Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors

Metabolic Engineering

Volumn 43, Issue , 2017, Pages 187-197

  Lorendeau, Doriane ^a,b   Rinaldi, Gianmarco ^a,b   Boon, Ruben ^b   Spincemaille, Pieter ^c   Metzger, Kristine ^a,b   Jäger, Christian ^d   Christen, Stefan ^a,b   Dong, Xiangyi ^d   Kuenen, Sabine ^a,b   Voordeckers, Karin ^a,b   Verstreken, Patrik ^a,b   Cassiman, David ^c   Vermeersch, Pieter ^b,c   Verfaillie, Catherine ^b   Hiller, Karsten ^d   Fendt, Sarah Maria ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

13C metabolic flux analysis; Ataxia; Complex I of the electron transport chain; Gastrointestinal stromal tumors; Leigh syndrome; Leukodystrophy; Mitochondrial respiration; Paraganglioma; Pyruvate carboxylase; Reductive glutamine metabolism; SDH mutations; Succinate dehydrogenase

Indexed keywords

AMINO ACIDS; ELECTRON TRANSPORT PROPERTIES; NEURODEGENERATIVE DISEASES; PHYSIOLOGY; TUMORS;

ATAXIA; ELECTRON TRANSPORT CHAIN; GASTROINTESTINAL STROMAL TUMORS; LEIGH SYNDROME; LEUKODYSTROPHY; METABOLIC FLUX ANALYSIS; MITOCHONDRIAL RESPIRATION; PARAGANGLIOMA; PYRUVATE CARBOXYLASE; SDH MUTATIONS; SUCCINATE DEHYDROGENASE;

METABOLISM;

GLUTAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE; TUMOR PROTEIN;

AMINO ACID METABOLISM; ARTICLE; CANCER CELL CULTURE; CELL METABOLISM; CHRONIC MYELOID LEUKEMIA; CHRONIC MYELOID LEUKEMIA CELL LINE; DEGENERATIVE DISEASE; ELECTRON TRANSPORT; ENZYME ACTIVITY; GENETIC MANIPULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MUTATION; NEOPLASM; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER CELL LINE; ENZYMOLOGY; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; ELECTRON TRANSPORT COMPLEX I; HUMANS; MUTATION; NEOPLASM PROTEINS; NEOPLASMS; NEURONS; SUCCINATE DEHYDROGENASE;

EID: 85006873383     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2016.11.005     Document Type: Article

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