-
1
-
-
25844475838
-
On the road to cancer: aneuploidy and the mitotic checkpoint
-
Kops G, Weaver B, Cleveland D (2005) On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5: 773–785
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 773-785
-
-
Kops, G.1
Weaver, B.2
Cleveland, D.3
-
2
-
-
79955398591
-
Otto Warburg's contributions to current concepts of cancer metabolism
-
Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325–337
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 325-337
-
-
Koppenol, W.H.1
Bounds, P.L.2
Dang, C.V.3
-
3
-
-
84866127673
-
Metabolic reprogramming of the tumor
-
Ferreira L, Hebrant A, Dumont JE (2012) Metabolic reprogramming of the tumor. Oncogene 31: 3999–4011
-
(2012)
Oncogene
, vol.31
, pp. 3999-4011
-
-
Ferreira, L.1
Hebrant, A.2
Dumont, J.E.3
-
4
-
-
0035902166
-
Cancer genetics
-
Ponder BA (2001) Cancer genetics. Nature 411: 336–341
-
(2001)
Nature
, vol.411
, pp. 336-341
-
-
Ponder, B.A.1
-
5
-
-
0001740285
-
The metabolism of carcinoma cells
-
Warburg O (1925) The metabolism of carcinoma cells. J Cancer Res 9: 148–163
-
(1925)
J Cancer Res
, vol.9
, pp. 148-163
-
-
Warburg, O.1
-
6
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O (1956) On the origin of cancer cells. Science 123: 309–314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
7
-
-
0017173150
-
The Warburg hypothesis fifty years later
-
Weinhouse S (1976) The Warburg hypothesis fifty years later. Z Krebsforsch Klin Onkol 87: 115–126
-
(1976)
Z Krebsforsch Klin Onkol
, vol.87
, pp. 115-126
-
-
Weinhouse, S.1
-
8
-
-
0032520197
-
-
Jurica M, Mesecar A, Heath PJ, Shi W, Nowak T, Stoddard BL (1998) Structure 2: 195–210
-
(1998)
Structure
, vol.2
, pp. 195-210
-
-
Jurica, M.1
Mesecar, A.2
Heath, P.J.3
Shi, W.4
Nowak, T.5
Stoddard, B.L.6
-
9
-
-
0030024484
-
Alternative splicing of the pyruvate kinase M gene in a minigene system
-
Takenaka M, Yamada K, Lu T, Kang R, Tanaka T, Noguchi T (1996) Alternative splicing of the pyruvate kinase M gene in a minigene system. Eur J Biochem 235: 366–371
-
(1996)
Eur J Biochem
, vol.235
, pp. 366-371
-
-
Takenaka, M.1
Yamada, K.2
Lu, T.3
Kang, R.4
Tanaka, T.5
Noguchi, T.6
-
10
-
-
0022930036
-
The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing
-
Noguchi T, Inoue H, Tanaka T (1986) The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem 261: 13807–13812
-
(1986)
J Biol Chem
, vol.261
, pp. 13807-13812
-
-
Noguchi, T.1
Inoue, H.2
Tanaka, T.3
-
11
-
-
21844468220
-
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
-
Dombrauckas JD, Santarsiero BD, Mesecar AD (2005) Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry 44: 9417–9429
-
(2005)
Biochemistry
, vol.44
, pp. 9417-9429
-
-
Dombrauckas, J.D.1
Santarsiero, B.D.2
Mesecar, A.D.3
-
12
-
-
0016140938
-
Pyruvate kinase isozyme changes in parenchymal cells of regenerating rat liver
-
Garnett ME, Dyson RD, Dost FN (1974) Pyruvate kinase isozyme changes in parenchymal cells of regenerating rat liver. J Biol Chem 249: 5222–5226
-
(1974)
J Biol Chem
, vol.249
, pp. 5222-5226
-
-
Garnett, M.E.1
Dyson, R.D.2
Dost, F.N.3
-
13
-
-
40749163248
-
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
-
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452: 230–233
-
