Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice

American Journal of Clinical Nutrition

Volumn 95, Issue 1, 2012, Pages 109-114

  Beaudin, Anna E ^a,b   Abarinov, Elena V ^a,c   Malysheva, Olga ^a   Perry, Cheryll A ^a   Caudill, Marie ^a   Stover, Patrick J ^a  

^a Department of Obstetrics Gynecology   (United States)

^b University of California Santa Cruz   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; ENZYME; FOLIC ACID; PROTEIN SHMT1; UNCLASSIFIED DRUG; URACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; EMBRYO; EMBRYO DEVELOPMENT; EXENCEPHALY; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; KNOCKOUT MOUSE; LIVER LEVEL; MALE; MATERNAL NUTRITION; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; RISK FACTOR; SENSITIZATION; VITAMIN DEFICIENCY;

ANIMALS; CHOLINE; CHOLINE DEFICIENCY; DIET; DISEASE MODELS, ANIMAL; ENERGY INTAKE; FOLIC ACID; FOLIC ACID DEFICIENCY; GLYCINE HYDROXYMETHYLTRANSFERASE; MICE; MICE, KNOCKOUT; NEURAL TUBE DEFECTS; RISK FACTORS;

EID: 84455160888     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.111.020305     Document Type: Article

References (23)

1. DeSesso JM, Scialli AR, Holson JF. Apparent lability of neural tube closure in laboratory animals and humans. Am J Med Genet 1999;87: 143-62. (Pubitemid 29530421)
2. Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 1993;86:703-8.
3. Relton CL, Wilding CS, Laffling AJ, Jonas PA, Burgess T, Binks K, Tawn EJ, Burn J. Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab 2004;81:273-81. (Pubitemid 38429990)
4. Christensen B, Arbour L, Tran P, Leclerc D, Sabbaghian N, Platt R, Gilfix BM, Rosenblatt DS, Gravel RA, Forbes P, et al. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 1999;84:151-7. (Pubitemid 29201082)
5. Fox JT, Stover PJ. Folate-mediated one-carbon metabolism. Vitam Horm 2008;79:1-44.
6. Lipton SA, Kim WK, Choi YB, Kumar S, D'Emilia DM, Rayadu PV, Arnell DR, Stamler JS. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci USA 1997;94:5923-8.
7. Shaw GM, Carmichael SL, Yang W, Selvin S, Schaffer DM. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol 2004;160:102-9. (Pubitemid 38962995)
8. Shaw GM, Finnell RH, Blom HJ, Carmichael SL, Vollset SE, Yang W, Ueland PM. Choline and risk of neural tube defects in a folate-fortified population. Epidemiology 2009;20:714-9.
9. Zeisel SH. Dietary choline: biochemistry, physiology, and pharmacology. Annu Rev Nutr 1981;1:95-121.
10. Zeisel SH. Importance of methyl donors during reproduction. Am J Clin Nutr 2009;89:673S-7S.
11. Fisher MC, Zeisel SH, Mar MH, Sadler TW. Inhibitors of choline uptake and metabolism cause developmental abnormalities in neurulating mouse embryos. Teratology 2001;64:114-22.
12. Fisher MC, Zeisel SH, Mar MH, Sadler TW. Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. FASEB J 2002;16:619-21.
13. Beaudin AE, Abarinov EV, Noden DM, Perry CY, Chu S, Stabler SP, Allen RH, Stover PJ. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr 2011;93:789-98.
14. MacFarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem 2008;283:25846-53.
15. McClive PJ, Sinclair AH. Rapid DNA extraction and PCR-sexing of mouse embryos. Mol Reprod Dev 2001;60:225-6. (Pubitemid 32847133)
16. Suh JR, Oppenheim EW, Girgis S, Stover PJ. Purification and properties of a folate-catabolizing enzyme. J Biol Chem 2000;275:35646-55.
17. Holm PI, Ueland PM, Kvalheim G, Lien EA. Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry. Clin Chem 2003;49:286-94. (Pubitemid 36143452)
18. Koc H, Mar MH, Ranasinghe A, Swenberg JA, Zeisel SH. Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/ electrospray ionization-isotope dilution mass spectrometry. Anal Chem 2002;74:4734-40.
19. Walzem RL, Clifford AJ. Folate deficiency in rats fed diets containing free amino acids or intact proteins. J Nutr 1988;118:1089-96.
20. Li Z, Agellon LB, Vance DE. Phosphatidylcholine homeostasis and liver failure. J Biol Chem 2005;280:37798-802. (Pubitemid 41642390)
21. Chan J, Deng L, Mikael LG, Yan J, Pickell L, Wu Q, Caudill MA, Rozen R. Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice. Am J Clin Nutr 2010;91:1035-43.
22. MacFarlane AJ, Perry CA, McEntee MF, Lin DM, Stover PJ. Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk. Cancer Res 2011;71:2098-107.
23. Rowe PB, McEwen SE. De novo purine synthesis in cultured rat embryos undergoing organogenesis. Proc Natl Acad Sci USA 1983;80:7333-6. (Pubitemid 14208852)