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Volumn 1, Issue 1, 2009, Pages 1-14

Plant sterols and stanols as cholesterol-lowering ingredients in functional foods

Author keywords

Cholesterol lowering; Functional foods; Health promoting effects; Plant stanols; Plant sterols

Indexed keywords

CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SITOSTEROL DERIVATIVE; STANOL ESTER; TRIACYLGLYCEROL;

EID: 78049423336     PISSN: 22127984     EISSN: 18761429     Source Type: Journal    
DOI: 10.2174/2212798410901010001     Document Type: Review
Times cited : (49)

References (103)
  • 2
    • 84958699501 scopus 로고
    • Successful prevention of experimental hypercholesterolemia and cholesterol atherosclerosis in the rabbit
    • Pollak OJ. Successful prevention of experimental hypercholesterolemia and cholesterol atherosclerosis in the rabbit. Circulation 1953;7(5):696-701.
    • (1953) Circulation , vol.7 , Issue.5 , pp. 696-701
    • Pollak, O.J.1
  • 3
    • 33947253738 scopus 로고
    • Reduction of blood cholesterol in man
    • Pollak OJ. reduction of blood cholesterol in man. Circulation 1953;7(5):702-706.
    • (1953) Circulation , vol.7 , Issue.5 , pp. 702-706
    • Pollak, O.J.1
  • 4
    • 0001391366 scopus 로고
    • Lowering of serum cholesterol by the administration of a plant sterol
    • Best MM, Duncan CH, Van Loon EJ, Wathen JD. Lowering of serum cholesterol by the administration of a plant sterol. Circulation 1954;10(8):201-206.
    • (1954) Circulation , vol.10 , Issue.8 , pp. 201-206
    • Best, M.M.1    Duncan, C.H.2    Van Loon, E.J.3    Wathen, J.D.4
  • 5
    • 0033005959 scopus 로고    scopus 로고
    • Regulation of cholesterol metabolism by dietary plant sterols
    • DOI 10.1097/00041433-199902000-00003
    • Miettinen TA, Gylling H. Regulation of cholesterol metabolism by dietary plant sterols. Curr Opin Lipidol 1999;10(1):9-14. (Pubitemid 29084103)
    • (1999) Current Opinion in Lipidology , vol.10 , Issue.1 , pp. 9-14
    • Miettinen, T.A.1    Gylling, H.2
  • 6
    • 42149115775 scopus 로고    scopus 로고
    • Novel plant sterol and stanol derivatives with beneficial properties: Efficacy and safety
    • DOI 10.2174/187221408783421309
    • Yanni AE. Novel plant sterol and stanol derivatives with beneficial properties: Efficacy and safety. Recent Patents Endocr Metabol Immune Drug Discov 2008;2(1):16-23. (Pubitemid 351541184)
    • (2008) Recent Patents on Endocrine, Metabolic and Immune Drug Discovery , vol.2 , Issue.1 , pp. 16-23
    • Yanni, A.E.1
  • 7
    • 67249119416 scopus 로고    scopus 로고
    • New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
    • Epub ahead of print
    • Calpe-Berdiel L, Escolà-Gil JC, Blanco-Vaca F. New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 2008, Epub ahead of print.
    • (2008) Atherosclerosis
    • Calpe-Berdiel, L.1    Escolà-Gil, J.C.2    Blanco-Vaca, F.3
  • 8
    • 0035987032 scopus 로고    scopus 로고
    • Phytosterols, phytostanols, and their conjugates in foods: Structural diversity, quantitative analysis, and health-promoting uses
    • Moreau R, Whitaker B, Hicks K. Phytosterols, phytostanols, and their conjugates in foods: Structural diversity, quantitative analysis, and health-promoting uses. Prog Lipid Res 2002;41(6):457-500.
    • (2002) Prog Lipid Res , vol.41 , Issue.6 , pp. 457-500
    • Moreau, R.1    Whitaker, B.2    Hicks, K.3
  • 9
    • 0036403449 scopus 로고    scopus 로고
    • Phytosterols in human nutrition
    • DOI 10.1146/annurev.nutr.22.020702.075220
    • Ostlund RE Jr. Phytosterols in human nutrition. Ann Rev Nutr 2002;22(4):533-549. (Pubitemid 35221472)
    • (2002) Annual Review of Nutrition , vol.22 , pp. 533-549
    • Ostlund Jr., R.E.1
  • 12
    • 0033230381 scopus 로고    scopus 로고
    • Effects of 4-methylsterols from algae and of β sitosterol on cholesterol metabolism in rats
    • DOI 10.1016/S0271-5317(99)00120-7, PII S0271531799001207
    • Kritchevsky D, Tepper SA, Czarnecki SK, Kyle DJ. Effects of 4-methylsterols from algae and of β-sitosterol on cholesterol metabolism in rats. Nutr Res 1999;19(11):1649-1654. (Pubitemid 29504067)
    • (1999) Nutrition Research , vol.19 , Issue.11 , pp. 1649-1654
    • Kritchevsky, D.1    Tepper, S.A.2    Czarnecki, S.K.3    Kyle, D.J.4
  • 13
    • 0033661520 scopus 로고    scopus 로고
    • Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans
    • Vissers MN, Zock PL, Meijer GW, Katan MB. Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans. Am J Clin Nutr 2000;72(6):1510-1515.