(2008)
Nature
, vol.452
, pp. 230-233
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Harris, M.H.3
Ramanathan, A.4
Gerszten, R.E.5
Wei, R.6
Fleming, M.D.7
Schreiber, S.L.8
Cantley, L.C.9
-
14
-
-
84965021899
-
Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
-
Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T et al (2016) Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev 30: 1020–1033
-
(2016)
Genes Dev
, vol.30
, pp. 1020-1033
-
-
Dayton, T.L.1
Gocheva, V.2
Miller, K.M.3
Israelsen, W.J.4
Bhutkar, A.5
Clish, C.B.6
Davidson, S.M.7
Luengo, A.8
Bronson, R.T.9
Jacks, T.10
-
15
-
-
79958103961
-
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells
-
Mazurek S (2010) Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 43: 969–980
-
(2010)
Int J Biochem Cell Biol
, vol.43
, pp. 969-980
-
-
Mazurek, S.1
-
16
-
-
78049416081
-
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged
-
David CJ, Manley JL (2010) Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev 24: 2343–2364
-
(2010)
Genes Dev
, vol.24
, pp. 2343-2364
-
-
David, C.J.1
Manley, J.L.2
-
17
-
-
76649102764
-
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism
-
Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR (2010) The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci USA 107: 1894–1899
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 1894-1899
-
-
Clower, C.V.1
Chatterjee, D.2
Wang, Z.3
Cantley, L.C.4
Vander Heiden, M.G.5
Krainer, A.R.6
-
18
-
-
40749099894
-
Pyruvate kinase M2 is a phosphotyrosine-binding protein
-
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (2008) Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452: 181–186
-
(2008)
Nature
, vol.452
, pp. 181-186
-
-
Christofk, H.R.1
Vander Heiden, M.G.2
Wu, N.3
Asara, J.M.4
Cantley, L.C.5
-
19
-
-
0038797314
-
Embden and the glycolytic pathway
-
Cori CF (1983) Embden and the glycolytic pathway. Trends Biochem Sci 8: 257–259
-
(1983)
Trends Biochem Sci
, vol.8
, pp. 257-259
-
-
Cori, C.F.1
-
20
-
-
0016303125
-
Some highlights of the early period of bioenergetics
-
Cori CF (1974) Some highlights of the early period of bioenergetics. Mol Cell Biochem 5: 47–53
-
(1974)
Mol Cell Biochem
, vol.5
, pp. 47-53
-
-
Cori, C.F.1
-
21
-
-
0038366899
-
A history of research on yeasts 5: the fermentation pathway
-
Barnett JA (2003) A history of research on yeasts 5: the fermentation pathway. Yeast 20: 509–543
-
(2003)
Yeast
, vol.20
, pp. 509-543
-
-
Barnett, J.A.1
-
22
-
-
22144484881
-
Red cell pyruvate kinase deficiency: molecular and clinical aspects
-
Zanella A, Fermo E, Bianchi P, Valentini G (2005) Red cell pyruvate kinase deficiency: molecular and clinical aspects. Br J Haemotol 130: 11–25
-
(2005)
Br J Haemotol
, vol.130
, pp. 11-25
-
-
Zanella, A.1
Fermo, E.2
Bianchi, P.3
Valentini, G.4
-
24
-
-
0014111814
-
Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues
-
Tanaka T, Harano Y, Sue F, Morimura H (1967) Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues. J Biochem 62: 71–91
-
(1967)
J Biochem
, vol.62
, pp. 71-91
-
-
Tanaka, T.1
Harano, Y.2
Sue, F.3
Morimura, H.4
-
25
-
-
0014410410
-
Some distinctive properties of pyruvate kinase purified from rat liver
-
