Interleukin-2 is essential for CD4+CD25+ regulatory T cell function

European Journal of Immunology

Volumn 34, Issue 9, 2004, Pages 2480-2488

  de la Rosa, Maurus ^a   Rutz, Sascha ^a   Dorninger, Heike ^a   Scheffold, Alexander ^a  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

Author keywords

Competition; IL 10; IL 2 receptor; Immune regulation; Suppression

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; COMPETITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE REPRESSION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RECEPTOR BLOCKING; REGULATORY MECHANISM; T LYMPHOCYTE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; COCULTURE; DRUG EFFECT; PHYSIOLOGY; REGULATORY T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COCULTURE TECHNIQUES; INTERLEUKIN-10; INTERLEUKIN-2; MICE; MICE, INBRED BALB C; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES, REGULATORY;

EID: 4644369302     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425274     Document Type: Article

References (43)

1. Bach, J. F., Regulatory T cells under scrutiny. Nat. Rev. Immunol 2003. 3: 189-198.
2. Sakaguchi, S., Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000. 101: 455-458.
3. Maloy, K. J. and Powrie, F., Regulatory T cells in the control of immune pathology. Nat. Immunol. 2001. 2: 816-822.
4. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995. 155: 1151-1164.
5. Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S., Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 1996. 184: 387-396.
6. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 1998. 188: 287-296.
7. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389-400.
8. Malek, T. R., The main function of IL-2 is to promote the development of T regulatory cells. J. Leukoc. Biol. 2003. 74: 961-965.
9. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004. 22: 531-562.
10. Papiernik, M., de Moraes, M. L., Pontoux, C., Vasseur, F. and Penit, C., Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int. Immunol. 1998. 10: 371-378.
11. Malek, T. R., Yu, A., Vincek, V., Scibelli, P. and Kong, L., CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002. 17: 167-178.
12. Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C. and Horak, I., Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993. 75: 253-261.
13. + T cells. Eur. J. Immunol. 1995. 25: 3053-3059.
14. Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., Schmits, R., Simard, J. J., Ohashi, P. S. and Griesser, H., Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995. 268: 1472-1476.
15. + regulatory T cell function. J. Exp. Med. 2002. 196: 851-857.
16. + T cell numbers. J. Immunol. 2002. 169: 4850-4860.
17. Snow, J. W., Abraham, N., Ma, M. C., Herndier, B. G., Pastuszak, A. W. and Goldsmith, M. A., Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice. J. Immunol. 2003. 171: 5042-5050.
18. + immunoregulatory T cells is antigen nonspecific. J. Immunol. 2000. 164: 183-190.
19. + T cells: evidence for two distinct regulatory mechanisms. Eur. J. Immunol. 2001. 31: 1637-1645.
20. + regulatory T cells. J. Immunol. 2003. 171: 3348-3352.
21. + T cell suppressor function. Eur. J. Immunol. 2004. 34: 366-376.
22. Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L. and Powrie, F., An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 1999. 190: 995-1004.
23. + regulatory T cells and IL-10. J. Immunol. 2003. 171: 971-978.
24. + regulatory T cells by oral antigen administration. J. Immunol. 2001. 167: 4245-4253.
25. + T cells. J. Exp. Med. 1996. 183: 2669-2674.
26. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol 1998. 10: 1969-1980.
27. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J. Exp. Med. 2002. 196: 237-246.
28. Klein, L., Khazaie, K., and von Boehmer, H., In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA 2003. 100: 8886-8891.
29. + regulatory T cells control Leishmania major persistence and immunity. Nature 2002. 420: 502-507.
30. Smith, K. A. and Cantrell, D. A., Interleukin 2 regulates its own receptors. Proc. Natl. Acad. Sci. USA 1985. 82: 864-868.
31. Reem, G. H. and Yeh, N. H., Interleukin 2 regulates expression of its receptor and synthesis of gamma interferon by human T lymphocytes. Science 1984. 225: 429-430.
32. Nakajima, H., Liu, X. W., Wynshaw-Boris, A., Rosenthal, L. A., Imada, K., Finbloom, D. S., Hennighausen, L. and Leonard, W. J., An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity 1997. 7: 691-701.
33. Manz, R., Assenmacher, M., Pfluger, E., Miltenyi, S. and Radbruch, A., Analysis and sorting of live cells according to secreted molecules, relocated to a cell-surface affinity matrix. Proc. Natl. Acad. Sci. USA 1995. 92: 1921-1925.
34. Assenmacher, M., Lohning, M., Scheffold, A., Manz, R. A., Schmitz, J. and Radbruch, A., Sequential production of IL-2, IFN-gamma and IL-10 by individual staphylococcal enterotoxin B-activated T helper lymphocytes. Eur. J. Immunol. 1998. 28: 1534-1543.
35. Mosmann, T. R. and Coffman, R. L., TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol 1989. 7: 145-173.
36. Lohning, M., Richter, A., Stamm, T., Hu-Li, J., Assenmacher, M., Paul, W. E. and Radbruch, A., Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation. Proc. Natl. Acad. Sci. USA 2003. 100: 12307-12312.
37. Klebb, G., Autenrieth, I. B., Haber, H., Gillert, E., Sadlack, B., Smith, K. A. and Horak, I., Interleukin-2 is indispensable for development of immunological self-tolerance. Clin. Immunol. Immunopathol. 1996. 81: 282-286.
38. Weissman, A. M., Harford, J. B., Svetlik, P. B., Leonard, W. L., Depper, J. M., Waldmann, T. A., Greene, W. C. and Klausner, R. D., Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc. Natl. Acad. Sci. USA 1986. 83: 1463-1466.
39. Duprez, V., Ferrer, M. and Dautry-Varsat, A., High-affinity interleukin 2 receptor alpha and beta chains are internalized and remain associated inside the cells after interleukin 2 endocytosis. J. Biol. Chem. 1992. 267: 18639-18643.
40. + T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J. Exp. Med. 2002. 196: 1335-1346.
41. Willerford, D. M., Chen, J., Ferry, J. A., Davidson, L., Me, A. and Alt, F. W., Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995. 3: 521-530.
42. + as well as. Proc. Natl. Acad. Sci. USA 2002. 99: 13031-13036.
43. Kunzendorf, U., Pohl, T., Bulfone-Paus,S., Krause, H., Notter, M., Onu, A., Walz, G.,and Diamantstein, T., Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunoglobulin fusion protein in mice. J. Clin. Invest. 1996. 97: 1204-1210.