-
1
-
-
33846910173
-
Global reconstruction of the human metabolic network based on genomic and bibliomic data
-
Duarte N, Becker SA. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci USA 2007, 104:1777–1782.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1777-1782
-
-
Duarte, N.1
Becker, S.A.2
-
2
-
-
84877315835
-
A community-driven global reconstruction of human metabolism
-
Thiele I, Swainston N, Fleming RMT, Hoppe A, Sahoo S, Aurich MK, Haraldsdottir H, Mo ML, Rolfsson O, Stobbe MD, et al. A community-driven global reconstruction of human metabolism. Nat Biotechnol 2013, 31:419–425.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 419-425
-
-
Thiele, I.1
Swainston, N.2
Fleming, R.M.T.3
Hoppe, A.4
Sahoo, S.5
Aurich, M.K.6
Haraldsdottir, H.7
Mo, M.L.8
Rolfsson, O.9
Stobbe, M.D.10
-
3
-
-
84955326448
-
The Emerging Hallmarks of Cancer Metabolism
-
Pavlova NN, Thompson CB. The Emerging Hallmarks of Cancer Metabolism. Cell Metab 2016, 23:27–47. DOI: https://doi.org/10.1016/j.cmet.2015.12.006.
-
(2016)
Cell Metab
, vol.23
, pp. 27-47
-
-
Pavlova, N.N.1
Thompson, C.B.2
-
4
-
-
84867434804
-
Metabolomics in drug target discovery
-
Rabinowitz JD, Purdy JG, Vastag L, Shenk T, Koyuncu E. Metabolomics in drug target discovery. Cold Spring Harb Symp Quant Biol 2011, 76:235–246.
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 235-246
-
-
Rabinowitz, J.D.1
Purdy, J.G.2
Vastag, L.3
Shenk, T.4
Koyuncu, E.5
-
5
-
-
84961589787
-
Organ-specific cancer metabolism and its potential for therapy
-
In, xxx, Springer International Publishing, (Accessed March 29, 2017)
-
Elia I, Schmieder R, Christen S, Fendt SM. Organ-specific cancer metabolism and its potential for therapy. In: Handbook of Experimental Pharmacology. xxx: Springer International Publishing; 2016, 321–353. Available at: http://link.springer.com/10.1007/164_2015_10. (Accessed March 29, 2017).
-
(2016)
Handbook of Experimental Pharmacology
, pp. 321-353
-
-
Elia, I.1
Schmieder, R.2
Christen, S.3
Fendt, S.M.4
-
6
-
-
85025465348
-
Is there a therapeutic window for metabolism-based cancer therapies?
-
Fendt S-M. Is there a therapeutic window for metabolism-based cancer therapies? Front Endocrinol (Lausanne) 2017, 8:1–5.
-
(2017)
Front Endocrinol (Lausanne)
, vol.8
, pp. 1-5
-
-
Fendt, S.-M.1
-
8
-
-
84938555849
-
Metabolic control of signalling pathways and metabolic auto-regulation
-
Lorendeau D, Christen S, Rinaldi G, Fendt SM. Metabolic control of signalling pathways and metabolic auto-regulation. Biol Cell 2015, 107:251–272.
-
(2015)
Biol Cell
, vol.107
, pp. 251-272
-
-
Lorendeau, D.1
Christen, S.2
Rinaldi, G.3
Fendt, S.M.4
-
9
-
-
84925969707
-
Metabolic pathways promoting cancer cell survival and growth
-
Boroughs LK, DeBerardinis RJ. Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol 2015, 17:351–359.
-
(2015)
Nat Cell Biol
, vol.17
, pp. 351-359
-
-
Boroughs, L.K.1
DeBerardinis, R.J.2
-
10
-
-
80054046029
-
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
-
Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011, 27:441–464.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
11
-
-
84883497454
-
Glutamine and cancer: cell biology, physiology, and clinical opportunities
-
Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Investig 2013, 123:3678–3684.
-
(2013)
J Clin Investig
, vol.123
, pp. 3678-3684
-
-
Hensley, C.T.1
Wasti, A.T.2
DeBerardinis, R.J.3
-
12
-
-
84923186422
-
Famine versus feast: understanding the metabolism of tumors in vivo
-
Mayers JR, Vander Heiden MG. Famine versus feast: understanding the metabolism of tumors in vivo. Trends Biochem Sci 2015, 40:130–140.
-
(2015)
Trends Biochem Sci
, vol.40
, pp. 130-140
-
-
Mayers, J.R.1
Vander Heiden, M.G.2
-
13
-
-
85013664984
-
Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis
-
Dong W, Keibler MA, Stephanopoulos G. Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis. Metab Eng 2017, pii:S1096-7176(17)30054-X. https://doi.org/10.1016/j.ymben.2017.02.002.
-
(2017)
Metab Eng
-
-
Dong, W.1
Keibler, M.A.2
Stephanopoulos, G.3
-
14
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns R, Harris I, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011, 11:85–95.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.1
Harris, I.2
Mak, T.3
-
15
-
-
84999723809
-
PKM2, cancer metabolism, and the road ahead
-
Dayton TL, Jacks T, Vander Heiden MG. PKM2, cancer metabolism, and the road ahead. EMBO Rep 2016, 17:1721–1730.
-
(2016)
EMBO Rep
, vol.17
, pp. 1721-1730
-
-
Dayton, T.L.1
Jacks, T.2
Vander Heiden, M.G.3
-
16
-
-
84920447418
-
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
-
Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PNM, et al. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell 2015, 57:95–107.
-
(2015)
Mol Cell
, vol.57
, pp. 95-107
-
-
Lunt, S.Y.1
Muralidhar, V.2
Hosios, A.M.3
Israelsen, W.J.4
Gui, D.Y.5
Newhouse, L.6
Ogrodzinski, M.7
Hecht, V.8
Xu, K.9
Acevedo, P.N.M.10
-
17
-
-
0034161904
-
Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells
-
Boros LG, Torday JS, Lim S, Bassilian S, Cascante M, Lee WNP. Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res 2000, 60:1183–1185.
-
(2000)
Cancer Res
, vol.60
, pp. 1183-1185
-
-
Boros, L.G.1
Torday, J.S.2
Lim, S.3
Bassilian, S.4
Cascante, M.5
Lee, W.N.P.6
-
18
-
-
84860321700
-
Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, et al. Oncogenic kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012, 149:656–670.
-
(2012)
Cell
, vol.149
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
Hua, S.4
Chu, G.C.5
Fletcher-Sananikone, E.6
Locasale, J.W.7
Son, J.8
Zhang, H.9
Coloff, J.L.10
-
19
-
-
21744431575
-
The sweet and sour of cancer: glycans as novel therapeutic targets
-
Fuster MM, Esko JD. The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer 2005, 5:526–542.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 526-542
-
-
Fuster, M.M.1
Esko, J.D.2
-
20
-
-
84908568394
-
Hexosamine pathway and (ER) protein quality control
-
Denzel MS, Antebi A. Hexosamine pathway and (ER) protein quality control. Curr Opin Cell Biol 2015, 33:14–18.
-
(2015)
Curr Opin Cell Biol
, vol.33
, pp. 14-18
-
-
Denzel, M.S.1
Antebi, A.2
-
21
-
-
84988431514
-
Serine and one-carbon metabolism in cancer
-
Yang M, Vousden KH. Serine and one-carbon metabolism in cancer. Nat Rev Cancer 2016, 16:650–662.
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 650-662
-
-
Yang, M.1
Vousden, K.H.2
-
22
-
-
84975455372
-
Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway
-
Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab 2016, 23:1140–1153.
-
(2016)
Cell Metab
, vol.23
, pp. 1140-1153
-
-
Ducker, G.S.1
Chen, L.2
Morscher, R.J.3
Ghergurovich, J.M.4
Esposito, M.5
Teng, X.6
Kang, Y.7
Rabinowitz, J.D.8
-
23
-
-
84897392385
-
Serine and glycine metabolism in cancer
-
Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G. Serine and glycine metabolism in cancer. Trends Biochem Sci 2014, 39:191–198.
-
(2014)
Trends Biochem Sci
, vol.39
, pp. 191-198
-
-
Amelio, I.1
Cutruzzolá, F.2
Antonov, A.3
Agostini, M.4
Melino, G.5
-
24
-
-
84861420588
-
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
-
Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 2012, 336:1040–1044.
