Nanostructured soy proteins: Fabrication and applications as delivery systems for bioactives (a review)

Food Hydrocolloids

Volumn 91, Issue , 2019, Pages 92-116

  Tang, Chuan He ^a,b  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

Author keywords

Bioactive compounds; Emulsion; Encapsulation; Glycinin; Nanocarrier; Nanoparticle; Nanostructure; Nanovehicle; Soy protein; Conglycinin

Indexed keywords

EID: 85060354143     PISSN: 0268005X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodhyd.2019.01.012     Document Type: Review

References (209)

1. Acevedo-Fani, A., Soliva-Fortuny, R., Martín-Belloso, O., Nanostructured emulsions and nanolaminates for delivery of active ingredients: Improving food safety and functionality. Trends in Food Science & Technology 60 (2017), 12–22.
2. Acosta, E., Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Current Opinion in Colloid & Interface Science 14 (2009), 3–15.
3. Akkermans, C., van der Goot, A.J., Venema, P., Gruppen, H., Vereijken, J.M., van der Linden, E., et al. Micrometer-sized fibrillar protein aggregates from soy glycinin and soy protein isolate. Journal of Agricultural and Food Chemistry 55 (2007), 9877–9882.
4. Akkermans, C., Venema, P., van der Goot, A.J., Gruppen, H., Bakx, E.J., Boom, R.M., et al. Peptides are building blocks of heat-induced fibrillar protein aggregates of β-lactoglobulin formed at pH 2. Biomacromolecules 9 (2008), 1474–1479.
5. Arditty, S., Schmitt, V., Giermanska-Kahn, J., Leal-Calderon, F., Materials based on solid-stabilized emulsions. Journal of Colloid and Interface Science 275 (2004), 659–664.
6. Badley, R.A., Atkinson, D., Hauser, H., Oldani, D., Green, J.P., Stubbs, J.M., The structure, physical and chemical properties of the soy bean protein glycinin. Biohimica et Biophysica Acta 412 (1975), 214–228.
7. Berton-Carabin, C.C., Schroën, K., Pickering emulsions for food applications: Background, trends, and challenges. Annual Review in Food Science and Technology, 6, 2015 12.1-12.35.
8. Bhushani, J.A., Karthik, P., Anandharamakrishnan, C., Nanoemulsion based delivery system for improved bioaccessibility and Caco-2 cell monolayer permeability of green tea catechins. Food Hydrocolloids 56 (2016), 372–382.
9. Boulet, M., Britten, M., Lamarche, F., Aggregation of some food proteins in aqueous dispersions: Effects of concentration, pH and ionic strength. Food Hydrocolloids 14 (2000), 135–144.
10. Bouyer, E., Mekhloufi, G., Le Potier, I., de Fou de Kerdaniel, T., Grossiord, J.-L., Rosilio, V., et al. Stabilization mechanism of oil-in-water emulsions by β-lactoglobulin. Journal of Colloid and Interface Science 354 (2011), 467–477.
11. Cao, W.J., Ou, S.Y., Lin, W.F., Tang, C.H., Food protein-based phytosterol nanoparticles: Fabrication and characterization. Food & Function 7 (2016), 3973–3980.
12. Chen, L., Bai, G., Yang, R., Zang, J., Zhou, T., Zhao, G., Encapsulation of β-carotene within ferritin nanocages greatly increases its water-solubility and thermal stability. Food Chemistry 149 (2014), 307–312.
13. Chen, N., Chassenieux, C., Nicolai, T., Kinetics of NaCl induced gelation of soy protein aggregates: Effects of temperature, aggregate size, and protein concentration. Food Hydrocolloids 77 (2018), 66–74.
14. Chen, N., Lin, L., Sun, W., Zhao, M., Stable and pH-sensitive protein nanogels made by self-assembly of heat denatured soy protein. Journal of Agricultural and Food Chemistry 62 (2014), 9553–9561.
15. Chen, F.P., Li, B.S., Tang, C.H., Nanocomplexation of curcumin and soy protein isolate: Influence on curcumin stability and/or bioaccessibility and in vitro protein digestibility. Journal of Agricultural and Food Chemistry 63 (2015), 3559–3569.
16. Chen, F.P., Li, B.S., Tang, C.H., Nanocomplexation of soy protein isolate with curcumin: Influence of ultrasonic treatment. Food Research International 75 (2015), 157–165.
17. Chen, F.P., Ou, S.Y., Tang, C.H., Core-shell soy protein-soy polysaccharide (nano)particles as carriers for improved stability and sustained-release of curcumin. Journal of Agricultural and Food Chemistry 64 (2016), 5053–5059.
18. Chen, L., Remondetto, G.E., Subirade, M., Food protein-based materials as nutraceutical delivery systems. Trends in Food Science & Technology 17 (2006), 272–283.
19. Chen, L.Y., Subirade, M., Chitosan/β-lactoglobulin core-shell nanoparticles as nutraceutical carriers. Biomaterials 26 (2005), 6041–6053.
20. Chen, S., Zhang, N., Tang, C.H., Influence of nanocomplexation with curcumin on emulsifying properties and emulsion oxidative stability of soy protein isolate at pH 3.0 and 7.0. Food Hydrocolloids 61 (2016), 102–112.
21. 10. LWT-Food Science and Technology 72 (2016), 125–133.
22. Chen, N., Zhao, M., Chassenieux, C., Nicolai, T., Thermal aggregation and gelation of soy globulin at neutral pH. Food Hydrocolloids 61 (2016), 740–746.
23. Chen, N., Zhao, M., Chassenieux, C., Nicolai, T., The effect of adding NaCl on thermal aggregation and gelation of soy protein isolate. Food Hydrocolloids 70 (2017), 88–95.
24. Chen, N., Zhao, M., Niepceron, F., Nicolai, T., Chassenieux, C., The effect of the pH on thermal aggregation and gelation of soy proteins. Food Hydrocolloids 66 (2017), 27–36.
