Release of lipophilic molecules during in vitro digestion of soy protein-stabilized emulsions

Molecular Nutrition and Food Research

Volumn 55, Issue SUPPL. 2, 2011, Pages

  Nik, Amir Malaki ^a   Corredig, Milena ^a   Wright, Amanda J ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

In vitro digestion; Lipolysis; Lipophilic bioactives; Micellization; Oil in water emulsion

Indexed keywords

BETA CAROTENE; COLECALCIFEROL; DRUG DERIVATIVE; PHYTOSTEROL; SOYBEAN PROTEIN; UBIDECARENONE; UBIQUINONE;

ARTICLE; CHEMISTRY; DIGESTION; DUODENUM; EMULSION; HYDROLYSIS; LIPOLYSIS; METABOLISM; MICELLE; SOLUBILITY; STOMACH JUICE;

BETA CAROTENE; CHOLECALCIFEROL; DIGESTION; DUODENUM; EMULSIONS; GASTRIC JUICE; HYDROLYSIS; LIPOLYSIS; MICELLES; PHYTOSTEROLS; SOLUBILITY; SOYBEAN PROTEINS; UBIQUINONE;

EID: 80053258356     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201000572     Document Type: Article

References (45)

1. Porter, C. J. H., Charman, W. N., In vitro assessment of oral lipid based formulations. Adv. Drug Deliver. Rev. 2001, 50, S127-S147.
2. Yonekura, L., Nagao, A., Intestinal absorption of dietary carotenoids. Mol. Nutr. Food Res. 2007, 51, 107-115.
3. Parada, J., Aguilera, J. M., Food microstructure affects the bioavailability of several nutrients. J. Food Sci. 2007, 72, R21-R32.
4. Rich, G. T., Faulks, R. M., Wickham, M. S. J., Fillery-Travis, A., Solubilization of carotenoids from carrot juice and spinach in lipid phases: II. Modeling the duodenal environment. Lipids 2003, 38, 947-956.
5. Grossmann, R. E., Tangpricha, V., Evaluation of vehicle substances on vitamin D bioavailability: A systematic review. Mol. Nutr. Food Res. 2010, 54, 1055-1061.
6. Bhagavan, H. N., Chopra, R. K., Craft, N. E., Chitchumroonchokchai, C., Failla, M. L., Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model. Int. J. Pharm. 2007, 333, 112-117.
7. Bhagavan, H. N., Chopra, R. K., Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 2007, 7, S78-S88.
8. Garrett, D. A., Failla, M. L., Sarama, R. J., Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J. Agric. Food Chem. 1999, 47, 4301-4309.
9. Tyssandier, V., Reboul, E., Dumas, J. F., Bougteloup-Demange, C. et al., Processing of vegetable-borne carotenoids in the human stomach and duodenum. Am. J. Physiol. Gastr. L. 2003, 284, G913-G923.
10. Granado-Lorencio, F., Olmedilla-Alonso, B., Herrero-Barbudo, C., Blanco-Navarro, I. et al., In vitro bioaccessibility of carotenoids and tocopherols from fruits and vegetables. Food Chem. 2007, 102, 641-648.
11. Borel, P., Grolier, P., Armand, M., Partier, A. et al., Carotenoids in biological emulsions: solubility, surface-to-core distribution, and release from lipid droplets. J. Lipid Res. 1996, 37, 250-261.
12. Veda, S., Kamath, A., Platel, K., Begum, K., Srinivasan, K., Determination of bioaccessibility of beta-carotene in vegetables by in vitro methods. Mol. Nutr. Food Res. 2006, 50, 1047-1052.
13. Choubert, G., Guillou, A., Tyssandier, V., Borel, P., Grolier, P., Health value of carotenoids. Sci. Aliment. 2001, 21, 467-480.
14. Snodderly, D. M., Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am. J. Clin. Nutr. 1995, 62, S1448-S1461.
15. Biesalski, H. K., Obermueller-Jevic, U. C., UV light, beta-carotene and human skin - beneficial and potentially harmful effects. Arch. Biochem. Biophys. 2001, 389, 1-6.
16. Campbell, J. K., Canene-Adams, K., Lindshield, B. L., Boileau, T. W. M. et al., Tomato phytochemicals and prostate cancer risk. J. Nutr. 2004, 134, 3486S-3492S.
17. Stahl, W., Sies, H., Bioactivity and protective effects of natural carotenoids. BBA Mol. Basis Dis. 2005, 1740, 101-107.
18. Ostlund, R. E., Phytosterols in human nutrition. Annu. Rev. Nutr. 2002, 22, 533-549.
19. Weihrauch, J. L., Gardner, J. M., Sterol content of foods of plant origin. J. Am. Diet. Assoc. 1978, 73, 39-47.
20. Quilez, J., Garcia-Lorda, P., Salas-Salvado, J., Potential uses and benefits of phytosterols in diet: present situation and future directions. Clin. Nutr. 2003, 22, 343-351.
21. Moghadasian, M. H., Frohlich, J. J., Effects of dietary phytosterols on cholesterol metabolism and atherosclerosis: clinical and experimental evidence. Am. J. Med. 1999, 107, 588-594.
