메뉴 건너뛰기




Volumn 10, Issue 1, 2018, Pages

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELL; CELL INTERACTION; CELL METABOLISM; CONCENTRATION (PARAMETERS); EPIGENETICS; HUMAN; MALIGNANT NEOPLASM; NONHUMAN; PHENOTYPE; REVIEW; TUMOR MICROENVIRONMENT; ANIMAL; CITRIC ACID CYCLE; METABOLISM; NEOPLASM; PATHOLOGY; PHYSIOLOGY;

EID: 85039545645     PISSN: 19395094     EISSN: 1939005X     Source Type: Journal    
DOI: 10.1002/wsbm.1397     Document Type: Review
Times cited : (54)

References (158)
  • 1
    • 33846910173 scopus 로고    scopus 로고
    • Global reconstruction of the human metabolic network based on genomic and bibliomic data
    • Duarte N, Becker SA. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc Natl Acad Sci USA 2007, 104:1777–1782.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1777-1782
    • Duarte, N.1    Becker, S.A.2
  • 3
    • 84955326448 scopus 로고    scopus 로고
    • The Emerging Hallmarks of Cancer Metabolism
    • Pavlova NN, Thompson CB. The Emerging Hallmarks of Cancer Metabolism. Cell Metab 2016, 23:27–47. DOI: https://doi.org/10.1016/j.cmet.2015.12.006.
    • (2016) Cell Metab , vol.23 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 5
    • 84961589787 scopus 로고    scopus 로고
    • Organ-specific cancer metabolism and its potential for therapy
    • In, xxx, Springer International Publishing, (Accessed March 29, 2017)
    • Elia I, Schmieder R, Christen S, Fendt SM. Organ-specific cancer metabolism and its potential for therapy. In: Handbook of Experimental Pharmacology. xxx: Springer International Publishing; 2016, 321–353. Available at: http://link.springer.com/10.1007/164_2015_10. (Accessed March 29, 2017).
    • (2016) Handbook of Experimental Pharmacology , pp. 321-353
    • Elia, I.1    Schmieder, R.2    Christen, S.3    Fendt, S.M.4
  • 6
    • 85025465348 scopus 로고    scopus 로고
    • Is there a therapeutic window for metabolism-based cancer therapies?
    • Fendt S-M. Is there a therapeutic window for metabolism-based cancer therapies? Front Endocrinol (Lausanne) 2017, 8:1–5.
    • (2017) Front Endocrinol (Lausanne) , vol.8 , pp. 1-5
    • Fendt, S.-M.1
  • 8
    • 84938555849 scopus 로고    scopus 로고
    • Metabolic control of signalling pathways and metabolic auto-regulation
    • Lorendeau D, Christen S, Rinaldi G, Fendt SM. Metabolic control of signalling pathways and metabolic auto-regulation. Biol Cell 2015, 107:251–272.
    • (2015) Biol Cell , vol.107 , pp. 251-272
    • Lorendeau, D.1    Christen, S.2    Rinaldi, G.3    Fendt, S.M.4
  • 9
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth
    • Boroughs LK, DeBerardinis RJ. Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol 2015, 17:351–359.
    • (2015) Nat Cell Biol , vol.17 , pp. 351-359
    • Boroughs, L.K.1    DeBerardinis, R.J.2
  • 10
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011, 27:441–464.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 11
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: cell biology, physiology, and clinical opportunities
    • Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Investig 2013, 123:3678–3684.
    • (2013) J Clin Investig , vol.123 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    DeBerardinis, R.J.3
  • 12
    • 84923186422 scopus 로고    scopus 로고
    • Famine versus feast: understanding the metabolism of tumors in vivo
    • Mayers JR, Vander Heiden MG. Famine versus feast: understanding the metabolism of tumors in vivo. Trends Biochem Sci 2015, 40:130–140.
    • (2015) Trends Biochem Sci , vol.40 , pp. 130-140
    • Mayers, J.R.1    Vander Heiden, M.G.2
  • 13
    • 85013664984 scopus 로고    scopus 로고
    • Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis
    • Dong W, Keibler MA, Stephanopoulos G. Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis. Metab Eng 2017, pii:S1096-7176(17)30054-X. https://doi.org/10.1016/j.ymben.2017.02.002.
    • (2017) Metab Eng
    • Dong, W.1    Keibler, M.A.2    Stephanopoulos, G.3
  • 14
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • Cairns R, Harris I, Mak T. Regulation of cancer cell metabolism. Nat Rev Cancer 2011, 11:85–95.
