메뉴 건너뛰기




Volumn 14, Issue 12, 2014, Pages 783-795

The IL-20 subfamily of cytokines-from host defence to tissue homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 22; INTERLEUKIN 24; INTERLEUKIN 26; INTERLEUKIN DERIVATIVE; INTERLEUKIN RECEPTOR; INTERLEUKIN-22;

EID: 84922479625     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri3766     Document Type: Review
Times cited : (303)

References (190)
  • 1
    • 79953048089 scopus 로고    scopus 로고
    • Regulation and functions of the IL-10 family of cytokines in inflammation and disease
    • Ouyang, W., Rutz, S., Crellin, N. K., Valdez, P. A., Hymowitz, S. G. Regulation and functions of the IL-10 family of cytokines in inflammation and disease. Annu. Rev. Immunol. 29, 71-109 (2011).
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 71-109
    • Ouyang, W.1    Rutz, S.2    Crellin, N.K.3    Valdez, P.A.4    Hymowitz, S.G.5
  • 2
    • 84891702406 scopus 로고    scopus 로고
    • Therapeutic opportunities of the IL-22-IL-22R1 system
    • Sabat, R., Ouyang, W., Wolk, K. Therapeutic opportunities of the IL-22-IL-22R1 system. Nature Rev. Drug Discov. 13, 21-38 (2014).
    • (2014) Nature Rev. Drug Discov. , vol.13 , pp. 21-38
    • Sabat, R.1    Ouyang, W.2    Wolk, K.3
  • 3
    • 78651375087 scopus 로고    scopus 로고
    • IL-19 IL-20 and IL-24: Potential therapeutic targets for autoimmune diseases
    • Leng, R.-X., Pan, H.-F., Tao, J.-H., Ye, D.-Q. IL-19, IL-20 and IL-24: potential therapeutic targets for autoimmune diseases. Expert Opin. Ther. Targets 15, 119-126 (2011).
    • (2011) Expert Opin. Ther. Targets , vol.15 , pp. 119-126
    • Leng, R.-X.1    Pan, H.-F.2    Tao, J.-H.3    Ye, D.-Q.4
  • 4
    • 0034303102 scopus 로고    scopus 로고
    • Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
    • Gallagher, G. et al. Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10). Genes Immun. 1, 442-450 (2000).
    • (2000) Genes Immun , vol.1 , pp. 442-450
    • Gallagher, G.1
  • 5
    • 17744373448 scopus 로고    scopus 로고
    • Interleukin 20: Discovery, receptor identification, and role in epidermal function
    • Blumberg, H. et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 104, 9-19 (2001).
    • (2001) Cell , vol.104 , pp. 9-19
    • Blumberg, H.1
  • 6
    • 0034651583 scopus 로고    scopus 로고
    • Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9
    • Dumoutier, L., Louahed, J., Renauld, J. C. Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9. J. Immunol. 164, 1814-1819 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 1814-1819
    • Dumoutier, L.1    Louahed, J.2    Renauld, J.C.3
  • 7
    • 0029558740 scopus 로고
    • Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression
    • Jiang, H., Lin, J. J., Su, Z. Z., Goldstein, N. I., Fisher, P. B. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene 11, 2477-2486 (1995).
    • (1995) Oncogene , vol.11 , pp. 2477-2486
    • Jiang, H.1    Lin, J.J.2    Su, Z.Z.3    Goldstein, N.I.4    Fisher, P.B.5
  • 8
    • 70450224084 scopus 로고    scopus 로고
    • Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family
    • Wang, T., Diaz-Rosales, P., Martin, S. A., Secombes, C. J. Cloning of a novel interleukin (IL)-20-like gene in rainbow trout Oncorhynchus mykiss gives an insight into the evolution of the IL-10 family. Dev. Comp. Immunol. 34, 158-167 (2010).
    • (2010) Dev. Comp. Immunol. , vol.34 , pp. 158-167
    • Wang, T.1    Diaz-Rosales, P.2    Martin, S.A.3    Secombes, C.J.4
  • 9
    • 0342803595 scopus 로고    scopus 로고
    • Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri
    • Knappe, A., Hor, S., Wittmann, S., Fickenscher, H. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. J. Virol. 74, 3881-3887 (2000).
    • (2000) J. Virol. , vol.74 , pp. 3881-3887
    • Knappe, A.1    Hor, S.2    Wittmann, S.3    Fickenscher, H.4
  • 10
    • 28244474539 scopus 로고    scopus 로고
    • Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster
    • Jones, E. A., Flavell, R. A. Distal enhancer elements transcribe intergenic RNA in the IL-10 family gene cluster. J. Immunol. 175, 7437-7446 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 7437-7446
    • Jones, E.A.1    Flavell, R.A.2
  • 11
    • 2342659126 scopus 로고    scopus 로고
    • Interleukin-10 and related cytokines and receptors
    • Pestka, S. et al. Interleukin-10 and related cytokines and receptors. Annu. Rev. Immunol. 22, 929-979 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 929-979
    • Pestka, S.1
  • 13
    • 0035877120 scopus 로고    scopus 로고
    • Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
    • Kotenko, S. V. et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J. Immunol. 166, 7096-7103 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 7096-7103
    • Kotenko, S.V.1
  • 14
    • 0035859898 scopus 로고    scopus 로고
    • A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist
    • Xu, W. et al. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc. Natl Acad. Sci. USA 98, 9511-9516 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 9511-9516
    • Xu, W.1
  • 15
    • 84890905720 scopus 로고    scopus 로고
    • Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid
    • Martin, J. C. et al. Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid. Mucosal Immunol. 7, 101-113 (2014).
    • (2014) Mucosal Immunol , vol.7 , pp. 101-113
    • Martin, J.C.1
  • 16
    • 84868615556 scopus 로고    scopus 로고
    • IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
    • Huber, S. et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491, 259-263 (2012).
    • (2012) Nature , vol.491 , pp. 259-263
    • Huber, S.1
  • 17
    • 84903479494 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 Stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia
    • Weathington, N. M. et al. Glycogen synthase kinase-3 stabilizes the interleukin (IL)-22 receptor from proteasomal degradation in murine lung epithelia. J. Biol. Chem. 289, 17610-17619 (2014).
    • (2014) J. Biol. Chem. , vol.289 , pp. 17610-17619
    • Weathington, N.M.1
  • 18
    • 0036604122 scopus 로고    scopus 로고
    • Cutting edge: Immune cells as sources and targets of the IL-10 family members?
    • Wolk, K., Kunz, S., Asadullah, K., Sabat, R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol. 168, 5397-5402 (2002).
    • (2002) J Immunol , vol.168 , pp. 5397-5402
    • Wolk, K.1    Kunz, S.2    Asadullah, K.3    Sabat, R.4
  • 19
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng, Y. et al. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648-651 (2007).
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1
  • 20
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • Zheng, Y. et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nature Med. 14, 282-289 (2008).
    • (2008) Nature Med , vol.14 , pp. 282-289
    • Zheng, Y.1
  • 21
    • 77953802446 scopus 로고    scopus 로고
    • IL-22 defines a novel immune pathway of antifungal resistance
    • de Luca, A. et al. IL-22 defines a novel immune pathway of antifungal resistance. Mucosal Immunol. 3, 361-373 (2010).