22. Romer, S., Garti, N., The activity and absorption relationship of cholesterol and phytosterols. Colloid. Surface A 2006, 282, 435-456.
23. Ostlund, R. E., Mcgill, J. B., Zeng, C. M., Covey, D. F. et al., Gastrointestinal absorption and plasma kinetics of soy delta(5)-phytosterols and phytostanols in humans. Am. J. Physiol. Endoc. M. 2002, 282, E911-E916.
24. Ely, J. T. A., Krone, C. A., A brief update on ubiquinone (coenzyme Q10). J. Orthomol. Med. 2010, 15, 63-68.
25. Thanatuksorn, P., Kawai, K., Hayakawa, M., Hayashi, M., Kajiwara, K., Improvement of the oral bioavailability of coenzyme Q(10) by emulsification with fats and emulsifiers used in the food industry. LWT-Food Sci. Tech. 2009, 42, 385-390.
26. Pravst, I., Zmitek, K., Zmitek, J., Coenzyme Q10 contents in foods and fortification strategies. Crit. Rev. Food Sci. 2010, 50, 269-280.
27. Zmitek, J., Smidovnik, A., Fir, M., Prosek, M. et al., Relative bioavailability of two forms of a novel water-soluble coenzyme Q10. Ann. Nutr. Metab. 2008, 52, 281-287.
28. Borel, P., Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids, and phytosterols). Clin. Chem. Lab Med. 2003, 41, 979-994.
29. Lu, Z., Chen, T. C., Zhang, A., Persons, K. S. et al., An evaluation of the vitamin D-3 content in fish: Is the vitamin D content adequate to satisfy the dietary requirement for vitamin D? J. Steroid Biochem. 2007, 103, 642-644.
30. Pfeifer, M., Begerow, B., Minne, H. W., Vitamin D and muscle function. Osteoporosis Int. 2002, 13, 187-194.
31. vandenBerg, H., Bioavailability of vitamin D. Eur. J. Clin. Nutr. 1997, 51, S76-S79.
32. McClements, D. J., Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components. Adv. Colloid Interface 2010, 159, 213-228.
33. Chu, B. S., Rich, G. T., Ridout, M. J., Faulks, R. M. et al., Modulating pancreatic lipase activity with galactolipids: effects of emulsion interfacial composition. Langmuir 2009, 25, 9352-9360.
34. Sarkar, A., Horne, D. S., Singh, H., Interactions of milk protein-stabilized oil-in-water emulsions with bile salts in a simulated upper intestinal model. Food Hydrocolloids. 2010, 24, 142-151.
35. Malaki Nik, A., Wright, A. J., Corredig, M., Impact of interfacial composition on emulsion digestion and rate of lipid hydrolysis using different in vitro digestion models. Colloid. Surface. B 2010, 83, 321-330.
36. Katan, M. B., Grundy, S. M., Jones, P., Law, M. et al., Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc. 2003, 78, 965-978.
37. Cooper, D. A., Webb, D. R., Peters, J. C., Evaluation of the potential for olestra to affect the availability of dietary phytochemicals. J. Nutr. 1997, 127, S1699-S1709.
38. Paradeike, J., Muller, R. H., Coenzyme Q10-loaded NLCs: preparation, occlusive properties and penetration enhancement. Pharm. Tech. Eur. 2007, 19, 46-49.
39. Wright, A. J., Pietrangelo, C., MacNaughton, A., Influence of simulated upper intestinal parameters on the efficiency of beta-carotene micellarization using an in vitro model of digestion. Food Chem. 2008, 107, 1253-1260.
40. Malaki Nik, A., Corredig, M., Wright, A. J., Changes in WPI-stabilized emulsion interfacial properties in relation to lipolysis and beta-carotene transfer during exposure to simulated gastric-duodenal fluids of variable composition. Food Digestion 2010, 1, 14-27.
41. Kommuru, T. R., Gurley, B., Khan, M. A., Reddy, I. K., Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q(10): formulation development and bioavailability assessment. Int. J. Pharm. 2001, 212, 233-246.
42. Vaikousi, H., Lazaridou, A., Biliaderis, C. G., Zawistowski, J., Phase transitions, solubility and crystallization kinetics of phytosterols and phytosterol-oil blends. J. Agr. Food Chem. 2007, 55, 1790-1798.
43. Rich, G. T., Bailey, A. L., Faulks, R. M., Parker, M. L. et al., Solubilization of carotenoids from carrot juice and spinach in lipid phases: I. Modeling the gastric lumen. Lipids 2003, 38, 933-945.
44. Kaukonen, A. M., Boyd, B. J., Porter, C. J. H., Charman, W. N., Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations. Pharm. Res. 2004, 21, 245-253.
45. Day, J. P. R., Rago, G., Domke, K. F., Velikov, K. P., Bonn, M., Label-free imaging of lipophilic bioactive molecules during lipid digestion by multiplex coherent anti-stokes raman scattering microspectroscopy. J. Am. Chem. Soc. 2010, 132, 8433-8439.