25. Damodaran, S., Amino acids, peptides, and proteins. Fennema, O.R., (eds.) Food chemistry, 1996, Marcel Dekker, New York, 321–429.
26. David, S., Zagury, Y., Livney, Y.D., Soy β-conglycinin-curcumin nanocomplexes for enrichment of clear beverages. Food Biophysics 10 (2015), 195–206.
27. Destribats, M., Rouvet, M., Gehin-Delval, C., Schmitt, C., Binks, B.P., Emulsions stabilised by whey protein microgel particles: Towards food-grade Pickering emulsions. Soft Matter 10 (2014), 6941–6949.
28. Dickinson, E., Food emulsions and foams: Stabilization by particles. Current Opinion in Colloid & Interface Science 15 (2010), 40–49.
29. Dickinson, E., Use of nanoparticles and microparticles in the formation and stabilization of food emulsions. Trends in Food Science & Technology 24 (2012), 4–12.
30. Dickinson, E., Biopolymer-based particles as stabilizing agents for emulsions and foams. Food Hydrocolloids 68 (2017), 219–231.
31. Ding, X., Yao, P., Soy protein/soy polysaccharide complex nanogels: Folic acid loading, protection, and controlled delivery. Langumir 29 (2013), 8636–8644.
32. Elzoghby, A.O., Samy, W.M., Elgindy, N.A., Protein-based nanocarriers as promising drug and gene delivery systems. Journal of Controlled Release 161 (2012), 38–49.
33. Ernster, L., Dallner, G., Biochemical, physiological and medical aspects of ubiquinone function. Biochimica et Biophysica Acta 1271 (1995), 195–204.
34. Ezhilarasi, P.N., Karthik, P., Chhanwal, N., Anandharamakrishnan, C., Nanoencapsulation techniques for food bioactive components: A review. Food and Bioprocess Technology 6 (2013), 628–647.
35. Fafaungwithayakul, N., Hongsprabhas, P., Hongsprabhas, P., Effect of soy soluble polysaccharide on the stability of soy-stabilised emulsions during in vitro protein digestion. Food Biophysics 6 (2011), 407–415.
36. FDA, Soy protein and coronary heart disease. Federal register, 1999, 1999, 5770057733.
37. Frelichowska, J., Bolzinger, M.A., Pelletier, J., Valour, J.P., Chevalier, Y., Topical delivery of lipophilic drugs from o/w Pickering emulsions. International Journal of Pharmaceutics 371 (2009), 56–63.
38. Friedman, M., Brandon, D.L., Nutritional and health effects of soy proteins. Journal of Agricultural and Food Chemistry 49 (2001), 1069–1086.
39. Gao, Z.M., Zhu, L.P., Yang, X.Q., He, X.T., Wang, J.M., Guo, J., et al. Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid. Food & Function 5 (2014), 1286–1293.
40. German, B., Damodaran, S., Kinsella, J.E., Thermal dissociation and association behavior of soy proteins. Journal of Agricultural and Food Chemistry 30 (1982), 807–811.
41. Girgih, A.T., Myrie, S.B., Aluko, R.E., Jones, P.J.H., Is category ‘A’ status assigned to soy protein and coronary heart disease risk reduction health claim by the United States Food and Drug Administration still justifiable?. Trends in Food Science & Technology 30 (2015), 121–132.
42. Gómez-Mascaraque, L.G., López-Rubio, A., Protein-based emulsion electrosprayed micro- and submicroparticles for the encapsulation and stabilization of thermosensitive hydrophobic bioactives. Journal of Colloid and Interface Science 465 (2016), 259–270.
43. Gomez-Mascaraque, L.G., Morfin, R.C., Pérez-Masiá R., Sanchez, G., Lopez-Rubio, A., Optimization of electrospraying conditions for the microencapsulation of probiotics and evaluation of their resistance during storage and in-vitro digestion. LWT-Food Science and Technology 69 (2016), 438–446.
44. Gómez-Mascaraque, L.G., Perez-Masiá R., González-Barrio, R., Periago, M.J., López-Rubio, A., Potential of microencapsulation through emulsion-electrospraying to improve the bioaccesibility of β-carotene. Food Hydrocolloids 73 (2017), 1–12.
45. Gómez-Mascaraque, L.G., Sanchez, G., López-Rubio, A., Impact of molecular weight on the formation of electrosprayed chitosan microencapsules as delivery vehicles for bioactive compounds. Carbohydrate Polymers 150 (2016), 121–130.
46. Grace, M.H., Guzman, I., Roopchand, D.E., Moskal, K., Cheng, D.M., Pogrebnyak, N., et al. Stable binding of alternative protein-enriched food matrices with concentrated cranberry bioflavonoids for functional food applications. Journal of Agricultural and Food Chemistry 61 (2013), 6856–6864.
47. Graveland-Bikker, J.F., de Kruif, C.G., Unique milk protein based nanotubes: Food and nanotechnology meet. Trends in Food Science & Technology 17 (2006), 196–203.
48. Gu, X., Campbell, L.J., Euston, S.R., Influence of sugars on the characteristics of glucono-δ-lactone-induced soy protein isolate gels. Food Hydrocolloids 23 (2009), 314–326.
49. Guo, F., Xiong, Y.L., Qin, F., Jian, H., Huang, X., Chen, J., Surface properties of heat-induced soluble soy protein aggregates of different molecular masses. Journal of Food Science 80 (2015), C279–C287.
50. Guo, J., Yang, X.Q., He, X.T., Wu, N.N., Wang, J.W., Gu, W., et al. Limited aggregation behavior of β-conglycinin and its terminating effect on glycinin aggregation during heating at pH 7.0. Journal of Agricultural and Food Chemistry 60 (2012), 3782–3791.
51. Guo, J., Zhou, Q., Liu, Y.C., Yang, X.Q., Wang, J.M., Yin, S.W., et al. Preparation of soy protein-based microgel particles using a hydrogel homogenizing strategy and their interfacial properties. Food Hydrocolloids 58 (2016), 324–334.