    • (2010) Mucosal Immunol , vol.3 , pp. 361-373
    • De Luca, A.1
  • 22
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • Pickert, G. et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465-1472 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1465-1472
    • Pickert, G.1
  • 23
    • 84881110953 scopus 로고    scopus 로고
    • IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
    • Zindl, C. L. et al. IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis. Proc. Natl Acad. Sci. USA 110, 12768-12773 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 12768-12773
    • Zindl, C.L.1
  • 24
    • 33745209428 scopus 로고    scopus 로고
    • Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects
    • Wang, F. et al. Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects. J. Investigative Dermatol. 126, 1590-1599 (2006).
    • (2006) J. Investigative Dermatol. , vol.126 , pp. 1590-1599
    • Wang, F.1
  • 25
    • 46949101054 scopus 로고    scopus 로고
    • Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes
    • Wolk, K. et al. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes. J. Leukoc. Biol. 83, 1181-1193 (2008).
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 1181-1193
    • Wolk, K.1
  • 26
    • 33846940253 scopus 로고    scopus 로고
    • The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis
    • Sa, S. M. et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J. Immunol. 178, 2229-2240 (2007)
    • (2007) J. Immunol. , vol.178 , pp. 2229-2240
    • Sa, S.M.1
  • 27
    • 36849036400 scopus 로고    scopus 로고
    • Transcriptional responses of human epidermal keratinocytes to cytokine interleukin-1
    • Yano, S., Banno, T., Walsh, R., Blumenberg, M. Transcriptional responses of human epidermal keratinocytes to cytokine interleukin-1. J. Cell. Physiol. 214, 1-13 (2008).
    • (2008) J. Cell. Physiol. , vol.214 , pp. 1-13
    • Yano, S.1    Banno, T.2    Walsh, R.3    Blumenberg, M.4
  • 28
    • 33750694954 scopus 로고    scopus 로고
    • Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes
    • Hunt, D. W. et al. Ultraviolet B light stimulates interleukin-20 expression by human epithelial keratinocytes. Photochem. Photobiol. 82, 1292-1300 (2006).
    • (2006) Photochem. Photobiol. , vol.82 , pp. 1292-1300
    • Hunt, D.W.1
  • 29
    • 73249116548 scopus 로고    scopus 로고
    • The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis
    • Wolk, K. et al. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur. J. Immunol. 39, 3570-3581 (2009).
    • (2009) Eur. J. Immunol. , vol.39 , pp. 3570-3581
    • Wolk, K.1
  • 30
    • 40049098958 scopus 로고    scopus 로고
    • IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
    • Aujla, S. J. et al. IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia. Nature Med. 14, 275-281 (2008).
    • (2008) Nature Med , vol.14 , pp. 275-281
    • Aujla, S.J.1
  • 31
    • 44649131954 scopus 로고    scopus 로고
    • Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma
    • Huang, F. et al. Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma. J. Allergy Clin. Immunol. 121, 1415-1421 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.121 , pp. 1415-1421
    • Huang, F.1
  • 32
  • 33
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang, W., Kolls, J. K., Zheng, Y. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28, 454-467 (2008).
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 34
    • 68249137286 scopus 로고    scopus 로고
    • Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity
    • Colonna, M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity 31, 15-23 (2009).
    • (2009) Immunity , vol.31 , pp. 15-23
    • Colonna, M.1
  • 35
    • 57849131584 scopus 로고    scopus 로고
    • Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells
    • Cupedo, T. et al. Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nature Immunol. 10, 66-74 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 66-74
    • Cupedo, T.1
  • 36
    • 68649126866 scopus 로고    scopus 로고
    • Interleukin-17-producing T cells selectively expand in response to pathogen products and environmental signals
    • Martin, B., Hirota, K., Cua, D. J., Stockinger, B., Veldhoen, M. Interleukin-17-producing T cells selectively expand in response to pathogen products and environmental signals. Immunity 31, 321-330 (2009).
    • (2009) Immunity , vol.31 , pp. 321-330
    • Martin, B.1    Hirota, K.2    Cua, D.J.3    Stockinger, B.4    Veldhoen, M.5
  • 37
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from T cells, amplifying Th17 responses and autoimmunity
    • Sutton, C. E. et al. Interleukin-1 and IL-23 induce innate IL-17 production from T cells, amplifying Th17 responses and autoimmunity. Immunity 31, 331-341 (2009).
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1
  • 38
    • 60549102720 scopus 로고    scopus 로고
    • Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
    • Takatori, H. et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206, 35-41 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 35-41
    • Takatori, H.1
  • 39
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-a proposal for uniform nomenclature
    • Spits, H. et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nature Rev. Immunology 13, 145-149 (2013).
    • (2013) Nature Rev. Immunology , vol.13 , pp. 145-149
    • Spits, H.1
  • 40
    • 57449118239 scopus 로고    scopus 로고
    • Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    • Satoh-Takayama, N. et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29, 958-970 (2008).
    • (2008) Immunity , vol.29 , pp. 958-970
    • Satoh-Takayama, N.1
  • 41
    • 57849145994 scopus 로고    scopus 로고
    • Influence of the transcription factor ROR?t on the development of NKp46+ cell populations in gut and skin
    • Luci, C. et al. Influence of the transcription factor ROR?t on the development of NKp46+ cell populations in gut and skin. Nature Immunol. 10, 75-82 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 75-82
    • Luci, C.1
  • 42
    • 57849117363 scopus 로고    scopus 로고
    • RORt and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    • Sanos, S. L. et al. ROR?t and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nature Immunol. 10, 83-91 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1
  • 43
    • 59649099774 scopus 로고    scopus 로고
    • A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    • Cella, M. et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature 457, 722-725 (2009).
    • (2009) Nature , vol.457 , pp. 722-725
    • Cella, M.1
  • 44
    • 77149135298 scopus 로고    scopus 로고
    • Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells
    • Crellin, N. K., Trifari, S., Kaplan, C. D., Cupedo, T., Spits, H. Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. J. Exp. Med. 207, 281-290 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 281-290
    • Crellin, N.K.1    Trifari, S.2    Kaplan, C.D.3    Cupedo, T.4    Spits, H.5
  • 45
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang, S. C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271-2279 (2006)
    • (2006) J. Exp. Med. , vol.203 , pp. 2271-2279
    • Liang, S.C.1
  • 46
    • 33751120140 scopus 로고    scopus 로고
    • Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes
    • Chung, Y. et al. Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res. 16, 902-907 (2006).
    • (2006) Cell Res , vol.16 , pp. 902-907
    • Chung, Y.1
  • 47
    • 2142659288 scopus 로고    scopus 로고
    • IL-22 a Th1 cytokine that targets the pancreas and select other peripheral tissues
    • Gurney, A. L. IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues. Int. Immunopharmacol. 4, 669-677 (2004).
    • (2004) Int. Immunopharmacol. , vol.4 , pp. 669-677
    • Gurney, A.L.1
  • 48
    • 67651154105 scopus 로고    scopus 로고
    • Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
    • Duhen, T., Geiger, R., Jarrossay, D., Lanzavecchia, A., Sallusto, F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nature Immunol. 10, 857-863 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 857-863
    • Duhen, T.1    Geiger, R.2    Jarrossay, D.3    Lanzavecchia, A.4    Sallusto, F.5
  • 49
    • 72849131815 scopus 로고    scopus 로고
    • Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling
    • Eyerich, S. et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J. Clin. Invest. 119, 3573-3585 (2009).