    • (2000) Am J Clin Nutr , vol.72 , Issue.6 , pp. 1510-1515
    • Vissers, M.N.1    Zock, P.L.2    Meijer, G.W.3    Katan, M.B.4
  • 14
  • 15
    • 0017688818 scopus 로고
    • Plant sterols as cholesterol lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance
    • Lees AM, Mok HYI, Lees RS, McCluskey MA, Grundy SM. Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atherosclerosis 1977;28(3):325-338. (Pubitemid 8225237)
    • (1977) Atherosclerosis , vol.28 , Issue.3 , pp. 325-338
    • Lees, A.M.1    Mok, H.Y.I.2    Lees, R.S.3
  • 17
    • 0022177837 scopus 로고
    • Effect of Plant sterols on lipids and atherosclerosis
    • Pollack OJ. Effect of Plant sterols on lipids and atherosclerosis. Pharmac Ther 1985;31(3):177-208.
    • (1985) Pharmac Ther , vol.31 , Issue.3 , pp. 177-208
    • Pollack, O.J.1
  • 18
    • 0028174622 scopus 로고
    • Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein e phenotypes
    • Miettinen TA, Vanhanen H. Dietary sitostanol related to absorption, synthesis and serum level of cholesterol in different apolipoprotein e phenotypes. Atherosclerosis 1994;105(2):217-226.
    • (1994) Atherosclerosis , vol.105 , Issue.2 , pp. 217-226
    • Miettinen, T.A.1    Vanhanen, H.2
  • 19
    • 0031749963 scopus 로고    scopus 로고
    • Short-term administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels
    • DOI 10.1016/S0026-0495(98)90041-5
    • Jones PJ, Howell T, MacDougall DE, Feng JY, Parsons W. Shortterm administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels. Metabolism 1998;47(6):751-756. (Pubitemid 28265182)
    • (1998) Metabolism: Clinical and Experimental , vol.47 , Issue.6 , pp. 751-756
    • Jones, P.J.H.1    Howell, T.2    MacDougall, D.E.3    Feng, J.Y.4    Parsons, W.5
  • 20
    • 0031745196 scopus 로고    scopus 로고
    • Plant sterol-enriched margarines and reduction of plasma total- and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects
    • Weststrate JA, Meijer GW. Plant sterol-enriched margarines and reduction of plasma total-and LDL-cholesterol concentrations in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1998;52(5):334-343. (Pubitemid 28230699)
    • (1998) European Journal of Clinical Nutrition , vol.52 , Issue.5 , pp. 334-343
    • Weststrate, J.A.1    Meijer, G.W.2
  • 21
    • 0032961863 scopus 로고    scopus 로고
    • Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects
    • Hendriks HF, Weststrate JA, van Vliet T, Meijer GW. Spreads Enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 1999;53(4):319-327. (Pubitemid 29164264)
    • (1999) European Journal of Clinical Nutrition , vol.53 , Issue.4 , pp. 319-327
    • Hendriks, H.F.J.1    Weststrate, J.A.2    Van Vliet, T.3    Meijer, G.W.4
  • 22
    • 0032868768 scopus 로고    scopus 로고
    • Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations
    • Sierksma A, Weststrate JA, Meijer GW. Spreads enriched with plant sterols, either esterified 4, 4-dimethylsterols or free 4-desmethylsterols, and plasma total-and LDL-cholesterol concentrations. Br J Nutr 1999;82(4):273-282. (Pubitemid 29481513)
    • (1999) British Journal of Nutrition , vol.82 , Issue.4 , pp. 273-282
    • Sierksma, A.1    Weststrate, J.A.2    Meijer, G.W.3
  • 23
    • 0033804429 scopus 로고    scopus 로고
    • Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet
    • Hallikainen MA, Sarkkinen ES, Gylling H, Erkkila AT, Uusitupa MI. Comparison of the effects of plant sterol ester and plant stanol ester-enriched margarines in lowering serum cholesterol concentrations in hypercholesterolaemic subjects on a low-fat diet. Eur J Clin Nutr 2000;54(9):715-725.
