Metabolic origins of spatial organization in the tumor microenvironment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 11, 2017, Pages 2934-2939

  Carmona Fontaine, Carlos ^a,b   Deforet, Maxime ^a   Akkari, Leila ^a,c   Thompson, Craig B ^a   Joyce, Johanna A ^a,c   Xavier, Joao B ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Cancer metabolism; Morphogens; Positional information; Tumor microenvironment; Tumor Associated macrophages

Indexed keywords

ARGINASE 1; MANNOSE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; LACTIC ACID; OXYGEN; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; CELL HYPOXIA; CELL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MATHEMATICAL MODEL; METABOLITE; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION; CLUSTER ANALYSIS; ENERGY METABOLISM; EXTRACELLULAR SPACE; GENE EXPRESSION PROFILING; GENETICS; HYPOXIA; MAPK SIGNALING; METABOLISM; NEOPLASM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHENOTYPE; TUMOR CELL LINE;

CELL LINE, TUMOR; CLUSTER ANALYSIS; ENERGY METABOLISM; EXTRACELLULAR SPACE; GENE EXPRESSION PROFILING; HUMANS; HYPOXIA; LACTIC ACID; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; PHENOTYPE; TRANSCRIPTOME; TUMOR MICROENVIRONMENT;

EID: 85015446714     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1700600114     Document Type: Article

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