메뉴 건너뛰기




Volumn 23, Issue 8, 2016, Pages 1271-1282

Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PH DOMAIN AND LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN KINASE B; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; EMD 638683; GLUCOSE; HYDRAZINE DERIVATIVE; IMMEDIATE EARLY PROTEIN; NUCLEAR PROTEIN; PHLPP1 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; RAS PROTEIN; SERUM-GLUCOCORTICOID REGULATED KINASE; SMALL INTERFERING RNA;

EID: 84959198270     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2016.15     Document Type: Article
Times cited : (60)

References (41)
  • 1
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen DX, Massague J. Genetic determinants of cancer metastasis. Nat Rev Genet 2007; 8: 341-352.
    • (2007) Nat Rev Genet , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 2
    • 84873055250 scopus 로고    scopus 로고
    • The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer
    • Li X, Stevens PD, Yang H, Gulhati P, Wang W, Evers BM, et al. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene 2013; 32: 471-478.
    • (2013) Oncogene , vol.32 , pp. 471-478
    • Li, X.1    Stevens, P.D.2    Yang, H.3    Gulhati, P.4    Wang, W.5    Evers, B.M.6
  • 3
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994; 124: 619-626.
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 4
    • 84906936187 scopus 로고    scopus 로고
    • Cancer cell survival during detachment from the ECM: Multiple barriers to tumour progression
    • Buchheit CL, Weigel KJ, Schafer ZT. Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression. Nat Rev Cancer 2014; 14: 632-641.
    • (2014) Nat Rev Cancer , vol.14 , pp. 632-641
    • Buchheit, C.L.1    Weigel, K.J.2    Schafer, Z.T.3
  • 5
    • 84861982020 scopus 로고    scopus 로고
    • The regulation of cancer cell death and metabolism by extracellular matrix attachment
    • Buchheit CL, Rayavarapu RR, Schafer ZT. The regulation of cancer cell death and metabolism by extracellular matrix attachment. Semin Cell Dev Biol 2012; 23: 402-411.
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 402-411
    • Buchheit, C.L.1    Rayavarapu, R.R.2    Schafer, Z.T.3
  • 6
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009; 461: 109-113.
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1    Grassian, A.R.2    Song, L.3    Jiang, Z.4    Gerhart-Hines, Z.5    Irie, H.Y.6
  • 7
    • 78651325975 scopus 로고    scopus 로고
    • Keeping a breast of recent developments in cancer metabolism
    • Davison CA, Schafer ZT. Keeping a breast of recent developments in cancer metabolism. Curr Drug Targets 2010; 11: 1112-1120.
    • (2010) Curr Drug Targets , vol.11 , pp. 1112-1120
    • Davison, C.A.1    Schafer, Z.T.2
  • 8
    • 80052342419 scopus 로고    scopus 로고
    • PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment
    • Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, et al. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol 2011; 31: 3616-3629.
    • (2011) Mol Cell Biol , vol.31 , pp. 3616-3629
    • Avivar-Valderas, A.1    Salas, E.2    Bobrovnikova-Marjon, E.3    Diehl, J.A.4    Nagi, C.5    Debnath, J.6
  • 9
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 2008; 19: 797-806.
    • (2008) Mol Biol Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 10
    • 84879074036 scopus 로고    scopus 로고
    • Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix
    • Davison CA, Durbin SM, Thau MR, Zellmer VR, Chapman SE, Diener J, et al. Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix. Cancer Res 2013; 73: 3704-3715.
    • (2013) Cancer Res , vol.73 , pp. 3704-3715
    • Davison, C.A.1    Durbin, S.M.2    Thau, M.R.3    Zellmer, V.R.4    Chapman, S.E.5    Diener, J.6
  • 11
  • 12
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 13
    • 84861147473 scopus 로고    scopus 로고
    • A comprehensive survey of Ras mutations in cancer
    • Prior IA, Lewis PD, Mattos C. A comprehensive survey of Ras mutations in cancer. Cancer Res 2012; 72: 2457-2467.