52. Horozov, T., Binks, B.P., Particle-stabilized emulsions: A bilayer or a bridging monolayer?. Angewandte Chemie International Edition, 53, 2006 4905-4090.
53. Hosseini, S.M.H., Emam-Djomeh, Z., Sabatino, P., Van der Meeren, P., Nanocomplexes arising from protein-polysaccharide electrostatic interaction as a promising carrier for nutraceutical compounds. Food Hydrocolloids 50 (2015), 16–26.
54. Hsiao, Y.H., Hsia, S.Y., Chan, Y.C., Hsieh, J.F., Complex coacervation of soy proteins, isoflavones and chitosan. Molecules, 22, 2017, 1022.
55. Huang, H., Krishnan, H.B., Pham, Q., Yu, L.L., Wang, T.T.Y., Soy and gut microbiota: Interaction and implication for human health. Journal of Agricultural and Food Chemistry 64 (2016), 8695–8709.
56. Huang, P.H., Lu, H.T., Wang, Y.T., Wu, M.C., Antioxidant activity and emulsion-stabilizing effect of pectic enzyme treated pectin in soy protein isolate-stabilized oil/water emulsion. Journal of Agricultural and Food Chemistry 59 (2011), 9623–9628.
57. Ikeda, S., Morris, V.J., Fine-stranded and particulate aggregates of heat-denatured whey proteins visualized by atomic force microscopy. Biomacromolecules 3 (2002), 382–389.
58. Imazu, M., Imaoka, T., Usui, H., Kinohara, N., Takeda, M., Reconstitution of urea-dissociated subunits of a pig heart phosphoprotein phosphatase. Journal of Biochemistry 90 (1981), 851–862.
59. Isaschar-Ovdat, S., Davidovich-Pinhas, M., Fishman, A., Modulating the gel properties of soy glycinin by crosslinking with tyrosinase. Food Research International 87 (2016), 42–49.
60. Isaschar-Ovdat, S., Fishman, A., Mechanistic insights into tyrosinase-mediated crosslinking of soy glycinin derived peptides. Food Chemistry 232 (2017), 587–594.
61. Isaschar-Ovdat, S., Rosenberg, M., Lesmes, U., Fishman, A., Characterization of oil-in-water emulsions stabilized by tyrosinase-crosslinked soy glycinin. Food Hydrocolloids 43 (2015), 493–500.
62. Iwabuchi, S., Shibasaki, K., Salt-induced reconstitution of β-conglycinin from its thermal dissociates. Agricultural & Biological Chemistry 46 (1982), 1481–1488.
63. Iwabuchi, S., Watanabe, H., Yamauchi, F., Thermal denaturation of β-conglycinin. Kinetic resolution of reaction mechanism. Journal of Agricultural and Food Chemistry 39 (1991), 27–33.
64. Jiang, J., Chen, J., Xiong, Y.L., Structural and emulsifying properties of soy protein isolate subjected to acid and alkaline pH-shifting processes. Journal of Agricultural and Food Chemistry 57 (2009), 7576–7583.
65. Jiang, J., Wang, Q., Xiong, Y.L., A pH shift approach to the improvement of interfacial properties of plant seed proteins. Current Opinion in Food Science 19 (2018), 50–56.
66. Jiang, J., Xiong, Y.L., Chen, J., pH shifting alters solubility characteristics and thermal stability of soy protein isolate and its globulin fractions in different pH, salt concentration, and temperature conditions. Journal of Agricultural and Food Chemistry 58 (2010), 8035–8042.
67. Jiang, J., Xiong, Y.L., Chen, J., Role of β-conglycinin and glycinin subunits in the pH-shifting-induced structural and physicochemical changes of soy protein isolate. Journal of Food Science 76 (2011), C293–C302.
68. Jin, H., Wang, X., Chen, Z., Li, Y., Liu, C., Xu, J., Fabrication of β-conglycinin-stabilized nanoemulsions via ultrasound process and influence of SDS and PEG 10000 co-emulsifiers on the physicochemical properties of nanoemulsions. Food Research International 106 (2018), 800–808.
69. Jones, O.G., McClements, D.J., Recent progress in biopolymer nanoparticle and microparticle formation by heat-treating electrostatic protein-polysaccharide complexes. Advances in Colloid and Interface Science 167 (2011), 49–62.
70. Jong, L., Characterization of soy protein nanoparticles prepared by high shear microfluidization. Journal of Dispersion Science and Technology 34 (2013), 469–475.
71. Kamal-Eldin, A., Moazzami, A., Plant sterols and stanols as cholesterol-lowering ingredients in functional foods. Recent Patents on Food, Nutrition & Agriculture 1 (2009), 1–14.
72. Kanoujia, J., Singh, M., Singh, P., Parashar, P., Tripathi, C.B., Arya, M., et al. Genipin crosslinked soy-whey based bioactive material for atorvastatin loaded nanoparticles: Preparation, characterization and in vivo antihyperlipidemic study. RSC Advances 6 (2016), 93275–93287.
73. Kargar, M., Fayazmanesh, K., Alavi, M., Spyropoulo, F., Norton, I.T., Investigation into the potential ability of Pickering emulsions (food-grade particles) to enhance the oxidative stability of oil-in-water emulsions. Journal of Colloid and Interface Science 366 (2012), 209–215.
74. Kargar, M., Spyropoulos, F., Norton, I.T., Microstructural design to reduce lipid oxidation in oil-in-water emulsions. Procedia Food Science 1 (2011), 104–108.
75. Kaya-Celiker, H., Mallikarjunan, K., Better nutrients and therapeutics delivery in food through nanotechnology. Food Engieering Reviews 4 (2012), 114–123.
76. Keerati-U-Rai, M., Corredig, M., Effect of dynamic high pressure homogenization on the aggregation state of soy protein. Journal of Agricultural and Food Chemistry 57 (2009), 3556–3562.
