Environment impacts the metabolic dependencies of ras-driven non-small cell lung cancer

Cell Metabolism

Volumn 23, Issue 3, 2016, Pages 517-528

  Davidson, Shawn M ^a,b   Papagiannakopoulos, Thales ^a   Olenchock, Benjamin A ^a,b,c   Heyman, Julia E ^a   Keibler, Mark A ^d   Luengo, Alba ^a   Bauer, Matthew R ^a   Jha, Abhishek K ^e   O'Brien, James P ^a   Pierce, Kerry A ^b   Gui, Dan Y ^a   Sullivan, Lucas B ^a   Wasylenko, Thomas M ^d   Subbaraj, Lakshmipriya ^a   Chin, Christopher R ^a   Stephanopolous, Gregory ^d   Mott, Bryan T ^f   Jacks, Tyler ^a   Clish, Clary B ^b   Van Der Heiden, Matthew G ^a,b,g  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d Massachusetts Institute of Technology Cambridge   (United States)

^e Elucidata Corporation   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

^g DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUTAMINE; LACTIC ACID; TRICARBOXYLIC ACID; GLUCOSE BLOOD LEVEL; KRAS PROTEIN, HUMAN; PROTEIN P21; PYRUVIC ACID;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER GROWTH; CARBOXYLATION; CARCINOGENESIS; CITRIC ACID CYCLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; ENVIRONMENTAL IMPACT; EPIGENETICS; GENE DELETION; GENE DISRUPTION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; IN VITRO STUDY; IN VIVO STUDY; LUNG PARENCHYMA; METABOLIC DISORDER; MITOCHONDRIAL RESPIRATION; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; ONCOGENE RAS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEADY STATE; TISSUE METABOLISM; TUMOR GROWTH; TUMOR VOLUME; 129 MOUSE; ANIMAL; C57BL MOUSE; CANCER TRANSPLANTATION; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; LUNG; LUNG TUMOR; METABOLISM; MISSENSE MUTATION; MITOCHONDRION; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR MICROENVIRONMENT;

ANIMALS; BLOOD GLUCOSE; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; GLUCOSE; HUMANS; LUNG; LUNG NEOPLASMS; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, NUDE; MITOCHONDRIA; MUTATION, MISSENSE; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS P21(RAS); PYRUVIC ACID; TUMOR MICROENVIRONMENT;

EID: 84958138936     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.01.007     Document Type: Article

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