Susor WA, Rutter WJ (1968) Some distinctive properties of pyruvate kinase purified from rat liver. Biochem Biophys Res Commun 30: 14–20
-
(1968)
Biochem Biophys Res Commun
, vol.30
, pp. 14-20
-
-
Susor, W.A.1
Rutter, W.J.2
-
26
-
-
0015924874
-
Pyruvate kinase isozymes: a comparative study in tissues of various mammalian species
-
Osterman J, Fritz PJ (1973) Pyruvate kinase isozymes: a comparative study in tissues of various mammalian species. Comp Biochem Physiol B 44: 1077–1085
-
(1973)
Comp Biochem Physiol B
, vol.44
, pp. 1077-1085
-
-
Osterman, J.1
Fritz, P.J.2
-
27
-
-
0016773154
-
Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues
-
Kamel R, Schwarzfischer F (1975) Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues. Humangenetik 28: 65–69
-
(1975)
Humangenetik
, vol.28
, pp. 65-69
-
-
Kamel, R.1
Schwarzfischer, F.2
-
28
-
-
0019509607
-
Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9
-
Peters J, Nash HR, Eicher EM, Bulfield G (1981) Polymorphism of kidney pyruvate kinase in the mouse is determined by a gene, Pk-3, on chromosome 9. Biochem Genet 19: 757–769
-
(1981)
Biochem Genet
, vol.19
, pp. 757-769
-
-
Peters, J.1
Nash, H.R.2
Eicher, E.M.3
Bulfield, G.4
-
29
-
-
0021689385
-
The Pk-3 gene determines both the heart, M1, and the kidney, M2, pyruvate kinase isozymes in the mouse; and a simple electrophoretic method for separating phosphoglucomutase-3
-
Peters J, Andrews SJ (1984) The Pk-3 gene determines both the heart, M1, and the kidney, M2, pyruvate kinase isozymes in the mouse; and a simple electrophoretic method for separating phosphoglucomutase-3. Biochem Genet 22: 1047–1063
-
(1984)
Biochem Genet
, vol.22
, pp. 1047-1063
-
-
Peters, J.1
Andrews, S.J.2
-
30
-
-
0025811030
-
Isolation and characterization of the human pyruvate kinase M gene
-
Takenaka M, Noguchi T, Sadahiro S, Hirai H, Yamada K, Matsuda T, Imai E, Tanaka T (1991) Isolation and characterization of the human pyruvate kinase M gene. Eur J Biochem 198: 101–106
-
(1991)
Eur J Biochem
, vol.198
, pp. 101-106
-
-
Takenaka, M.1
Noguchi, T.2
Sadahiro, S.3
Hirai, H.4
Yamada, K.5
Matsuda, T.6
Imai, E.7
Tanaka, T.8
-
31
-
-
0017357617
-
Differentiation in vivo and in vitro of pyruvate kinase isozymes in rat muscle
-
Guguen-Guillouzo C, Szajnert MF, Marie J, Delain D, Schapira F (1977) Differentiation in vivo and in vitro of pyruvate kinase isozymes in rat muscle. Biochimie 59: 65–71
-
(1977)
Biochimie
, vol.59
, pp. 65-71
-
-
Guguen-Guillouzo, C.1
Szajnert, M.F.2
Marie, J.3
Delain, D.4
Schapira, F.5
-
32
-
-
0037431006
-
Tumor M2-pyruvate kinase in the follow-up of inoperable lung cancer patients: a pilot study
-
Schneider J, Neu K, Velcovsky H-G, Morr H, Eigenbrodt E (2003) Tumor M2-pyruvate kinase in the follow-up of inoperable lung cancer patients: a pilot study. Cancer Lett 193: 91–98
-
(2003)
Cancer Lett
, vol.193
, pp. 91-98
-
-
Schneider, J.1
Neu, K.2
Velcovsky, H.-G.3
Morr, H.4
Eigenbrodt, E.5
-
33
-
-
0020047158
-
Expression of multimolecular forms of pyruvate kinase in normal, benign, and malignant breast tissue
-
Ibsen KH, Orlando RA, Garratt KN, Hernandez AM, Giorlando S, Nungaray G (1982) Expression of multimolecular forms of pyruvate kinase in normal, benign, and malignant breast tissue. Cancer Research 42: 888–892
-
(1982)
