-
1
-
-
84925969707
-
Metabolic pathways promoting cancer cell survival and growth
-
L.K. Boroughs, and R.J. DeBerardinis Metabolic pathways promoting cancer cell survival and growth Nat. Cell Biol. 17 2015 351 359
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 351-359
-
-
Boroughs, L.K.1
DeBerardinis, R.J.2
-
2
-
-
84923596826
-
A roadmap for interpreting (13)C metabolite labeling patterns from cells
-
J.M. Buescher, M.R. Antoniewicz, L.G. Boros, S.C. Burgess, H. Brunengraber, C.B. Clish, R.J. DeBerardinis, O. Feron, C. Frezza, B. Ghesquiere, and et al. A roadmap for interpreting (13)C metabolite labeling patterns from cells Curr. Opin. Biotechnol. 34 2015 189 201
-
(2015)
Curr. Opin. Biotechnol.
, vol.34
, pp. 189-201
-
-
Buescher, J.M.1
Antoniewicz, M.R.2
Boros, L.G.3
Burgess, S.C.4
Brunengraber, H.5
Clish, C.B.6
DeBerardinis, R.J.7
Feron, O.8
Frezza, C.9
Ghesquiere, B.10
-
3
-
-
84867595989
-
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma
-
P. Caro, A.U. Kishan, E. Norberg, I.A. Stanley, B. Chapuy, S.B. Ficarro, K. Polak, D. Tondera, J. Gounarides, H. Yin, and et al. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma Cancer Cell 22 2012 547 560
-
(2012)
Cancer Cell
, vol.22
, pp. 547-560
-
-
Caro, P.1
Kishan, A.U.2
Norberg, E.3
Stanley, I.A.4
Chapuy, B.5
Ficarro, S.B.6
Polak, K.7
Tondera, D.8
Gounarides, J.9
Yin, H.10
-
4
-
-
79957774646
-
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells
-
T. Cheng, J. Sudderth, C. Yang, A.R. Mullen, E.S. Jin, J.M. Matés, and R.J. DeBerardinis Pyruvate carboxylase is required for glutamine-independent growth of tumor cells Proc. Natl. Acad. Sci. USA 108 2011 8674 8679
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 8674-8679
-
-
Cheng, T.1
Sudderth, J.2
Yang, C.3
Mullen, A.R.4
Jin, E.S.5
Matés, J.M.6
DeBerardinis, R.J.7
-
5
-
-
84958138936
-
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
-
Published online February 4, 2016
-
S.M. Davidson, T. Papagiannakopoulos, B.A. Olenchock, J.E. Heyman, M.A. Keibler, A. Luengo, M.R. Bauer, A.K. Jha, J.P. O'Brien, K.A. Pierce, and et al. Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer Cell Metab 2016 10.1016/j.cmet.2016.01.007 Published online February 4, 2016
-
(2016)
Cell Metab
-
-
Davidson, S.M.1
Papagiannakopoulos, T.2
Olenchock, B.A.3
Heyman, J.E.4
Keibler, M.A.5
Luengo, A.6
Bauer, M.R.7
Jha, A.K.8
O'Brien, J.P.9
Pierce, K.A.10
-
6
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
R.J. DeBerardinis, J.J. Lum, G. Hatzivassiliou, and C.B. Thompson The biology of cancer: metabolic reprogramming fuels cell growth and proliferation Cell Metab. 7 2008 11 20
-
(2008)
Cell Metab.
, vol.7
, pp. 11-20
-
-
DeBerardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
7
-
-
84907227069
-
Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival
-
M. Eilertsen, S. Andersen, S. Al-Saad, Y. Kiselev, T. Donnem, H. Stenvold, I. Pettersen, K. Al-Shibli, E. Richardsen, L.T. Busund, and R.M. Bremnes Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival PLoS ONE 9 2014 e105038
-
(2014)
PLoS ONE
, vol.9
, pp. e105038
-
-
Eilertsen, M.1
Andersen, S.2
Al-Saad, S.3
Kiselev, Y.4
Donnem, T.5
Stenvold, H.6
Pettersen, I.7
Al-Shibli, K.8
Richardsen, E.9
Busund, L.T.10
Bremnes, R.M.11
-
8
-
-
68549085318
-
Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
-
T.W. Fan, A.N. Lane, R.M. Higashi, M.A. Farag, H. Gao, M. Bousamra, and D.M. Miller Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM) Mol. Cancer 8 2009 41
-
(2009)
Mol. Cancer
, vol.8
, pp. 41
-
-
Fan, T.W.1
Lane, A.N.2
Higashi, R.M.3
Farag, M.A.4
Gao, H.5
Bousamra, M.6
Miller, D.M.7
-
9
-
-
40449093361
-
Recommendations on the use of 18F-FDG PET in oncology
-
J.W. Fletcher, B. Djulbegovic, H.P. Soares, B.A. Siegel, V.J. Lowe, G.H. Lyman, R.E. Coleman, R. Wahl, J.C. Paschold, N. Avril, and et al. Recommendations on the use of 18F-FDG PET in oncology J. Nucl. Med. 49 2008 480 508
-
(2008)