    • (2000) Eur J Clin Nutr , vol.54 , Issue.9 , pp. 715-725
    • Hallikainen, M.A.1    Sarkkinen, E.S.2    Gylling, H.3    Erkkila, A.T.4    Uusitupa, M.I.5
  • 24
    • 0033661520 scopus 로고    scopus 로고
    • Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans
    • Vissers MN, Zock PL, Meijer GW, Katan MB. Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans. Am J Clin Nutr 2000;72(6):1510-1515.
    • (2000) Am J Clin Nutr , vol.72 , Issue.6 , pp. 1510-1515
    • Vissers, M.N.1    Zock, P.L.2    Meijer, G.W.3    Katan, M.B.4
  • 25
    • 0033794852 scopus 로고    scopus 로고
    • Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters
    • Plat J, van Onselen EN, van Heugten MM, Mensink RP. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 2000;54(9):671-677.
    • (2000) Eur J Clin Nutr , vol.54 , Issue.9 , pp. 671-677
    • Plat, J.1    Van Onselen, E.N.2    Van Heugten, M.M.3    Mensink, R.P.4
  • 29
    • 0035014931 scopus 로고    scopus 로고
    • Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread
    • DOI 10.1016/S0021-9150(00)00653-5, PII S0021915000006535
    • Neil HA, Meijer GW, Roe LS. Randomised controlled trial of use by hypercholesterolaemic patients of a vegetable oil sterol-enriched fat spread. Atherosclerosis 2001;156(2):329-337. (Pubitemid 32522913)
    • (2001) Atherosclerosis , vol.156 , Issue.2 , pp. 329-337
    • Neil, H.A.W.1    Meijer, G.W.2    Roe, L.S.3
  • 30
    • 0035203661 scopus 로고    scopus 로고
    • Cholesterol-lowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods
    • DOI 10.1038/sj.ejcn.1601264
    • Nestel P, Cehun M, Pomeroy S, Abbey M, Weldon G. Cholesterollowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods. Eur J Clin Nutr 2001;55(12):1084-1090. (Pubitemid 33114681)
    • (2001) European Journal of Clinical Nutrition , vol.55 , Issue.12 , pp. 1084-1090
    • Nestel, P.1    Cehun, M.2    Pomeroy, S.3    Abbey, M.4    Weldon, G.5
  • 32
    • 0035889532 scopus 로고    scopus 로고
    • Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterol
    • DOI 10.1016/S0002-9149(01)02053-7, PII S0002914901020537
    • Tikkanen MJ, Högström P, Tuomilehto J, Keinänen- Kiukaanniemi S, Sundvall J, Karppanen H. Effect of a diet based on low-fat foods enriched with non-esterified plant sterols and mineral nutrients on serum cholesterol. Am J Cardiol 2001;88(10):1157-1162. (Pubitemid 33043850)
    • (2001) American Journal of Cardiology , vol.88 , Issue.10 , pp. 1157-1162
    • Tikkanen, M.J.1    Hogstrom, P.2    Tuomilehto, J.3    Keinanen-Kiukaanniemi, S.4    Sundvall, J.5    Karppanen, H.6
  • 35
    • 0036182234 scopus 로고    scopus 로고
    • Effects of phytosterol ester-enriched margarine on plasma lipoproteins in mild to moderate hypercholesterolemia are related to basal cholesterol and fat intake
    • DOI 10.1053/meta.2002.29988
    • Mussner MJ, Parhofer KG, von Bergmann K, Schwandt P, Broedl U, Otto C. Effects of phytosterol ester-enriched margarine on plasma lipoproteins in mild to moderate hypercholesterolemia are related to basal cholesterol and fat intake. Metabolism 2002;51(2):189-194. (Pubitemid 34168231)
    • (2002) Metabolism: Clinical and Experimental , vol.51 , Issue.2 , pp. 189-194
    • Mussner, M.J.1    Parhofer, K.G.2    Von Bergmann, K.3    Schwandt, P.4    Broedl, U.5    Otto, C.6
  • 36
    • 0036252637 scopus 로고    scopus 로고
    • No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet
    • DOI 10.1053/meta.2002.32021
    • Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Jones PJ. No changes in serum fat-soluble vitamin and carotenoid concentrations with the intake of plant sterol/stanol esters in the context of a controlled diet. Metabolism 2002;51:652-656. (Pubitemid 34516523)
    • (2002) Metabolism: Clinical and Experimental , vol.51 , Issue.5 , pp. 652-656
    • Raeini-Sarjaz, M.1    Ntanios, F.Y.2    Vanstone, C.A.3    Jones, P.J.H.4
  • 37
    • 0036136111 scopus 로고    scopus 로고
    • An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations
    • Noakes M, Clifton P, Ntanios F, Shrapnel W, Record I, McInerney J. An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations. Am J Clin Nutr 2002;75(1):79-86. (Pubitemid 34008024)
    • (2002) American Journal of Clinical Nutrition , vol.75 , Issue.1 , pp. 79-86
    • Noakes, M.1    Clifton, P.2    Ntanios, F.3    Shrapnel, W.4    Record, I.5    McInerney, J.6