Cancer Research
, vol.42
, pp. 888-892
-
-
Ibsen, K.H.1
Orlando, R.A.2
Garratt, K.N.3
Hernandez, A.M.4
Giorlando, S.5
Nungaray, G.6
-
35
-
-
0015288970
-
Fetal-type isoenzymes in hepatic and nonhepatic rat tumors
-
Farron F, Hsu HH, Knox WE (1972) Fetal-type isoenzymes in hepatic and nonhepatic rat tumors. Cancer Res 32: 302–308
-
(1972)
Cancer Res
, vol.32
, pp. 302-308
-
-
Farron, F.1
Hsu, H.H.2
Knox, W.E.3
-
36
-
-
34147116745
-
Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase
-
Siwko S, Mochly-Rosen D (2007) Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase. Int J Biochem Cell Biol 39: 978–987
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 978-987
-
-
Siwko, S.1
Mochly-Rosen, D.2
-
37
-
-
34547130319
-
Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase
-
Hoshino A, Hirst JA, Fujii H (2007) Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase. J Biol Chem 282: 17706–17711
-
(2007)
J Biol Chem
, vol.282
, pp. 17706-17711
-
-
Hoshino, A.1
Hirst, J.A.2
Fujii, H.3
-
38
-
-
0032906762
-
Nutrient and hormonal regulation of pyruvate kinase gene expression
-
Yamada K, Noguchi T (1999) Nutrient and hormonal regulation of pyruvate kinase gene expression. Biochem J 337: 1–11
-
(1999)
Biochem J
, vol.337
, pp. 1-11
-
-
Yamada, K.1
Noguchi, T.2
-
39
-
-
0023918674
-
Hormonal regulation of hepatic gluconeogenesis and glycolysis
-
Pilkis SJ, El-Maghrabi MR (1988) Hormonal regulation of hepatic gluconeogenesis and glycolysis. Ann Rev Biochem 57: 755–783
-
(1988)
Ann Rev Biochem
, vol.57
, pp. 755-783
-
-
Pilkis, S.J.1
El-Maghrabi, M.R.2
-
41
-
-
0017364944
-
Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review
-
Ibsen KH (1977) Interrelationships and functions of the pyruvate kinase isozymes and their variant forms: a review. Cancer Res 37: 341–353
-
(1977)
Cancer Res
, vol.37
, pp. 341-353
-
-
Ibsen, K.H.1
-
42
-
-
0030795097
-
Conversion of non-allosteric pyruvate kinase isozyme into an allosteric enzyme by a single amino acid substitution
-
Ikeda Y, Tanaka T, Noguchi T (1997) Conversion of non-allosteric pyruvate kinase isozyme into an allosteric enzyme by a single amino acid substitution. J Biol Chem 272: 20495–20501
-
(1997)
J Biol Chem
, vol.272
, pp. 20495-20501
-
-
Ikeda, Y.1
Tanaka, T.2
Noguchi, T.3
-
43
-
-
84948094800
-
Pyruvate kinase: function, regulation and role in cancer
-
Israelsen WJ, Vander Heiden MG (2015) Pyruvate kinase: function, regulation and role in cancer. Semin Cell Dev Biol 43: 43–51
-
(2015)
Semin Cell Dev Biol
, vol.43
, pp. 43-51
-
-
Israelsen, W.J.1
Vander Heiden, M.G.2
-
44
-
-
0032524663
-
Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact
-
Ikeda Y, Noguchi T (1998) Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact. J Biol Chem 273: 12227–12233
-
(1998)
J Biol Chem
, vol.273
, pp. 12227-12233
-
-
Ikeda, Y.1
Noguchi, T.2
-
45
-
-
0033574227
-
Regulation of pyruvate kinase M gene expression
-
Yamada K, Noguchi T (1999) Regulation of pyruvate kinase M gene expression. Biochem Biophys Res Commun 256: 257–262
-
(1999)
Biochem Biophys Res Commun
, vol.256
, pp. 257-262
-
-
Yamada, K.1
Noguchi, T.2
-
46
-
-
84866842363
-
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
-
