-
1
-
-
45549104823
-
Involvement of estrogenrelated receptors in transcriptional response to hypoxia and growth of solid tumors
-
Ao A, Wang H, Kamarajugadda S, Lu J. 2008. Involvement of estrogenrelated receptors in transcriptional response to hypoxia and growth of solid tumors. Proc. Natl. Acad. Sci. U.S.A. 105:7821-7826.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 7821-7826
-
-
Ao, A.1
Wang, H.2
Kamarajugadda, S.3
Lu, J.4
-
2
-
-
33646865314
-
Identification of ERRα as a specific partner of PGC-1α for the activation of PDK4 gene expression in muscle
-
Araki M, Motojima K. 2006. Identification of ERRα as a specific partner of PGC-1α for the activation of PDK4 gene expression in muscle. FEBS J. 273:1669-1680.
-
(2006)
FEBS J
, vol.273
, pp. 1669-1680
-
-
Araki, M.1
Motojima, K.2
-
5
-
-
34547956322
-
Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta
-
Degenhardt T, et al. 2007. Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta. J. Mol. Biol. 372:341-355.
-
(2007)
J. Mol. Biol.
, vol.372
, pp. 341-355
-
-
Degenhardt, T.1
-
6
-
-
50149097983
-
Hypoxia, HIF1 and glucose metabolism in the solid tumour
-
Denko NC. 2008. Hypoxia, HIF1 and glucose metabolism in the solid tumour. Nat. Rev. Cancer 8:705-713.
-
(2008)
Nat. Rev. Cancer.
, vol.8
, pp. 705-713
-
-
Denko, N.C.1
-
7
-
-
34247554887
-
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRα and α
-
Dufour CR, et al. 2007. Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRα and α. Cell. Metab. 5:345-356.
-
(2007)
Cell. Metab.
, vol.5
, pp. 345-356
-
-
Dufour, C.R.1
-
9
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ. 2004. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4:891-899.
-
(2004)
Nat Rev. Cancer.
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
10
-
-
53849088227
-
Transcriptional control of energy homeostasis by the estrogen-related receptors
-
Giguère V. 2008. Transcriptional control of energy homeostasis by the estrogen-related receptors. Endocr. Rev. 29:677-696.
-
(2008)
Endocr. Rev.
, vol.29
, pp. 677-696
-
-
Giguère, V.1
-
11
-
-
70349329549
-
How adhesion signals reach a mitochondrial conclusion: ECM regulation of apoptosis
-
Gilmore AP, Owens TW, Foster FM, Lindsay J. 2009. How adhesion signals reach a mitochondrial conclusion: ECM regulation of apoptosis. Curr. Opin. Cell Biol. 21:654-661.
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 654-661
-
-
Gilmore, A.P.1
Owens, T.W.2
Foster, F.M.3
Lindsay, J.4
-
12
-
-
84860389289
-
Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation
-
Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. 2011. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 25:1716-1733.
-
(2011)
Genes Dev
, vol.25
, pp. 1716-1733
-
-
Grassian, A.R.1
Metallo, C.M.2
Coloff, J.L.3
Stephanopoulos, G.4
Brugge, J.S.5
-
13
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell 144:646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
14
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP, Sabatini DM. 2008. Cancer cell metabolism: Warburg and beyond. Cell 134:703-707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
16
-
-
35649014840
-
Hypoxiainducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
Kim JW, Gao P, Liu YC, Semenza GL, Dang CV. 2007. Hypoxiainducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol. Cell. Biol. 27:7381-7393.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 7381-7393
-
-
Kim, J.W.1
Gao, P.2
Liu, Y.C.3
Semenza, G.L.4
Dang, C.V.5
-
17
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim JW, Tchernyshyov I, Semenza GL, Dang CV. 2006. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell. Metab. 3:177-185.
-
(2006)
Cell. Metab.
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
18
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, Dang CV. 2011. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 11:325-337.
-
(2011)
Nat. Rev. Cancer.
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
19
-
-
44449147036
-
Tumor cell metabolism: cancer's Achilles' heel
-
Kroemer G, Pouyssegur J. 2008. Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13:472-482.
-
(2008)
Cancer Cell
, vol.13
, pp. 472-482
-
-
Kroemer, G.1
Pouyssegur, J.2
-
20
-
-
78649711427
-
The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
-
Levine AJ, Puzio-Kuter AM. 2010. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330:1340-1344.