77. Keerati-u-rai, M., Miriani, M., Iametti, S., Bonomi, F., Corredig, M., Structural changes of soy proteins at the oil-water interface studied by fluorescence spectroscopy. Colloids and Surfaces B: Biointerfaces 93 (2012), 41–48.
78. Kella, N.K., Barbeau, W., Kinsella, J.E., Effect of disulfide bond cleavage on the structure and conformation of glycinin. International Journal of Peptide & Protein Research 27 (1986), 421–432.
79. Kuipers, B.J.H., van Koningsveld, G.A., Alting, A.C., Driehuis, F., Gruppen, H., Voragen, A.G.J., Enzymatic hydrolysis as a means of expanding the cold gelation conditions of soy proteins. Journal of Agricultural and Food Chemistry 53 (2005), 1031–1038.
80. Lakemond, C.M., de Jongh, H.H.J., Hessing, M., Gruppen, H., Voragen, A.G., Soy glycinin: Influence of pH and ionic strength on solubility and molecular structure at ambient temperature. Journal of Agricultural and Food Chemistry 48 (2000), 1985–1990.
81. Lam, S., Velikov, K.P., Velev, O.D., Pickering stabilization of foams and emulsions with particles of biological origin. Current Opinion in Colloid & Interface Science 19 (2014), 490–500.
82. Lee, K.H., Ryu, H.S., Rhee, K.C., Protein solubility characteristics of commercial soy protein products. Journal of the American Oil Chemists’ Society 80 (2003), 85–90.
83. Lee, H., Yildiz, G., dos Santos, L.C., Jiang, S., Andrade, J.E., Engeseth, N.J., et al. Soy protein nano-aggregates with improved functional properties prepared with sequential pH treatment and ultrasonication. Food Hydrocolloids 55 (2016), 200–209.
84. Levinson, Y., Israeli-Lev, G., Livney, Y.D., Soybean β-conglycinin nanoparticles for delivery of hydrophobic nutraceuticals. Food Biophysics 9 (2014), 332–340.
85. Li, X., Li, Y., Hua, Y., Qiu, A., Yang, C., Cui, S., Effect of concentration, ionic strength and freeze-drying on the heat-induced aggregation of soy proteins. Food Chemistry 104 (2007), 1410–1417.
86. van der Linden, E., Venema, P., Self-assembly and aggregation of proteins. Current Opinion in Colloid & Interface Science 12 (2007), 158–165.
87. Liu, Q., Geng, R., Zhao, J., Chen, Q., Kong, B., Structural and gel textural properties of soy protein isolate when subjected to extreme acid pH-shifting and mild heating processes. Journal of Agricultural and Food Chemistry 63 (2015), 4853–4861.
88. 2+-induced soy protein nanoparticles as Pickering stabilizers: Fabrication and characterization. Food Hydrocolloids 65 (2017), 175–186.
89. Liu, F., Tang, C.H., Cold, gel-like whey protein emulsions by microfluidisation emulsification: Rheological properties and microstructures. Food Chemistry 127 (2012), 1641–1647.
90. Liu, F., Tang, C.H., Soy protein nanoparticle aggregates as Pickering stabilizers for oil-in-water emulsions. Journal of Agricultural and Food Chemistry 61 (2013), 8888–8898.
91. Liu, F., Tang, C.H., Emulsifying properties of soy protein nanoparticles: Influence of protein concentration and/or emulsification process. Journal of Agricultural and Food Chemistry 62 (2014), 2644–2654.
92. Liu, F., Tang, C.H., Soy glycinin as food-grade Pickering stabilizers: Part. I. Structural characteristics, emulsifying properties, and interfacial adsorption/arrangement at interface. Food Hydrocolloids 60 (2016), 606–619.
93. Liu, F., Tang, C.H., Soy glycinin as food-grade Pickering stabilizers: Part. II. Improvement of emulsification and interfacial adsorption by electrostatic screening. Food Hydrocolloids 60 (2016), 620–630.
94. Liu, F., Tang, C.H., Soy glycinin as food-grade Pickering stabilizers: Part. III. Fabrication of gel-like emulsions and their potential as sustained-release delivery systems for β-carotene. Food Hydrocolloids 56 (2016), 434–444.
95. Li, Y., Wu, C.L., Liu, J., Zhu, Y., Zhang, X.Y., Jiang, L.Z., et al. Soy protein isolate-phosphatidylcholine nanoemulsions prepared using high-pressure homogenization. Nanomaterials, 8, 2018, 307.
96. Li, D., Xia, Y., Electrospinning of nanofibers: Reinventing the wheel?. Advanced Materials 16 (2004), 1151–1170.
97. López-Rubio, A., Lagaron, J.M., Whey protein capsules obtained through electrospraying for the encapsulation of bioactives. Innovative Food Science & Emerging Technologies 13 (2012), 200–206.
98. Luo, L.J., Liu, F., Tang, C.H., The role of glycinin in the formation of gel-like soy protein-stabilized emulsions. Food Hydrocolloids 32 (2013), 97–105.
99. MacKay, D.S., Jones, P.J.H., Phystosterols in human nutrition: Type, formulation, delivery, and physiological function. European Journal of Lipid Science and Technology 113 (2011), 1427–1432.
100. Maltais, A., Remondetto, G.E., Gonzalez, R., Subirade, M., Formation of soy protein cold-set gels: Protein and salt effects. Journal of Food Science 70 (2005), C67–C73.
101. Maltais, A., Remondetto, G.E., Subirade, M., Soy protein cold-set hydrogels as controlled delivery devices for nutraceutical compounds. Food Hydrocolloids 23 (2009), 1647–1653.
102. Maltais, A., Remondetto, G.E., Subirade, M., Tabletted soy protein cold-set hydrogels as carriers of nutraceutical substances. Food Hydrocolloids 24 (2010), 518–524.
103. Marcone, M.F., Biochemical and biophysical properties of plant storage proteins: A current understanding with emphasis on 11S seed globulins. Food Research International 32 (1999), 79–92.