  • 38
    • 0036895750 scopus 로고    scopus 로고
    • Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons
    • Vanstone CA, Raeini-Sarjaz M, Parsons WE, Jones PJ. Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. Am J Clin Nutr 2002;76(6):1272-1278. (Pubitemid 35416562)
    • (2002) American Journal of Clinical Nutrition , vol.76 , Issue.6 , pp. 1272-1278
    • Vanstone, C.A.1    Raeini-Sarjaz, M.2    Parsons, W.E.3    Jones, P.J.H.4
  • 39
    • 0027164626 scopus 로고
    • Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different apoE phenotypes during dietary sitostanol ester treatment
    • Vanhanen HT, Blomqvist S, Ehnholm C, et al. Serum cholesterol, cholesterol precursors, and plant sterols in hypercholesterolemic subjects with different ApoE phenotypes during dietary sitostanol ester treatment. J Lipid Res 1993;34(9):1535-1544. (Pubitemid 23264326)
    • (1993) Journal of Lipid Research , vol.34 , Issue.9 , pp. 1535-1544
    • Vanhanen, H.T.1    Blomqvist, S.2    Ehnholm, C.3    Hyvonen, M.4    Jauhiainen, M.5    Torstila, I.6    Miettinen, T.A.7
  • 40
    • 0036900285 scopus 로고    scopus 로고
    • A A spread enriched with plant sterol esters lowers plasma cholesterol and lipoproteins without affecting vitamins A and E in normal and hypercholesterolemic Japanese men and women
    • Ntanios FY, Homma Y, Ushiro S. A A spread enriched with plant sterol esters lowers plasma cholesterol and lipoproteins without affecting vitamins A and E in normal and hypercholesterolemic Japanese men and women, J Nutr 2002, 132:3650-3655.
    • J Nutr 2002 , vol.132 , pp. 3650-3655
    • Ntanios, F.Y.1    Homma, Y.2    Ushiro, S.3
  • 41
    • 0027941063 scopus 로고
    • Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment
    • Gylling H, Miettinen TA. Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment. Diabetologia 1994;37(8):773-780.
    • (1994) Diabetologia , vol.37 , Issue.8 , pp. 773-780
    • Gylling, H.1    Miettinen, T.A.2
  • 42
    • 0028237805 scopus 로고
    • Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects
    • Vanhanen HT, Kajander J, Lehtovirta H, Miettinen TA. Serum levels, absorption efficiency, faecal elimination and synthesis of cholesterol during increasing doses of dietary sitostanol esters in hypercholesterolaemic subjects. Clin Sci (London) 1994;87(1):61-67. (Pubitemid 24220272)
    • (1994) Clinical Science , vol.87 , Issue.1 , pp. 61-67
    • Vanhanen, H.T.1    Kajander, J.2    Lehtovirta, H.3    Miettinen, T.A.4
  • 43
    • 0028822216 scopus 로고
    • Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population
    • Miettinen TA, Puska P, Gylling H, Vanhanen HT, Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 1995;333(20):1308-1312.
    • (1995) N Engl J Med , vol.333 , Issue.20 , pp. 1308-1312
    • Miettinen, T.A.1    Puska, P.2    Gylling, H.3    Vanhanen, H.T.4    Vartiainen, E.5
  • 44
    • 0031470415 scopus 로고    scopus 로고
    • Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine: Women and dietary sitostanol
    • Gylling H, Radhakrishnan R, Miettinen TA. Reduction of serum cholesterol in post-menopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine. Circulation 1997;96(12):4226-4231. (Pubitemid 28007448)
    • (1997) Circulation , vol.96 , Issue.12 , pp. 4226-4231
    • Gylling, H.1    Radhakrishnan, R.2    Miettinen, T.A.3
  • 45
    • 0030986088 scopus 로고    scopus 로고
    • Cholesterol-lowering effect and sensory properties of sitostanol ester margarine in normocholesterolemic adults
    • Niinikoski H, Viikari J, Palmu T. Cholesterol-lowering effect and sensory properties of sitostanol ester margarine in normocholesterolemic adults. Scand J Nutr 1997;41(1):9-12. (Pubitemid 27166097)
    • (1997) Scandinavian Journal of Nutrition/Naringsforskning , vol.41 , Issue.1 , pp. 9-12
    • Niinikoski, H.1    Viikari, J.2    Palmu, T.3
  • 46
    • 0032718878 scopus 로고    scopus 로고
    • Cholesterol-lowering effects of a stanol ester-containing low-fat margarine used in conjunction with a strict lipid-lowering diet
    • Andersson A, Karlström B, Mohsen R, Vessby B. Cholesterollowering effects of a stanol ester-containing low-fat margarine used in conjunction with a strict lipid-lowering diet. Eur Heart J 1999;1(suppl.):S80-S90. (Pubitemid 29525366)
    • (1999) European Heart Journal, Supplement , vol.1 , Issue.SUPPL.