-
(2012)
Science
, vol.336
, pp. 1040-1044
-
-
Jain, M.1
Nilsson, R.2
Sharma, S.3
Madhusudhan, N.4
Kitami, T.5
Souza, A.L.6
Kafri, R.7
Kirschner, M.W.8
Clish, C.B.9
Mootha, V.K.10
-
25
-
-
37449034854
-
Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 2007, 104:19345–19350.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19345-19350
-
-
DeBerardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
Nissim, I.4
Yudkoff, M.5
Wehrli, S.6
Thompson, C.B.7
-
26
-
-
84885357137
-
Exploiting the bad eating habits of Ras-driven cancers
-
White E. Exploiting the bad eating habits of Ras-driven cancers. Genes Develop 2013, 27:2065–2071.
-
(2013)
Genes Develop
, vol.27
, pp. 2065-2071
-
-
White, E.1
-
27
-
-
84878396462
-
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
-
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 2013, 497:633–637.
-
(2013)
Nature
, vol.497
, pp. 633-637
-
-
Commisso, C.1
Davidson, S.M.2
Soydaner-Azeloglu, R.G.3
Parker, S.J.4
Kamphorst, J.J.5
Hackett, S.6
Grabocka, E.7
Nofal, M.8
Drebin, J.A.9
Thompson, C.B.10
-
28
-
-
84938234308
-
Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
-
Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell 2015, 162:552–563.
-
(2015)
Cell
, vol.162
, pp. 552-563
-
-
Sullivan, L.B.1
Gui, D.Y.2
Hosios, A.M.3
Bush, L.N.4
Freinkman, E.5
Vander Heiden, M.G.6
-
29
-
-
84938232611
-
An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
-
Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 2015, 162:540–551.
-
(2015)
Cell
, vol.162
, pp. 540-551
-
-
Birsoy, K.1
Wang, T.2
Chen, W.W.3
Freinkman, E.4
Abu-Remaileh, M.5
Sabatini, D.M.6
-
30
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2011, 481:380–384.
-
(2011)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
Jewell, C.M.7
Johnson, Z.R.8
Irvine, D.J.9
Guarente, L.10
-
31
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, Chen P-H, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2012, 481:385–388.
-
(2012)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.-H.4
Sullivan, L.B.5
Cheng, T.6
Yang, Y.7
Linehan, W.M.8
Chandel, N.S.9
DeBerardinis, R.J.10
-
32
-
-
84881329062
-
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
-
Fendt S-M, Bell EL, Keibler MA, Olenchock BA, Mayers JR, Wasylenko TM, Vokes NI, Guarente L, Vander Heiden MG, Stephanopoulos G. Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells. Nat Commun 2013, 4:2236.
-
(2013)
Nat Commun
, vol.4
, pp. 2236
-
-
Fendt, S.-M.1
Bell, E.L.2
Keibler, M.A.3
Olenchock, B.A.4
Mayers, J.R.5
Wasylenko, T.M.6
Vokes, N.I.7
Guarente, L.8
Vander Heiden, M.G.9
Stephanopoulos, G.10
-
33
-
-
83755178091
-
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
-
Wise DR, Ward PS, Shay JES, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci USA 2011, 108:19611–19616.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 19611-19616
-
-
Wise, D.R.1
Ward, P.S.2
Shay, J.E.S.3
Cross, J.R.4
Gruber, J.J.5
Sachdeva, U.M.6
Platt, J.M.7
DeMatteo, R.G.8
Simon, M.C.9
Thompson, C.B.10
-
34
-
-
84880876347
-
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
-
Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res 2013, 73:4429–4438.
-
(2013)
Cancer Res
, vol.73
, pp. 4429-4438
-
-
Fendt, S.M.1
Bell, E.L.2
Keibler, M.A.3
Davidson, S.M.4
Wirth, G.J.5
Fiske, B.6
Mayers, J.R.7
Schwab, M.8
Bellinger, G.9
Csibi, A.10
-
35
-
-
84923148982
-
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
-
Kamphorst JJ, Chung MK, Fan J, Rabinowitz JD. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab 2014, 2:23.
-
(2014)
Cancer Metab
, vol.2
, pp. 23
-
-
Kamphorst, J.J.1
Chung, M.K.2
Fan, J.3
Rabinowitz, J.D.4
-
36
-
-
85017120623
-
Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase
-
Cantor JR, Abu-Remaileh M, Kanarek N, Freinkman E, Gao X, Louissaint A, Lewis CA, Sabatini DM. Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase. Cell 2017, 169:258–272.e17.
-
(2017)
Cell
, vol.169
, pp. 258-272
-
-
Cantor, J.R.1
Abu-Remaileh, M.2
Kanarek, N.3
Freinkman, E.4
Gao, X.5
Louissaint, A.6
Lewis, C.A.7
Sabatini, D.M.8
-
37
-
-
79951892537
-
The human serum metabolome
-
Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, Sinelnikov I, Krishnamurthy R, Eisner R, Gautam B, et al. The human serum metabolome. PLoS One 2011, 6:e16957.
-
(2011)
PLoS One
, vol.6
-
-
Psychogios, N.1
Hau, D.D.2
Peng, J.3
Guo, A.C.4
Mandal, R.5
Bouatra, S.6
Sinelnikov, I.7
Krishnamurthy, R.8
Eisner, R.9
Gautam, B.10
-
38
-
-
84948701108
-
Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
-
Tardito S, Oudin A, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen PØ, Weinstock A, Wagner A, et al. Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma. Nat Cell Biol 2015, 17:1556–1568.
-
(2015)
Nat Cell Biol
, vol.17
, pp. 1556-1568
-
-
Tardito, S.1
Oudin, A.2
Ahmed, S.U.3
Fack, F.4
Keunen, O.5
Zheng, L.6
Miletic, H.7
Sakariassen, P.Ø.8
Weinstock, A.9
Wagner, A.10
-
39
-
-
84874614138
-
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
-
Guillaumond F, Leca J, Olivares O, Lavaut M-N, Vidal N, Berthezène P, Dusetti NJ, Loncle C, Calvo E, Turrini O, et al. Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. Proc Natl Acad Sci USA 2013, 110:3919–3924.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 3919-3924
-
-
Guillaumond, F.1
Leca, J.2
Olivares, O.3
Lavaut, M.-N.4
Vidal, N.5
Berthezène, P.6
Dusetti, N.J.7
Loncle, C.8
Calvo, E.9
Turrini, O.10
-
40
-
-
74849087878
-
The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
-
Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle 2009, 8:3984–4001.
-
(2009)
Cell Cycle
, vol.8
, pp. 3984-4001
-
-
Pavlides, S.1
Whitaker-Menezes, D.2
Castello-Cros, R.3
Flomenberg, N.4
Witkiewicz, A.K.5
Frank, P.G.6
Casimiro, M.C.7
Wang, C.8
Fortina, P.9
Addya, S.10
-
41
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 2008, 118:3930–3942.
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
Végran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
De Saedeleer, C.J.7
Kennedy, K.M.8
Diepart, C.9
Jordan, B.F.10
-
42
-
-
85017274951
-
Metabolic hallmarks of tumor and immune cells in the tumor microenvironment
-
Renner K, Singer K, Koehl GE, Geissler EK, Peter K, Siska PJ, Kreutz M. Metabolic hallmarks of tumor and immune cells in the tumor microenvironment. Front Immunol 2017, 8:248.
-
(2017)
Front Immunol
, vol.8
, pp. 248
-
-
Renner, K.1
Singer, K.2
Koehl, G.E.3
Geissler, E.K.4
Peter, K.5
Siska, P.J.6
Kreutz, M.7
-
43
-
-
84923596826
-
13C metabolite labeling patterns from cells
-
13C metabolite labeling patterns from cells. Curr Opin Biotechnol 2015, 34:189–201.
-
(2015)
Curr Opin Biotechnol
, vol.34
, pp. 189-201
-
-
Buescher, J.M.1
Antoniewicz, M.R.2
Boros, L.G.3
Burgess, S.C.4
Brunengraber, H.5
Clish, C.B.6
DeBerardinis, R.J.7
Feron, O.8
Frezza, C.9
Ghesquiere, B.10
-
45
-
-
68549085318
-
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
-
Fan TWM, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, Miller DM. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 2009, 8:41.