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A et al (2012) Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol 8: 839–847
-
(2012)
Nat Chem Biol
, vol.8
, pp. 839-847
-
-
Anastasiou, D.1
Yu, Y.2
Israelsen, W.J.3
Jiang, J.K.4
Boxer, M.B.5
Hong, B.S.6
Tempel, W.7
Dimov, S.8
Shen, M.9
Jha, A.10
-
47
-
-
0025884038
-
An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate
-
Ashizawa K, McPhie P, Lin KH, Cheng SY (1991) An in vitro novel mechanism of regulating the activity of pyruvate kinase M2 by thyroid hormone and fructose 1, 6-bisphosphate. Biochemistry 30: 7105–7111
-
(1991)
Biochemistry
, vol.30
, pp. 7105-7111
-
-
Ashizawa, K.1
McPhie, P.2
Lin, K.H.3
Cheng, S.Y.4
-
48
-
-
84876058530
-
M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
-
Morgan HP, O'Reilly FJ, Wear MA, O'Neill JR, Fothergill Gilmore LA, Hupp T, Walkinshaw MD (2013) M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proc Natl Acad Sci USA 110: 5881–5886
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 5881-5886
-
-
Morgan, H.P.1
O'Reilly, F.J.2
Wear, M.A.3
O'Neill, J.R.4
Fothergill Gilmore, L.A.5
Hupp, T.6
Walkinshaw, M.D.7
-
49
-
-
84869888609
-
SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions
-
Keller KE, Tan IS, Lee YS (2012) SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science 338: 1069–1072
-
(2012)
Science
, vol.338
, pp. 1069-1072
-
-
Keller, K.E.1
Tan, I.S.2
Lee, Y.S.3
-
50
-
-
33646347609
-
Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase
-
Williams R, Holyoak T, McDonald G, Gui C, Fenton A (2006) Differentiating a ligand's chemical requirements for allosteric interactions from those for protein binding. Phenylalanine inhibition of pyruvate kinase. Biochemistry 45: 5421–5429
-
(2006)
Biochemistry
, vol.45
, pp. 5421-5429
-
-
Williams, R.1
Holyoak, T.2
McDonald, G.3
Gui, C.4
Fenton, A.5
-
51
-
-
77449131347
-
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
-
Hitosugi T, Kang S, Vander Heiden MG, Chung T-W, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ et al (2009) Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Sci Signal 2: ra73
-
(2009)
Sci Signal
, vol.2
, pp. ra73
-
-
Hitosugi, T.1
Kang, S.2
Vander Heiden, M.G.3
Chung, T.-W.4
Elf, S.5
Lythgoe, K.6
Dong, S.7
Lonial, S.8
Wang, X.9
Chen, G.Z.10
-
52
-
-
0024261927
-
Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus
-
Presek P, Reinacher M, Eigenbrodt E (1988) Pyruvate kinase type M2 is phosphorylated at tyrosine residues in cells transformed by Rous sarcoma virus. FEBS Lett 242: 194–198
-
(1988)
FEBS Lett
, vol.242
, pp. 194-198
-
-
Presek, P.1
Reinacher, M.2
Eigenbrodt, E.3
-
53
-
-
84896764451
-
SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells
-
Keller KE, Doctor ZM, Dwyer ZW, Lee Y-S (2014) SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. Mol Cell 53: 700–709
-
(2014)
Mol Cell
, vol.53
, pp. 700-709
-
-
Keller, K.E.1
Doctor, Z.M.2
Dwyer, Z.W.3
Lee, Y.-S.4
-
54
-
-
79959371914
-
Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth
-
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y et al (2011) Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell 42: 719–730
-
(2011)
Mol Cell
, vol.42
, pp. 719-730
-
-
Lv, L.1
Li, D.2
Zhao, D.3
Lin, R.4
Chu, Y.5
Zhang, H.6
Zha, Z.7
Liu, Y.8
Li, Z.9
