Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation

Cell Reports

Volumn 18, Issue 3, 2017, Pages 647-658

  Bulusu, Vinay ^a,b   Tumanov, Sergey ^a,b   Michalopoulou, Evdokia ^a,b   van den Broek, Niels J ^a   MacKay, Gillian ^a   Nixon, Colin ^a   Dhayade, Sandeep ^a   Schug, Zachary T ^a   Vande Voorde, Johan ^a   Blyth, Karen ^a   Gottlieb, Eyal ^a   Vazquez, Alexei ^a   Kamphorst, Jurre J ^a,b  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

acetate; acetyl CoA synthetase 2; cancer metabolism; enzyme localization; histone acetylation; histone deacetylation; hypoxia; lipogenesis; metabolite compartmentalization; stable isotope tracing

Indexed keywords

ACETATE COENZYME A LIGASE; ACETATE COENZYME A SYNTHASE 2; ACETIC ACID; ACETYL COENZYME A; HISTONE ACETYLTRANSFERASE; OXYGEN; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; CARBON; HISTONE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL METABOLISM; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; GENE EXPRESSION; HISTONE ACETYLATION; LIPOGENESIS; METABOLISM; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SERUM; TRANSCRIPTION REGULATION; TUMOR HYPOXIA; ACETYLATION; ANTAGONISTS AND INHIBITORS; CELL HYPOXIA; CHEMISTRY; CULTURE MEDIUM; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; METABOLOME; RNA INTERFERENCE; TUMOR CELL LINE;

ACETATE-COA LIGASE; ACETATES; ACETYL COENZYME A; ACETYLATION; CARBON ISOTOPES; CELL HYPOXIA; CELL LINE, TUMOR; CELL NUCLEUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; HISTONES; HUMANS; MASS SPECTROMETRY; METABOLOME; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; RNA INTERFERENCE; RNA, SMALL INTERFERING; SERUM;

EID: 85009820292     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.12.055     Document Type: Article

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