메뉴 건너뛰기




Volumn 54, Issue , 2017, Pages 50-57

Metabolic interactions with cancer epigenetics

Author keywords

Acetyl CoA; Methionine; One carbon metabolism; S Adenosyl methionine; Serine; Ketoglutarate

Indexed keywords

2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ACETYL COENZYME A; ACYL COA SYNTHETASE SHORT CHAIN FAMILY MEMBER 2; ADENOSINE TRIPHOSPHATE CITRATE SYNTHASE; BUTYRIC ACID; DNA METHYLTRANSFERASE; FUMARATE HYDRATASE; GLUTAMATE DEHYDROGENASE; GLYCINE; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE GCN5; HISTONE ACETYLTRANSFERASE MYST; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE 1; HISTONE DEMETHYLASE; HISTONE METHYLTRANSFERASE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; ISOCITRATE DEHYDROGENASE 3; LONG CHAIN FATTY ACID COENZYME A LIGASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHOGLYCERATE DEHYDROGENASE; S ADENOSYLMETHIONINE; SERINE; SPERMIDINE; SPERMINE; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; HISTONE;

EID: 84994497591     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2016.09.001     Document Type: Review
Times cited : (39)

References (107)
  • 1
    • 78751676934 scopus 로고    scopus 로고
    • KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism
    • Albaugh, B.N., Arnold, K.M., Denu, J.M., KAT(ching) metabolism by the tail: insight into the links between lysine acetyltransferases and metabolism. Chembiochem 12:2 (2011), 290–298.
    • (2011) Chembiochem , vol.12 , Issue.2 , pp. 290-298
    • Albaugh, B.N.1    Arnold, K.M.2    Denu, J.M.3
  • 2
    • 84864010293 scopus 로고    scopus 로고
    • Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation
    • Anderson, O.S., Sant, K.E., Dolinoy, D.C., Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. J. Nutr. Biochem 23:8 (2012), 853–859.
    • (2012) J. Nutr. Biochem , vol.23 , Issue.8 , pp. 853-859
    • Anderson, O.S.1    Sant, K.E.2    Dolinoy, D.C.3
  • 3
    • 80053144962 scopus 로고    scopus 로고
    • A decade of exploring the cancer epigenome – biological and translational implications
    • Baylin, S.B., Jones, P.A., A decade of exploring the cancer epigenome – biological and translational implications. Nat. Rev. Cancer 11:10 (2011), 726–734.
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.10 , pp. 726-734
    • Baylin, S.B.1    Jones, P.A.2
  • 4
    • 84455160888 scopus 로고    scopus 로고
    • Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice
    • Beaudin, A.E., Abarinov, E.V., Malysheva, O., Perry, C.A., Caudill, M., Stover, P.J., Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am. J. Clin. Nutr 95:1 (2012), 109–114.
    • (2012) Am. J. Clin. Nutr , vol.95 , Issue.1 , pp. 109-114
    • Beaudin, A.E.1    Abarinov, E.V.2    Malysheva, O.3    Perry, C.A.4    Caudill, M.5    Stover, P.J.6
  • 5
    • 84856298658 scopus 로고    scopus 로고
    • Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
    • Borger, D.R., Tanabe, K.K., Fan, K.C., Lopez, H.U., Fantin, V.R., Straley, K.S., et al. Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping. Oncologist 17:1 (2012), 72–79.
    • (2012) Oncologist , vol.17 , Issue.1 , pp. 72-79
    • Borger, D.R.1    Tanabe, K.K.2    Fan, K.C.3    Lopez, H.U.4    Fantin, V.R.5    Straley, K.S.6
  • 6
    • 84925969707 scopus 로고    scopus 로고
    • Metabolic pathways promoting cancer cell survival and growth
    • Boroughs, L.K., DeBerardinis, R.J., Metabolic pathways promoting cancer cell survival and growth. Nat. Cell Biol 17:4 (2015), 351–359.
    • (2015) Nat. Cell Biol , vol.17 , Issue.4 , pp. 351-359
    • Boroughs, L.K.1    DeBerardinis, R.J.2
  • 7
    • 79955960768 scopus 로고    scopus 로고
    • Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
    • Cai, L., Sutter, B.M., Li, B., Tu, B.P., Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol. Cell 42:4 (2011), 426–437.
    • (2011) Mol. Cell , vol.42 , Issue.4 , pp. 426-437
    • Cai, L.1    Sutter, B.M.2    Li, B.3    Tu, B.P.4
  • 8
    • 78650306174 scopus 로고    scopus 로고
    • IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia
    • Caramazza, D., Lasho, T.L., Finke, C.M., Gangat, N., Dingli, D., Knudson, R.A., et al. IDH mutations and trisomy 8 in myelodysplastic syndromes and acute myeloid leukemia. Leukemia 24:12 (2010), 2120–2122.
    • (2010) Leukemia , vol.24 , Issue.12 , pp. 2120-2122
    • Caramazza, D.1    Lasho, T.L.2    Finke, C.M.3    Gangat, N.4    Dingli, D.5    Knudson, R.A.6
  • 9
    • 84925503908 scopus 로고    scopus 로고
    • Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells
    • Carey, B.W., Finley, L.W., Cross, J.R., Allis, C.D., Thompson, C.B., Intracellular alpha-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518:7539 (2015), 413–416.