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.1    Harris, I.2    Mak, T.3
  • 15
    • 84999723809 scopus 로고    scopus 로고
    • PKM2, cancer metabolism, and the road ahead
    • Dayton TL, Jacks T, Vander Heiden MG. PKM2, cancer metabolism, and the road ahead. EMBO Rep 2016, 17:1721–1730.
    • (2016) EMBO Rep , vol.17 , pp. 1721-1730
    • Dayton, T.L.1    Jacks, T.2    Vander Heiden, M.G.3
  • 17
    • 0034161904 scopus 로고    scopus 로고
    • Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells
    • Boros LG, Torday JS, Lim S, Bassilian S, Cascante M, Lee WNP. Transforming growth factor beta2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res 2000, 60:1183–1185.
    • (2000) Cancer Res , vol.60 , pp. 1183-1185
    • Boros, L.G.1    Torday, J.S.2    Lim, S.3    Bassilian, S.4    Cascante, M.5    Lee, W.N.P.6
  • 19
    • 21744431575 scopus 로고    scopus 로고
    • The sweet and sour of cancer: glycans as novel therapeutic targets
    • Fuster MM, Esko JD. The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer 2005, 5:526–542.
    • (2005) Nat Rev Cancer , vol.5 , pp. 526-542
    • Fuster, M.M.1    Esko, J.D.2
  • 20
    • 84908568394 scopus 로고    scopus 로고
    • Hexosamine pathway and (ER) protein quality control
    • Denzel MS, Antebi A. Hexosamine pathway and (ER) protein quality control. Curr Opin Cell Biol 2015, 33:14–18.
    • (2015) Curr Opin Cell Biol , vol.33 , pp. 14-18
    • Denzel, M.S.1    Antebi, A.2
  • 21
    • 84988431514 scopus 로고    scopus 로고
    • Serine and one-carbon metabolism in cancer
    • Yang M, Vousden KH. Serine and one-carbon metabolism in cancer. Nat Rev Cancer 2016, 16:650–662.
    • (2016) Nat Rev Cancer , vol.16 , pp. 650-662
    • Yang, M.1    Vousden, K.H.2
  • 25
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 2007, 104:19345–19350.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 26
    • 84885357137 scopus 로고    scopus 로고
    • Exploiting the bad eating habits of Ras-driven cancers
    • White E. Exploiting the bad eating habits of Ras-driven cancers. Genes Develop 2013, 27:2065–2071.
    • (2013) Genes Develop , vol.27 , pp. 2065-2071
    • White, E.1
  • 28
    • 84938234308 scopus 로고    scopus 로고
    • Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells
    • Sullivan LB, Gui DY, Hosios AM, Bush LN, Freinkman E, Vander Heiden MG. Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells. Cell 2015, 162:552–563.
    • (2015) Cell , vol.162 , pp. 552-563
    • Sullivan, L.B.1    Gui, D.Y.2    Hosios, A.M.3    Bush, L.N.4    Freinkman, E.5    Vander Heiden, M.G.6
  • 29
    • 84938232611 scopus 로고    scopus 로고
    • An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis
    • Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 2015, 162:540–551.
    • (2015) Cell , vol.162 , pp. 540-551
    • Birsoy, K.1    Wang, T.2    Chen, W.W.3    Freinkman, E.4    Abu-Remaileh, M.5    Sabatini, D.M.6
  • 35
    • 84923148982 scopus 로고    scopus 로고
    • Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
    • Kamphorst JJ, Chung MK, Fan J, Rabinowitz JD. Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab 2014, 2:23.
    • (2014) Cancer Metab , vol.2 , pp. 23
    • Kamphorst, J.J.1    Chung, M.K.2    Fan, J.3    Rabinowitz, J.D.4
  • 45
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    • Fan TWM, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, Miller DM. Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 2009, 8:41.
    • (2009) Mol Cancer , vol.8 , pp. 41
    • Fan, T.W.M.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5    Bousamra, M.6    Miller, D.M.7
  • 53
    • 85008947585 scopus 로고    scopus 로고
    • In vivo cancer metabolism is defined by the nutrient microenvironment
    • Elia I, Fendt S-M. In vivo cancer metabolism is defined by the nutrient microenvironment. Transl Cancer Res 2016, 5:S1284–S1287.
    • (2016) Transl Cancer Res , vol.5 , pp. S1284-S1287
    • Elia, I.1    Fendt, S.-M.2
  • 57
    • 0000851342 scopus 로고
    • The free amino acids of human blood plasma
    • Stein WH, Moore S. The free amino acids of human blood plasma. J Biol Chem 1954, 211:915–926.