    • Andersson, A.1    Karlstrom, B.2    Mohsen, R.3    Vessby, B.4
  • 47
    • 0032894986 scopus 로고    scopus 로고
    • Cholesterol reduction by different plant stanol mixtures and with variable fat intake
    • DOI 10.1016/S0026-0495(99)90053-7
    • Gylling H, Miettinen TA. Cholesterol reduction by different plant stanol mixtures and with variable fat intake. Metabolism 1999;48(5):575-580. (Pubitemid 29230516)
    • (1999) Metabolism: Clinical and Experimental , vol.48 , Issue.5 , pp. 575-580
    • Gylling, H.1    Miettinen, T.A.2
  • 48
    • 0032966743 scopus 로고    scopus 로고
    • Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects
    • Hallikainen MA, Uusitupa MI. Effects of 2 low-fat stanol estercontaining margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. Am J Clin Nutr 1999;69(3):403-410. (Pubitemid 29104559)
    • (1999) American Journal of Clinical Nutrition , vol.69 , Issue.3 , pp. 403-410
    • Hallikainen, M.A.1    Uusitupa, M.I.J.2
  • 49
    • 0033049497 scopus 로고    scopus 로고
    • Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men
    • Jones PJ, Ntanios FY, Raeini-Sarjaz M, Vanstone CA. Cholesterollowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am J Clin Nutr 1999;69(6):1144-1150. (Pubitemid 29252046)
    • (1999) American Journal of Clinical Nutrition , vol.69 , Issue.6 , pp. 1144-1150
    • Jones, P.J.H.1    Ntanios, F.Y.2    Raeini-Sarjaz, M.3    Vanstone, C.A.4
  • 50
    • 0032738755 scopus 로고    scopus 로고
    • Cholesterollowering effect of stanol ester in a us population of mildly hypercholesterolemic men and women: A randomized controlled trial
    • Nguyen TT, Dale LC, von Bergmann K, Croghan IT. Cholesterollowering effect of stanol ester in a us population of mildly hypercholesterolemic men and women: A randomized controlled trial. Mayo Clin Proc 1999;74(12):1198-1206.
    • (1999) Mayo Clin Proc , vol.74 , Issue.12 , pp. 1198-1206
    • Nguyen, T.T.1    Dale, L.C.2    Von Bergmann, K.3    Croghan, I.T.4
  • 51
    • 0034237228 scopus 로고    scopus 로고
    • Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy
    • DOI 10.1016/S0002-9149(00)00976-0, PII S0002914900009760
    • Blair SN, Capuzzi DM, Gottlieb SO, Nguyen T, Morgan JM, Cater NB. Incremental reduction of serum total cholesterol and lowdensity lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy. Am J Cardiol 2000;86(1):46-52. (Pubitemid 30365142)
    • (2000) American Journal of Cardiology , vol.86 , Issue.1 , pp. 46-52
    • Blair, S.N.1    Capuzzi, D.M.2    Gottlieb, S.O.3    Nguyen, T.4    Morgan, J.M.5    Cater, N.B.6
  • 52
    • 0041936426 scopus 로고    scopus 로고
    • Cholesterol and apolipoprotein-lowering effect of plant stanol ester in healthy Japanese men and women
    • Homma Y, Ishikawa T, Tateno M, Mitaniyama A, Sugano M. Cholesterol and apolipoprotein-lowering effect of plant stanol ester in healthy Japanese men and women. J Jpn Soc Nutr Food Sci 2000;53(2):155-162.
    • (2000) J Jpn Soc Nutr Food Sci , vol.53 , Issue.2 , pp. 155-162
    • Homma, Y.1    Ishikawa, T.2    Tateno, M.3    Mitaniyama, A.4    Sugano, M.5
  • 54
    • 0033990558 scopus 로고    scopus 로고
    • Vegetable oil-based versus wood-based stanol ester mixtures: Effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects
    • Plat J, Mensink RP. Vegetable oil-based versus wood-based stanol ester mixtures: effects on serum lipids and hemostatic factors in non- hypercholesterolemic subjects. Atherosclerosis 2000;148(1):101-112.
