Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

Science

Volumn 353, Issue 6304, 2016, Pages 1161-1165

  Mayers, Jared R ^a   Torrence, Margaret E ^a   Danai, Laura V ^a   Papagiannakopoulos, Thales ^a,f   Davidson, Shawn M ^a   Bauer, Matthew R ^a   Lau, Allison N ^a   Ji, Brian W ^b   Dixit, Purushottam D ^b   Hosios, Aaron M ^a   Muir, Alexander ^a   Chin, Christopher R ^a   Freinkman, Elizaveta ^a,c,d   Jacks, Tyler ^a   Wolpin, Brian M ^e   Vitkup, Dennis ^b   Vander Heiden, Matthew G ^a,d,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCAT1 PROTEIN; BCAT2 PROTEIN; BCKDH PROTEIN; BRANCHED CHAIN AMINO ACID; HEAT SHOCK PROTEIN 90; K RAS PROTEIN; MESSENGER RNA; NITROGEN; PROTEIN; PROTEIN P53; SLC7A5 PROTEIN; UNCLASSIFIED DRUG; VINCULIN; AMINOTRANSFERASE; BCAT1 PROTEIN, HUMAN; BCAT2 PROTEIN, HUMAN; KRAS PROTEIN, HUMAN; MINOR HISTOCOMPATIBILITY ANTIGEN; PLACENTA PROTEIN; PROTEIN P21;

AMINO ACID; CANCER; CELLS AND CELL COMPONENTS; GENE; METABOLISM; MUTATION; PHENOTYPE; RODENT; TUMOR;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; GENE EXPRESSION; GENE MUTATION; LUNG CARCINOGENESIS; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG TUMOR; MALE; METABOLISM; MUTATION; PANCREAS CARCINOMA; PANCREAS TUMOR;

MUS;

AMINO ACIDS, BRANCHED-CHAIN; ANIMALS; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, PANCREATIC DUCTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE; MICE, INBRED C57BL; MINOR HISTOCOMPATIBILITY ANTIGENS; MUTATION; NITROGEN; ORGAN SPECIFICITY; PANCREATIC NEOPLASMS; PREGNANCY PROTEINS; PROTO-ONCOGENE PROTEINS P21(RAS); TRANSAMINASES;

EID: 84987719019     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf5171     Document Type: Article

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