    • (2009) J. Clin. Invest. , vol.119 , pp. 3573-3585
    • Eyerich, S.1
  • 50
    • 67651171182 scopus 로고    scopus 로고
    • Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17 TH1 and TH2 cells
    • Trifari, S., Kaplan, C. D., Tran, E. H., Crellin, N. K., Spits, H. Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells. Nature Immunol. 10, 864-871 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 864-871
    • Trifari, S.1    Kaplan, C.D.2    Tran, E.H.3    Crellin, N.K.4    Spits, H.5
  • 51
    • 84870876967 scopus 로고    scopus 로고
    • Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria
    • Basu, R. et al. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity 37, 1061-1075 (2012).
    • (2012) Immunity , vol.37 , pp. 1061-1075
    • Basu, R.1
  • 52
    • 36248965294 scopus 로고    scopus 로고
    • TGF-and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology
    • McGeachy, M. J. et al. TGF-? and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology. Nature Immunol. 8, 1390-1397 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 1390-1397
    • McGeachy, M.J.1
  • 53
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva, R. et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448, 480-483 (2007).
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1
  • 54
    • 40049103352 scopus 로고    scopus 로고
    • IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg, K. et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179, 8098-8104 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 8098-8104
    • Kreymborg, K.1
  • 55
    • 65549142116 scopus 로고    scopus 로고
    • Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis
    • Siegemund, S. et al. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis. Int. Immunol. 21, 555-565 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 555-565
    • Siegemund, S.1
  • 56
    • 77950548359 scopus 로고    scopus 로고
    • Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis
    • Mus, A. M. C. et al. Interleukin-23 promotes Th17 differentiation by inhibiting T-bet and FoxP3 and is required for elevation of interleukin-22, but not interleukin-21, in autoimmune experimental arthritis. Arthritis Rheum. 62, 1043-1050 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1043-1050
    • Mus, A.M.C.1
  • 57
    • 67649216137 scopus 로고    scopus 로고
    • Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    • Mukherjee, S., Schaller, M. A., Neupane, R., Kunkel, S. L., Lukacs, N. W. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J. Immunol. 182, 7381-7388 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 7381-7388
    • Mukherjee, S.1    Schaller, M.A.2    Neupane, R.3    Kunkel, S.L.4    Lukacs, N.W.5
  • 58
    • 77950534839 scopus 로고    scopus 로고
    • Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor
    • Alam, M. S. et al. Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor. Proc. Natl Acad. Sci. USA 107, 5943-5948 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 5943-5948
    • Alam, M.S.1
  • 59
    • 60549095448 scopus 로고    scopus 로고
    • Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells
    • Veldhoen, M., Hirota, K., Christensen, J., O.&apos, Garra, A., Stockinger, B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J. Exp. Med. 206, 43-49 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 43-49
    • Veldhoen, M.1    Hirota, K.2    Christensen, J.O.3    Apos4    Garra, A.5    Stockinger, B.6
  • 60
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    • Veldhoen, M. et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109 (2008).
    • (2008) Nature , vol.453 , pp. 106-109
    • Veldhoen, M.1
  • 61
    • 0035873471 scopus 로고    scopus 로고
    • Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells
    • Schaefer, G., Venkataraman, C., Schindler, U. Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells. J. Immunol. 166, 5859-5863 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 5859-5863
    • Schaefer, G.1    Venkataraman, C.2    Schindler, U.3
  • 62
    • 33845589222 scopus 로고    scopus 로고
    • Involvement of GATA3 in protein kinase C ?-induced Th2 cytokine expression
    • Stevens, L. et al. Involvement of GATA3 in protein kinase C ?-induced Th2 cytokine expression. Eur. J. Immunol. 36, 3305-3314 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , pp. 3305-3314
    • Stevens, L.1
  • 63
    • 79955043870 scopus 로고    scopus 로고
    • Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression
    • Sahoo, A. et al. Stat6 and c-Jun mediate Th2 cell-specific IL-24 gene expression. J. Immunol. 186, 4098-4109 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 4098-4109
    • Sahoo, A.1
  • 64
    • 34548133583 scopus 로고    scopus 로고
    • Development, cytokine profile and function of human interleukin 17-producing helper T cells
    • Wilson, N. J. et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nature Immunol. 8, 950-957 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 950-957
    • Wilson, N.J.1
  • 65
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human TH-17 cells requires transforming growth factor-and induction of the nuclear receptor RORt
    • Manel, N., Unutmaz, D., Littman, D. R. The differentiation of human TH-17 cells requires transforming growth factor-? and induction of the nuclear receptor ROR?t. Nature Immunol. 9, 641-649 (2008).
    • (2008) Nature Immunol , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 66
    • 78650183459 scopus 로고    scopus 로고
    • Regulation of cytokine secretion in human CD127+ LTi-like innate lymphoid cells by Toll-like receptor 2
    • Crellin, N. K. et al. Regulation of cytokine secretion in human CD127+ LTi-like innate lymphoid cells by Toll-like receptor 2. Immunity 33, 752-764 (2010).
    • (2010) Immunity , vol.33 , pp. 752-764
    • Crellin, N.K.1
  • 67
    • 84883172356 scopus 로고    scopus 로고
    • Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
    • Satpathy, A. T. et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature Immunol. 14, 937-948 (2013).
    • (2013) Nature Immunol , vol.14 , pp. 937-948
    • Satpathy, A.T.1
  • 68
    • 77955499820 scopus 로고    scopus 로고
    • TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3negCD127+ immune cells in spleen and mucosa
    • Van Maele, L. et al. TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3negCD127+ immune cells in spleen and mucosa. J. Immunol. 185, 1177-1185 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 1177-1185
    • Van Maele, L.1
  • 69
    • 70049098070 scopus 로고    scopus 로고
    • Origin of the lamina propria dendritic cell network
    • Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513-525 (2009).
    • (2009) Immunity , vol.31 , pp. 513-525
    • Bogunovic, M.1
  • 70
    • 70049099836 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cell subsets have different origin and functions
    • Varol, C. et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31, 502-512 (2009).
    • (2009) Immunity , vol.31 , pp. 502-512
    • Varol, C.1
  • 71
    • 34249298734 scopus 로고    scopus 로고
    • Control of intestinal homeostasis by regulatory T cells and dendritic cells
    • Coombes, J. L., Maloy, K. J. Control of intestinal homeostasis by regulatory T cells and dendritic cells. Semin. Immunol. 19, 116-126 (2007).
    • (2007) Semin. Immunol. , vol.19 , pp. 116-126
    • Coombes, J.L.1    Maloy, K.J.2
  • 72
    • 84857444876 scopus 로고    scopus 로고
    • Interleukin 23 production by intestinal CD103+CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    • Kinnebrew, M. A. et al. Interleukin 23 production by intestinal CD103+CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36, 276-287 (2012).
