Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site

Immunity

Volumn 15, Issue 1, 2001, Pages 35-46

  Josephson, Kristopher ^a,b   Logsdon, Naomi J ^a   Walter, Mark R ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; RECEPTOR SUBTYPE;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0034897552     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00169-8     Document Type: Article

References (50)

1. Structural design and molecular evolution of a cytokine receptor superfamily
2. Shared architecture of hormone binding domain in type I and II interferon receptors
3. Interleukin 20: Discovery, receptor identification, and role in epidermal function
4. Crystal structure of a cytokine-binding region of gp130
5. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
6. Crystallography and NMR system (CNS): A new software suite for macromolecular structure determination
7. Ribbons
8. A hot spot of binding energy in a hormone-receptor interface
9. The CCP4 suite: Programs for protein crystallography
10. Miscellaneous algorithms for density modification
11. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
12. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9
13. Human interleukin-10-related T cell-derived inducible factor: Molecular cloning and functional characterization as an hepatocyte-stimulating factor
14. A homolog of interleukin-10 is encoded by the poxvirus orf virus
15. Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
16. Crystal structure of the extracellular region of human tissue factor
17. Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures
18. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth
19. Design and analysis of an engineered human interleukin-10 monomer
20. A solution for the best rotation to relate two sets of vectors
21. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri
22. Identification and functional characterization of a second chain of the interleukin-10 receptor complex
23. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
24. Identification of the functional IL-22 receptor complex
25. Procheck: A program to check stereochemical quality of protein structures
26. Radiation inactivation of human gamma-interferon: Cellular activation requires two dimers
27. Expression cloning and characterization of a human IL-10 receptor
28. The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor
29. Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å
30. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
31. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
32. Interleukin-10 and the interleukin-10 receptor
33. AmoRe: An automated package for molecular replacement
34. Processing of X-ray diffraction data collected in oscillation mode
35. Treatment of multiwavelength anomalous diffraction data as a special case of multiple isomorphous replacement
36. The structure and activity of a monomeric interferon-γ: α-chain receptor signaling complex
37. Mapping of the interleukin-10/interleukin-10 receptor combining site
38. Erythropoietin receptor activation by a ligand-induced conformational change
39. Molecular characterization and determination of the coding capacity of the genome of equine herpesvirus type 2 between the genome coordinates 0.235 and 0.258 (the EcoRI DNA fragment N; 4.2 kbp)
40. Chain: A crystallographic modeling package
41. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor
42. Characterization of recombinant extracellular domain of human interleukin-10 receptor
43. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-γ receptor complex
44. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI
45. Crystal structure of interleukin 10 reveals an interferon gamma-like fold
46. Crystal structure of a complex between interferon-γ and its soluble high affinity receptor
47. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R
48. Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma
49. Crystal structure of human interleukin-10 at 1.6 Å resolution and a model of a complex with its soluble receptor
50. Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10