Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Nature Communications

Volumn 8, Issue , 2017, Pages

  Elia, Ilaria ^a,b   Broekaert, Dorien ^a,b   Christen, Stefan ^a,b   Boon, Ruben ^b   Radaelli, Enrico ^b   Orth, Martin F ^c   Verfaillie, Catherine ^b   Grünewald, Thomas G P ^c   Fendt, Sarah Maria ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; ALANINE; ANTIMETASTATIC AGENT; ANTIMYCIN A1; ASPARTIC ACID; CITRIC ACID; FUMARIC ACID; LACTIC ACID; MALIC ACID; OXIDOREDUCTASE INHIBITOR; PROLINE; PROLINE DEHYDROGENASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); TETRAHYDRO 2 FUROIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; DELTA-1-PYRROLINE-5-CARBOXYLATE REDUCTASE; DELTA1-PYRROLINE-5-CARBOXYLATE SYNTHASE, HUMAN; PRODH PROTEIN, HUMAN; PYRROLINE 5 CARBOXYLATE REDUCTASE;

AMINO ACID; CANCER; CELLS AND CELL COMPONENTS; DRUG; ENZYME; ENZYME ACTIVITY; GENE; GENE EXPRESSION; MORTALITY; PHENOTYPE;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER GROWTH; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; ANIMAL; C57BL MOUSE; CELL CULTURE TECHNIQUE; CELL PROLIFERATION; LUNG TUMOR; METABOLISM; MULTICELLULAR SPHEROID; PATHOLOGY; SECONDARY; TRANSFORMED CELL LINE; TUMOR CELL LINE;

MUS;

ADENOSINE TRIPHOSPHATE; ALDEHYDE DEHYDROGENASE; ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LUNG NEOPLASMS; MICE, INBRED C57BL; PROLINE; PROLINE OXIDASE; PYRROLINE CARBOXYLATE REDUCTASES; SPHEROIDS, CELLULAR;

EID: 85025454842     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms15267     Document Type: Article

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