LKB1 promotes metabolic flexibility in response to energy stress

Metabolic Engineering

Volumn 43, Issue , 2017, Pages 208-217

  Parker, Seth J ^a   Svensson, Robert U ^b   Divakaruni, Ajit S ^c   Lefebvre, Austin E ^a   Murphy, Anne N ^c   Shaw, Reuben J ^b   Metallo, Christian M ^a,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Cancer metabolism; Glutaminase; LKB1; Metabolic flux analysis; Mitochondria; Phenformin

Indexed keywords

AMINO ACIDS; BIOELECTRIC POTENTIALS; CELL GROWTH; CELLS; CYTOLOGY; DISEASES; ENZYME ACTIVITY; ENZYMES; FATTY ACIDS; METABOLISM; MITOCHONDRIA; PHYSIOLOGY; TUMORS;

AMP-ACTIVATED PROTEIN KINASE; GLUTAMINASE; LKB1; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL PATHWAYS; MITOCHONDRIAL SUBSTRATES; NON SMALL CELL LUNG CANCER; PHENFORMIN;

CELL SIGNALING;

FATTY ACID; GLUTAMINASE; GLUTAMINE; PROTEIN KINASE LKB1; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, HUMAN; TUMOR PROTEIN;

AMPK SIGNALING; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG NON-SMALL CELL CARCINOMA CELL LINE; METABOLIC STRESS; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THERAPEUTIC INDEX; A-549 CELL LINE; ENERGY METABOLISM; GENETICS; LUNG TUMOR; METABOLISM; MITOCHONDRION; NON SMALL CELL LUNG CANCER; PATHOLOGY; PHYSIOLOGICAL STRESS;

A549 CELLS; CARCINOMA, NON-SMALL-CELL LUNG; ENERGY METABOLISM; HUMANS; LUNG NEOPLASMS; MITOCHONDRIA; NEOPLASM PROTEINS; PROTEIN-SERINE-THREONINE KINASES; STRESS, PHYSIOLOGICAL;

EID: 85008440096     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.12.010     Document Type: Article

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