Vitamin C and L-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum

Stem Cell Reports

Volumn 8, Issue 1, 2017, Pages 1-10

  D'Aniello, Cristina ^a   Habibi, Ehsan ^b   Cermola, Federica ^a   Paris, Debora ^c   Russo, Francesco ^c   Fiorenzano, Alessandro ^a   Di Napoli, Gabriele ^a   Melck, Dominique J ^c   Cobellis, Gilda ^d   Angelini, Claudia ^c   Fico, Annalisa ^a   Blelloch, Robert ^e   Motta, Andrea ^c   Stunnenberg, Hendrik G ^b   De Cesare, Dario ^a   Patriarca, Eduardo J ^a   Minchiotti, Gabriella ^a  

^a INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c CNR   (Italy)

^d SECOND UNIVERSITY OF NAPLES   (Italy)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA methylation; early primed pluripotency; L proline; metabolic reprogramming; metabolomics; naive pluripotency; vitamin C

Indexed keywords

ACTIVIN A; ALKALINE PHOSPHATASE; ASCORBIC ACID; BETA TUBULIN; BIOLOGICAL MARKER; DNA; DPPA 2 PROTEIN; DPPA 3 PROTEIN; DPPA 4 PROTEIN; DPPA 5A PROTEIN; ESRRB PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GBX2 PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; KRUPPEL LIKE FACTOR 2; KRUPPEL LIKE FACTOR 4; MICRORNA; MICRORNA 290; MICRORNA 302; PROLINE; REX1 PROTEIN; SMAD2 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; DNA METHYLATION; EMBRYONIC STEM CELL; ENERGY METABOLISM; EPIGENETICS; GENE EXPRESSION; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL DIFFERENTIATION; CELL SELF-RENEWAL; CLUSTER ANALYSIS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; METABOLOME; METABOLOMICS; PROCEDURES;

ANIMALS; ASCORBIC ACID; CELL DIFFERENTIATION; CELL SELF RENEWAL; CLUSTER ANALYSIS; DNA METHYLATION; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION PROFILING; METABOLOME; METABOLOMICS; MICE; MICRORNAS; PLURIPOTENT STEM CELLS; PROLINE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 85009084580     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2016.11.011     Document Type: Article

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