Xu, Y.10
-
55
-
-
82755166890
-
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
-
Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang J-K, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS et al (2011) Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 334: 1278–1283
-
(2011)
Science
, vol.334
, pp. 1278-1283
-
-
Anastasiou, D.1
Poulogiannis, G.2
Asara, J.M.3
Boxer, M.B.4
Jiang, J.-K.5
Shen, M.6
Bellinger, G.7
Sasaki, A.T.8
Locasale, J.W.9
Auld, D.S.10
-
56
-
-
0026467983
-
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
-
Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R (1992) Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog 3: 91–115
-
(1992)
Crit Rev Oncog
, vol.3
, pp. 91-115
-
-
Eigenbrodt, E.1
Reinacher, M.2
Scheefers-Borchel, U.3
Scheefers, H.4
Friis, R.5
-
57
-
-
0026467983
-
Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
-
Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R (1992) Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog 3: 91–115
-
(1992)
Crit Rev Oncog
, vol.3
, pp. 91-115
-
-
Eigenbrodt, E.1
Reinacher, M.2
Scheefers-Borchel, U.3
Scheefers, H.4
Friis, R.5
-
58
-
-
84866697915
-
Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
-
Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, Delabarre B, Cianchetta G, Sethumadhavan S, Wang X et al (2012) Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chem Biol 19: 1187–1198
-
(2012)
Chem Biol
, vol.19
, pp. 1187-1198
-
-
Kung, C.1
Hixon, J.2
Choe, S.3
Marks, K.4
Gross, S.5
Murphy, E.6
Delabarre, B.7
Cianchetta, G.8
Sethumadhavan, S.9
Wang, X.10
-
59
-
-
84869082905
-
Serine is a natural ligand and allosteric activator of pyruvate kinase M2
-
Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH et al (2012) Serine is a natural ligand and allosteric activator of pyruvate kinase M2. Nature 491: 458–462
-
(2012)
Nature
, vol.491
, pp. 458-462
-
-
Chaneton, B.1
Hillmann, P.2
Zheng, L.3
Martin, A.C.4
Maddocks, O.D.5
Chokkathukalam, A.6
Coyle, J.E.7
Jankevics, A.8
Holding, F.P.9
Vousden, K.H.10
-
60
-
-
80051923932
-
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
-
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK et al (2011) Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 476: 346–350
-
(2011)
Nature
, vol.476
, pp. 346-350
-
-
Possemato, R.1
Marks, K.M.2
Shaul, Y.D.3
Pacold, M.E.4
Kim, D.5
Birsoy, K.6
Sethumadhavan, S.7
Woo, H.K.8
Jang, H.G.9
Jha, A.K.10
-
61
-
-
80052258995
-
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
-
Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H et al (2011) Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 43: 869–874
-
(2011)
Nat Genet
, vol.43
, pp. 869-874
-
-
Locasale, J.W.1
Grassian, A.R.2
Melman, T.3
Lyssiotis, C.A.4
Mattaini, K.R.5
Bass, A.J.6
Heffron, G.7
Metallo, C.M.8
Muranen, T.9
Sharfi, H.10
-
62
-
-
84862017246
-
Resurgence of serine: an often neglected but indispensable amino Acid
-
Kalhan SC, Hanson RW (2012) Resurgence of serine: an often neglected but indispensable amino Acid. J Biol Chem 287: 19786–19791
-
(2012)
J Biol Chem
, vol.287
, pp. 19786-19791
-
-
Kalhan, S.C.1
Hanson, R.W.2
-
63
-
-
84872905650
-
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
-