    • (2000) Atherosclerosis , vol.148 , Issue.1 , pp. 101-112
    • Plat, J.1    Mensink, R.P.2
  • 55
    • 0036147485 scopus 로고    scopus 로고
    • Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations
    • DOI 10.1016/S0021-9150(01)00562-7, PII S0021915001005627
    • Mensink RP, Ebbing S, Lindhout M, Plat J, van Heugten MM. Effects of plant stanol esters supplied in a low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis 2002;160(1):205-213. (Pubitemid 34076656)
    • (2002) Atherosclerosis , vol.160 , Issue.1 , pp. 205-213
    • Mensink, R.P.1    Ebbing, S.2    Lindhout, M.3    Plat, J.4    Van Heugten, M.M.5
  • 56
    • 0042206849 scopus 로고    scopus 로고
    • Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    • Katan MB, Grundy SM, Jones P, Law M, Mittinen T, Paoletti R. Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clinic Proceedings 2003;78(8):965-978. (Pubitemid 36936128)
    • (2003) Mayo Clinic Proceedings , vol.78 , Issue.8 , pp. 965-978
    • Katan, M.B.1    Grundy, S.M.2    Jones, P.3    Law, M.4    Miettinen, T.5    Paoletti, R.6
  • 57
    • 2942564338 scopus 로고    scopus 로고
    • Plant sterols: Factors affecting their efficacy and safety as functional food ingredients
    • Berger A, Jones PJH, Abumweis SS. Plant sterols: Factors affecting their efficacy and safety as functional food ingredients. Lipids Health Dis 2004;3:5.
    • (2004) Lipids Health Dis , vol.3 , pp. 5
    • Berger, A.1    Jones, P.J.H.2    Abumweis, S.S.3
  • 58
    • 84874553040 scopus 로고    scopus 로고
    • FDA letter regarding enforcement discretion with respect to expanded use of an interim final rule about sterol/stanol esters and reduced risk of coronary heart disease
    • Accessed June 17, 2008
    • Taylor CL. FDA letter regarding enforcement discretion with respect to expanded use of an interim final rule about sterol/stanol esters and reduced risk of coronary heart disease. Available at: http://www.cfsan. fda.gov/~dms/ds-ltr30.html Accessed June 17, 2008.
    • Available At
    • Taylor, C.L.1
  • 62
    • 84874554728 scopus 로고    scopus 로고
    • FDA authorizes new coronary heart disease health claim for plant sterol and plant stanol esters
    • Accessed June 17, 2008
    • FDA, FDA authorizes new coronary heart disease health claim for plant sterol and plant stanol esters. FDA Talk Paper. Available at: http://www.cfsan. fda.gov/~lrd/tpsterol.html Accessed June 17, 2008.
    • FDA Talk Paper
  • 64
    • 21244487468 scopus 로고    scopus 로고
    • Plant stanol and sterol esters in the control of blood cholesterol levels: Mechanism and safety aspects
    • DOI 10.1016/j.amjcard.2005.03.015, PII S0002914905004534
    • Plat J, Mensink RP. Plant stanol and sterol esters in the control of blood cholesterol levels: Mechanism and safety aspects. Am J Cardiol 2005;96(1 A):15D-22D. (Pubitemid 40898165)
    • (2005) American Journal of Cardiology , vol.96 , Issue.1 SUPPL.
    • Plat, J.1    Mensink, R.P.2
  • 65
    • 33644816753 scopus 로고    scopus 로고
    • Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolaemic subjects
    • DOI 10.1038/sj.ejcn.1602318, PII 1602318
    • Doornbos AME, Meynen EM, Duchateau GSMJE, van der Knaap HCM, Trautwein EA. Intake occasion affects the serum cholesterol lowering of a plant sterol-enriched single-dose yoghurt drink in mildly hypercholesterolemic subjects. Eur J Clin Nutr 2006;60(10):325-333. (Pubitemid 43354925)
    • (2006) European Journal of Clinical Nutrition , vol.60 , Issue.3 , pp. 325-333
    • Doornbos, A.M.E.1    Meynen, E.M.2    Duchateau, G.S.M.J.E.3    Van Der Knaap, H.C.M.4    Trautwein, E.A.5
  • 66
    • 0036099122 scopus 로고    scopus 로고
    • Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans
    • Ostlund RE, Racette SB, Okeke A, Stenson WF. Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. Am J Clin Nutr 2002;75(6):1000-1004. (Pubitemid 34547528)
    • (2002) American Journal of Clinical Nutrition , vol.75 , Issue.6 , pp. 1000-1004
    • Ostlund Jr., R.E.1    Racette, S.B.2    Okeke, A.3    Stenson, W.F.4
  • 67
    • 0038239392 scopus 로고    scopus 로고
    • Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ
    • Ostlund RE, Racette SB, Stenson WF. Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ. Am J Clin Nutr 2003;77(6):1385-1389. (Pubitemid 39655270)
    • (2003) American Journal of Clinical Nutrition , vol.77 , Issue.6 , pp. 1385-1389
    • Ostlund Jr., R.E.1    Racette, S.B.2    Stenson, W.F.3
  • 73
    • 0347824361 scopus 로고    scopus 로고
    • Can cholesterol absorption be reduced by phytosterols and phytostanols via a cocrystallization mechanism?