    • (2012) Immunity , vol.36 , pp. 276-287
    • Kinnebrew, M.A.1
  • 73
    • 75749133608 scopus 로고    scopus 로고
    • Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection
    • Kinnebrew, M. A. et al. Bacterial flagellin stimulates Toll-like receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J. Infect. Dis. 201, 534-543 (2010).
    • (2010) J. Infect. Dis. , vol.201 , pp. 534-543
    • Kinnebrew, M.A.1
  • 74
    • 80052966918 scopus 로고    scopus 로고
    • IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
    • Ota, N. et al. IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nature Immunol. 12, 941-948 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 941-948
    • Ota, N.1
  • 75
    • 79960500206 scopus 로고    scopus 로고
    • Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge
    • Tumanov, A. V. et al. Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe 10, 44-53 (2011).
    • (2011) Cell Host Microbe , vol.10 , pp. 44-53
    • Tumanov, A.V.1
  • 76
    • 7644235586 scopus 로고    scopus 로고
    • The lymphotoxin-receptor is critical for control of murine Citrobacter rodentium-induced colitis
    • Spahn, T. W. et al. The lymphotoxin-receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology 127, 1463-1473 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 1463-1473
    • Spahn, T.W.1
  • 77
    • 77950022870 scopus 로고    scopus 로고
    • Lymphotoxin receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection
    • Wang, Y. et al. Lymphotoxin ? receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity 32, 403-413 (2010).
    • (2010) Immunity , vol.32 , pp. 403-413
    • Wang, Y.1
  • 78
    • 84874082076 scopus 로고    scopus 로고
    • CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
    • Manta, C. et al. CX3CR1+ macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium. Mucosal Immunol. 6, 177-188 (2013)
    • (2013) Mucosal Immunol , vol.6 , pp. 177-188
    • Manta, C.1
  • 79
    • 78751706261 scopus 로고    scopus 로고
    • CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut
    • Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A., Artis, D. CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 34, 122-134 (2011).
    • (2011) Immunity , vol.34 , pp. 122-134
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3    Fouser, L.A.4    Artis, D.5
  • 80
    • 84870900504 scopus 로고    scopus 로고
    • Ly6Chi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
    • Zigmond, E. et al. Ly6Chi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 37, 1076-1090 (2012).
    • (2012) Immunity , vol.37 , pp. 1076-1090
    • Zigmond, E.1
  • 81
    • 79956319462 scopus 로고    scopus 로고
    • The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes
    • Kim, Y.-G. et al. The Nod2 sensor promotes intestinal pathogen eradication via the chemokine CCL2-dependent recruitment of inflammatory monocytes. Immunity 34, 769-780 (2011).
    • (2011) Immunity , vol.34 , pp. 769-780
    • Kim, Y.-G.1
  • 82
    • 78449291921 scopus 로고    scopus 로고
    • Skin function for human CD1a-reactive T cells
    • Colonna, M. Skin function for human CD1a-reactive T cells. Nature Immunol. 11, 1079-1080 (2010).
    • (2010) Nature Immunol , vol.11 , pp. 1079-1080
    • Colonna, M.1
  • 83
    • 78449298644 scopus 로고    scopus 로고
    • CD1a-autoreactive T cells are a normal component of the human T cell repertoire
    • de Jong, A. et al. CD1a-autoreactive T cells are a normal component of the human T cell repertoire. Nature Immunol. 11, 1102-1109 (2010).
    • (2010) Nature Immunol , vol.11 , pp. 1102-1109
    • De Jong, A.1
  • 84
    • 79955030498 scopus 로고    scopus 로고
    • Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    • Sonnenberg, G. F., Fouser, L. A., Artis, D. Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nature Immunol. 12, 383-390 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 383-390
    • Sonnenberg, G.F.1    Fouser, L.A.2    Artis, D.3
  • 85
    • 84883883299 scopus 로고    scopus 로고
    • Modulation of respiratory dendritic cells during Klebsiella pneumonia infection
    • Hackstein, H. et al. Modulation of respiratory dendritic cells during Klebsiella pneumonia infection. Respir. Res. 14, 91 (2013).
    • (2013) Respir. Res. , vol.14 , pp. 91
    • Hackstein, H.1
  • 86
    • 80053898773 scopus 로고    scopus 로고
    • IL10 family member genes IL19 and IL20 are associated with recurrent wheeze after respiratory syncytial virus bronchiolitis
    • Ermers, M. J. et al. IL10 family member genes IL19 and IL20 are associated with recurrent wheeze after respiratory syncytial virus bronchiolitis. Pediatr. Res. 70, 518-523 (2011).
    • (2011) Pediatr. Res. , vol.70 , pp. 518-523
    • Ermers, M.J.1
  • 87
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • Sonnenberg, G. F. et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336, 1321-1325 (2012).
    • (2012) Science , vol.336 , pp. 1321-1325
    • Sonnenberg, G.F.1
  • 89
    • 84858587977 scopus 로고    scopus 로고
    • Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: Potential role in protection against lung epithelial damages
    • Paget, C. et al. Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages. J. Biol. Chem. 287, 8816-8829 (2012).
    • (2012) J. Biol. Chem. , vol.287 , pp. 8816-8829
    • Paget, C.1
  • 90
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: A potential role in psoriasis
    • Wolk, K. et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36, 1309-1323 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , pp. 1309-1323
    • Wolk, K.1
  • 91
    • 14844342604 scopus 로고    scopus 로고
    • IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    • Boniface, K. et al. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J. Immunol. 174, 3695-3702 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 3695-3702
    • Boniface, K.1
  • 92
    • 68849124464 scopus 로고    scopus 로고
    • The role of the novel Th17 cytokine IL-26 in intestinal inflammation
    • Dambacher, J. et al. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut 58, 1207-1217 (2009).
    • (2009) Gut , vol.58 , pp. 1207-1217
    • Dambacher, J.1
  • 93
    • 84894055913 scopus 로고    scopus 로고
    • The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria
    • Behnsen, J. et al. The cytokine IL-22 promotes pathogen colonization by suppressing related commensal bacteria. Immunity 40, 262-273 (2014).
    • (2014) Immunity , vol.40 , pp. 262-273
    • Behnsen, J.1
  • 94
    • 84863338466 scopus 로고    scopus 로고
    • Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut
    • Liu, J. Z. et al. Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut. Cell Host Microbe 11, 227-239 (2012).
    • (2012) Cell Host Microbe , vol.11 , pp. 227-239
    • Liu, J.Z.1
  • 95
    • 65549099573 scopus 로고    scopus 로고
    • Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
    • Raffatellu, M. et al. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 5, 476-486 (2009).
    • (2009) Cell Host Microbe , vol.5 , pp. 476-486
    • Raffatellu, M.1
  • 96
    • 79958246450 scopus 로고    scopus 로고
    • Salmonella-induced mucosal lectin RegIII kills competing gut microbiota
    • Stelter, C. et al. Salmonella-induced mucosal lectin RegIII kills competing gut microbiota. PLoS ONE 6, e20749 (2011).
    • (2011) PLoS ONE , vol.6 , pp. e20749
    • Stelter, C.1
  • 97
    • 84876501381 scopus 로고    scopus 로고
    • The dynamics of gut-associated microbial communities during inflammation
    • Winter, S. E., Lopez, C. A., Baumler, A. J. The dynamics of gut-associated microbial communities during inflammation. EMBO Rep. 14, 319-327 (2013).