104. Marcone, M.F., Beniac, D.R., Harauz, G., Yada, R.Y., Quaternay structure and the model of oligomeric seed globulin from Amaranthus hypochondriacus K343. Journal of Agricultural and Food Chemistry 42 (1994), 2675–2678.
105. Maruyama, N., Katsube, T., Wada, Y., Oh, M.H., Barba de la Rosa, A.P., Okuda, E., et al. The roles of the N-linked glycans and extensive regions of soybean β-conglycinin in folding, assembly and structural features. European Journal of Biochemistry 258 (1998), 854–862.
106. Maruyama, N., Salleh, M.R.M., Takahashi, K., Yagasaki, K., Goto, H., Hontani, N., et al. The effect of the N-linked glycans on structural features and physicochemical functions of soybean β-conglycinin homotrimers. Journal of the American Oil Chemists’ Society 79 (2002), 139–144.
107. Maruyama, N., Salleh, M.R.M., Takahashi, K., Yagasaki, K., Goto, H., Hontani, N., et al. Structure-physicochemical function relationships of soybean β-conglycinin heterotrimers. Journal of Agricultural and Food Chemistry 50 (2002), 4323–4326.
108. Matalanis, A., Jones, O.G., McClements, D.J., Structured biopolymer-based delivery systems for encapsulation, protection, and release of lipophilic components. Food Hydrocolloids 25 (2011), 1865–1880.
109. Matsumiya, K., Murray, B.S., Soybean protein isolate gel particles as foaming and emulsifying agents. Food Hydrocolloids 60 (2016), 206–215.
110. McClements, D.J., Emulsion design to improve the delivery of functional lipophilic components. Annual Review in Food Science and Technology 1 (2010), 241–269.
111. McClements, D.J., Food-grade nanoemulsions: Formulation, fabrication, properties, performance, biological fate, and potential toxicity. Critical Reviews in Food Science and Nutrition 51 (2011), 285–330.
112. McClements, D.J., Decker, E.A., Weiss, J., Emulsion-based delivery systems for lipophilic bioactive components. Journal of Food Science 72 (2007), R109–R124.
113. Meshulam, D., Lesmes, U., Responsiveness of emulsions stabilized by lactoferrin nano-particles to simulated intestinal conditions. Food & Function 5 (2014), 65–73.
114. Messina, M.J., Potential public health implications of the hypocholesterolemic effects of soy protein. Nutrition 19 (2003), 280–281.
115. Mills, E.N.C., Huang, L., Noel, T.R., Gunning, A.P., Morris, V.J., Formation of thermally induced aggregates of the soya globulin β-conglycinin. Biochimica et Biophysica Acta 1547 (2001), 339–350.
116. Mills, E.N.C., Marigheto, N.A., Wellner, N., Fairhurst, S.A., Jenkins, J.A., Mann, R., et al. Thermally induced structural changes in glycinin, the 11S globulin of soya bean (Glycine max) – an in situ spectroscopic study. Biochimica et Biophysica Acta 1648 (2003), 105–114.
117. Miriani, M., Keerati-u-rai, M., Corredig, M., Iametti, S., Bonomi, F., Denaturation of soy proteins in solution and at the oil-water interface: A fluorescence study. Food Hydrocolloids 25 (2011), 620–626.
118. Molina, E., Defaye, A.B., Ledward, D.A., Soy protein pressure-induced gels. Food Hydrocolloids 16 (2002), 625–632.
119. Moure, A., Sineiro, J., Domínguez, H., Parajó J.C., Functionality of oilseed protein products: A review. Food Research International 39 (2006), 945–963.
120. Nagano, T., Hirotsuka, M., Mori, H., Kohyama, K., Nishinari, K., Dynamic viscoelastic study on the gelation of 7S globulin from soybeans. Journal of Agricultural and Food Chemistry 40 (1992), 941–944.
121. Nakamura, T., Utsumi, S., Mori, T., Network structure formation in thermally induced gelation of glycinin. Journal of Agricultural and Food Chemistry 32 (1984), 349–352.
122. Nik, A.M., Corredig, M., Wright, A.J., Release of lipophilic molecules during in vitro digestion of soy protein-stabilized emulsions. Molecular Nutrition & Food Research 55 (2011), S278–S289.
123. Nik, A.M., Wright, A.J., Corredig, M., Micellization of beta-carotene from soy-protein stabilized oil-in-water emulsions under in vitro conditions of lipolysis. Journal of the American Oil Chemists’ Society 88 (2011), 1397–1407.
124. Nillson, M.R., Techniques to study amyloid fibril formation in vitro. Methods 34 (2004), 151–160.
125. Nishinari, K., Fang, Y., Guo, S., Phillips, G.O., Soy proteins: A review on composition, aggregation and emulsification. Food Hydrocolloids 39 (2014), 301–318.
126. de Oca-Ávalos, J.M.M., Candal, R.J., Herrera, M.L., Nanoemulsions: Stability and physical properties. Current Opinion in Food Science 16 (2017), 1–6.
127. Ochnio, M.E., Martinez, J.H., Allievi, M.C., Palavecino, M., Martínez, K.D., Pérez, O.Z., Proteins as nano-carriers for bioactive compounds. The case of 7S and 11S soy globulins and folic acid complexation. Polymers, 10, 2018, 149.
128. Pan, K., Luo, Y., Gan, Y., Baek, S.J., Zhong, Q., pH-driven encapsulation of curcumin in self-assembled casein nanoparticles for enhanced dispersibility and bioactivity. Soft Matter 10 (2014), 6820–6830.
129. Park, S.K., Bae, D.H., Rhee, K.C., Soy protein biopolymers cross-linked with glutaraldehyde. Journal of the American Oil Chemists’ Society 77 (2000), 879–883.
130. Pérez-Masiá R., Lagaron, J.M., López-Rubio, A., Development and optimization of novel encapsulation structures of interest in functional foods through electrospraying. Food and Bioprocess Technology 7 (2014), 3236–3245.