J. Nucl. Med.
, vol.49
, pp. 480-508
-
-
Fletcher, J.W.1
Djulbegovic, B.2
Soares, H.P.3
Siegel, B.A.4
Lowe, V.J.5
Lyman, G.H.6
Coleman, R.E.7
Wahl, R.8
Paschold, J.C.9
Avril, N.10
-
10
-
-
64749116346
-
C-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
-
P. Gao, I. Tchernyshyov, T.-C. Chang, Y.-S. Lee, K. Kita, T. Ochi, K.I. Zeller, A.M. De Marzo, J.E. Van Eyk, J.T. Mendell, and C.V. Dang c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism Nature 458 2009 762 765
-
(2009)
Nature
, vol.458
, pp. 762-765
-
-
Gao, P.1
Tchernyshyov, I.2
Chang, T.-C.3
Lee, Y.-S.4
Kita, K.5
Ochi, T.6
Zeller, K.I.7
De Marzo, A.M.8
Van Eyk, J.E.9
Mendell, J.T.10
Dang, C.V.11
-
11
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
R.A. Gatenby, and R.J. Gillies Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4 2004 891 899
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
12
-
-
84874614138
-
Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma
-
F. Guillaumond, J. Leca, O. Olivares, M.-N. Lavaut, N. Vidal, P. Berthezène, N.J. Dusetti, C. Loncle, E. Calvo, O. Turrini, and et al. Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma Proc. Natl. Acad. Sci. USA 110 2013 3919 3924
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 3919-3924
-
-
Guillaumond, F.1
Leca, J.2
Olivares, O.3
Lavaut, M.-N.4
Vidal, N.5
Berthezène, P.6
Dusetti, N.J.7
Loncle, C.8
Calvo, E.9
Turrini, O.10
-
13
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
14
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
H. Ji, M.R. Ramsey, D.N. Hayes, C. Fan, K. McNamara, P. Kozlowski, C. Torrice, M.C. Wu, T. Shimamura, S.A. Perera, and et al. LKB1 modulates lung cancer differentiation and metastasis Nature 448 2007 807 810
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
-
15
-
-
84884192379
-
Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer
-
K.M. Kennedy, P.M. Scarbrough, A. Ribeiro, R. Richardson, H. Yuan, P. Sonveaux, C.D. Landon, J.T. Chi, S. Pizzo, T. Schroeder, and M.W. Dewhirst Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer PLoS ONE 8 2013 e75154
-
(2013)
PLoS ONE
, vol.8
, pp. e75154
-
-
Kennedy, K.M.1
Scarbrough, P.M.2
Ribeiro, A.3
Richardson, R.4
Yuan, H.5
Sonveaux, P.6
Landon, C.D.7
Chi, J.T.8
Pizzo, S.9
Schroeder, T.10
Dewhirst, M.W.11
-
16
-
-
34249874331
-
Diffusion-weighted MRI in the body: Applications and challenges in oncology
-
D.M. Koh, and D.J. Collins Diffusion-weighted MRI in the body: applications and challenges in oncology AJR Am. J. Roentgenol. 188 2007 1622 1635
-
(2007)
AJR Am. J. Roentgenol.
, vol.188
, pp. 1622-1635
-
-
Koh, D.M.1
Collins, D.J.2
-
17
-
-
84868117861
-
Metabolism of [U-13 C]glucose in human brain tumors in vivo
-
E.A. Maher, I. Marin-Valencia, R.M. Bachoo, T. Mashimo, J. Raisanen, K.J. Hatanpaa, A. Jindal, F.M. Jeffrey, C. Choi, C. Madden, and et al. Metabolism of [U-13 C]glucose in human brain tumors in vivo NMR Biomed. 25 2012 1234 1244
-
(2012)
NMR Biomed.