    • (1954) J Biol Chem , vol.211 , pp. 915-926
    • Stein, W.H.1    Moore, S.2
  • 62
    • 84955515590 scopus 로고    scopus 로고
    • Metastatic colonization by circulating tumour cells
    • Massagué J, Obenauf AC. Metastatic colonization by circulating tumour cells. Nature 2016, 529:298–306.
    • (2016) Nature , vol.529 , pp. 298-306
    • Massagué, J.1    Obenauf, A.C.2
  • 63
    • 85016030399 scopus 로고    scopus 로고
    • Macrophage metabolism as therapeutic target for cancer, atherosclerosis, and obesity
    • Geeraerts X, Bolli E, Fendt S-M, Van Ginderachter JA. Macrophage metabolism as therapeutic target for cancer, atherosclerosis, and obesity. Front Immunol 2017, 8:289.
    • (2017) Front Immunol , vol.8 , pp. 289
    • Geeraerts, X.1    Bolli, E.2    Fendt, S.-M.3    Van Ginderachter, J.A.4
  • 65
    • 79953329777 scopus 로고    scopus 로고
    • Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL-8 pathway that drives tumor angiogenesis
    • Végran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 2011, 71:2550–2560.
    • (2011) Cancer Res , vol.71 , pp. 2550-2560
    • Végran, F.1    Boidot, R.2    Michiels, C.3    Sonveaux, P.4    Feron, O.5
  • 71
    • 85018451598 scopus 로고    scopus 로고
    • Fatty acid metabolism in breast cancer subtypes
    • Monaco ME. Fatty acid metabolism in breast cancer subtypes. Oncotarget 2017, 8:29487–29500.
    • (2017) Oncotarget , vol.8 , pp. 29487-29500
    • Monaco, M.E.1
  • 73
    • 78049348481 scopus 로고    scopus 로고
    • Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to b-catenin in different cancers
    • He L, Lu Y, Wang P, Zhang J, Yin C, Qu S. Up-regulated expression of type II very low density lipoprotein receptor correlates with cancer metastasis and has a potential link to b-catenin in different cancers. BCM Cancer 2010, 10:601.
    • (2010) BCM Cancer , vol.10 , pp. 601
    • He, L.1    Lu, Y.2    Wang, P.3    Zhang, J.4    Yin, C.5    Qu, S.6
  • 75
    • 74449083411 scopus 로고    scopus 로고
    • Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer
    • Tang XY, Umemura S, Tsukamoto H, Kumaki N, Tokuda Y, Osamura RY. Overexpression of fatty acid binding protein-7 correlates with basal-like subtype of breast cancer. Pathol Res Pract 2010, 206:98–101.
    • (2010) Pathol Res Pract , vol.206 , pp. 98-101
    • Tang, X.Y.1    Umemura, S.2    Tsukamoto, H.3    Kumaki, N.4    Tokuda, Y.5    Osamura, R.Y.6
  • 76
    • 84867571186 scopus 로고    scopus 로고
    • A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer
    • Liu R-Z, Graham K, Glubrecht DD, Lai R, Mackey JR, Godbout R. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. J Pathol 2012, 228:310–321.
    • (2012) J Pathol , vol.228 , pp. 310-321
    • Liu, R.-Z.1    Graham, K.2    Glubrecht, D.D.3    Lai, R.4    Mackey, J.R.5    Godbout, R.6
  • 77
    • 84991113250 scopus 로고    scopus 로고
    • Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation
    • Corbet C, Pinto A, Martherus R, Santiago de Jesus JP, Polet F, Feron O. Acidosis drives the reprogramming of fatty acid metabolism in cancer cells through changes in mitochondrial and histone acetylation. Cell Metab 2016, 24:311–323.
    • (2016) Cell Metab , vol.24 , pp. 311-323
    • Corbet, C.1    Pinto, A.2    Martherus, R.3    Santiago de Jesus, J.P.4    Polet, F.5    Feron, O.6
  • 78
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 79
    • 85019649022 scopus 로고    scopus 로고
    • Metabolism during ECM detachment: Achilles heel of cancer cells?
    • Mason JA, Hagel KR, Hawk MA, Schafer ZT. Metabolism during ECM detachment: Achilles heel of cancer cells? Trends Cancer 2017, 3:475–481.