131. Pérez-Masiá R., López-Nicolás, R., Periago, M.J., Ros, G., Lagaron, J.M., López-Rubio, A., Encapsulation of folic acid in food hydrocolloids through nanospray drying and electrospraying for nutraceutical applications. Food Chemistry 168 (2015), 124–133.
132. Petruccelli, S., Añón, M.C., Thermal aggregation of soy protein isolate. Journal of Agricultural and Food Chemistry 43 (1995), 3035–3041.
133. Petruccelli, S., Añón, M.C., pH-Induced modifications in the thermal stability of soybean protein isolates. Journal of Agricultural and Food Chemistry 44 (1996), 3005–3009.
134. Primozic, M., Duchek, A., Nickerson, M., Ghosh, S., Effect of lentil proteins isolate concentration on the formation, stability and rheological behavior of oil-in-water nanoemulsions. Food Chemistry 237 (2017), 65–74.
135. Pujara, N., Jambhrunkar, S., Wong, K.Y., McGuckin, M., Popat, A., Enhanced colloidal stability, solubility and rapid dissolution of resveratrol by nanocomplexation with soy protein isolate. Journal of Colloid and Interface Science 488 (2017), 303–308.
136. Rafieian-Kopaei, M., Beigrezaei, S., Nasri, H., Kafeshani, M., Soy protein and chromic kidney disease: An updated review. International Journal of Preventive Medicine, 8, 2017, 105.
137. Rayner, M., Marku, D., Eriksson, M., Sjöö M., Dejmek, P., Wahlgren, M., Biomass-based particles for the formulation of Pickering type emulsions in food and topical applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects 458 (2014), 48–62.
138. Ray, M., Rousseau, D., Stabilization of oil-in-water emulsions using mixtures of denatured soy whey proteins and soluble soybean polysaccharides. Food Research International 52 (2013), 298–307.
139. Ren, C., Tang, L., Zhang, M., Guo, S., Structural characterization of heat-induced particles in soy milk. Journal of Agricultural and Food Chemistry 57 (2009), 1921–1926.
140. Ries, D., Ye, A., Haisman, D., Singh, H., Antioxidant properties of caseins and whey proteins in model oil-in-water emulsions. International Dairy Journal 20 (2010), 72–78.
141. Roopchand, D.E., Krueger, C.G., Moskal, K., Fridlender, B., Lila, M.A., Raskin, I., Food-compatible method for the efficient extraction and stabilization of cranberry pomace polyphenols. Food Chemistry 141 (2013), 3664–3669.
142. Ruiz-Henestrosa, V.M.P., Martinez, M.J., Patino, J.M.R., Pilosof, A.M.R., A dynamic light scattering study on the complex assembly of glycinin soy globulin in aqueous solutions. Journal of the American Oil Chemists’ Society 89 (2012), 1183–1191.
143. Sacks, F.M., Lichtenstein, A., van Horn, L., Harris, W., Kris-Etherton, P., Winston, M., Soy protein, isoflavones, and cardiovascular health. A summary of a statement for professionals from the American Heart Association Nutrition Committee. Arteriosclerosis, Thrombosis, and Vascular Biology 26 (2006), 1689–1692.
144. Sáiz-Abajo, M.J., González-Ferrero, C., Moreno-Ruiz, A., Romo-Hualde, A., González-Navarro, C.J., Thermal protection of β-carotene in re-assembled casein micelles during different processing technologies applied in food industry. Food Chemistry 138 (2013), 1581–1587.
145. Salvia-Trujillo, L., Qian, C., Martín-Belloso, O., McClements, D.J., Influence of particle size on lipid digestion and β-carotene bioaccessibility in emulsions and nanoemulsions. Food Chemistry 141 (2013), 1472–1480.
146. Sanguansri, P., Augustin, M.A., Nanoscale materials development – a food industry perspective. Trends in Food Science & Technology 17 (2006), 547–556.
147. de Santana, M.B., Mandarino, M.G., Cardoso, J.R., Dichi, I., Dichi, J.B., Camargo, A.E.I., et al. Association between soy and green tea (Camellia sinensis) diminishes hypercholesterolemia and increases total plasma antioxidant potential in dyslipidemic subjects. Nutrition 24 (2008), 562–568.
148. Santiago, L.G., Maldonado-Valderrama, J., Martín-Molina, A., Haro-Pérez, C., García-Martínez, J., Martín-Rodríguez, A., et al. Adsorption of soy protein isolate at air-water and oil-water interface. Colloids and Surfaces A: Physicochemical and Engineering Aspects 323 (2008), 155–162.
149. Sato, A.C.K., Moraes, K.E.F.P., Cunha, R.L., Development of gelled emulsions with improved oxidative and pH stability. Food Hydrocolloids 34 (2014), 184–192.
150. Semenova, M., Protein-polysaccharide associative interactions in the design of tailor-made colloidal particles. Current Opinion in Colloid & Interface Science 28 (2017), 15–21.
151. Semo, E., Kesselman, E., Danino, D., Livney, Y.D., Casein micelle as a natural nano-capsular vehicle for nutraceuticals. Food Hydrocolloids 21 (2007), 936–942.
152. Shao, Y., Tang, C.H., Characteristics and oxidative stability of soy protein-stabilized oil-in-water emulsions: Influence of ionic strength and heat pretreatment. Food Hydrocolloids 37 (2014), 149–158.
153. Shao, Y., Tang, C.H., Gel-like pea protein Pickering emulsions at pH 3.0 as a potential intestine-targeted and sustained-release delivery system for β-carotene. Food Research International 79 (2016), 64–72.
154. Shen, L., Tang, C.H., Microfluidization as a potential technique to modify surface properties of soy protein isolate. Food Research International 48 (2012), 108–118.
155. Simovic, S., Prestidge, C.A., Nanoparticle layers controlling drug release form emulsions. European Journal of Pharmaceutics and Biopharmaceutics 67 (2007), 39–47.
156. Singh, S., Gupta, B., Size-controlled preparation of nanosoy for potential biomedical applications. Polymer International 65 (2016), 1373–1381.
