pp. 170-176
    • Greiner, K.1    Murphy, C.C.2    Willermain, F.3    Duncan, L.4    Plskova, J.5    Hale, G.6
  • 38
    • 0030769165 scopus 로고    scopus 로고
    • The role of TNF alpha and related cytokines in the development and function of the autoreactive T-cell repertoire
    • Cope A, Ettinger R, McDevitt H. The role of TNF alpha and related cytokines in the development and function of the autoreactive T-cell repertoire. Res Immunol (1997) 148:307-12. doi:10.1016/S0923-2494(97)87239-2
    • (1997) Res Immunol , vol.148 , pp. 307-312
    • Cope, A.1    Ettinger, R.2    McDevitt, H.3
  • 39
    • 0027978457 scopus 로고
    • Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis
    • Cope AP, Londei M, Chu NR, Cohen SB, Elliott MJ, Brennan FM, et al. Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis. J Clin Invest (1994) 94:749-60. doi:10.1172/JCI117394
    • (1994) J Clin Invest , vol.94 , pp. 749-760
    • Cope, A.P.1    Londei, M.2    Chu, N.R.3    Cohen, S.B.4    Elliott, M.J.5    Brennan, F.M.6
  • 40
    • 84895966383 scopus 로고    scopus 로고
    • Inhibition of TNF receptor signaling by anti-TNFa biologicals primes naïve CD4+ T cells towards IL-10+ T cells with a regulatory phenotype and function
    • Boks MA, Kager-Groenland JR, Mousset CM, van Ham SM, ten Brinke A. Inhibition of TNF receptor signaling by anti-TNFa biologicals primes naïve CD4+ T cells towards IL-10+ T cells with a regulatory phenotype and function. Clin Immunol (2014) 151(2):136-45. doi:10.1016/j.clim.2014.02.008
    • (2014) Clin Immunol , vol.151 , Issue.2 , pp. 136-145
    • Boks, M.A.1    Kager-Groenland, J.R.2    Mousset, C.M.3    van Ham, S.M.4    ten Brinke, A.5
  • 41
    • 62049085168 scopus 로고    scopus 로고
    • Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10
    • Sun J, Madan R, Karp CL, Braciale TJ. Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10. Nat Med (2009) 15(3):277-84. doi:10.1038/nm.1929
    • (2009) Nat Med , vol.15 , Issue.3 , pp. 277-284
    • Sun, J.1    Madan, R.2    Karp, C.L.3    Braciale, T.J.4
  • 42
    • 84874631971 scopus 로고    scopus 로고
    • Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection
    • Cyktor JC, Carruthers B, Beamer GL, Turner J. Clonal expansions of CD8+ T cells with IL-10 secreting capacity occur during chronic Mycobacterium tuberculosis infection. PLoS One (2013) 8(3):e58612. doi:10.1371/journal.pone.0058612
    • (2013) PLoS One , vol.8 , Issue.3
    • Cyktor, J.C.1    Carruthers, B.2    Beamer, G.L.3    Turner, J.4
  • 43
    • 79953222926 scopus 로고    scopus 로고
    • Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis
    • Trandem K, Zhao J, Fleming E, Perlman S. Highly activated cytotoxic CD8 T cells express protective IL-10 at the peak of coronavirus-induced encephalitis. J Immunol (2011) 186(6):3642-52. doi:10.4049/jimmunol.1003292
    • (2011) J Immunol , vol.186 , Issue.6 , pp. 3642-3652
    • Trandem, K.1    Zhao, J.2    Fleming, E.3    Perlman, S.4
  • 44
    • 30744448157 scopus 로고    scopus 로고
    • HIV-specific IL-10-positive CD8+ T cells are increased in advanced disease and are associated with decreased HIV-specific cytolysis
    • Elrefaei M, Barugahare B, Ssali F, Mugyenyi P, Cao H. HIV-specific IL-10-positive CD8+ T cells are increased in advanced disease and are associated with decreased HIV-specific cytolysis. J Immunol (2006) 176(2):1274-80. doi:10.4049/jimmunol.176.2.1274
    • (2006) J Immunol , vol.176 , Issue.2 , pp. 1274-1280
    • Elrefaei, M.1    Barugahare, B.2    Ssali, F.3    Mugyenyi, P.4    Cao, H.5
  • 45
    • 33845650186 scopus 로고    scopus 로고
    • Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection
