Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

Cell

Volumn 169, Issue 2, 2017, Pages 258-272.e17

  Cantor, Jason R ^a,b,c   Abu Remaileh, Monther ^a,b,c   Kanarek, Naama ^a,b,c   Freinkman, Elizaveta ^a   Gao, Xin ^a,d   Louissaint, Abner ^e   Lewis, Caroline A ^a   Sabatini, David M ^a,b,c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c KOCH INSTITUTE FOR INTEGRATIVE CANCER RESEARCH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

cell culture; human like; metabolism; metabolomics; plasma; pyrimidine synthesis; serum; UMPS; uric acid

Indexed keywords

ALANINE; ALLOPURINOL; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; AZAURIDINE; DOXORUBICIN; FLUOROURACIL; GLUCOSE; INORGANIC SALT; LACTIC ACID; LIPID; NUCLEOTIDE; OROTIC ACID; OROTIDINE; PYRUVIC ACID; SYNTHETASE; TAURINE; UNCLASSIFIED DRUG; URIC ACID; URIDINE PHOSPHATE SYNTHASE; CULTURE MEDIUM; MULTIENZYME COMPLEX; OROTATE PHOSPHORIBOSYLTRANSFERASE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; URIDINE 5'-MONOPHOSPHATE SYNTHASE;

ACUTE MYELOID LEUKEMIA; ADHERENT CELL; ADULT; AGED; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL CULTURE; CELL METABOLISM; CELL PROLIFERATION; CELL SUSPENSION; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; EC50; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE INTAKE; GLUCOSE UTILIZATION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; K-562 CELL LINE; LEUKEMIA CELL; LIPID METABOLISM; LIPIDOMICS; MALE; METABOLOME; METABOLOMICS; MITOCHONDRIAL RESPIRATION; MOUSE; NITROGEN METABOLISM; NONHUMAN; NUCLEOTIDE METABOLISM; OSMOLALITY; OXIDATION REDUCTION STATE; PLASMA; PRIORITY JOURNAL; PYRIMIDINE METABOLISM; PYRIMIDINE SYNTHESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL CULTURE TECHNIQUE; CHEMISTRY; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROTEIN DOMAIN; TUMOR CELL LINE;

AGED; ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CULTURE MEDIA; FLUOROURACIL; GLUCOSE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; MIDDLE AGED; MULTIENZYME COMPLEXES; OROTATE PHOSPHORIBOSYLTRANSFERASE; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; PROTEIN DOMAINS; PYRIMIDINES; URIC ACID;

EID: 85017120623     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.03.023     Document Type: Article

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