Polymeric curcumin nanoparticle pharmacokinetics and metabolism in bile duct cannulated rats

Molecular Pharmaceutics

Volumn 10, Issue 5, 2013, Pages 1977-1987

  Zou, Peng ^a   Helson, Lawrence ^b   Maitra, Anirban ^c   Stern, Stephan T ^a   McNeil, Scott E ^a  

^a SAIC FREDERICK INC   (United States)

^b SignPath Pharma Inc   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

biliary excretion; curcumin; metabolite profile; nanoformulation; urinary excretion

Indexed keywords

CURCUMIN; NANOCURCUMIN; NANOPARTICLE; SOLVENT SOLUBILIZED CURCUMIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; NANOCAPSULE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE DUCT; BILIARY EXCRETION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FORMULATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENTIATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION; ANIMAL; BILE; CATHETERIZATION; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG DELIVERY SYSTEM; INTRAVENOUS DRUG ADMINISTRATION; MEDICINAL CHEMISTRY; METABOLISM; SOLUBILITY; SPRAGUE DAWLEY RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; BILE; BILE DUCTS; CATHETERIZATION; CHEMISTRY, PHARMACEUTICAL; CURCUMIN; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; INJECTIONS, INTRAVENOUS; MALE; NANOCAPSULES; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84877251818     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4000019     Document Type: Article

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