    • (2017) Trends Cancer , vol.3 , pp. 475-481
    • Mason, J.A.1    Hagel, K.R.2    Hawk, M.A.3    Schafer, Z.T.4
  • 81
    • 84860389289 scopus 로고    scopus 로고
    • Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
    • Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev 2011, 25:1716–1733.
    • (2011) Genes Dev , vol.25 , pp. 1716-1733
    • Grassian, A.R.1    Metallo, C.M.2    Coloff, J.L.3    Stephanopoulos, G.4    Brugge, J.S.5
  • 89
    • 84861891911 scopus 로고    scopus 로고
    • Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
    • Liu W, Le A, Hancock C, Lane AN, Dang CV, Fan TW-M, Phang JM. Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC. Proc Natl Acad Sci USA 2012, 109:8983–8988.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 8983-8988
    • Liu, W.1    Le, A.2    Hancock, C.3    Lane, A.N.4    Dang, C.V.5    Fan, T.W.-M.6    Phang, J.M.7
  • 91
    • 35548936833 scopus 로고    scopus 로고
    • Models, mechanisms and clinical evidence for cancer dormancy
    • Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007, 7:834–846.
    • (2007) Nat Rev Cancer , vol.7 , pp. 834-846
    • Aguirre-Ghiso, J.A.1
  • 92
    • 82255169482 scopus 로고    scopus 로고
    • The essence of quiescence
    • Coller HA. The essence of quiescence. Science 2011, 334:1074–1075.
    • (2011) Science , vol.334 , pp. 1074-1075
    • Coller, H.A.1
  • 94
    • 84904173553 scopus 로고    scopus 로고
    • Metabolism of stromal and immune cells in health and disease
    • Ghesquière B, Wong BW, Kuchnio A, Carmeliet P. Metabolism of stromal and immune cells in health and disease. Nature 2014, 511:167–176.
    • (2014) Nature , vol.511 , pp. 167-176
    • Ghesquière, B.1    Wong, B.W.2    Kuchnio, A.3    Carmeliet, P.4
  • 95
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity 2013, 38:633–643.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 99
    • 85017623215 scopus 로고    scopus 로고
    • Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design
    • Macpherson JA, Anastasiou D. Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design. Curr Opin Biotechnol 2017, 48:102–110.
    • (2017) Curr Opin Biotechnol , vol.48 , pp. 102-110
    • Macpherson, J.A.1    Anastasiou, D.2
  • 100
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suva ML, Riggi N, Bernstein BE. Epigenetic reprogramming in cancer. Science 2013, 339:1567–1570.
    • (2013) Science , vol.339 , pp. 1567-1570
    • Suva, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 102
    • 84859893371 scopus 로고    scopus 로고
    • Histone methylation: a dynamic mark in health, disease and inheritance
    • Greer EL, Shi Y. Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012, 13:343–357.
    • (2012) Nat Rev Genet , vol.13 , pp. 343-357
    • Greer, E.L.1    Shi, Y.2
  • 103
    • 84994497591 scopus 로고    scopus 로고
    • Metabolic interactions with cancer epigenetics
    • Gao X, Reid MA, Kong M, Locasale JW. Metabolic interactions with cancer epigenetics. Mol Aspects Med 2016, 54:50–57. https://doi.org/10.1016/j.mam.2016.09.001.
    • (2016) Mol Aspects Med , vol.54 , pp. 50-57
    • Gao, X.1    Reid, M.A.2    Kong, M.3    Locasale, J.W.4
  • 104
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B. Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 1983, 301:89–92.
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 106
    • 0024365892 scopus 로고
    • Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
    • Greger V, Passarge E, Höpping W, Messmer E, Horsthemke B. Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet 1989, 83:155–158.
    • (1989) Hum Genet , vol.83 , pp. 155-158
    • Greger, V.1    Passarge, E.2    Höpping, W.3    Messmer, E.4    Horsthemke, B.5
  • 108
    • 84901742791 scopus 로고    scopus 로고
    • DNA sequence explains seemingly disordered methylation levels in partially methylated domains of mammalian genomes
    • Gaidatzis D, Burger L, Murr R, Lerch A, Dessus-Babus S, Schübeler D, Stadler MB. DNA sequence explains seemingly disordered methylation levels in partially methylated domains of mammalian genomes. PLoS Genet 2014, 10:e1004143.