-
(2009)
Mol Cancer
, vol.8
, pp. 41
-
-
Fan, T.W.M.1
Lane, A.N.2
Higashi, R.M.3
Farag, M.A.4
Gao, H.5
Bousamra, M.6
Miller, D.M.7
-
46
-
-
84961287801
-
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation
-
Sellers K, Fox MP, Ii MB, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, et al. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation. J Clin Invest 2015, 125:687–698.
-
(2015)
J Clin Invest
, vol.125
, pp. 687-698
-
-
Sellers, K.1
Fox, M.P.2
Ii, M.B.3
Slone, S.P.4
Higashi, R.M.5
Miller, D.M.6
Wang, Y.7
Yan, J.8
Yuneva, M.O.9
Deshpande, R.10
-
47
-
-
79957774646
-
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
-
Cheng T, Sudderth J, Yang C, Mullen AR, Jin ES, Matés JM, DeBerardinis RJ. Pyruvate carboxylase is required for glutamine-independent growth of tumor cells. Proc Natl Acad Sci USA 2011, 108:8674–8679.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 8674-8679
-
-
Cheng, T.1
Sudderth, J.2
Yang, C.3
Mullen, A.R.4
Jin, E.S.5
Matés, J.M.6
DeBerardinis, R.J.7
-
48
-
-
84862016091
-
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
-
Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Cell Metab 2012, 15:827–837.
-
(2012)
Cell Metab
, vol.15
, pp. 827-837
-
-
Marin-Valencia, I.1
Yang, C.2
Mashimo, T.3
Cho, S.4
Baek, H.5
Yang, X.L.6
Rajagopalan, K.N.7
Maddie, M.8
Vemireddy, V.9
Zhao, Z.10
-
49
-
-
84958138936
-
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
-
Davidson SM, Papagiannakopoulos T, Olenchock BA, Heyman JE, Keibler MA, Luengo A, Bauer MR, Jha AK, O'Brien JP, Pierce KA, et al. Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer. Cell Metab 2016, 23:517–528.
-
(2016)
Cell Metab
, vol.23
, pp. 517-528
-
-
Davidson, S.M.1
Papagiannakopoulos, T.2
Olenchock, B.A.3
Heyman, J.E.4
Keibler, M.A.5
Luengo, A.6
Bauer, M.R.7
Jha, A.K.8
O'Brien, J.P.9
Pierce, K.A.10
-
50
-
-
84992195909
-
Breast cancer-derived lung metastases show increased pyruvate carboxylase-dependent anaplerosis
-
Christen S, Lorendeau D, Schmieder R, Broekaert D, Metzger K, Veys K, Elia I, Buescher JM, Orth MF, Davidson SM, et al. Breast cancer-derived lung metastases show increased pyruvate carboxylase-dependent anaplerosis. Cell Rep 2016, 17:837–848.
-
(2016)
Cell Rep
, vol.17
, pp. 837-848
-
-
Christen, S.1
Lorendeau, D.2
Schmieder, R.3
Broekaert, D.4
Metzger, K.5
Veys, K.6
Elia, I.7
Buescher, J.M.8
Orth, M.F.9
Davidson, S.M.10
-
51
-
-
84966671557
-
Metabolite concentrations, fluxes and free energies imply efficient enzyme usage
-
Park JO, Rubin SA, Xu Y-F, Amador-noguez D, Fan J, Shlomi T, Rabinowitz JD. Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. Nat Chem Biol 2016, 12:482–489.
-
(2016)
Nat Chem Biol
, vol.12
, pp. 482-489
-
-
Park, J.O.1
Rubin, S.A.2
Xu, Y.-F.3
Amador-noguez, D.4
Fan, J.5
Shlomi, T.6
Rabinowitz, J.D.7
-
52
-
-
84958120328
-
Metabolic heterogeneity in human lung tumors
-
Hensley CT, Faubert B, Yuan Q, Lev-Cohain N, Jin E, Kim J, Jiang L, Ko B, Skelton R, Loudat L, et al. Metabolic heterogeneity in human lung tumors. Cell 2016, 164:681–694. Available at: 10.1016/j.cell.2015.12.034.
-
(2016)
Cell
, vol.164
, pp. 681-694
-
-
Hensley, C.T.1
Faubert, B.2
Yuan, Q.3
Lev-Cohain, N.4
Jin, E.5
Kim, J.6
Jiang, L.7
Ko, B.8
Skelton, R.9
Loudat, L.10
-
53
-
-
85008947585
-
In vivo cancer metabolism is defined by the nutrient microenvironment
-
Elia I, Fendt S-M. In vivo cancer metabolism is defined by the nutrient microenvironment. Transl Cancer Res 2016, 5:S1284–S1287.
-
(2016)
Transl Cancer Res
, vol.5
, pp. S1284-S1287
-
-
Elia, I.1
Fendt, S.-M.2
-
54
-
-
84947648620
-
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
-
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 2015, 27:57–71.
-
(2015)
Cancer Cell
, vol.27
, pp. 57-71
-
-
Schug, Z.T.1
Peck, B.2
Jones, D.T.3
Zhang, Q.4
Grosskurth, S.5
Alam, I.S.6
Goodwin, L.M.7
Smethurst, E.8
Mason, S.9
Blyth, K.10
-
55
-
-
85069238546
-
Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments
-
Peck B, Schug ZT, Zhang Q, Dankworth B, Jones DT, Smethurst E, Patel R, Mason S, Jiang M, Saunders R, et al. Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments. Cancer Metab 2016, 4:6.
-
(2016)
Cancer Metab
, vol.4
, pp. 6
-
-
Peck, B.1
Schug, Z.T.2
Zhang, Q.3
Dankworth, B.4
Jones, D.T.5
Smethurst, E.6
Patel, R.7
Mason, S.8
Jiang, M.9
Saunders, R.10
-
56
-
-
84863011452
-
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
-
Yuneva MO, Fan TWM, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, Matés JM, Alonso FJ, Wang C, Seo Y, et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab 2012, 15:157–170.
-
(2012)
Cell Metab
, vol.15
, pp. 157-170
-
-
Yuneva, M.O.1
Fan, T.W.M.2
Allen, T.D.3
Higashi, R.M.4
Ferraris, D.V.5
Tsukamoto, T.6
Matés, J.M.7
Alonso, F.J.8
Wang, C.9
Seo, Y.10
-
57
-
-
0000851342
-
The free amino acids of human blood plasma
-
Stein WH, Moore S. The free amino acids of human blood plasma. J Biol Chem 1954, 211:915–926.
-
(1954)
J Biol Chem
, vol.211
, pp. 915-926
-
-
Stein, W.H.1
Moore, S.2
-
58
-
-
84880291912
-
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
-
Tonjes M, Barbus S, Park YJ, Wang W, Schlotter M, Lindroth AM, Pleier SV, Bai AH, Karra D, Piro RM, et al. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nat Med 2013, 19:901–908.
-
(2013)
Nat Med
, vol.19
, pp. 901-908
-
-
Tonjes, M.1
Barbus, S.2
Park, Y.J.3
Wang, W.4
Schlotter, M.5
Lindroth, A.M.6
Pleier, S.V.7
Bai, A.H.8
Karra, D.9
Piro, R.M.10
-
59
-
-
84987719019
-
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
-
Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, et al. Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers. Science 2016, 353:1161–1165.
-
(2016)
Science
, vol.353
, pp. 1161-1165
-
-
Mayers, J.R.1
Torrence, M.E.2
Danai, L.V.3
Papagiannakopoulos, T.4
Davidson, S.M.5
Bauer, M.R.6
Lau, A.N.7
Ji, B.W.8
Dixit, P.D.9
Hosios, A.M.10
-
60
-
-
84921950738
-
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
-
Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, Yuan C, Bao Y, Townsend MK, Tworoger SS, et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med 2014, 20:1193–1198.
-
(2014)
Nat Med
, vol.20
, pp. 1193-1198
-
-
Mayers, J.R.1
Wu, C.2
Clish, C.B.3
Kraft, P.4
Torrence, M.E.5
Fiske, B.P.6
Yuan, C.7
Bao, Y.8
Townsend, M.K.9
Tworoger, S.S.10
-
61
-
-
85022209242
-
Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions
-
Olivares O, Mayers JR, Gouirand V, Torrence ME, Gicquel T, Borge L, Lac S, Roques J, Lavaut MN, Berthezène P, et al. Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions. Nat Commun 2017, 8:16031. Available at: https://www.nature.com/articles/ncomms16031.pdf.