, vol.25
, pp. 1234-1244
-
-
Maher, E.A.1
Marin-Valencia, I.2
Bachoo, R.M.3
Mashimo, T.4
Raisanen, J.5
Hatanpaa, K.J.6
Jindal, A.7
Jeffrey, F.M.8
Choi, C.9
Madden, C.10
-
18
-
-
84862016091
-
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
-
I. Marin-Valencia, C. Yang, T. Mashimo, S. Cho, H. Baek, X.-L. Yang, K.N. Rajagopalan, M. Maddie, V. Vemireddy, Z. Zhao, and et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo Cell Metab. 15 2012 827 837
-
(2012)
Cell Metab.
, vol.15
, pp. 827-837
-
-
Marin-Valencia, I.1
Yang, C.2
Mashimo, T.3
Cho, S.4
Baek, H.5
Yang, X.-L.6
Rajagopalan, K.N.7
Maddie, M.8
Vemireddy, V.9
Zhao, Z.10
-
19
-
-
84919903877
-
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
-
T. Mashimo, K. Pichumani, V. Vemireddy, K.J. Hatanpaa, D.K. Singh, S. Sirasanagandla, S. Nannepaga, S.G. Piccirillo, Z. Kovacs, C. Foong, and et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases Cell 159 2014 1603 1614
-
(2014)
Cell
, vol.159
, pp. 1603-1614
-
-
Mashimo, T.1
Pichumani, K.2
Vemireddy, V.3
Hatanpaa, K.J.4
Singh, D.K.5
Sirasanagandla, S.6
Nannepaga, S.7
Piccirillo, S.G.8
Kovacs, Z.9
Foong, C.10
-
20
-
-
84874025568
-
Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas
-
M.L. McCleland, A.S. Adler, L. Deming, E. Cosino, L. Lee, E.M. Blackwood, M. Solon, J. Tao, L. Li, D. Shames, and et al. Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas Clin. Cancer Res. 19 2013 773 784
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 773-784
-
-
McCleland, M.L.1
Adler, A.S.2
Deming, L.3
Cosino, E.4
Lee, L.5
Blackwood, E.M.6
Solon, M.7
Tao, J.8
Li, L.9
Shames, D.10
-
21
-
-
76149095916
-
Reproducibility of perfusion parameters in dynamic contrast-enhanced MRI of lung and liver tumors: Effect on estimates of patient sample size in clinical trials and on individual patient responses
-
C.S. Ng, D.L. Raunig, E.F. Jackson, E.A. Ashton, F. Kelcz, K.B. Kim, R. Kurzrock, and T.M. McShane Reproducibility of perfusion parameters in dynamic contrast-enhanced MRI of lung and liver tumors: effect on estimates of patient sample size in clinical trials and on individual patient responses AJR Am. J. Roentgenol. 194 2010 W134 W140
-
(2010)
AJR Am. J. Roentgenol.
, vol.194
, pp. W134-W140
-
-
Ng, C.S.1
Raunig, D.L.2
Jackson, E.F.3
Ashton, E.A.4
Kelcz, F.5
Kim, K.B.6
Kurzrock, R.7
McShane, T.M.8
-
22
-
-
84923685116
-
Assessment of bronchial and pulmonary blood supply in non-small cell lung cancer subtypes using computed tomography perfusion
-
T.D. Nguyen-Kim, T. Frauenfelder, K. Strobel, P. Veit-Haibach, and M.W. Huellner Assessment of bronchial and pulmonary blood supply in non-small cell lung cancer subtypes using computed tomography perfusion Invest. Radiol. 50 2015 179 186
-
(2015)
Invest. Radiol.
, vol.50
, pp. 179-186
-
-
Nguyen-Kim, T.D.1
Frauenfelder, T.2
Strobel, K.3
Veit-Haibach, P.4
Huellner, M.W.5
-
23
-
-
74849087878
-
The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
-
S. Pavlides, D. Whitaker-Menezes, R. Castello-Cros, N. Flomenberg, A.K. Witkiewicz, P.G. Frank, M.C. Casimiro, C. Wang, P. Fortina, S. Addya, and et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma Cell Cycle 8 2009 3984 4001
-
(2009)
Cell Cycle
, vol.8
, pp. 3984-4001
-
-
Pavlides, S.1
Whitaker-Menezes, D.2
Castello-Cros, R.3
Flomenberg, N.4
Witkiewicz, A.K.5
Frank, P.G.6
Casimiro, M.C.7
Wang, C.8
Fortina, P.9
Addya, S.10
-
24
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
R. Possemato, K.M. Marks, Y.D. Shaul, M.E. Pacold, D. Kim, K. Birsoy, S. Sethumadhavan, H.K. Woo, H.G. Jang, A.K. Jha, and et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer Nature 476 2011 346 350
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
-
25
-
-
84976235132
-
Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells
-
K.N. Rajagopalan, R.A. Egnatchik, M.A. Calvaruso, A.T. Wasti, M.S. Padanad, L.K. Boroughs, B. Ko, C.T. Hensley, M. Acar, Z. Hu, and et al. Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells Cancer Metab. 3 2015 7
-
(2015)
Cancer Metab.