    • DOI 10.1016/j.chemphyslip.2003.08.007
    • Mel'nikov SM, Seijen ten Hoorn JW, Bertrand B. Can cholesterol absorption be reduced by phytosterols ans phytostanols via a cocrystallization mechanism? Chem Phys Lipids 2004;127:15-33. (Pubitemid 38045456)
    • (2004) Chemistry and Physics of Lipids , vol.127 , Issue.1 , pp. 15-33
    • Mel'nikov, S.M.1    Seijen Ten Hoorn, J.W.M.2    Bertrand, B.3
  • 74
    • 67249119416 scopus 로고    scopus 로고
    • New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism
    • doi:10.1016 online
    • Calpe-Berdiel L, Escolà-Gil JC, Blanco-Vaca F. New insights into the molecular actions of plant sterols and stanols in cholesterol metabolism. Atherosclerosis 2008; doi:10.1016 (online).
    • (2008) Atherosclerosis
    • Calpe-Berdiel, L.1    Escolà-Gil, J.C.2    Blanco-Vaca, F.3
  • 78
    • 17744390348 scopus 로고    scopus 로고
    • Accumulation of Dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters
    • Berge KEH, Tian GA, Graf L, et al. Accumulation of Dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000;290(5497):1771-1775.
    • (2000) Science , vol.290 , Issue.5497 , pp. 1771-1775
    • Berge, K.E.H.1    Tian, G.A.2    Graf, L.3
  • 79
    • 0034915332 scopus 로고    scopus 로고
    • Two genes that map to the STSL locus cause sitosterolemia: Genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively
    • Lu KMH, Lee S, Hazard A, et al. Two genes that map to the STSL locus cause sitosterolemia: Genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet 2001;69(2):278-290.
    • (2001) Am J Hum Genet , vol.69 , Issue.2 , pp. 278-290
    • Lu, K.M.H.1    Lee, S.2    Hazard, A.3
  • 81
    • 10044226295 scopus 로고    scopus 로고
    • Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression
    • DOI 10.1194/jlr.M400208-JLR200
    • Field FJ, Born E, Mathur SN. Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and niemann-pick C1-like 1 protein gene expression. J Lipid Res 2004;45(12):2252-2259. (Pubitemid 39602972)
    • (2004) Journal of Lipid Research , vol.45 , Issue.12 , pp. 2252-2259
    • Field, F.J.1    Born, E.2    Mathur, S.N.3
  • 83
    • 0032725927 scopus 로고    scopus 로고
    • Cholesterol-lowering activity of naringenin via inhibition of 8-hydroxy-3-methylglutaryl coenzyme a reductase and acyl coenzyme A:cholesterol acyltransferase in rats
    • DOI 10.1159/000012783
    • Lee SH, Park YB, Bae KH, et al. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methyl-glutaryl coenzyme a reductase and acyl coenzyme A: Cholesterol acyltransferase in rats. Ann Nutr Metab 1999;43(3):173-180. (Pubitemid 29494862)
    • (1999) Annals of Nutrition and Metabolism , vol.43 , Issue.3 , pp. 173-180
    • Lee, S.H.1    Park, Y.B.2    Bae, K.H.3    Bok, S.H.4    Kwon, Y.K.5    Lee, E.S.6    Choi, M.S.7
  • 89
    • 58749094968 scopus 로고    scopus 로고
    • Safety assessment of common foods enriched with natural nonesterified plant sterols
    • Epub ahead of print
    • Tuomilehto J, Tikkanen MJ, Högström P, et al. Safety assessment of common foods enriched with natural nonesterified plant sterols. Eur J Clin Nutr 2008; Epub ahead of print.