-
(2010)
Science
, vol.330
, pp. 1340-1344
-
-
Levine, A.J.1
Puzio-Kuter, A.M.2
-
21
-
-
0033588007
-
A role for reactive oxygen species in endothelial cell anoikis
-
Li AE, et al. 1999. A role for reactive oxygen species in endothelial cell anoikis. Circ. Res. 85:304-310.
-
(1999)
Circ. Res.
, vol.85
, pp. 304-310
-
-
Li, A.E.1
-
22
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale JW, et al. 2011. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43:869-874.
-
(2011)
Nat. Genet.
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
-
23
-
-
80052845698
-
Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer
-
Lu CW, et al. 2011. Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer. Am. J. Pathol. 179:1405-1414.
-
(2011)
Am. J. Pathol.
, vol.179
, pp. 1405-1414
-
-
Lu, C.W.1
-
24
-
-
33750443923
-
Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer
-
Lyng H, et al. 2006. Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer. BMC Genomics 7:268.
-
(2006)
BMC Genomics
, vol.7
, pp. 268
-
-
Lyng, H.1
-
25
-
-
33745684527
-
Metastasis: a question of life or death
-
Mehlen P, Puisieux A. 2006. Metastasis: a question of life or death. Nat. Rev. Cancer 6:449-458.
-
(2006)
Nat. Rev. Cancer.
, vol.6
, pp. 449-458
-
-
Mehlen, P.1
Puisieux, A.2
-
27
-
-
33644622570
-
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
-
Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. 2006. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell. Metab. 3:187-197.
-
(2006)
Cell. Metab.
, vol.3
, pp. 187-197
-
-
Papandreou, I.1
Cairns, R.A.2
Fontana, L.3
Lim, A.L.4
Denko, N.C.5
-
28
-
-
33645958257
-
Regulation of the pyruvate dehydrogenase complex
-
Patel MS, Korotchkina LG. 2006. Regulation of the pyruvate dehydrogenase complex. Biochem. Soc. Trans. 34:217-222.
-
(2006)
Biochem. Soc. Trans.
, vol.34
, pp. 217-222
-
-
Patel, M.S.1
Korotchkina, L.G.2
-
29
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato R, et al. 2011. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476:346-350.
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
-
30
-
-
0034050902
-
Systematic variation in gene expression patterns in human cancer cell lines
-
Ross DT, et al. 2000. Systematic variation in gene expression patterns in human cancer cell lines. Nat. Genet. 24:227-235.
-
(2000)
Nat. Genet.
, vol.24
, pp. 227-235
-
-
Ross, D.T.1
-
31
-
-
69949101473
-
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
-
Schafer ZT, et al. 2009. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 461:109-113.
-
(2009)
Nature
, vol.461
, pp. 109-113
-
-
Schafer, Z.T.1
-
32
-
-
79957952535
-
Hypoxia-inducible factor :1 regulator of mitochondrial metabolism and mediator of ischemic preconditioning
-
Semenza GL. 2011. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim. Biophys. Acta 1813:1263-1268.
-
(2011)
Biochim. Biophys. Acta
, vol.1813
, pp. 1263-1268
-
-
Semenza, G.L.1
-
33
-
-
77956095537
-
Mitochondria and cell death: outer membrane permeabilization and beyond
-
Tait SW, Green DR. 2010. Mitochondria and cell death: outer membrane permeabilization and beyond. Nat. Rev. Mol. Cell Biol. 11:621-632.
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 621-632
-
-
Tait, S.W.1
Green, D.R.2
-
34
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
35
-
-
57049132739
-
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
-
Vaughn AE, Deshmukh M. 2008. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat. Cell Biol. 10:1477-1483.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 1477-1483
-
-
Vaughn, A.E.1
Deshmukh, M.2
-
36
-
-
28544438180
-
PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: a mechanism for transcriptional control of muscle glucose metabolism
-
Wende AR, Huss JM, Schaeffer PJ, Giguère V, Kelly DP. 2005. PGC-1α coactivates PDK4 gene expression via the orphan nuclear receptor ERRα: a mechanism for transcriptional control of muscle glucose metabolism. Mol. Cell. Biol. 25:10684-10694.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10684-10694
-
-
Wende, A.R.1
Huss, J.M.2
Schaeffer, P.J.3
Giguère, V.4
Kelly, D.P.5
-
37
-
-
33845973409
-
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression
-
Zhang Y, et al. 2006. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J. Biol. Chem. 281:39897-39906.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39897-39906
-
-
Zhang, Y.1
|