, vol.3
, pp. 7
-
-
Rajagopalan, K.N.1
Egnatchik, R.A.2
Calvaruso, M.A.3
Wasti, A.T.4
Padanad, M.S.5
Boroughs, L.K.6
Ko, B.7
Hensley, C.T.8
Acar, M.9
Hu, Z.10
-
26
-
-
84961287801
-
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation
-
K. Sellers, M.P. Fox, M. Bousamra 2nd, S.P. Slone, R.M. Higashi, D.M. Miller, Y. Wang, J. Yan, M.O. Yuneva, R. Deshpande, and et al. Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation J. Clin. Invest. 125 2015 687 698
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 687-698
-
-
Sellers, K.1
Fox, M.P.2
Bousamra, M.3
Slone, S.P.4
Higashi, R.M.5
Miller, D.M.6
Wang, Y.7
Yan, J.8
Yuneva, M.O.9
Deshpande, R.10
-
27
-
-
84875894714
-
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
-
J. Son, C.A. Lyssiotis, H. Ying, X. Wang, S. Hua, M. Ligorio, R.M. Perera, C.R. Ferrone, E. Mullarky, N. Shyh-Chang, and et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature 496 2013 101 105
-
(2013)
Nature
, vol.496
, pp. 101-105
-
-
Son, J.1
Lyssiotis, C.A.2
Ying, H.3
Wang, X.4
Hua, S.5
Ligorio, M.6
Perera, R.M.7
Ferrone, C.R.8
Mullarky, E.9
Shyh-Chang, N.10
-
28
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
P. Sonveaux, F. Végran, T. Schroeder, M.C. Wergin, J. Verrax, Z.N. Rabbani, C.J. De Saedeleer, K.M. Kennedy, C. Diepart, B.F. Jordan, and et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice J. Clin. Invest. 118 2008 3930 3942
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
Végran, F.2
Schroeder, T.3
Wergin, M.C.4
Verrax, J.5
Rabbani, Z.N.6
De Saedeleer, C.J.7
Kennedy, K.M.8
Diepart, C.9
Jordan, B.F.10
-
29
-
-
84892939615
-
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
-
A. Terunuma, N. Putluri, P. Mishra, E.A. Mathé, T.H. Dorsey, M. Yi, T.A. Wallace, H.J. Issaq, M. Zhou, J.K. Killian, and et al. MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis J. Clin. Invest. 124 2014 398 412
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 398-412
-
-
Terunuma, A.1
Putluri, N.2
Mishra, P.3
Mathé, E.A.4
Dorsey, T.H.5
Yi, M.6
Wallace, T.A.7
Issaq, H.J.8
Zhou, M.9
Killian, J.K.10
-
30
-
-
80052242132
-
Targeting cancer metabolism: A therapeutic window opens
-
M.G. Vander Heiden Targeting cancer metabolism: a therapeutic window opens Nat. Rev. Drug Discov. 10 2011 671 684
-
(2011)
Nat. Rev. Drug Discov.
, vol.10
, pp. 671-684
-
-
Vander Heiden, M.G.1
-
31
-
-
0001221508
-
On respiratory impairment in cancer cells
-
O. Warburg On respiratory impairment in cancer cells Science 124 1956 269 270
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
32
-
-
34248665600
-
Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition, Analysis, and Examples
-
T.E. Yankeelov, and J.C. Gore Dynamic Contrast Enhanced Magnetic Resonance Imaging in Oncology: Theory, Data Acquisition, Analysis, and Examples Curr. Med. Imaging Rev. 3 2009 91 107
-
(2009)
Curr. Med. Imaging Rev.
, vol.3
, pp. 91-107
-
-
Yankeelov, T.E.1
Gore, J.C.2
-
33
-
-
84863011452
-
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
-
M.O. Yuneva, T.W. Fan, T.D. Allen, R.M. Higashi, D.V. Ferraris, T. Tsukamoto, J.M. Matés, F.J. Alonso, C. Wang, Y. Seo, and et al. The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type Cell Metab. 15 2012 157 170
-
(2012)
Cell Metab.
, vol.15
, pp. 157-170
-
-
Yuneva, M.O.1
Fan, T.W.2
Allen, T.D.3
Higashi, R.M.4
Ferraris, D.V.5
Tsukamoto, T.6
Matés, J.M.7
Alonso, F.J.8
Wang, C.9
Seo, Y.10
|