    • (2014) PLoS Genet , vol.10
    • Gaidatzis, D.1    Burger, L.2    Murr, R.3    Lerch, A.4    Dessus-Babus, S.5    Schübeler, D.6    Stadler, M.B.7
  • 110
    • 77049099785 scopus 로고    scopus 로고
    • Histone methyltransferases in cancer
    • Albert M, Helin K. Histone methyltransferases in cancer. Sem Cell Develop Biol 2010, 21:209–220.
    • (2010) Sem Cell Develop Biol , vol.21 , pp. 209-220
    • Albert, M.1    Helin, K.2
  • 111
    • 84860215207 scopus 로고    scopus 로고
    • Molecular mechanisms and potential functions of histone demethylases
    • Kooistra SM, Helin K. Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol 2012, 13:297.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 297
    • Kooistra, S.M.1    Helin, K.2
  • 112
    • 84889573275 scopus 로고    scopus 로고
    • Histone lysine demethylases as targets for anticancer therapy
    • Højfeldt JW, Agger K, Helin K. Histone lysine demethylases as targets for anticancer therapy. Nat Rev Drug Discov 2013, 12:917–930.
    • (2013) Nat Rev Drug Discov , vol.12 , pp. 917-930
    • Højfeldt, J.W.1    Agger, K.2    Helin, K.3
  • 113
    • 84881177291 scopus 로고    scopus 로고
    • Serine, glycine and one-carbon units: cancer metabolism in full circle
    • Locasale JW. Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat Rev Cancer 2013, 13:572–583.
    • (2013) Nat Rev Cancer , vol.13 , pp. 572-583
    • Locasale, J.W.1
  • 116
    • 84949655663 scopus 로고    scopus 로고
    • One-carbon metabolism and epigenetics: understanding the specificity
    • Mentch SJ, Locasale JW. One-carbon metabolism and epigenetics: understanding the specificity. Ann N Y Acad Sci 2016, 1363:91–98.
    • (2016) Ann N Y Acad Sci , vol.1363 , pp. 91-98
    • Mentch, S.J.1    Locasale, J.W.2
  • 119
    • 0035874520 scopus 로고    scopus 로고
    • Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
    • Matsuo K, Suzuki R, Hamajima N, Ogura M, Kagami Y, Taji H, Kondoh E, Maeda S, Asakura S, Kaba S, et al. Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 2001, 97:3205–3209.
    • (2001) Blood , vol.97 , pp. 3205-3209
    • Matsuo, K.1    Suzuki, R.2    Hamajima, N.3    Ogura, M.4    Kagami, Y.5    Taji, H.6    Kondoh, E.7    Maeda, S.8    Asakura, S.9    Kaba, S.10
  • 120
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the c677t polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern LL, Mason JB, Selhub J, Choi S-W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the c677t polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol Prev Biomarkers 2000, 9:849–853.
    • (2000) Cancer Epidemiol Prev Biomarkers , vol.9 , pp. 849-853
    • Stern, L.L.1    Mason, J.B.2    Selhub, J.3    Choi, S.-W.4
  • 122
    • 84922621952 scopus 로고    scopus 로고
    • Function and information content of DNA methylation
    • Schübeler D. Function and information content of DNA methylation. Nature 2015, 517:321–326.
    • (2015) Nature , vol.517 , pp. 321-326
    • Schübeler, D.1
  • 123
    • 84925503908 scopus 로고    scopus 로고
    • Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
    • Carey BW, Finley LWS, Cross JR, Allis CD, Thompson CB. Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 2014, 518:413–416.
    • (2014) Nature , vol.518 , pp. 413-416
    • Carey, B.W.1    Finley, L.W.S.2    Cross, J.R.3    Allis, C.D.4    Thompson, C.B.5
  • 125
    • 84867420094 scopus 로고    scopus 로고
    • Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases
    • Kaelin WG. Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases. Cold Spring Harb Symp Quant Biol 2011, 76:335–345.
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 335-345
    • Kaelin, W.G.1
  • 126
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 2012, 26:1326–1338.
    • (2012) Genes Dev , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6    Liu, L.7    Liu, Y.8    Yang, C.9    Xu, Y.10
  • 134
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P, Schlenk RF, Gaidzik VI, Habdank M, Krönke J, Bullinger L, Späth D, Kayser S, Zucknick M, Götze K, et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010, 28:3636–3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Krönke, J.5    Bullinger, L.6    Späth, D.7    Kayser, S.8    Zucknick, M.9    Götze, K.10
  • 136
  • 140
    • 84988345850 scopus 로고    scopus 로고
    • Metabolic control of epigenetics in cancer
    • Kinnaird A, Zhao S, Wellen KE, Michelakis ED. Metabolic control of epigenetics in cancer. Nat Rev Cancer 2016, 16:694–707. Available at: http://www.nature.com/doifinder/10.1038/nrc.2016.82.