-
(2017)
Nat Commun
, vol.8
, pp. 16031
-
-
Olivares, O.1
Mayers, J.R.2
Gouirand, V.3
Torrence, M.E.4
Gicquel, T.5
Borge, L.6
Lac, S.7
Roques, J.8
Lavaut, M.N.9
Berthezène, P.10
-
62
-
-
84955515590
-
Metastatic colonization by circulating tumour cells
-
Massagué J, Obenauf AC. Metastatic colonization by circulating tumour cells. Nature 2016, 529:298–306.
-
(2016)
Nature
, vol.529
, pp. 298-306
-
-
Massagué, J.1
Obenauf, A.C.2
-
63
-
-
85016030399
-
Macrophage metabolism as therapeutic target for cancer, atherosclerosis, and obesity
-
Geeraerts X, Bolli E, Fendt S-M, Van Ginderachter JA. Macrophage metabolism as therapeutic target for cancer, atherosclerosis, and obesity. Front Immunol 2017, 8:289.
-
(2017)
Front Immunol
, vol.8
, pp. 289
-
-
Geeraerts, X.1
Bolli, E.2
Fendt, S.-M.3
Van Ginderachter, J.A.4
-
64
-
-
84875053754
-
Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice
-
Porporato PE, Payen VL, De Saedeleer CJ, Préat V, Thissen JP, Feron O, Sonveaux P. Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice. Angiogenesis 2012, 15:581–592.
-
(2012)
Angiogenesis
, vol.15
, pp. 581-592
-
-
Porporato, P.E.1
Payen, V.L.2
De Saedeleer, C.J.3
Préat, V.4
Thissen, J.P.5
Feron, O.6
Sonveaux, P.7
-
65
-
-
79953329777
-
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL-8 pathway that drives tumor angiogenesis
-
Végran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 2011, 71:2550–2560.
-
(2011)
Cancer Res
, vol.71
, pp. 2550-2560
-
-
Végran, F.1
Boidot, R.2
Michiels, C.3
Sonveaux, P.4
Feron, O.5
-
66
-
-
85015446714
-
Metabolic origins of spatial organization in the tumor microenvironment
-
Carmona-Fontaine C, Deforet M, Akkari L, Thompson CB, Joyce JA, Xavier JB. Metabolic origins of spatial organization in the tumor microenvironment. Proc Natl Acad Sci 2017, 114:201700600.
-
(2017)
Proc Natl Acad Sci
, vol.114
, pp. 201700600
-
-
Carmona-Fontaine, C.1
Deforet, M.2
Akkari, L.3
Thompson, C.B.4
Joyce, J.A.5
Xavier, J.B.6
-
67
-
-
84984704073
-
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
-
Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, et al. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature 2016, 536:479–483.
-
(2016)
Nature
, vol.536
, pp. 479-483
-
-
Sousa, C.M.1
Biancur, D.E.2
Wang, X.3
Halbrook, C.J.4
Sherman, M.H.5
Zhang, L.6
Kremer, D.7
Hwang, R.F.8
Witkiewicz, A.K.9
Ying, H.10
-
68
-
-
84865080615
-
The pancreas cancer microenvironment
-
Feig C, Gopinathan A, Neesse A, Chan DS, Cook N, Tuveson DA. The pancreas cancer microenvironment. Clin Cancer Res 2012, 18:4266–4276.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 4266-4276
-
-
Feig, C.1
Gopinathan, A.2
Neesse, A.3
Chan, D.S.4
Cook, N.5
Tuveson, D.A.6
-
69
-
-
84961288972
-
Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
-
Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res 2015, 75:544–553.
-
(2015)
Cancer Res
, vol.75
, pp. 544-553
-
-
Kamphorst, J.J.1
Nofal, M.2
Commisso, C.3
Hackett, S.R.4
Lu, W.5
Grabocka, E.6
Vander Heiden, M.G.7
Miller, G.8
Drebin, J.A.9
Bar-Sagi, D.10
-
70
-
-
81255157465
-
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
-
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med 2011, 17:1498–1503.
-
(2011)
Nat Med
, vol.17
, pp. 1498-1503
-
-
Nieman, K.M.1
Kenny, H.A.2
Penicka, C.V.3
Ladanyi, A.4
Buell-Gutbrod, R.5
Zillhardt, M.R.6
Romero, I.L.7
Carey, M.S.8
Mills, G.B.9
Hotamisligil, G.S.10
-
71
-
-
85018451598
-
Fatty acid metabolism in breast cancer subtypes
-
Monaco ME. Fatty acid metabolism in breast cancer subtypes. Oncotarget 2017, 8:29487–29500.
-
(2017)
Oncotarget
, vol.8
, pp. 29487-29500
-
-
Monaco, M.E.1
-
72
-
-
79955761333
-
Lipoprotein lipase links dietary fat to solid tumor cell proliferation
-
Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, Pettus JR, Froehlich HM, Memoli VA, Morganelli PM, et al. Lipoprotein lipase links dietary fat to solid tumor cell proliferation. Mol Cancer Ther 2011, 10:427–436.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 427-436
-
-
Kuemmerle, N.B.1
Rysman, E.2
Lombardo, P.S.3
Flanagan, A.J.4
Lipe, B.C.5
Wells, W.A.6
Pettus, J.R.7
Froehlich, H.M.8
Memoli, V.A.9
Morganelli, P.M.10
-
73
-
-
78049348481
-
Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to b-catenin in different cancers
-
He L, Lu Y, Wang P, Zhang J, Yin C, Qu S. Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to b-catenin in different cancers. BCM Cancer 2010, 10:601.
-
(2010)
BCM Cancer
, vol.10
, pp. 601
-
-
He, L.1
Lu, Y.2
Wang, P.3
Zhang, J.4
Yin, C.5
Qu, S.6
-
74
-
-
79952772664
-
Association of FABP5 expression with poor survival in triple-negative breast cancer
-
Liu R-Z, Graham K, Glubrecht DD, Germain DR, Mackey JR, Godbout R. Association of FABP5 expression with poor survival in triple-negative breast cancer. Am J Pathol 2011, 178:997–1008.
-
(2011)
Am J Pathol
, vol.178
, pp. 997-1008
-
-
Liu, R.-Z.1
Graham, K.2
Glubrecht, D.D.3
Germain, D.R.4
Mackey, J.R.5
Godbout, R.6
-
75
-
-
74449083411
-
Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer
-
Tang XY, Umemura S, Tsukamoto H, Kumaki N, Tokuda Y, Osamura RY. Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer. Pathol Res Pract 2010, 206:98–101.
-
(2010)
Pathol Res Pract
, vol.206
, pp. 98-101
-
-
Tang, X.Y.1
Umemura, S.2
Tsukamoto, H.3
Kumaki, N.4
Tokuda, Y.5
Osamura, R.Y.6
-
76
-
-
84867571186
-
A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer
-
Liu R-Z, Graham K, Glubrecht DD, Lai R, Mackey JR, Godbout R. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. J Pathol 2012, 228:310–321.
-
(2012)
J Pathol
, vol.228
, pp. 310-321
-
-
Liu, R.-Z.1
Graham, K.2
Glubrecht, D.D.3
Lai, R.4
Mackey, J.R.5
Godbout, R.6
-
77
-
-
84991113250
-
Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation
-
Corbet C, Pinto A, Martherus R, Santiago de Jesus JP, Polet F, Feron O. Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation. Cell Metab 2016, 24:311–323.
-
(2016)
Cell Metab
, vol.24
, pp. 311-323
-
-
Corbet, C.1
Pinto, A.2
Martherus, R.3
Santiago de Jesus, J.P.4
Polet, F.5
Feron, O.6
-
78
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646–674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
79
-
-
85019649022
-
Metabolism during ECM detachment: Achilles heel of cancer cells?
-
Mason JA, Hagel KR, Hawk MA, Schafer ZT. Metabolism during ECM detachment: Achilles heel of cancer cells? Trends Cancer 2017, 3:475–481.