    • (2013) EMBO Rep , vol.14 , pp. 319-327
    • Winter, S.E.1    Lopez, C.A.2    Baumler, A.J.3
  • 98
    • 84880821538 scopus 로고    scopus 로고
    • Signaling via the IL-20 receptor inhibits cutaneous production of IL-1? and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus
    • Myles, I. A. et al. Signaling via the IL-20 receptor inhibits cutaneous production of IL-1? and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nature Immunol. 14, 804-811 (2013).
    • (2013) Nature Immunol , vol.14 , pp. 804-811
    • Myles, I.A.1
  • 99
    • 30444459066 scopus 로고    scopus 로고
    • MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus
    • Miller, L. S. et al. MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus. Immunity 24, 79-91 (2006).
    • (2006) Immunity , vol.24 , pp. 79-91
    • Miller, L.S.1
  • 100
    • 77951861324 scopus 로고    scopus 로고
    • IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice
    • Cho, J. S. et al. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J. Clin. Invest. 120, 1762-1773 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 1762-1773
    • Cho, J.S.1
  • 101
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes, M. A., Bowcock, A. M., Krueger, J. G. Pathogenesis and therapy of psoriasis. Nature 445, 866-873 (2007).
    • (2007) Nature , vol.445 , pp. 866-873
    • Lowes, M.A.1    Bowcock, A.M.2    Krueger, J.G.3
  • 102
    • 77949889459 scopus 로고    scopus 로고
    • IL-24 transgenic mice: In vivo evidence of overlapping functions for IL-20 IL-22 and IL-24 in the epidermis
    • He, M., Liang, P. IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. J. Immunol. 184, 1793-1798 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 1793-1798
    • He, M.1    Liang, P.2
  • 103
    • 67349195975 scopus 로고    scopus 로고
    • IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN- are not
    • Wolk, K. et al. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN- are not. J. Mol. Med. 87, 523-536 (2009).
    • (2009) J. Mol. Med. , vol.87 , pp. 523-536
    • Wolk, K.1
  • 104
    • 4143095716 scopus 로고    scopus 로고
    • IL-22 increases the innate immunity of tissues
    • Wolk, K. et al. IL-22 increases the innate immunity of tissues. Immunity 21, 241-254 (2004)
    • (2004) Immunity , vol.21 , pp. 241-254
    • Wolk, K.1
  • 105
    • 0346364791 scopus 로고    scopus 로고
    • Epidermal overexpression of interleukin-19 and-20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol
    • Romer, J. et al. Epidermal overexpression of interleukin-19 and-20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol. J. Invest. Dermatol. 121, 1306-1311 (2003).
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 1306-1311
    • Romer, J.1
  • 106
    • 27544481752 scopus 로고    scopus 로고
    • The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis
    • Otkjaer, K. et al. The dynamics of gene expression of interleukin-19 and interleukin-20 and their receptors in psoriasis. Br. J. Dermatol. 153, 911-918 (2005).
    • (2005) Br. J. Dermatol. , vol.153 , pp. 911-918
    • Otkjaer, K.1
  • 107
    • 78649690842 scopus 로고    scopus 로고
    • Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease
    • Ouyang, W. Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease. Cytokine Growth Factor Rev. 21, 435-441 (2010).
    • (2010) Cytokine Growth Factor Rev , vol.21 , pp. 435-441
    • Ouyang, W.1
  • 108
    • 33645829078 scopus 로고    scopus 로고
    • IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    • Brand, S. et al. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G827-G838 (2006).
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290 , pp. G827-G838
    • Brand, S.1
  • 109
    • 24144477540 scopus 로고    scopus 로고
    • Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    • Andoh, A. et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 129, 969-984 (2005).
    • (2005) Gastroenterology , vol.129 , pp. 969-984
    • Andoh, A.1
  • 110
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto, K. et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 534-544
    • Sugimoto, K.1
  • 111
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • Zenewicz, L. A. et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 29, 947-957 (2008).
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1
  • 112
    • 77953143699 scopus 로고    scopus 로고
    • Activation of epithelial STAT3 regulates intestinal homeostasis
    • Neufert, C. et al. Activation of epithelial STAT3 regulates intestinal homeostasis. Cell Cycle 9, 652-655 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 652-655
    • Neufert, C.1
  • 113
  • 114
    • 84879880293 scopus 로고    scopus 로고
    • IL-10-and IL-20-expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis
    • Fonseca-Camarillo, G., Furuzawa-Carballeda, J., Llorente, L., Yamamoto-Furusho, J. K. IL-10-and IL-20-expressing epithelial and inflammatory cells are increased in patients with ulcerative colitis. J. Clin. Immunol. 33, 640-648 (2013).
    • (2013) J. Clin. Immunol. , vol.33 , pp. 640-648
    • Fonseca-Camarillo, G.1    Furuzawa-Carballeda, J.2    Llorente, L.3    Yamamoto-Furusho, J.K.4
  • 115
    • 68949122797 scopus 로고    scopus 로고
    • Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease
    • Andoh, A. et al. Expression of IL-24, an activator of the JAK1/STAT3/SOCS3 cascade, is enhanced in inflammatory bowel disease. J. Immunol. 183, 687-695 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 687-695
    • Andoh, A.1
  • 116
    • 77952716486 scopus 로고    scopus 로고
    • Interleukin-19 protects mice from innate-mediated colonic inflammation
    • Azuma, Y. T. et al. Interleukin-19 protects mice from innate-mediated colonic inflammation. Inflamm. Bowel Dis. 16, 1017-1028 (2010).
    • (2010) Inflamm. Bowel Dis. , vol.16 , pp. 1017-1028
    • Azuma, Y.T.1
  • 117
    • 44849111860 scopus 로고    scopus 로고
    • Expression of IL-19 and its receptors in RA: Potential role for synovial hyperplasia formation
    • Sakurai, N. et al. Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation. Rheumatol. 47, 815-820 (2008).
    • (2008) Rheumatol , vol.47 , pp. 815-820
    • Sakurai, N.1
  • 118
    • 17244381180 scopus 로고    scopus 로고
    • Expression of interleukin-22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine
    • Ikeuchi, H. et al. Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine. Arthritis Rheum. 52, 1037-1046 (2005).
    • (2005) Arthritis Rheum , vol.52 , pp. 1037-1046
    • Ikeuchi, H.1
  • 119
    • 37449013636 scopus 로고    scopus 로고
    • The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy
    • Kragstrup, T. W. et al. The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy. Cytokine 41, 16-23 (2008).
    • (2008) Cytokine , vol.41 , pp. 16-23
    • Kragstrup, T.W.1
  • 120
    • 84866714220 scopus 로고    scopus 로고
    • IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation
    • Corvaisier, M. et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 10, e1001395 (2012).
    • (2012) PLoS Biol , vol.10 , pp. e1001395
    • Corvaisier, M.1
  • 121
    • 77950243426 scopus 로고    scopus 로고
    • Expression of IL-10 family cytokines in rheumatoid arthritis: Elevated levels of IL-19 in the joints
    • Alanara, T., Karstila, K., Moilanen, T., Silvennoinen, O., Isomaki, P. Expression of IL-10 family cytokines in rheumatoid arthritis: elevated levels of IL-19 in the joints. Scand. J. Rheumatol 39, 118-126 (2010).