    • (2012) Cancer Res , vol.72 , pp. 2457-2467
    • Prior, I.A.1    Lewis, P.D.2    Mattos, C.3
  • 15
    • 0034928862 scopus 로고    scopus 로고
    • Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase
    • McFall A, Ulku A, Lambert QT, Kusa A, Rogers-Graham K, Der CJ. Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase. Mol Cell Biol 2001; 21: 5488-5499.
    • (2001) Mol Cell Biol , vol.21 , pp. 5488-5499
    • McFall, A.1    Ulku, A.2    Lambert, Q.T.3    Kusa, A.4    Rogers-Graham, K.5    Der, C.J.6
  • 16
    • 3042742432 scopus 로고    scopus 로고
    • Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis
    • Eckert LB, Repasky GA, Ulku AS, McFall A, Zhou H, Sartor CI, et al. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res 2004; 64: 4585-4592.
    • (2004) Cancer Res , vol.64 , pp. 4585-4592
    • Eckert, L.B.1    Repasky, G.A.2    Ulku, A.S.3    McFall, A.4    Zhou, H.5    Sartor, C.I.6
  • 17
    • 0036270751 scopus 로고    scopus 로고
    • Regulated transport of the glucose transporter GLUT4
    • Bryant NJ, Govers R, James DE. Regulated transport of the glucose transporter GLUT4. Nat Rev Mol Cell Biol 2002; 3: 267-277.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 267-277
    • Bryant, N.J.1    Govers, R.2    James, D.E.3
  • 19
    • 84887432285 scopus 로고    scopus 로고
    • Serum- and glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death
    • Brickley DR, Agyeman AS, Kopp RF, Hall BA, Harbeck MC, Belova L, et al. Serum- And glucocorticoid-induced protein kinase 1 (SGK1) is regulated by store-operated Ca2+ entry and mediates cytoprotection against necrotic cell death. J Biol Chem 2013; 288: 32708-32719.
    • (2013) J Biol Chem , vol.288 , pp. 32708-32719
    • Brickley, D.R.1    Agyeman, A.S.2    Kopp, R.F.3    Hall, B.A.4    Harbeck, M.C.5    Belova, L.6
  • 20
    • 0033151832 scopus 로고    scopus 로고
    • Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway
    • Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 1999; 18: 3024-3033.
    • (1999) EMBO J. , vol.18 , pp. 3024-3033
    • Park, J.1    Leong, M.L.2    Buse, P.3    Maiyar, A.C.4    Firestone, G.L.5    Hemmings, B.A.6
  • 21
    • 34447314234 scopus 로고    scopus 로고
    • Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1
    • Kim MJ, Chae JS, Kim KJ, Hwang SG, Yoon KW, Kim EK, et al. Negative regulation of SEK1 signaling by serum- And glucocorticoid-inducible protein kinase 1. EMBO J. 2007; 26: 3075-3085.
    • (2007) EMBO J. , vol.26 , pp. 3075-3085
    • Kim, M.J.1    Chae, J.S.2    Kim, K.J.3    Hwang, S.G.4    Yoon, K.W.5    Kim, E.K.6
  • 24
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18: 13-24.
    • (2005) Mol Cell , vol.18 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 25
    • 77952562926 scopus 로고    scopus 로고
    • Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis
    • Qiao M, Wang Y, Xu X, Lu J, Dong Y, TaoWet al. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell 2010; 38: 512-523.
    • (2010) Mol Cell , vol.38 , pp. 512-523
    • Qiao, M.1    Wang, Y.2    Xu, X.3    Lu, J.4    Dong, Y.5    Tao, W.6
  • 26
    • 78650306314 scopus 로고    scopus 로고
    • Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells
    • Suljagic M, Laurenti L, Tarnani M, Alam M, Malek SN, Efremov DG. Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells. Leukemia 2010; 24: 2063-2071.
    • (2010) Leukemia , vol.24 , pp. 2063-2071
    • Suljagic, M.1    Laurenti, L.2    Tarnani, M.3    Alam, M.4    Malek, S.N.5    Efremov, D.G.6
  • 27
    • 33646859435 scopus 로고    scopus 로고
    • MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer
    • Xu L, Chen S, Bergan RC. MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer. Oncogene 2006; 25: 2987-2998.