-
(2017)
Trends Cancer
, vol.3
, pp. 475-481
-
-
Mason, J.A.1
Hagel, K.R.2
Hawk, M.A.3
Schafer, Z.T.4
-
80
-
-
84910072170
-
3D cell culture systems: advantages and applications
-
Ravi M, Paramesh V, Kaviya SR, Anuradha E, Solomon FDP. 3D cell culture systems: advantages and applications. J Cell Physiol 2015, 230:16–26.
-
(2015)
J Cell Physiol
, vol.230
, pp. 16-26
-
-
Ravi, M.1
Paramesh, V.2
Kaviya, S.R.3
Anuradha, E.4
Solomon, F.D.P.5
-
81
-
-
84860389289
-
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
-
Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev 2011, 25:1716–1733.
-
(2011)
Genes Dev
, vol.25
, pp. 1716-1733
-
-
Grassian, A.R.1
Metallo, C.M.2
Coloff, J.L.3
Stephanopoulos, G.4
Brugge, J.S.5
-
82
-
-
84861354408
-
Glucose oxidation modulates anoikis and tumor metastasis
-
Kamarajugadda S, Stemboroski L, Cai Q, Simpson NE, Nayak S, Tan M, Lu J. Glucose oxidation modulates anoikis and tumor metastasis. Mol Cell Biol 2012, 32:1893–1907.
-
(2012)
Mol Cell Biol
, vol.32
, pp. 1893-1907
-
-
Kamarajugadda, S.1
Stemboroski, L.2
Cai, Q.3
Simpson, N.E.4
Nayak, S.5
Tan, M.6
Lu, J.7
-
83
-
-
69949101473
-
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
-
Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009, 461:109–113.
-
(2009)
Nature
, vol.461
, pp. 109-113
-
-
Schafer, Z.T.1
Grassian, A.R.2
Song, L.3
Jiang, Z.4
Gerhart-Hines, Z.5
Irie, H.Y.6
Gao, S.7
Puigserver, P.8
Brugge, J.S.9
-
84
-
-
85008440096
-
LKB1 promotes metabolic flexibility in response to energy stress
-
Parker SJ, Svensson RU, Divakaruni AS, Lefebvre AE, Murphy AN, Shaw RJ, Metallo CM. LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng 2016:1–10. DOI: https://doi.org/10.1016/j.ymben.2016.12.010.
-
(2016)
Metab Eng
, pp. 1-10
-
-
Parker, S.J.1
Svensson, R.U.2
Divakaruni, A.S.3
Lefebvre, A.E.4
Murphy, A.N.5
Shaw, R.J.6
Metallo, C.M.7
-
85
-
-
84959198270
-
Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells
-
Mason JA, Davison-Versagli CA, Leliaert AK, Pape DJ, McCallister C, Zuo J, Durbin SM, Buchheit CL, Zhang S, Schafer ZT. Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death Differ 2016, 23:1271–1282.
-
(2016)
Cell Death Differ
, vol.23
, pp. 1271-1282
-
-
Mason, J.A.1
Davison-Versagli, C.A.2
Leliaert, A.K.3
Pape, D.J.4
McCallister, C.5
Zuo, J.6
Durbin, S.M.7
Buchheit, C.L.8
Zhang, S.9
Schafer, Z.T.10
-
86
-
-
84964374713
-
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
-
Jiang L, Shestov AA, Swain P, Yang C, Parker SJ, Wang QA, Terada LS, Adams ND, McCabe MT, Pietrak B, et al. Reductive carboxylation supports redox homeostasis during anchorage-independent growth. Nature 2016, 532:255–258.
-
(2016)
Nature
, vol.532
, pp. 255-258
-
-
Jiang, L.1
Shestov, A.A.2
Swain, P.3
Yang, C.4
Parker, S.J.5
Wang, Q.A.6
Terada, L.S.7
Adams, N.D.8
McCabe, M.T.9
Pietrak, B.10
-
87
-
-
84946903513
-
Oxidative stress inhibits distant metastasis by human melanoma cells
-
Piskounova E, Agathocleous M, Murphy MM, Hu Z, Huddlestun SE, Zhao Z, Leitch AM, Johnson TM, DeBerardinis RJ, Morrison SJ. Oxidative stress inhibits distant metastasis by human melanoma cells. Nature 2015, 527:186–191.
-
(2015)
Nature
, vol.527
, pp. 186-191
-
-
Piskounova, E.1
Agathocleous, M.2
Murphy, M.M.3
Hu, Z.4
Huddlestun, S.E.5
Zhao, Z.6
Leitch, A.M.7
Johnson, T.M.8
DeBerardinis, R.J.9
Morrison, S.J.10
-
88
-
-
85025454842
-
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells
-
Elia I, Broekaert D, Christen S, Boon R, Radaelli E, Orth MF, Verfaillie C, Grünewald TGP, Fendt SM. Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells. Nat Commun 2017, 8:15267.
-
(2017)
Nat Commun
, vol.8
, pp. 15267
-
-
Elia, I.1
Broekaert, D.2
Christen, S.3
Boon, R.4
Radaelli, E.5
Orth, M.F.6
Verfaillie, C.7
Grünewald, T.G.P.8
Fendt, S.M.9
-
89
-
-
84861891911
-
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
-
Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW-M, Phang JM. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA 2012, 109:8983–8988.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 8983-8988
-
-
Liu, W.1
Le, A.2
Hancock, C.3
Lane, A.N.4
Dang, C.V.5
Fan, T.W.-M.6
Phang, J.M.7
-
90
-
-
84943143136
-
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
-
Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, et al. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells. Nature 2015, 526:131–135.
-
(2015)
Nature
, vol.526
, pp. 131-135
-
-
Lawson, D.A.1
Bhakta, N.R.2
Kessenbrock, K.3
Prummel, K.D.4
Yu, Y.5
Takai, K.6
Zhou, A.7
Eyob, H.8
Balakrishnan, S.9
Wang, C.Y.10
-
91
-
-
35548936833
-
Models, mechanisms and clinical evidence for cancer dormancy
-
Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007, 7:834–846.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 834-846
-
-
Aguirre-Ghiso, J.A.1
-
92
-
-
82255169482
-
The essence of quiescence
-
Coller HA. The essence of quiescence. Science 2011, 334:1074–1075.
-
(2011)
Science
, vol.334
, pp. 1074-1075
-
-
Coller, H.A.1
-
93
-
-
84860778451
-
Staying alive
-
Valcourt JR, Lemons JMS, Haley EM, Kojima M, Demuren OO, Coller HA. Staying alive. Cell Cycle 2012, 11:1680–1696.
-
(2012)
Cell Cycle
, vol.11
, pp. 1680-1696
-
-
Valcourt, J.R.1
Lemons, J.M.S.2
Haley, E.M.3
Kojima, M.4
Demuren, O.O.5
Coller, H.A.6
-
94
-
-
84904173553
-
Metabolism of stromal and immune cells in health and disease
-
Ghesquière B, Wong BW, Kuchnio A, Carmeliet P. Metabolism of stromal and immune cells in health and disease. Nature 2014, 511:167–176.
-
(2014)
Nature
, vol.511
, pp. 167-176
-
-
Ghesquière, B.1
Wong, B.W.2
Kuchnio, A.3
Carmeliet, P.4
-
95
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity 2013, 38:633–643.
-
(2013)
Immunity
, vol.38
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
96
-
-
78149378853
-
Quiescent fibroblasts exhibit high metabolic activity
-
Lemons JMS, Feng X-J, Bennett BD, Legesse-Miller A, Johnson EL, Raitman I, Pollina EA, Rabitz HA, Rabinowitz JD. Quiescent fibroblasts exhibit high metabolic activity. PLoS Biol 2010, 8:e1000514.
-
(2010)
PLoS Biol
, vol.8
-
-
Lemons, J.M.S.1
Feng, X.-J.2
Bennett, B.D.3
Legesse-Miller, A.4
Johnson, E.L.5
Raitman, I.6
Pollina, E.A.7
Rabitz, H.A.8
Rabinowitz, J.D.9
-
97
-
-
84964619842
-
Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells
-
Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells. Cell Metab 2016, 23:867–880.
