Tumour hypoxia causes DNA hypermethylation by reducing TET activity

Nature

Volumn 537, Issue 7618, 2016, Pages 63-68

  Thienpont, Bernard ^a,b   Steinbacher, Jessica ^c   Zhao, Hui ^a,b   D'Anna, Flora ^a,b   Kuchnio, Anna ^a,d   Ploumakis, Athanasios ^e   Ghesquière, Bart ^a   Van Dyck, Laurien ^a,b   Boeckx, Bram ^a,b   Schoonjans, Luc ^a,d   Hermans, Els ^f   Amant, Frederic ^f   Kristensen, Vessela N ^g,h   Koh, Kian Peng ^d   Mazzone, Massimiliano ^a,d   Coleman, Mathew L ^e   Carell, Thomas ^c   Carmeliet, Peter ^a,d   Lambrechts, DIether ^a,b  

^a Vesalius Research Center   (Belgium)

^b University of Leuven   (Belgium)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^g OSLO UNIVERSITY HOSPITAL   (Norway)

^h AKERSHUS UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; DNA; ENZYME; HYPOXIA INDUCIBLE FACTOR; REACTIVE OXYGEN METABOLITE; TEN ELEVEN TRANSLOCATION ENZYME; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; MIXED FUNCTION OXIDASE; ONCOPROTEIN; OXYGEN; TET1 PROTEIN, HUMAN; TET2 PROTEIN, MOUSE;

CANCER; CELLS AND CELL COMPONENTS; DNA; ENZYME ACTIVITY; GENE; HYPOXIA; OXYGENATION; RODENT; TRANSLOCATION; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; ENZYME METABOLISM; EXPERIMENTAL HYPOXIA; EXPERIMENTAL NEOPLASM; FEMALE; GENE LOCUS; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STROMA CELL; TUMOR SUPPRESSOR GENE; ANIMAL; DEFICIENCY; DRUG EFFECTS; EXPERIMENTAL MAMMARY NEOPLASM; GENE SILENCING; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; TUMOR HYPOXIA;

5-METHYLCYTOSINE; ANIMALS; CELL PROLIFERATION; DNA METHYLATION; DNA-BINDING PROTEINS; FEMALE; GENE SILENCING; GENES, TUMOR SUPPRESSOR; HUMANS; MALE; MAMMARY NEOPLASMS, ANIMAL; MICE; MIXED FUNCTION OXYGENASES; OXIDATION-REDUCTION; OXYGEN; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; STROMAL CELLS; TUMOR HYPOXIA;

EID: 84984629881     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature19081     Document Type: Article

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