    • (2010) Scand. J. Rheumatol , vol.39 , pp. 118-126
    • Alanara, T.1    Karstila, K.2    Moilanen, T.3    Silvennoinen, O.4    Isomaki, P.5
  • 122
    • 33749320939 scopus 로고    scopus 로고
    • Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis
    • Hsu, Y.-H. et al. Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis. Arthritis Rheum. 54, 2722-2733 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 2722-2733
    • Hsu, Y.-H.1
  • 123
    • 47249125726 scopus 로고    scopus 로고
    • Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes
    • P?ne, J. et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol. 180, 7423-7430 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 7423-7430
    • Pne, J.1
  • 124
    • 66449133523 scopus 로고    scopus 로고
    • Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis
    • Shen, H., Goodall, J. C., Hill Gaston, J. S. Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum. 60, 1647-1656 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 1647-1656
    • Shen, H.1    Goodall, J.C.2    Hill Gaston, J.S.3
  • 125
    • 79959811817 scopus 로고    scopus 로고
    • Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis
    • Leipe, J. et al. Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis. Ann. Rheum. Dis. 70, 1453-1457 (2011).
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 1453-1457
    • Leipe, J.1
  • 126
    • 84859237495 scopus 로고    scopus 로고
    • Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis
    • Zhang, L. et al. Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis. PLoS ONE 7, e31000 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e31000
    • Zhang, L.1
  • 127
    • 84857551794 scopus 로고    scopus 로고
    • Interleukin-19 blockade attenuates collagen-induced arthritis in rats
    • Hsu, Y. H., Hsieh, P. P., Chang, M. S. Interleukin-19 blockade attenuates collagen-induced arthritis in rats. Rheumatol. 51, 434-442 (2012).
    • (2012) Rheumatol , vol.51 , pp. 434-442
    • Hsu, Y.H.1    Hsieh, P.P.2    Chang, M.S.3
  • 128
    • 80555150814 scopus 로고    scopus 로고
    • Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis
    • Zhang, L. et al. Elevated Th22 cells correlated with Th17 cells in patients with rheumatoid arthritis. J. Clin. Immunol. 31, 606-614 (2011).
    • (2011) J. Clin. Immunol. , vol.31 , pp. 606614
    • Zhang, L.1
  • 129
    • 84863507522 scopus 로고    scopus 로고
    • Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity
    • da Rocha, L. F. et al. Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity. J. Rheumatol. 39, 1320-1325 (2012).
    • (2012) J. Rheumatol. , vol.39 , pp. 1320-1325
    • Da Rocha, L.F.1
  • 130
    • 59649086053 scopus 로고    scopus 로고
    • Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice
    • Geboes, L. et al. Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL/6 mice. Arthritis Rheum. 60, 390-395 (2009).
    • (2009) Arthritis Rheum , vol.60 , pp. 390-395
    • Geboes, L.1
  • 131
    • 84899835126 scopus 로고    scopus 로고
    • Endogenous IL-22 plays a dual role in arthritis: Regulation of established arthritis via IFN- responses
    • Justa, S., Zhou, X., Sarkar, S. Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN- responses. PLoS ONE 9, e93279 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e93279
    • Justa, S.1    Zhou, X.2    Sarkar, S.3
  • 132
    • 80053510122 scopus 로고    scopus 로고
    • Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation
    • Marijnissen, R. J. et al. Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation. Arthritis Rheum. 63, 2939-2948 (2011).
    • (2011) Arthritis Rheum , vol.63 , Issue.2939-2948
    • Marijnissen, R.J.1
  • 133
    • 84863697312 scopus 로고    scopus 로고
    • IL-23 induces spondyloarthropathy by acting on ROR-?t+ CD3+CD4-CD8-entheseal resident T cells
    • Sherlock, J. P. et al. IL-23 induces spondyloarthropathy by acting on ROR-?t+ CD3+CD4-CD8-entheseal resident T cells. Nature Med. 18, 1069-1076 (2012).
    • (2012) Nature Med , vol.18 , pp. 1069-1076
    • Sherlock, J.P.1
  • 134
    • 84903473100 scopus 로고    scopus 로고
    • IL-23-mediates the intestinal response to microbial ?-glucan and the development of spondyloarthritis pathology in SKG mice
    • Benham, H. et al. IL-23-mediates the intestinal response to microbial ?-glucan and the development of spondyloarthritis pathology in SKG mice. Arthritis Rheumatol. 66, 1755-1767 (2014).
    • (2014) Arthritis Rheumatol , vol.66 , pp. 1755-1767
    • Benham, H.1
  • 135
    • 84884573774 scopus 로고    scopus 로고
    • Th17 and Th22 cells in psoriatic arthritis and psoriasis
    • Benham, H. et al. Th17 and Th22 cells in psoriatic arthritis and psoriasis. Arthritis Res. Ther. 15, R136 (2013).
    • (2013) Arthritis Res. Ther. , vol.15 , pp. R136
    • Benham, H.1
  • 136
    • 0029834058 scopus 로고    scopus 로고
    • Aetiology and pathogenesis of psoriasis
    • Ortonne, J. P. Aetiology and pathogenesis of psoriasis. Br. J. Dermatol. 135 (Suppl. 49), 1-5 (1996).
    • (1996) Br. J. Dermatol. , vol.135 , pp. 1-5
    • Ortonne, J.P.1
  • 137
    • 13444269249 scopus 로고    scopus 로고
    • Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
    • Sano, S. et al. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nature Med. 11, 43-49 (2005).
    • (2005) Nature Med , vol.11 , pp. 43-49
    • Sano, S.1
  • 138
    • 84877828212 scopus 로고    scopus 로고
    • Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression
    • Sun, D. P. et al. Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression. Cytokine 62, 360-368 (2013).
    • (2013) Cytokine , vol.62 , pp. 360-368
    • Sun, D.P.1
  • 139
    • 84876681730 scopus 로고    scopus 로고
    • IL-22 promotes fibroblast-mediated wound repair in the skin
    • McGee, H. M. et al. IL-22 promotes fibroblast-mediated wound repair in the skin. J. Invest. Dermatol. 133, 1321-1329 (2013)
    • (2013) J. Invest. Dermatol. , vol.133 , pp. 1321-1329
    • McGee, H.M.1
  • 140
    • 77954851839 scopus 로고    scopus 로고
    • IL-24 is expressed during wound repair and inhibits TGF?-induced migration and proliferation of keratinocytes
    • Poindexter, N. J. et al. IL-24 is expressed during wound repair and inhibits TGF?-induced migration and proliferation of keratinocytes. Exp. Dermatol. 19, 714-722 (2010).
    • (2010) Exp. Dermatol. , vol.19 , pp. 714-722
    • Poindexter, N.J.1
  • 141
    • 64849116779 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor in wound healing
    • Bao, P. et al. The role of vascular endothelial growth factor in wound healing. J. Surg. Res. 153, 347-358 (2009).