-
(2016)
Cell Metab
, vol.23
, pp. 867-880
-
-
Coloff, J.L.1
Murphy, J.P.2
Braun, C.R.3
Harris, I.S.4
Shelton, L.M.5
Kami, K.6
Gygi, S.P.7
Selfors, L.M.8
Brugge, J.S.9
-
98
-
-
85006873383
-
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
-
Lorendeau D, Rinaldi G, Boon R, Spincemaille P, Metzger K, Jäger C, Christen S, Dong X, Kuenen S, Voordeckers K, et al. Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors. Metab Eng 2016, S1096-7176(16)30217-8.
-
(2016)
Metab Eng
, pp. S1096-S1098
-
-
Lorendeau, D.1
Rinaldi, G.2
Boon, R.3
Spincemaille, P.4
Metzger, K.5
Jäger, C.6
Christen, S.7
Dong, X.8
Kuenen, S.9
Voordeckers, K.10
-
99
-
-
85017623215
-
Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design
-
Macpherson JA, Anastasiou D. Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design. Curr Opin Biotechnol 2017, 48:102–110.
-
(2017)
Curr Opin Biotechnol
, vol.48
, pp. 102-110
-
-
Macpherson, J.A.1
Anastasiou, D.2
-
100
-
-
84875537133
-
Epigenetic reprogramming in cancer
-
Suva ML, Riggi N, Bernstein BE. Epigenetic reprogramming in cancer. Science 2013, 339:1567–1570.
-
(2013)
Science
, vol.339
, pp. 1567-1570
-
-
Suva, M.L.1
Riggi, N.2
Bernstein, B.E.3
-
102
-
-
84859893371
-
Histone methylation: a dynamic mark in health, disease and inheritance
-
Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012, 13:343–357.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
103
-
-
84994497591
-
Metabolic interactions with cancer epigenetics
-
Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med 2016, 54:50–57. https://doi.org/10.1016/j.mam.2016.09.001.
-
(2016)
Mol Aspects Med
, vol.54
, pp. 50-57
-
-
Gao, X.1
Reid, M.A.2
Kong, M.3
Locasale, J.W.4
-
104
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301:89–92.
-
(1983)
Nature
, vol.301
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
105
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994, 91:9700–9704.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
Samid, D.7
Duan, D.S.8
Gnarra, J.R.9
Linehan, W.M.10
-
106
-
-
0024365892
-
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
-
Greger V, Passarge E, Höpping W, Messmer E, Horsthemke B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 1989, 83:155–158.
-
(1989)
Hum Genet
, vol.83
, pp. 155-158
-
-
Greger, V.1
Passarge, E.2
Höpping, W.3
Messmer, E.4
Horsthemke, B.5
-
108
-
-
84901742791
-
DNA sequence explains seemingly disordered methylation levels in partially methylated domains of mammalian genomes
-
Gaidatzis D, Burger L, Murr R, Lerch A, Dessus-Babus S, Schübeler D, Stadler MB. DNA sequence explains seemingly disordered methylation levels in partially methylated domains of mammalian genomes. PLoS Genet 2014, 10:e1004143.
-
(2014)
PLoS Genet
, vol.10
-
-
Gaidatzis, D.1
Burger, L.2
Murr, R.3
Lerch, A.4
Dessus-Babus, S.5
Schübeler, D.6
Stadler, M.B.7
-
109
-
-
84919469035
-
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia
-
Landau DA, Clement K, Ziller MJ, Boyle P, Fan J, Gu H, Stevenson K, Sougnez C, Wang L, Li S, et al. Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia. Cancer Cell 2014, 26:813–825.
-
(2014)
Cancer Cell
, vol.26
, pp. 813-825
-
-
Landau, D.A.1
Clement, K.2
Ziller, M.J.3
Boyle, P.4
Fan, J.5
Gu, H.6
Stevenson, K.7
Sougnez, C.8
Wang, L.9
Li, S.10
-
110
-
-
77049099785
-
Histone methyltransferases in cancer
-
Albert M, Helin K. Histone methyltransferases in cancer. Sem Cell Develop Biol 2010, 21:209–220.
-
(2010)
Sem Cell Develop Biol
, vol.21
, pp. 209-220
-
-
Albert, M.1
Helin, K.2
-
111
-
-
84860215207
-
Molecular mechanisms and potential functions of histone demethylases
-
Kooistra SM, Helin K. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 2012, 13:297.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 297
-
-
Kooistra, S.M.1
Helin, K.2
-
112
-
-
84889573275
-
Histone lysine demethylases as targets for anticancer therapy
-
Højfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov 2013, 12:917–930.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 917-930
-
-
Højfeldt, J.W.1
Agger, K.2
Helin, K.3
-
113
-
-
84881177291
-
Serine, glycine and one-carbon units: cancer metabolism in full circle
-
Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer 2013, 13:572–583.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 572-583
-
-
Locasale, J.W.1
-
114
-
-
84948412126
-
Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
-
Mentch SJ, Mehrmohamadi M, Huang L, Liu X, Gupta D, Mattocks D, Gómez Padilla P, Ables G, Bamman MM, Thalacker-Mercer AE, et al. Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism. Cell Metab 2015, 22:861–873.
-
(2015)
Cell Metab
, vol.22
, pp. 861-873
-
-
Mentch, S.J.1
Mehrmohamadi, M.2
Huang, L.3
Liu, X.4
Gupta, D.5
Mattocks, D.6
Gómez Padilla, P.7
Ables, G.8
Bamman, M.M.9
Thalacker-Mercer, A.E.10
-
115
-
-
84455160888
-
Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice
-
Beaudin AE, Abarinov EV, Malysheva O, Perry CA, Caudill M, Stover PJ. Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am J Clin Nutr 2012, 95:109–114.
-
(2012)
Am J Clin Nutr
, vol.95
, pp. 109-114
-
-
Beaudin, A.E.1
Abarinov, E.V.2
Malysheva, O.3
Perry, C.A.4
Caudill, M.5
Stover, P.J.6
-
116
-
-
84949655663
-
One-carbon metabolism and epigenetics: understanding the specificity
-
Mentch SJ, Locasale JW. One-carbon metabolism and epigenetics: understanding the specificity. Ann N Y Acad Sci 2016, 1363:91–98.
-
(2016)
Ann N Y Acad Sci
, vol.1363
, pp. 91-98
-
-
Mentch, S.J.1
Locasale, J.W.2
-
117
-
-
0037117501
-
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
-
Friso S, Choi S-W, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci USA 2002, 99:5606–5611.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5606-5611
-
-
Friso, S.1
Choi, S.-W.2
Girelli, D.3
Mason, J.B.4
Dolnikowski, G.G.5
Bagley, P.J.6
Olivieri, O.7
Jacques, P.F.8
Rosenberg, I.H.9
Corrocher, R.10
-
118
-
-
2942608990
-
Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults
-
Gemmati D, Ongaro A, Scapoli GL, Della Porta M, Tognazzo S, Serino ML, Di Bona E, Rodeghiero F, Gilli G, Reverberi R, et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Prev Biomarkers 2004, 13:787–794.
-
(2004)
Cancer Epidemiol Prev Biomarkers
, vol.13
, pp. 787-794
-
-
Gemmati, D.1
Ongaro, A.2
Scapoli, G.L.3
Della Porta, M.4
Tognazzo, S.5
Serino, M.L.6
Di Bona, E.7
Rodeghiero, F.8
Gilli, G.9
Reverberi, R.10
-
119
-
-
0035874520
-
Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
-
Matsuo K, Suzuki R, Hamajima N, Ogura M, Kagami Y, Taji H, Kondoh E, Maeda S, Asakura S, Kaba S, et al. Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 2001, 97:3205–3209.
-
(2001)
Blood
, vol.97
, pp. 3205-3209
-
-
Matsuo, K.1
Suzuki, R.2
Hamajima, N.3
Ogura, M.4
Kagami, Y.5
Taji, H.6
Kondoh, E.7
Maeda, S.8
Asakura, S.9
Kaba, S.10
-
120
-
-
0033846460
-
Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the c677t polymorphism in the methylenetetrahydrofolate reductase gene
-
Stern LL, Mason JB, Selhub J, Choi S-W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the c677t polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Prev Biomarkers 2000, 9:849–853.
-
(2000)
Cancer Epidemiol Prev Biomarkers
, vol.9
, pp. 849-853
-
-
Stern, L.L.1
Mason, J.B.2
Selhub, J.3
Choi, S.-W.4
-
121
-
-
85006051826
-
Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism
-
Mehrmohamadi M, Mentch LK, Clark AG, Locasale JW, Jones PA, Schubeler D, Hansen KD, Mack SC, Timp W, Feinberg AP, et al. Integrative modelling of tumour DNA methylation quantifies the contribution of metabolism. Nat Commun 2016, 7:13666.
