Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

Nature Cell Biology

Volumn 17, Issue 12, 2015, Pages 1556-1568

  Tardito, Saverio ^a   Oudin, Anaïs ^b   Ahmed, Shafiq U ^c   Fack, Fred ^b   Keunen, Olivier ^b   Zheng, Liang ^a   Miletic, Hrvoje ^d   Sakariassen, Per Øystein ^d   Weinstock, Adam ^e   Wagner, Allon ^e   Lindsay, Susan L ^c   Hock, Andreas K ^a   Barnett, Susan C ^c   Ruppin, Eytan ^e   Harald MØrkve, Svein ^f   Lund Johansen, Morten ^d,f   Chalmers, Anthony J ^c   Bjerkvig, Rolf ^b,d   Niclou, Simone P ^b,d   Gottlieb, Eyal ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b LUXEMBOURG INSTITUTE OF HEALTH   (Luxembourg)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF BERGEN   (Norway)

^e TEL AVIV UNIVERSITY   (Israel)

^f HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; NUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; FEMALE; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; GLIOMA CELL; GLIOMA STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PURINE SYNTHESIS; TUMOR GROWTH; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; BRAIN TUMOR; CANCER STEM CELL; CELL CULTURE; COCULTURE; CYTOLOGY; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; CITRIC ACID CYCLE; COCULTURE TECHNIQUES; FEMALE; GLIOBLASTOMA; GLUTAMATE-AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; HUMANS; MALE; MICE, INBRED NOD; MICE, SCID; MODELS, BIOLOGICAL; NEOPLASTIC STEM CELLS; NUCLEOTIDES; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 84948701108     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb3272     Document Type: Article

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