    • Abel M, Sène D, Pol S, Bourlière M, Poynard T, Charlotte F, et al. Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection. Hepatology (2006) 44(6):1607-16. doi:10.1002/hep.21438
    • (2006) Hepatology , vol.44 , Issue.6 , pp. 1607-1616
    • Abel, M.1    Sène, D.2    Pol, S.3    Bourlière, M.4    Poynard, T.5    Charlotte, F.6
  • 46
    • 84888789471 scopus 로고    scopus 로고
    • IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism
    • Zhao Y, Zhao H, Sun Y, Hao J, Qi X, Zhou X, et al. IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism. J Leukoc Biol (2013) 94(6):1103-12. doi:10.1189/jlb.0213064
    • (2013) J Leukoc Biol , vol.94 , Issue.6 , pp. 1103-1112
    • Zhao, Y.1    Zhao, H.2    Sun, Y.3    Hao, J.4    Qi, X.5    Zhou, X.6
  • 47
    • 33744479144 scopus 로고    scopus 로고
    • Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage
    • Noble A, Giorgini A, Leggat JA. Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage. Blood (2006) 107(11):4475-83. doi:10.1182/blood-2005-10-3994
    • (2006) Blood , vol.107 , Issue.11 , pp. 4475-4483
    • Noble, A.1    Giorgini, A.2    Leggat, J.A.3
  • 48
    • 0033846725 scopus 로고    scopus 로고
    • Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production
    • Richards DF, Fernandez M, Caulfield J, Hawrylowicz CM. Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol (2000) 30:2344-54. doi:10.1002/1521-4141(2000)30:8<2344::AID-IMMU2344>3.0.CO;2-7
    • (2000) Eur J Immunol , vol.30 , pp. 2344-2354
    • Richards, D.F.1    Fernandez, M.2    Caulfield, J.3    Hawrylowicz, C.M.4
  • 49
    • 36248970702 scopus 로고    scopus 로고
    • Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
    • Fitzgerald DC, Zhang GX, El-Behi M, Fonseca-Kelly Z, Li H, Yu S, et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol (2007) 8(12):1372-9. doi:10.1038/ni1540
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1372-1379
    • Fitzgerald, D.C.1    Zhang, G.X.2    El-Behi, M.3    Fonseca-Kelly, Z.4    Li, H.5    Yu, S.6
  • 50
    • 36248970701 scopus 로고    scopus 로고
    • A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells
    • Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol (2007) 8(12):1380-9. doi:10.1038/ni1541
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1380-1389
    • Awasthi, A.1    Carrier, Y.2    Peron, J.P.3    Bettelli, E.4    Kamanaka, M.5    Flavell, R.A.6
  • 51
    • 70149105112 scopus 로고    scopus 로고
    • IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells
    • Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol (2009) 183(4):2435-43. doi:10.4049/jimmunol.0900568
    • (2009) J Immunol , vol.183 , Issue.4 , pp. 2435-2443
    • Murugaiyan, G.1    Mittal, A.2    Lopez-Diego, R.3    Maier, L.M.4    Anderson, D.E.5    Weiner, H.L.6
  • 52
    • 79952317431 scopus 로고    scopus 로고
    • IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3
    • Wang H, Meng R, Li Z, Yang B, Liu Y, Huang F, et al. IL-27 induces the differentiation of Tr1-like cells from human naive CD4+ T cells via the phosphorylation of STAT1 and STAT3. Immunol Lett (2011) 136(1):21-8. doi:10.1016/j.imlet.2010.11.007
    • (2011) Immunol Lett , vol.136 , Issue.1 , pp. 21-28
    • Wang, H.1    Meng, R.2    Li, Z.3    Yang, B.4    Liu, Y.5    Huang, F.6
  • 53
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines
    • Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, et al. In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)-and Th2-inducing cytokines. J Exp Med (2002) 195(5):603-16. doi:10.1084/jem.20011629
    • (2002) J Exp Med , vol.195 , Issue.5 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3    Richards, D.F.4    Crain, C.5    Savelkoul, H.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.