157. Singh, Y., Meher, J.G., Raval, K., Khan, F.A., Chaurasia, M., Jain, N.K., et al. Nanoemulsions: Concepts, development and applications in drug delivery. Journal of Controlled Release 252 (2017), 28–49.
158. Song, F., Zhang, L.M., Gelation modification of soy protein isolate by a naturally occurring cross-linking agent and its potential biomedical application. Industrial & Engineering Chemistry Research 48 (2009), 7077–7083.
159. Sun, X.S., Wang, D., Zhang, L., Mo, X., Zhu, L., Morphology and phase separation of hydrophobic clusters of soy globular protein polymers. Macromolecular Bioscience 8 (2008), 295–303.
160. Tandang-Silvas, M.R., Tecson-Mendoza, E.M., Mikami, B., Utsumi, S., Maruyama, N., Molecular design of seed storage proteins for enhanced food physicochemical properties. Annual Review in Food Science and Technology 2 (2010), 59–73.
161. Tang, C.H., Emulsifying properties of soy proteins: A critical review with emphasis on the role of conformational flexibility. Critical Reviews in Food Science and Nutrition 57 (2017), 2636–2679.
162. Tang, C.H., Liu, F., Cold, gel-like soy protein emulsions by microfluidization: Emulsion characteristics, rheological and microstructural properties, and gelling mechanism. Food Hydrocolloids 30 (2013), 61–72.
163. Tang, C.H., Ma, C.Y., Effect of high pressure treatment on aggregation and structural properties of soy protein isolate. LWT-Food Science and Technology 42 (2009), 606–611.
164. Tang, C.H., Wang, C.S., Formation and characterization of amyloid-like fibrils from soy β-conglycinin and glycinin. Journal of Agricultural and Food Chemistry 58 (2010), 11058–11066.
165. Tang, C.H., Wang, X.Y., Yang, X.Q., Li, L., Formation of soluble aggregates from insoluble commercial soy protein isolate by means of ultrasonic treatment and their gelling properties. Journal of Food Engineering 92 (2009), 432–437.
166. Tang, C.H., Wu, H., Yu, H.P., Li, L., Chen, Z., Yang, X.Q., Coagulation and gelation of soy protein isolates induced by microbial transglutaminase. Journal of Food Biochemistry 30 (2006), 35–55.
167. Tang, C.H., Zhang, Y.H., Wen, Q.B., Huang, Q.R., Formation of amyloid fibrils from kidney bean 7S globulin (phaseolin) at pH 2.0. Journal of Agricultural and Food Chemistry 58 (2010), 8061–8068.
168. Tan, H., Sun, G., Lin, W., Mu, C., Ngai, T., Gelatin particle-stabilized high internal phase emulsions as nutraceutical containers. ACS Applied Materials & Interfaces 6 (2014), 13977–13984.
169. Tan, T.B., Yussof, N.S., Abas, F., Mirhosseini, H., Nehdi, I.A., Tan, C.P., Stability evaluation of lutein nanodispersions prepared via solvent displacement method: The effect of emulsifiers with different stabilizing mechanisms. Food Chemistry 205 (2016), 155–162.
170. Tapal, A., Tiku, P.K., Complexation of curcumin with soy protein isolate and its implications on solubility and stability of curcumin. Food Chemistry 130 (2012), 960–965.
171. Tarhini, M., Greige-Gerges, H., Elaissari, A., Protein-based nanoparticles: From preparation to encapsulation of active molecules. International Journal of Pharmaceutics 522 (2017), 172–197.
172. Tavernier, I., Patel, A.R., van der Meeren, P., Dewettinck, K., Emulsion-templated liquid oil structuring with soy protein and soy protein: κ-Carrageenan complexes. Food Hydrocolloids 65 (2017), 107–120.
173. Tavernier, I., Wijaya, W., van der Meeren, P., Dewettinck, K., Patel, A.R., Food-grade particles for emulsion stabilization. Trends in Food Science & Technology 50 (2016), 159–174.
174. Teng, Z., Luo, Y., Wang, Q., Nanoparticles synthesized from soy protein: Preparation, characterization, and application for nutraceutical encapsulation. Journal of Agricultural and Food Chemistry 60 (2012), 2712–2720.
175. Teng, Z., Luo, Y., Wang, T., Zhang, B., Wang, Q., Development and application of nanoparticles synthesized with folic acid conjugated soy protein. Journal of Agricultural and Food Chemistry 61 (2013), 2556–2564.
176. Thanh, V.H., Shibasaki, K., Major proteins of soybean seeds: A straightforward fractionation and their characterization. Journal of Agricultural and Food Chemistry 24 (1976), 1117–1121.
177. Thanh, V.H., Shibasaki, K., Major proteins of soybean seeds. Subunit structure of β-conglycinin. Journal of Agricultural and Food Chemistry 26 (1978), 692–695.
178. Thanh, V.H., Shibasaki, K., Major proteins of soybean seeds. Reconstitution of β-conglycinin from its subunits. Journal of Agricultural and Food Chemistry 26 (1978), 695–699.
179. Thanh, V.H., Shibasaki, K., Major proteins of soybean seeds. Reversible and irreversible dissociation of β-conglycinin. Journal of Agricultural and Food Chemistry 27 (1978), 805–809.
180. Tran, T., Rousseau, D., Stabilization of acidic soy protein-based dispersions and emulsions by soy soluble polysaccharides. Food Hydrocolloids 30 (2013), 382–392.
181. Tzoumaki, M.V., Moschakis, T., Scholten, E., Biliaderis, C.G., In vitro lipid digestion of chitin nanocrystal stabilized o/w emulsions. Food & Function 4 (2013), 121–129.
182. Utsumi, S., Kinsella, J.E., Structure-function relationships in food proteins: Subunit interactions in heat-induced gelation of 7S, 11S, and soy isolate proteins. Journal of Agricultural and Food Chemistry 33 (1985), 297–303.