Maddocks ODK, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, Vousden KH (2013) Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature 493: 542–546
-
(2013)
Nature
, vol.493
, pp. 542-546
-
-
Maddocks, O.D.K.1
Berkers, C.R.2
Mason, S.M.3
Zheng, L.4
Blyth, K.5
Gottlieb, E.6
Vousden, K.H.7
-
64
-
-
84949102276
-
NRF2 regulates serine biosynthesis in non-small cell lung cancer
-
DeNicola GM, Chen P-H, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE et al (2015) NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nat Genet 47: 1475–1481
-
(2015)
Nat Genet
, vol.47
, pp. 1475-1481
-
-
DeNicola, G.M.1
Chen, P.-H.2
Mullarky, E.3
Sudderth, J.A.4
Hu, Z.5
Wu, D.6
Tang, H.7
Xie, Y.8
Asara, J.M.9
Huffman, K.E.10
-
65
-
-
84959467603
-
Pyruvate and metabolic flexibility: illuminating a path toward selective cancer therapies
-
Olson KA, Schell JC, Rutter J (2016) Pyruvate and metabolic flexibility: illuminating a path toward selective cancer therapies. Trends Biochem Sci 41: 219–230
-
(2016)
Trends Biochem Sci
, vol.41
, pp. 219-230
-
-
Olson, K.A.1
Schell, J.C.2
Rutter, J.3
-
66
-
-
79957567239
-
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
-
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'meally R, Cole RN, Pandey A, Semenza GL (2011) Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145: 732–744.
-
(2011)
Cell
, vol.145
, pp. 732-744
-
-
Luo, W.1
Hu, H.2
Chang, R.3
Zhong, J.4
Knabel, M.5
O'meally, R.6
Cole, R.N.7
Pandey, A.8
Semenza, G.L.9
-
67
-
-
84891953688
-
JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism
-
Wang H-J, Hsieh Y-J, Cheng W-C, Lin C-P, Lin Y-S, Yang S-F, Chen C-C, Izumiya Y, Yu J-S, Kung H-J et al (2014) JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism. Proc Natl Acad Sci USA 111: 279–284
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 279-284
-
-
Wang, H.-J.1
Hsieh, Y.-J.2
Cheng, W.-C.3
Lin, C.-P.4
Lin, Y.-S.5
Yang, S.-F.6
Chen, C.-C.7
Izumiya, Y.8
Yu, J.-S.9
Kung, H.-J.10
-
68
-
-
82555170271
-
Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation
-
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z (2011) Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation. Nature 480: 118–122
-
(2011)
Nature
, vol.480
, pp. 118-122
-
-
Yang, W.1
Xia, Y.2
Ji, H.3
Zheng, Y.4
Liang, J.5
Huang, W.6
Gao, X.7
Aldape, K.8
Lu, Z.9
-
69
-
-
84870598190
-
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
-
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z (2012) ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 14: 1295–1304
-
(2012)
Nat Cell Biol
, vol.14
, pp. 1295-1304
-
-
Yang, W.1
Zheng, Y.2
Xia, Y.3
Ji, H.4
Chen, X.5
Guo, F.6
Lyssiotis, C.A.7
Aldape, K.8
Cantley, L.C.9
Lu, Z.10
-
70
-
-
84862776933
-
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
-
Gao X, Wang H, Yang JJ, Liu X, Liu Z-R (2012) Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell 45: 598–609
-
(2012)
Mol Cell
, vol.45
, pp. 598-609
-
-
Gao, X.1
Wang, H.2
Yang, J.J.3
Liu, X.4
Liu, Z.-R.5
-
71
-
-
84878414647
-
Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals
-
Gao X, Wang H, Yang JJ, Chen J, Jie J, Li L, Zhang Y, Liu Z-R (2013) Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals. J Biol Chem 288: 15971–15979
-
(2013)
J Biol Chem
, vol.288