    • (2008) Eur J Clin Nutr
    • Tuomilehto, J.1    Tikkanen, M.J.2    Högström, P.3
  • 90
    • 85039676341 scopus 로고    scopus 로고
    • Accessed on June 17, 2008
    • Rulis AM. GRAS notice no. GRN 000112. 2003. Available at: http://www.cfsan. fda.gov/~rdb/opa-g112.html. Accessed on June 17, 2008.
    • (2003) GRAS notice no. GRN 000112
    • Rulis, A.M.1
  • 91
  • 92
    • 0025740575 scopus 로고
    • Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hypercholesterolemic probands and their first-degree relatives
    • Gluek CJ, Speirs J, Tracy T, Streicher P, Illig E, Vandegrift J. Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hypercholesterolemic probands and their first-degree relatives. Metabolism 1991;40:842-848.
    • (1991) Metabolism , vol.40 , pp. 842-848
    • Gluek, C.J.1    Speirs, J.2    Tracy, T.3    Streicher, P.4    Illig, E.5    Vandegrift, J.6
  • 93
    • 0036916821 scopus 로고    scopus 로고
    • Serum plant sterols as a potential risk factor for coronary heart disease
    • DOI 10.1053/meta.2002.36298
    • Sudhop T, Gottwald BM, von Bergmann K. Serum plant sterols as a potential risk factor for coronary heart disease. Metabolism 2002;51:1519-1521. (Pubitemid 36018822)
    • (2002) Metabolism: Clinical and Experimental , vol.51 , Issue.12 , pp. 1519-1521
    • Sudhop, T.1    Gottwald, B.M.2    Von Bergmann, K.3
  • 94
    • 33645519199 scopus 로고    scopus 로고
    • Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: Results of a nested casecontrol analysis of the Prospective Cardiovascular Munster (PROCAM) study
    • Assmann G, Cullen P, Erbey J, Ramey DR, Kannenberg F, Schulte H. Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: Results of a nested casecontrol analysis of the Prospective Cardiovascular Munster (PROCAM) study. Nutr Metab Cardiovasc Dis 2006;16:13-21.
    • (2006) Nutr Metab Cardiovasc Dis , vol.16 , pp. 13-21
    • Assmann, G.1    Cullen, P.2    Erbey, J.3    Ramey, D.R.4    Kannenberg, F.5    Schulte, H.6
  • 96
    • 0042830812 scopus 로고    scopus 로고
    • Potential uses and benefits of phytosterols in diet: Present situation and future directions
    • DOI 10.1016/S0261-5614(03)00060-8
    • Quilez J, Garcia-Lorda P, Salas-Salvado J. Potential uses and benefits of phytosterols in diet: Present situation and future directions. Clin Nutr 2003;22(4):343-351. (Pubitemid 37063294)
    • (2003) Clinical Nutrition , vol.22 , Issue.4 , pp. 343-351
    • Quilez, J.1    Garcia-Lorda, P.2    Salas-Salvado, J.3
  • 97
    • 33947241794 scopus 로고    scopus 로고
    • Phytosterols: Application and recovery methods
    • Fernandes P, Cabral JMS. Phytosterols: Application and recovery methods. Bioresource Technol 2007;98(12):2335-2350.
    • (2007) Bioresource Technol , vol.98 , Issue.12 , pp. 2335-2350
    • Fernandes, P.1    Cabral, J.M.S.2
  • 99
    • 84862560772 scopus 로고    scopus 로고
    • Minor components in vegetable oils
    • Chapter 12. Edible Oil and Fat Products: Specialty Oils and Oil Products, Fereidoon Shahidi Editor, John Wiley & Sons, Sussex, UK
    • Kamal-Eldin A. Minor components in vegetable oils., In: Baileys Industrial Fats and Oils, Volume 3, Chapter 12. Edible Oil and Fat Products: Specialty Oils and Oil Products, Fereidoon Shahidi (Editor), John Wiley & Sons, Sussex, UK 2005;319-359.
    • (2005) Baileys Industrial Fats and Oils , vol.3 , pp. 319-359
    • Kamal-Eldin, A.1
  • 100
    • 38149064840 scopus 로고    scopus 로고
    • Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols
    • ahead of print
    • Clifton PM, Mano M, Duchateau GSMJE, van der Knaap HCM, Trautwein EA. Dose-response effects of different plant sterol sources in fat spreads on serum lipids and C-reactive protein and on the kinetic behavior of serum plant sterols. Eur J Clin Nutr 2007; ahead of print.
    • (2007) Eur J Clin Nutr
    • Clifton, P.M.1    Mano, M.2    Duchateau, G.S.M.J.E.3    Van Der Knaap, H.C.M.4    Trautwein, E.A.5


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