    • (2016) Nat Rev Cancer , vol.16 , pp. 694-707
    • Kinnaird, A.1    Zhao, S.2    Wellen, K.E.3    Michelakis, E.D.4
  • 141
    • 84904872156 scopus 로고    scopus 로고
    • The growing landscape of lysine acetylation links metabolism and cell signalling
    • Choudhary C, Weinert BT, Nishida Y, Verdin E, Mann M. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol 2014, 15:536–550.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , pp. 536-550
    • Choudhary, C.1    Weinert, B.T.2    Nishida, Y.3    Verdin, E.4    Mann, M.5
  • 142
    • 79955960768 scopus 로고    scopus 로고
    • Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    • Cai L, Sutter BM, Li B, Tu BP. Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell 2011, 42:426–437.
    • (2011) Mol Cell , vol.42 , pp. 426-437
    • Cai, L.1    Sutter, B.M.2    Li, B.3    Tu, B.P.4
  • 143
    • 84876891033 scopus 로고    scopus 로고
    • Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae
    • Shi L, Tu BP. Acetyl-CoA induces transcription of the key G1 cyclin CLN3 to promote entry into the cell division cycle in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2013, 110:7318–7323.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 7318-7323
    • Shi, L.1    Tu, B.P.2
  • 145
    • 78449243673 scopus 로고    scopus 로고
    • Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry
    • Morrish F, Noonan J, Perez-Olsen C, Gafken PR, Fitzgibbon M, Kelleher J, VanGilst M, Hockenbery D. Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry. J Biol Chem 2010, 285:36267–36274.
    • (2010) J Biol Chem , vol.285 , pp. 36267-36274
    • Morrish, F.1    Noonan, J.2    Perez-Olsen, C.3    Gafken, P.R.4    Fitzgibbon, M.5    Kelleher, J.6    VanGilst, M.7    Hockenbery, D.8
  • 146
    • 0037072780 scopus 로고    scopus 로고
    • The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
    • Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM. The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. J Biol Chem 2002, 277:33895–33900.
    • (2002) J Biol Chem , vol.277 , pp. 33895-33900
    • Berwick, D.C.1    Hers, I.2    Heesom, K.J.3    Moule, S.K.4    Tavare, J.M.5
  • 149
    • 84863613036 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase regulates global histone acetylation
    • Galdieri L, Vancura A. Acetyl-CoA carboxylase regulates global histone acetylation. J Biol Chem 2012, 287:23865–23876.
    • (2012) J Biol Chem , vol.287 , pp. 23865-23876
    • Galdieri, L.1    Vancura, A.2
  • 151
    • 84856090681 scopus 로고    scopus 로고
    • Connecting threads: epigenetics and metabolism
    • Katada S, Imhof A, Sassone-Corsi P. Connecting threads: epigenetics and metabolism. Cell 2012, 148:24–28. DOI: https://doi.org/10.1016/j.cell.2012.01.001.
    • (2012) Cell , vol.148 , pp. 24-28
    • Katada, S.1    Imhof, A.2    Sassone-Corsi, P.3
  • 154
    • 0035986095 scopus 로고    scopus 로고
    • Dynamics of histone acetylation in vivo. A function for acetylation turnover?
    • Waterborg JH. Dynamics of histone acetylation in vivo. A function for acetylation turnover? Biochem Cell Biol 2002, 80:363–378.
    • (2002) Biochem Cell Biol , vol.80 , pp. 363-378
    • Waterborg, J.H.1
  • 155
    • 84881179223 scopus 로고    scopus 로고
    • Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites
    • Zheng Y, Thomas PM, Kelleher NL, Toczyski DP, Smith RD. Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nat Commun 2013, 4:966–968.
    • (2013) Nat Commun , vol.4 , pp. 966-968
    • Zheng, Y.1    Thomas, P.M.2    Kelleher, N.L.3    Toczyski, D.P.4    Smith, R.D.5
  • 156
    • 84942372058 scopus 로고    scopus 로고
    • The multifaceted functions of sirtuins in cancer
    • Chalkiadaki A, Guarente L. The multifaceted functions of sirtuins in cancer. Nat Rev Cancer 2015, 15:608–624.
    • (2015) Nat Rev Cancer , vol.15 , pp. 608-624
    • Chalkiadaki, A.1    Guarente, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.