, pp. 15971-15979
-
-
Gao, X.1
Wang, H.2
Yang, J.J.3
Chen, J.4
Jie, J.5
Li, L.6
Zhang, Y.7
Liu, Z.-R.8
-
72
-
-
84923350831
-
PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells
-
Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX et al (2014) PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nat Commun 5: 5566
-
(2014)
Nat Commun
, vol.5
, pp. 5566
-
-
Jiang, Y.1
Wang, Y.2
Wang, T.3
Hawke, D.H.4
Zheng, Y.5
Li, X.6
Zhou, Q.7
Majumder, S.8
Bi, E.9
Liu, D.X.10
-
73
-
-
84892366115
-
PKM2 regulates chromosome segregation and mitosis progression of tumor cells
-
Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y et al (2014) PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell 53: 75–87
-
(2014)
Mol Cell
, vol.53
, pp. 75-87
-
-
Jiang, Y.1
Li, X.2
Yang, W.3
Hawke, D.H.4
Zheng, Y.5
Xia, Y.6
Aldape, K.7
Wei, C.8
Guo, F.9
Chen, Y.10
-
74
-
-
84885589840
-
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
-
Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW et al (2013) PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 155: 397–409
-
(2013)
Cell
, vol.155
, pp. 397-409
-
-
Israelsen, W.J.1
Dayton, T.L.2
Davidson, S.M.3
Fiske, B.P.4
Hosios, A.M.5
Bellinger, G.6
Li, J.7
Yu, Y.8
Sasaki, M.9
Horner, J.W.10
-
75
-
-
84908058792
-
Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis
-
Wang Y-H, Israelsen WJ, Lee D, Yu VWC, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT (2014) Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell 158: 1309–1323
-
(2014)
Cell
, vol.158
, pp. 1309-1323
-
-
Wang, Y.-H.1
Israelsen, W.J.2
Lee, D.3
Yu, V.W.C.4
Jeanson, N.T.5
Clish, C.B.6
Cantley, L.C.7
Vander Heiden, M.G.8
Scadden, D.T.9
-
77
-
-
84920447418
-
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation
-
Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PNM et al (2015) Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell 57: 95–107
-
(2015)
Mol Cell
, vol.57
, pp. 95-107
-
-
Lunt, S.Y.1
Muralidhar, V.2
Hosios, A.M.3
Israelsen, W.J.4
Gui, D.Y.5
Newhouse, L.6
Ogrodzinski, M.7
Hecht, V.8
Xu, K.9
Acevedo, P.N.M.10
-
78
-
-
84920591180
-
Pyruvate kinase M2 regulates hif-1alpha; activity and IL-1beta; induction and is a critical determinant of the Warburg effect in LPS-activated macrophages
-
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MAR, Sheedy FJ, Gleeson LE, van den Bosch MWM, Quinn SR, Domingo-Fernandez R, Johnston DGW et al (2015) Pyruvate kinase M2 regulates hif-1alpha; activity and IL-1beta; induction and is a critical determinant of the Warburg effect in LPS-activated macrophages. Cell Metab 21: 65–80
-
(2015)
Cell Metab
, vol.21
, pp. 65-80
-
-
Palsson-McDermott, E.M.1
Curtis, A.M.2
Goel, G.3
Lauterbach, M.A.R.4
Sheedy, F.J.5
Gleeson, L.E.6
van den Bosch, M.W.M.7
Quinn, S.R.8
Domingo-Fernandez, R.9
Johnston, D.G.W.10
-
79
-
-
84964211524
-
Integrative phosphoproteomics links IL-23R signaling with metabolic adaptation in lymphocytes
-
Lochmatter C, Fischer R, Charles PD, Yu Z, Powrie F, Kessler BM (2016) Integrative phosphoproteomics links IL-23R signaling with metabolic adaptation in lymphocytes. Sci Rep 6: 24491
-
(2016)
Sci Rep
, vol.6
, pp. 24491
-
-
Lochmatter, C.1
Fischer, R.2
Charles, P.D.3
Yu, Z.4
Powrie, F.5
Kessler, B.M.6
|