    • (2009) J. Surg. Res. , vol.153 , pp. 347-358
    • Bao, P.1
  • 142
    • 84896385770 scopus 로고    scopus 로고
    • Integrative biology approach identifies cytokine targeting strategies for psoriasis
    • Perera, G. K. et al. Integrative biology approach identifies cytokine targeting strategies for psoriasis. Sci. Transl. Med. 6, 223ra22 (2014).
    • (2014) Sci. Transl. Med. , vol.6 , pp. 223ra22
    • Perera, G.K.1
  • 143
    • 84865401664 scopus 로고    scopus 로고
    • Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease
    • Hanash, A. M. et al. Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity 37, 339-350 (2012).
    • (2012) Immunity , vol.37 , pp. 339-350
    • Hanash, A.M.1
  • 144
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva, S., Sun, R., Pan, H. N., Hong, F., Gao, B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39, 1332-1342 (2004).
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 145
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    • Zenewicz, L. A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647-659 (2007).
    • (2007) Immunity , vol.27 , pp. 647-659
    • Zenewicz, L.A.1
  • 146
    • 2342458559 scopus 로고    scopus 로고
    • Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3
    • Pan, H., Hong, F., Radaeva, S., Gao, B. Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3. Cell. Mol. Immunol. 1, 43-49 (2004).
    • (2004) Cell. Mol. Immunol. , vol.1 , pp. 43-49
    • Pan, H.1    Hong, F.2    Radaeva, S.3    Gao, B.4
  • 147
    • 79955776494 scopus 로고    scopus 로고
    • In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression
    • Park, O. et al. In vivo consequences of liver-specific interleukin-22 expression in mice: implications for human liver disease progression. Hepatology 54, 252-261 (2011).
    • (2011) Hepatology , vol.54 , pp. 252-261
    • Park, O.1
  • 148
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
    • Ki, S. H. et al. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52, 1291-1300 (2010).
    • (2010) Hepatology , vol.52 , pp. 1291-1300
    • Ki, S.H.1
  • 149
    • 84865564349 scopus 로고    scopus 로고
    • Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
    • Kong, X. et al. Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice. Hepatology 56, 1150-1159 (2012).
    • (2012) Hepatology , vol.56 , pp. 1150-1159
    • Kong, X.1
  • 151
    • 84869754821 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis
    • Xue, J., Nguyen, D. T., Habtezion, A. Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis. Gastroenterology 143, 1670-1680 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 1670-1680
    • Xue, J.1    Nguyen, D.T.2    Habtezion, A.3
  • 152
    • 84862915680 scopus 로고    scopus 로고
    • Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway
    • Feng, D. et al. Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway. Int. J. Biol. Sci. 8, 249-257 (2012).
    • (2012) Int. J. Biol. Sci. , vol.8 , pp. 249-257
    • Feng, D.1
  • 153
    • 84906539304 scopus 로고    scopus 로고
    • Toll-like receptor 4-induced IL-22 accelerates kidney regeneration
    • Kulkarni, O. P. et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J. Am. Soc. Nephrol. 25, 978-989 (2014).
    • (2014) J. Am. Soc. Nephrol. , vol.25 , pp. 978-989
    • Kulkarni, O.P.1
  • 154
    • 84902109613 scopus 로고    scopus 로고
    • IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium
    • Xu, M. J. et al. IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium. J. Am. Soc. Nephrol. 25, 967-977 (2014).
    • (2014) J. Am. Soc. Nephrol. , vol.25 , pp. 967-977
    • Xu, M.J.1
  • 155
    • 84859497086 scopus 로고    scopus 로고
    • Interleukin-22 drives endogenous thymic regeneration in mice
    • Dudakov, J. A. et al. Interleukin-22 drives endogenous thymic regeneration in mice. Science 336, 91-95 (2012).
    • (2012) Science , vol.336 , pp. 91-95
    • Dudakov, J.A.1
  • 156
    • 84874485590 scopus 로고    scopus 로고
    • Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury
    • Hsu, Y. H. et al. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. PLoS ONE 8, e56028 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e56028
    • Hsu, Y.H.1
  • 157
    • 84906940502 scopus 로고    scopus 로고
    • IL-20 and IL-20R1 antibodies protect against liver fibrosis
    • Chiu, Y. S., Wei, C. C., Lin, Y. J., Hsu, Y. H., Chang, M. S. IL-20 and IL-20R1 antibodies protect against liver fibrosis. Hepatology 60, 1003-1014 (2014).
    • (2014) Hepatology , vol.60 , pp. 1003-1014
    • Chiu, Y.S.1    Wei, C.C.2    Lin, Y.J.3    Hsu, Y.H.4    Chang, M.S.5
  • 158
    • 84863165532 scopus 로고    scopus 로고
    • Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models
    • Hsu, Y. H. et al. Anti-IL-20 monoclonal antibody suppresses breast cancer progression and bone osteolysis in murine models. J. Immunol. 188, 1981-1991 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 1981-1991
    • Hsu, Y.H.1
  • 159
    • 80051490289 scopus 로고    scopus 로고
    • IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF
    • Baird, A. M., Gray, S. G., O'Byrne, K. J. IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF. Eur. J. Cancer 47, 1908-1918 (2011).
    • (2011) Eur. J. Cancer , vol.47 , pp. 1908-1918
    • Baird, A.M.1    Gray, S.G.2    O'Byrne, K.J.3
  • 160
    • 84869228833 scopus 로고    scopus 로고
    • Anti-IL-20 monoclonal antibody alleviates inflammation in oral cancer and suppresses tumor growth
    • Hsu, Y. H., Wei, C. C., Shieh, D. B., Chan, C. H., Chang, M. S. Anti-IL-20 monoclonal antibody alleviates inflammation in oral cancer and suppresses tumor growth. Mol. Cancer Res. 10, 1430-1439 (2012).
    • (2012) Mol. Cancer Res. , vol.10 , pp. 1430-1439
    • Hsu, Y.H.1    Wei, C.C.2    Shieh, D.B.3    Chan, C.H.4    Chang, M.S.5
  • 161
    • 84874343878 scopus 로고    scopus 로고
    • Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (ERK)-mediated MMP-9 protein expression leading to nuclear factor (NF-?B) activation by inducing the up-regulation of p21WAF1 protein expression
    • Lee, S. J. et al. Interleukin-20 promotes migration of bladder cancer cells through extracellular signal-regulated kinase (ERK)-mediated MMP-9 protein expression leading to nuclear factor (NF-?B) activation by inducing the up-regulation of p21WAF1 protein expression. J. Biol. Chem. 288, 5539-5552 (2013).
    • (2013) J. Biol. Chem. , vol.288 , pp. 5539-5552
    • Lee, S.J.1
  • 162
    • 84866010102 scopus 로고    scopus 로고
    • Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; The roles of IL-5 IL-20, and IL-28A
    • Lee, S. J. et al. Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A. PLoS ONE 7, e40267 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e40267
    • Lee, S.J.1
  • 163
    • 8444223078 scopus 로고    scopus 로고
    • Expression of interleukin-22 in murine carcinoma cells did not influence tumour growth in vivo but did improve survival of the inoculated hosts
    • Nagakawa, H. et al. Expression of interleukin-22 in murine carcinoma cells did not influence tumour growth in vivo but did improve survival of the inoculated hosts. Scand. J. Immunol. 60, 449-454 (2004).