-
(2016)
Nat Commun
, vol.7
, pp. 13666
-
-
Mehrmohamadi, M.1
Mentch, L.K.2
Clark, A.G.3
Locasale, J.W.4
Jones, P.A.5
Schubeler, D.6
Hansen, K.D.7
Mack, S.C.8
Timp, W.9
Feinberg, A.P.10
-
122
-
-
84922621952
-
Function and information content of DNA methylation
-
Schübeler D. Function and information content of DNA methylation. Nature 2015, 517:321–326.
-
(2015)
Nature
, vol.517
, pp. 321-326
-
-
Schübeler, D.1
-
123
-
-
84925503908
-
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
-
Carey BW, Finley LWS, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 2014, 518:413–416.
-
(2014)
Nature
, vol.518
, pp. 413-416
-
-
Carey, B.W.1
Finley, L.W.S.2
Cross, J.R.3
Allis, C.D.4
Thompson, C.B.5
-
124
-
-
84979742769
-
α-Ketoglutarate accelerates the initial differentiation of primed human pluripotent stem cells
-
TeSlaa T, Chaikovsky AC, Lipchina I, Escobar SL, Hochedlinger K, Huang J, Graeber TG, Braas D, Teitell MA. α-Ketoglutarate accelerates the initial differentiation of primed human pluripotent stem cells. Cell Metab 2015, 24:485–493. Available at: http://linkinghub.elsevier.com/retrieve/pii/S1550413116303138.
-
(2015)
Cell Metab
, vol.24
, pp. 485-493
-
-
TeSlaa, T.1
Chaikovsky, A.C.2
Lipchina, I.3
Escobar, S.L.4
Hochedlinger, K.5
Huang, J.6
Graeber, T.G.7
Braas, D.8
Teitell, M.A.9
-
125
-
-
84867420094
-
Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
-
Kaelin WG. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol 2011, 76:335–345.
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 335-345
-
-
Kaelin, W.G.1
-
126
-
-
84862632865
-
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
-
Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 2012, 26:1326–1338.
-
(2012)
Genes Dev
, vol.26
, pp. 1326-1338
-
-
Xiao, M.1
Yang, H.2
Xu, W.3
Ma, S.4
Lin, H.5
Zhu, H.6
Liu, L.7
Liu, Y.8
Yang, C.9
Xu, Y.10
-
127
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 2010, 17:510–522.
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
Phillips, H.S.4
Pujara, K.5
Berman, B.P.6
Pan, F.7
Pelloski, C.E.8
Sulman, E.P.9
Bhat, K.P.10
-
128
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt tet2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt tet2 function, and impair hematopoietic differentiation. Cancer Cell 2010, 18:553–567.
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vasanthakumar, A.9
Fernandez, H.F.10
-
129
-
-
0034964421
-
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
-
Astuti D, Latif F, Dallol A, Dahia PLM, Douglas F, George E, Sköldberg F, Husebye ES, Eng C, Maher ER. Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 2001, 69:49–54.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 49-54
-
-
Astuti, D.1
Latif, F.2
Dallol, A.3
Dahia, P.L.M.4
Douglas, F.5
George, E.6
Sköldberg, F.7
Husebye, E.S.8
Eng, C.9
Maher, E.R.10
-
130
-
-
78651082042
-
Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations
-
Janeway KA, Kim SY, Lodish M, Nosé V, Rustin P, Gaal J, Dahia PLM, Liegl B, Ball ER, Raygada M, et al. Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations. Proc Natl Acad Sci USA 2011, 108:314–318.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 314-318
-
-
Janeway, K.A.1
Kim, S.Y.2
Lodish, M.3
Nosé, V.4
Rustin, P.5
Gaal, J.6
Dahia, P.L.M.7
Liegl, B.8
Ball, E.R.9
Raygada, M.10
-
131
-
-
18544365990
-
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IPM, Alam NA, Rowan AJ, Barclay E, Jaeger EEM, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 2002, 30:406–410.
-
(2002)
Nat Genet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.M.1
Alam, N.A.2
Rowan, A.J.3
Barclay, E.4
Jaeger, E.E.M.5
Kelsell, D.6
Leigh, I.7
Gorman, P.8
Lamlum, H.9
Rahman, S.10
-
133
-
-
84856298658
-
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
-
Borger DR, Tanabe KK, Fan KC, Lopez HU, Fantin VR, Straley KS, Schenkein DP, Hezel AF, Ancukiewicz M, Liebman HM, et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist 2012, 17:72–79.
-
(2012)
Oncologist
, vol.17
, pp. 72-79
-
-
Borger, D.R.1
Tanabe, K.K.2
Fan, K.C.3
Lopez, H.U.4
Fantin, V.R.5
Straley, K.S.6
Schenkein, D.P.7
Hezel, A.F.8
Ancukiewicz, M.9
Liebman, H.M.10
-
134
-
-
77955907891
-
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
-
Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Krönke J, Bullinger L, Späth D, Kayser S, Zucknick M, Götze K, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010, 28:3636–3643.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3636-3643
-
-
Paschka, P.1
Schlenk, R.F.2
Gaidzik, V.I.3
Habdank, M.4
Krönke, J.5
Bullinger, L.6
Späth, D.7
Kayser, S.8
Zucknick, M.9
Götze, K.10
-
135
-
-
56749156414
-
Analysis of the IDH1 codon 132 mutation in brain tumors
-
Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 2008, 116:597–602.
-
(2008)
Acta Neuropathol
, vol.116
, pp. 597-602
-
-
Balss, J.1
Meyer, J.2
Mueller, W.3
Korshunov, A.4
Hartmann, C.5
von Deimling, A.6
-
136
-
-
84904204533
-
Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate
-
Luka Z, Pakhomova S, Loukachevitch LV, Calcutt MW, Newcomer ME, Wagner C. Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate. Protein Sci 2014, 23:993–998.
-
(2014)
Protein Sci
, vol.23
, pp. 993-998
-
-
Luka, Z.1
Pakhomova, S.2
Loukachevitch, L.V.3
Calcutt, M.W.4
Newcomer, M.E.5
Wagner, C.6
-
137
-
-
84958174087
-
Folate deficiency affects histone methylation
-
Garcia BA, Luka Z, Loukachevitch LV, Bhanu NV, Wagner C. Folate deficiency affects histone methylation. Med Hypotheses 2016, 88:63–67.
-
(2016)
Med Hypotheses
, vol.88
, pp. 63-67
-
-
Garcia, B.A.1
Luka, Z.2
Loukachevitch, L.V.3
Bhanu, N.V.4
Wagner, C.5
-
138
-
-
84984629881
-
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
-
Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, et al. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature 2016, 537:63–68.
-
(2016)
Nature
, vol.537
, pp. 63-68
-
-
Thienpont, B.1
Steinbacher, J.2
Zhao, H.3
D'Anna, F.4
Kuchnio, A.5
Ploumakis, A.6
Ghesquière, B.7
Van Dyck, L.8
Boeckx, B.9
Schoonjans, L.10
-
139
-
-
85009084580
-
Vitamin C and l-proline antagonistic effects capture alternative states in the pluripotency continuum
-
D'Aniello C, Habibi E, Cermola F, Paris D, Russo F, Fiorenzano A, Di Napoli G, Melck DJ, Cobellis G, Angelini C, et al. Vitamin C and l-proline antagonistic effects capture alternative states in the pluripotency continuum. Stem Cell Rep 2017, 8:1–10.
-
(2017)
Stem Cell Rep
, vol.8
, pp. 1-10
-
-
D'Aniello, C.1
Habibi, E.2
Cermola, F.3
Paris, D.4
Russo, F.5
Fiorenzano, A.6
Di Napoli, G.7
Melck, D.J.8
Cobellis, G.9
Angelini, C.10
-
140
-
-
84988345850
-
Metabolic control of epigenetics in cancer
-
Kinnaird A, Zhao S, Wellen KE, Michelakis ED. Metabolic control of epigenetics in cancer. Nat Rev Cancer 2016, 16:694–707. Available at: http://www.nature.com/doifinder/10.1038/nrc.2016.82.