    • (2006) Oncogene , vol.25 , pp. 2987-2998
    • Xu, L.1    Chen, S.2    Bergan, R.C.3
  • 29
    • 84926512814 scopus 로고    scopus 로고
    • The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment
    • Rayavarapu RR, Heiden B, Pagani N, Shaw MM, Shuff S, Zhang S, et al. The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. J Biol Chem 2015; 290: 8722-8733.
    • (2015) J Biol Chem , vol.290 , pp. 8722-8733
    • Rayavarapu, R.R.1    Heiden, B.2    Pagani, N.3    Shaw, M.M.4    Shuff, S.5    Zhang, S.6
  • 32
    • 54749127362 scopus 로고    scopus 로고
    • Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic
    • Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, TriznaWet al. Development of a small-molecule serum- And glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. Cancer Res 2008; 68: 7475-7483.
    • (2008) Cancer Res , vol.68 , pp. 7475-7483
    • Sherk, A.B.1    Frigo, D.E.2    Schnackenberg, C.G.3    Bray, J.D.4    Laping, N.J.5    Trizna, W.6
  • 33
    • 84888116498 scopus 로고    scopus 로고
    • Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer
    • Skor MN, Wonder EL, Kocherginsky M, Goyal A, Hall BA, Cai Y, et al. Glucocorticoid receptor antagonism as a novel therapy for triple-negative breast cancer. Clin Cancer Res 2013; 19: 6163-6172.
    • (2013) Clin Cancer Res , vol.19 , pp. 6163-6172
    • Skor, M.N.1    Wonder, E.L.2    Kocherginsky, M.3    Goyal, A.4    Hall, B.A.5    Cai, Y.6
  • 35
    • 84877724724 scopus 로고    scopus 로고
    • The serum- and glucocorticoidinduced protein kinase-1 (Sgk-1 mitochondria connection: Identification of the IF-1 inhibitor of the F 1)F 0)-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1
    • O'Keeffe BA, Cilia S, Maiyar AC, Vaysberg M, Firestone GL. The serum- And glucocorticoidinduced protein kinase-1 (Sgk-1) mitochondria connection: identification of the IF-1 inhibitor of the F(1)F(0)-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1. Biochimie 2013; 95: 1258-1265.
    • (2013) Biochimie , vol.95 , pp. 1258-1265
    • O'Keeffe, B.A.1    Cilia, S.2    Maiyar, A.C.3    Vaysberg, M.4    Firestone, G.L.5
  • 36
    • 84899821715 scopus 로고    scopus 로고
    • Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt
    • Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell 2014; 54: 378-391.
    • (2014) Mol Cell , vol.54 , pp. 378-391
    • Wang, P.1    Zhou, Z.2    Hu, A.3    Ponte De Albuquerque, C.4    Zhou, Y.5    Hong, L.6
  • 37
    • 84887008822 scopus 로고    scopus 로고
    • Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells
    • Wen YA, Stevens PD, Gasser ML, Andrei R, Gao T. Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. Mol Cell Biol 2013; 33: 4594-4605.
    • (2013) Mol Cell Biol , vol.33 , pp. 4594-4605
    • Wen, Y.A.1    Stevens, P.D.2    Gasser, M.L.3    Andrei, R.4    Gao, T.5
  • 38
    • 84883478160 scopus 로고    scopus 로고
    • MiR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer
    • Cai J, Fang L, Huang Y, Li R, Yuan J, Yang Y, et al. miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer. Cancer Res 2013; 73: 5402-5415.
    • (2013) Cancer Res , vol.73 , pp. 5402-5415
    • Cai, J.1    Fang, L.2    Huang, Y.3    Li, R.4    Yuan, J.5    Yang, Y.6
  • 39
    • 84856741945 scopus 로고    scopus 로고
    • Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): A new player in cell signaling
    • Warfel NA, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling. J Biol Chem 2012; 287: 3610-3616.
    • (2012) J Biol Chem , vol.287 , pp. 3610-3616
    • Warfel, N.A.1    Newton, A.C.2
  • 40
    • 33846630384 scopus 로고    scopus 로고
    • BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms
    • Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell 2007; 12: 221-234.
    • (2007) Dev Cell , vol.12 , pp. 221-234
    • Mailleux, A.A.1    Overholtzer, M.2    Schmelzle, T.3    Bouillet, P.4    Strasser, A.5    Brugge, J.S.6
  • 41
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.