183. Utsumi, S., Matsumura, Y., Mori, T., Structure-function relationships of soy proteins. Damodaran, S., Paraf, A., (eds.) Food proteins and their applications, 1997, Marcel Dekker, New York, USA, 257–292.
184. Vang, O., Ahmad, N., Baile, C.A., Baur, J.A., Brown, K., Csiszar, A., et al. What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One, 6, 2011, e19881.
185. 2+-induced cold gelation process for β-lactoglobulin. Journal of Agricultural and Food Chemistry 51 (2003), 3880–3885.
186. Visschers, R.W., de Jongh, H.H.J., Disulphide bond formation in food protein aggregation and gelation. Biotechnology Advances 23 (2005), 75–80.
187. Wagner, J.R., Sorgentini, D.A., Añón, M.C., Thermal and electrophoretic behavior, hydrophobicity, and some functional properties of acid-treated soy isolates. Journal of Agricultural and Food Chemistry 44 (1996), 1881–1889.
188. Wang, L.J., Chang, Y.C., Osmanson, A.T., Zhang, J., Li, L., Facile continuous production of soy peptide nanogels via nanoscale flash desovation for drug entrapment. International Journal of Pharmaceutics 549 (2018), 13–20.
189. Wang, S., Gong, G., Su, H., Liu, W., Wang, Z., Li, L., Self-assembly of plasma protein through disulfide bond breaking and its use as a nanocarrier for lipophilic drugs. Polymer Chemistry 5 (2014), 4871–4874.
190. Wang, C., Johnson, L.A., Functional properties of hydrothermally cooked soy protein products. Journal of the American Oil Chemists’ Society 78 (2001), 189–195.
191. Wang, J.M., Yang, X.Q., Yin, S.W., Zhang, Y., Tang, C.H., Li, B.S., et al. Structural rearrangement of ethanol-denatured soy proteins by high hydrostatic pressure treatment. Journal of Agricultural and Food Chemistry 59 (2011), 7324–7332.
192. Wan, Z.L., Wang, J.M., Wang, L.Y., Yuan, Y., Yang, X.Q., Complexation of resveratrol with soy protein and its improvement on oxidative stability of corn oil/water emulsions. Food Chemistry 161 (2014), 324–331.
193. Xu, Y.T., Liu, L.L., Structural and functional properties of soy protein isolates modified by soy soluble polysaccharides. Journal of Agricultural and Food Chemistry 64 (2016), 7275–7284.
194. Xu, Y.T., Liu, T.X., Tang, C.H., Novel Pickering high internal phase emulsion gels stabilized solely by soy β-conglycinin. Food Hydrocolloids 80 (2019), 21–30.
195. Xu, J., Mukherjee, D., Chang, S.K.C., Physicochemical properties and storage stability of soybean protien nanoemulsions prepared by ultra-high pressure homogenization. Food Chemistry 240 (2018), 1005–1013.
196. Xu, Y.T., Tang, C.H., Liu, T.X., Liu, R.H., Ovalbumin as an outstanding Pickering nano-stabilizer for high internal phase emulsions. Journal of Agricultural and Food Chemistry 66 (2018), 8795–8804.
197. Yallapu, M.M., Jaggi, M., Chauhan, S.C., Curcumin nanoformulations: A future nanomedicine for cancer. Drug Discovery Today 17 (2012), 71–80.
198. Yi, J., Lam, T.I., Yokoyama, W., Cheng, L.W., Zhong, F., Beta-carotene encapsulated in food protein nanoparticles reduces peroxyl oxidation in Caco-2 cells. Food Hydrocolloids 43 (2015), 31–40.
199. Yildiz, G., Andrade, J., Engeseth, N.E., Feng, H., Functionalizing soy protein nano-aggregates with pH-shifting and mano-thermo-sonication. Journal of Colloid and Interface Science 505 (2017), 836–846.
200. Yin, B., Deng, W., Xu, K., Huang, L., Yao, P., Stable nano-sized emulsions produced from soy protein and soy polysaccharide complexes. Journal of Colloid and Interface Science 380 (2012), 51–59.
201. 2+ -induced associations of soybean proteins. Journal of Agricultural and Food Chemistry 50 (2002), 4953–4958.
202. Zhang, J., Liang, L., Tian, Z., Chen, L., Subirade, M., Preparation and in vitro evaluation of calcium-induced soy protein isolate nanoparticles and their formation mechanism study. Food Chemistry 133 (2012), 390–399.
203. 12. The Journal of Physical Chemistry B 117 (2013), 14018–14028.
204. Zhang, R., Zhang, Z., Zhang, H., Decker, E.A., McClements, D.J., Influence of emulsifer type on gastrointestinal fate of oil-in-water emulsions containing anionic dietary fiber (pectin). Food Hydrocolloids 45 (2015), 175–185.
205. Zhao, X.H., Tang, C.H., Spray-drying microencapsulation of CoQ10 in olive oil for enhanced water dispersion, stability and bioaccessibility: Influence of type of emulsifers and/or wall materials. Food Hydrocolloids 61 (2016), 20–30.
206. Zhao, J., Xiang, J., Wei, T., Yuan, F., Gao, Y., Influence of environmental stresses on the physicochemical stability of orange oil bilayer emulsions coated by lactoferrin-soybean soluble polysaccharides and lactoferrin-beet pectin. Food Research International 66 (2014), 216–227.
207. Zhong, F., Yang, X., Li, Y., Shoemaker, C.F., Papain-induced gelation of soy glycinin (11S). Journal of Food Science 71 (2006), E232–E237.
208. Zimet, P., Rosenberg, D., Livney, Y.D., Re-assembled casein micelles and casein nanoparticles as nano-vehicles for ω-3 polyunsaturated fatty acids. Food Hydrocolloids 25 (2011), 1270–1276.
209. Zou, P., Helson, L., Maitra, A., Stern, S.T., McNeil, S.E., Polymeric curcumin nanoparticle pharmacokinetics and metabolism in bile Duct cannulated rats. Molecular Pharmaceutics 10 (2013), 1977–1987.