-
(2016)
Nat Rev Cancer
, vol.16
, pp. 694-707
-
-
Kinnaird, A.1
Zhao, S.2
Wellen, K.E.3
Michelakis, E.D.4
-
141
-
-
84904872156
-
The growing landscape of lysine acetylation links metabolism and cell signalling
-
Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol 2014, 15:536–550.
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, pp. 536-550
-
-
Choudhary, C.1
Weinert, B.T.2
Nishida, Y.3
Verdin, E.4
Mann, M.5
-
142
-
-
79955960768
-
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
-
Cai L, Sutter BM, Li B, Tu BP. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell 2011, 42:426–437.
-
(2011)
Mol Cell
, vol.42
, pp. 426-437
-
-
Cai, L.1
Sutter, B.M.2
Li, B.3
Tu, B.P.4
-
143
-
-
84876891033
-
Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
-
Shi L, Tu BP. Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2013, 110:7318–7323.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 7318-7323
-
-
Shi, L.1
Tu, B.P.2
-
144
-
-
84962028922
-
Dysregulated metabolism contributes to oncogenesis
-
Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, et al. Dysregulated metabolism contributes to oncogenesis. Semin Cancer Biol 2015, 35:S129–S150.
-
(2015)
Semin Cancer Biol
, vol.35
, pp. S129-S150
-
-
Hirschey, M.D.1
DeBerardinis, R.J.2
Diehl, A.M.E.3
Drew, J.E.4
Frezza, C.5
Green, M.F.6
Jones, L.W.7
Ko, Y.H.8
Le, A.9
Lea, M.A.10
-
145
-
-
78449243673
-
Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry
-
Morrish F, Noonan J, Perez-Olsen C, Gafken PR, Fitzgibbon M, Kelleher J, VanGilst M, Hockenbery D. Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry. J Biol Chem 2010, 285:36267–36274.
-
(2010)
J Biol Chem
, vol.285
, pp. 36267-36274
-
-
Morrish, F.1
Noonan, J.2
Perez-Olsen, C.3
Gafken, P.R.4
Fitzgibbon, M.5
Kelleher, J.6
VanGilst, M.7
Hockenbery, D.8
-
146
-
-
0037072780
-
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
-
Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM. The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. J Biol Chem 2002, 277:33895–33900.
-
(2002)
J Biol Chem
, vol.277
, pp. 33895-33900
-
-
Berwick, D.C.1
Hers, I.2
Heesom, K.J.3
Moule, S.K.4
Tavare, J.M.5
-
147
-
-
84905816638
-
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
-
Lee JV, Carrer A, Shah S, Snyder NW, Wei S, Venneti S, Worth AJ, Yuan ZF, Lim HW, Liu S, et al. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metab 2014, 20:306–319.
-
(2014)
Cell Metab
, vol.20
, pp. 306-319
-
-
Lee, J.V.1
Carrer, A.2
Shah, S.3
Snyder, N.W.4
Wei, S.5
Venneti, S.6
Worth, A.J.7
Yuan, Z.F.8
Lim, H.W.9
Liu, S.10
-
148
-
-
84995584854
-
Lipids reprogram metabolism to become a major carbon source for histone acetylation
-
McDonnell E, Crown SB, Fox DB, Kitir B, Ilkayeva OR, Olsen CA, Grimsrud PA, Hirschey MD. Lipids reprogram metabolism to become a major carbon source for histone acetylation. Cell Rep 2016, 17:1463–1472. DOI: https://doi.org/10.1016/j.celrep.2016.10.012.
-
(2016)
Cell Rep
, vol.17
, pp. 1463-1472
-
-
McDonnell, E.1
Crown, S.B.2
Fox, D.B.3
Kitir, B.4
Ilkayeva, O.R.5
Olsen, C.A.6
Grimsrud, P.A.7
Hirschey, M.D.8
-
149
-
-
84863613036
-
Acetyl-CoA carboxylase regulates global histone acetylation
-
Galdieri L, Vancura A. Acetyl-CoA carboxylase regulates global histone acetylation. J Biol Chem 2012, 287:23865–23876.
-
(2012)
J Biol Chem
, vol.287
, pp. 23865-23876
-
-
Galdieri, L.1
Vancura, A.2
-
150
-
-
85009820292
-
Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation
-
Bulusu V, Tumanov S, Michalopoulou E, van den Broek NJ, MacKay G, Nixon C, Dhayade S, Schug ZT, Vande Voorde J, Blyth K, et al. Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation. Cell Rep 2017, 18:647–658.
-
(2017)
Cell Rep
, vol.18
, pp. 647-658
-
-
Bulusu, V.1
Tumanov, S.2
Michalopoulou, E.3
van den Broek, N.J.4
MacKay, G.5
Nixon, C.6
Dhayade, S.7
Schug, Z.T.8
Vande Voorde, J.9
Blyth, K.10
-
151
-
-
84856090681
-
Connecting threads: epigenetics and metabolism
-
Katada S, Imhof A, Sassone-Corsi P. Connecting threads: epigenetics and metabolism. Cell 2012, 148:24–28. DOI: https://doi.org/10.1016/j.cell.2012.01.001.
-
(2012)
Cell
, vol.148
, pp. 24-28
-
-
Katada, S.1
Imhof, A.2
Sassone-Corsi, P.3
-
152
-
-
79951974172
-
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
-
Katoh Y, Ikura T, Hoshikawa Y, Tashiro S, Ito T, Ohta M, Kera Y, Noda T, Igarashi K. Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein. Mol Cell 2011, 41:554–566.
-
(2011)
Mol Cell
, vol.41
, pp. 554-566
-
-
Katoh, Y.1
Ikura, T.2
Hoshikawa, Y.3
Tashiro, S.4
Ito, T.5
Ohta, M.6
Kera, Y.7
Noda, T.8
Igarashi, K.9
-
153
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB. ATP-citrate lyase links cellular metabolism to histone acetylation. Science 2009, 324:1076–1080.
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
Hatzivassiliou, G.2
Sachdeva, U.M.3
Bui, T.V.4
Cross, J.R.5
Thompson, C.B.6
-
154
-
-
0035986095
-
Dynamics of histone acetylation in vivo. A function for acetylation turnover?
-
Waterborg JH. Dynamics of histone acetylation in vivo. A function for acetylation turnover? Biochem Cell Biol 2002, 80:363–378.
-
(2002)
Biochem Cell Biol
, vol.80
, pp. 363-378
-
-
Waterborg, J.H.1
-
155
-
-
84881179223
-
Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites
-
Zheng Y, Thomas PM, Kelleher NL, Toczyski DP, Smith RD. Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nat Commun 2013, 4:966–968.
-
(2013)
Nat Commun
, vol.4
, pp. 966-968
-
-
Zheng, Y.1
Thomas, P.M.2
Kelleher, N.L.3
Toczyski, D.P.4
Smith, R.D.5
-
156
-
-
84942372058
-
The multifaceted functions of sirtuins in cancer
-
Chalkiadaki A, Guarente L. The multifaceted functions of sirtuins in cancer. Nat Rev Cancer 2015, 15:608–624.
-
(2015)
Nat Rev Cancer
, vol.15
, pp. 608-624
-
-
Chalkiadaki, A.1
Guarente, L.2
-
157
-
-
84871362358
-
Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells
-
Thakur BK, Dittrich T, Chandra P, Becker A, Kuehnau W, Klusmann J-H, Reinhardt D, Welte K. Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells. Int J Cancer 2013, 132:766–774.
-
(2013)
Int J Cancer
, vol.132
, pp. 766-774
-
-
Thakur, B.K.1
Dittrich, T.2
Chandra, P.3
Becker, A.4
Kuehnau, W.5
Klusmann, J.-H.6
Reinhardt, D.7
Welte, K.8
-
158
-
-
84881367747
-
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
-
Galli U, Travelli C, Massarotti A, Fakhfouri G, Rahimian R, Tron GC, Genazzani AA. Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. J Med Chem 2013, 56:6279–6296.
-
(2013)
J Med Chem
, vol.56
, pp. 6279-6296
-
-
Galli, U.1
Travelli, C.2
Massarotti, A.3
Fakhfouri, G.4
Rahimian, R.5
Tron, G.C.6
Genazzani, A.A.7
|