    • (2004) Scand. J. Immunol. , vol.60 , pp. 449-454
    • Nagakawa, H.1
  • 164
    • 84891674362 scopus 로고    scopus 로고
    • High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma
    • Wen, Z. et al. High expression of interleukin-22 and its receptor predicts poor prognosis in pancreatic ductal adenocarcinoma. Ann. Surg. Oncol. 21, 125-132 (2014).
    • (2014) Ann. Surg. Oncol. , vol.21 , pp. 125-132
    • Wen, Z.1
  • 165
    • 84902077790 scopus 로고    scopus 로고
    • The role of the IL-22/IL-22R1 axis in cancer
    • Lim, C., Savan, R. The role of the IL-22/IL-22R1 axis in cancer. Cytokine Growth Factor Rev. 25, 257-271 (2014).
    • (2014) Cytokine Growth Factor Rev , vol.25 , pp. 257-271
    • Lim, C.1    Savan, R.2
  • 166
    • 66149138884 scopus 로고    scopus 로고
    • Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24
    • Emdad, L. et al. Historical perspective and recent insights into our understanding of the molecular and biochemical basis of the antitumor properties of mda-7/IL-24. Cancer Biol. Ther. 8, 391-400 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , pp. 391-400
    • Emdad, L.1
  • 167
  • 168
    • 57149138049 scopus 로고    scopus 로고
    • IL-24: A classic cytokine and/or a potential cure for cancer? J
    • Kreis, S., Philippidou, D., Margue, C., Behrmann, I. IL-24: a classic cytokine and/or a potential cure for cancer? J. Cell. Mol. Med. 16, 2505-2510 (2008).
    • (2008) Cell. Mol. Med. , vol.16 , pp. 2505-2510
    • Kreis, S.1    Philippidou, D.2    Margue, C.3    Behrmann, I.4
  • 169
    • 44949199373 scopus 로고    scopus 로고
    • Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
    • Kreis, S. et al. Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells. PLoS ONE 2, e1300 (2007).
    • (2007) PLoS ONE , vol.2 , pp. e1300
    • Kreis, S.1
  • 170
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu, H., Pardoll, D., Jove, R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nature Rev. Cancer 9, 798-809 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 171
    • 77249098774 scopus 로고    scopus 로고
    • Stat3 is a negative regulator of intestinal tumor progression in ApcMin mice
    • 1-5
    • Musteanu, M. et al. Stat3 is a negative regulator of intestinal tumor progression in ApcMin mice. Gastroenterology 138, 1003-1011.e1-5 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 1003-1011
    • Musteanu, M.1
  • 172
    • 84878003390 scopus 로고    scopus 로고
    • IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation
    • You, W. et al. IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation. PLoS ONE 8, e63588 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e63588
    • You, W.1
  • 173
    • 46749127004 scopus 로고    scopus 로고
    • DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
    • Meira, L. B. et al. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J. Clin. Invest. 118, 2516-2525 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 2516-2525
    • Meira, L.B.1
  • 174
    • 84879571464 scopus 로고    scopus 로고
    • Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
    • Kirchberger, S. et al. Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model. J. Exp. Med. 210, 917-931 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 917-931
    • Kirchberger, S.1
  • 175
    • 77955308513 scopus 로고    scopus 로고
    • Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
    • Yang, L. et al. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J. Hepatol. 53, 339-347 (2010)
    • (2010) J. Hepatol. , vol.53 , pp. 339-347
    • Yang, L.1
  • 176
    • 84864118287 scopus 로고    scopus 로고
    • Immunological complications of obesity
    • Kanneganti, T. D., Dixit, V. D. Immunological complications of obesity. Nature Immunol. 13, 707-712 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 707-712
    • Kanneganti, T.D.1    Dixit, V.D.2
  • 177
    • 11144357516 scopus 로고    scopus 로고
    • Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    • Inoue, H. et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nature Med. 10, 168-174 (2004).
    • (2004) Nature Med , vol.10 , pp. 168-174
    • Inoue, H.1
  • 178
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar, M. et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328, 228-231 (2010).
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1
  • 179
    • 84908311821 scopus 로고    scopus 로고
    • Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
    • Wang, X. et al. Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes. Nature 514, 237-241 (2014).
    • (2014) Nature , vol.514 , pp. 237-241
    • Wang, X.1
  • 180
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation atherosclerosis, and coronary artery disease
    • Hansson, G. K. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 352, 1685-1695 (2005).
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 181
    • 67449110958 scopus 로고    scopus 로고
    • Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality
    • Prodanovich, S. et al. Association of psoriasis with coronary artery, cerebrovascular, and peripheral vascular diseases and mortality. Arch. Dermatol. 145, 700-703 (2009).
    • (2009) Arch. Dermatol. , vol.145 , pp. 700-703
    • Prodanovich, S.1
  • 182
    • 84885070573 scopus 로고    scopus 로고
    • Attenuation of experimental atherosclerosis by interleukin-19
    • Ellison, S. et al. Attenuation of experimental atherosclerosis by interleukin-19. Arterioscler Thromb. Vasc. Biol. 33, 2316-2324 (2013).
    • (2013) Arterioscler Thromb. Vasc. Biol. , vol.33 , pp. 2316-2324
    • Ellison, S.1
  • 183
    • 33747431572 scopus 로고    scopus 로고
    • IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis
    • Chen, W. Y., Cheng, B. C., Jiang, M. J., Hsieh, M. Y., Chang, M. S. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, Thromb. Vascular Biol. 26, 2090-2095 (2006).
    • (2006) Thromb. Vascular Biol. , vol.26 , pp. 2090-2095
    • Chen, W.Y.1    Cheng, B.C.2    Jiang, M.J.3    Hsieh, M.Y.4    Chang, M.S.5
  • 184
    • 84877839153 scopus 로고    scopus 로고
    • IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
    • Zenewicz, L. A. et al. IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic. J. Immunol. 190, 5306-5312 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 5306-5312
    • Zenewicz, L.A.1
  • 185
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau, V. et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31, 677-689 (2009).
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1
  • 186
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 187
    • 77953913586 scopus 로고    scopus 로고
    • Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
    • Wu, H.-J. et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 32, 815-827 (2010).
    • (2010) Immunity , vol.32 , pp. 815-827
    • Wu, H.-J.1
  • 188
    • 79952748674 scopus 로고    scopus 로고
    • Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
    • Lee, Y. K., Menezes, J. S., Umesaki, Y., Mazmanian, S. K. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA 108 (Suppl. 1), 4615-4622 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4615-4622
    • Lee, Y.K.1    Menezes, J.S.2    Umesaki, Y.3    Mazmanian, S.K.4
  • 189
    • 84882668842 scopus 로고    scopus 로고
    • Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora
    • Qiu, J. et al. Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity 39, 386-399 (2013).
    • (2013) Immunity , vol.39 , pp. 386-399
    • Qiu, J.1
  • 190
    • 84866547629 scopus 로고    scopus 로고
    • Lymphotoxin regulates commensal responses to enable diet-induced obesity
    • Upadhyay, V. et al. Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nature Immunol. 13, 947-953 (2012).
    • (2012) Nature Immunol , vol.13 , pp. 947-953
    • Upadhyay, V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.