    • (2015) Nature , vol.518 , Issue.7539 , pp. 413-416
    • Carey, B.W.1    Finley, L.W.2    Cross, J.R.3    Allis, C.D.4    Thompson, C.B.5
  • 10
    • 84912002823 scopus 로고    scopus 로고
    • Metabolism and epigenetics: a link cancer cells exploit
    • Carrer, A., Wellen, K.E., Metabolism and epigenetics: a link cancer cells exploit. Curr. Opin. Biotechnol 34 (2015), 23–29.
    • (2015) Curr. Opin. Biotechnol , vol.34 , pp. 23-29
    • Carrer, A.1    Wellen, K.E.2
  • 11
    • 84861701419 scopus 로고    scopus 로고
    • A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension
    • Cavuoto, P., Fenech, M.F., A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat. Rev 38:6 (2012), 726–736.
    • (2012) Cancer Treat. Rev , vol.38 , Issue.6 , pp. 726-736
    • Cavuoto, P.1    Fenech, M.F.2
  • 12
    • 84942372058 scopus 로고    scopus 로고
    • The multifaceted functions of sirtuins in cancer
    • Chalkiadaki, A., Guarente, L., The multifaceted functions of sirtuins in cancer. Nat. Rev. Cancer 15:10 (2015), 608–624.
    • (2015) Nat. Rev. Cancer , vol.15 , Issue.10 , pp. 608-624
    • Chalkiadaki, A.1    Guarente, L.2
  • 13
    • 0030023025 scopus 로고    scopus 로고
    • Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy
    • Chen, Z.H., Zhang, H., Savarese, T.M., Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the alpha- and beta-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. Cancer Res 56:5 (1996), 1083–1090.
    • (1996) Cancer Res , vol.56 , Issue.5 , pp. 1083-1090
    • Chen, Z.H.1    Zhang, H.2    Savarese, T.M.3
  • 14
    • 85013861713 scopus 로고    scopus 로고
    • The rate of glycolysis quantitatively mediates specific histone acetylation sites
    • Cluntun, A.A., Huang, H., Dai, L., Liu, X., Zhao, Y., Locasale, J.W., The rate of glycolysis quantitatively mediates specific histone acetylation sites. Cancer Metab, 3, 2015, 10.
    • (2015) Cancer Metab , vol.3 , pp. 10
    • Cluntun, A.A.1    Huang, H.2    Dai, L.3    Liu, X.4    Zhao, Y.5    Locasale, J.W.6
  • 16
    • 0347564583 scopus 로고
    • Isocitrate dehydrogenase and related oxidative decarboxylases
    • Dalziel, K., Isocitrate dehydrogenase and related oxidative decarboxylases. FEBS Lett 117:Suppl. (1980), K45–K55.
    • (1980) FEBS Lett , vol.117 , pp. K45-K55
    • Dalziel, K.1
  • 17
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang, L., White, D.W., Gross, S., Bennett, B.D., Bittinger, M.A., Driggers, E.M., et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:7274 (2009), 739–744.
    • (2009) Nature , vol.462 , Issue.7274 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3    Bennett, B.D.4    Bittinger, M.A.5    Driggers, E.M.6
  • 18
    • 77956265489 scopus 로고    scopus 로고
    • IDH mutations in glioma and acute myeloid leukemia
    • Dang, L., Jin, S., Su, S.M., IDH mutations in glioma and acute myeloid leukemia. Trends Mol. Med 16:9 (2010), 387–397.
    • (2010) Trends Mol. Med , vol.16 , Issue.9 , pp. 387-397
    • Dang, L.1    Jin, S.2    Su, S.M.3
  • 20
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: from mechanism to therapy
    • Dawson, M.A., Kouzarides, T., Cancer epigenetics: from mechanism to therapy. Cell 150:1 (2012), 12–27.
    • (2012) Cell , vol.150 , Issue.1 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 21
    • 84943456112 scopus 로고    scopus 로고
    • s-adenosylmethionine levels govern innate immunity through distinct methylation-dependent pathways
    • Ding, W., Smulan, L.J., Hou, N.S., Taubert, S., Watts, J.L., Walker, A.K., s-adenosylmethionine levels govern innate immunity through distinct methylation-dependent pathways. Cell Metab 22:4 (2015), 633–645.
    • (2015) Cell Metab , vol.22 , Issue.4 , pp. 633-645
    • Ding, W.1    Smulan, L.J.2    Hou, N.S.3    Taubert, S.4    Watts, J.L.5    Walker, A.K.6
  • 22
    • 84870389262 scopus 로고    scopus 로고
    • The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation
    • Donohoe, D.R., Collins, L.B., Wali, A., Bigler, R., Sun, W., Bultman, S.J., The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol. Cell 48:4 (2012), 612–626.
    • (2012) Mol. Cell , vol.48 , Issue.4 , pp. 612-626
    • Donohoe, D.R.1    Collins, L.B.2    Wali, A.3    Bigler, R.4    Sun, W.5    Bultman, S.J.6
  • 23
    • 84911993839 scopus 로고    scopus 로고
    • A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner
    • Donohoe, D.R., Holley, D., Collins, L.B., Montgomery, S.A., Whitmore, A.C., Hillhouse, A., et al. A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner. Cancer Discov 4:12 (2014), 1387–1397.
    • (2014) Cancer Discov , vol.4 , Issue.12 , pp. 1387-1397
    • Donohoe, D.R.1    Holley, D.2    Collins, L.B.3    Montgomery, S.A.4    Whitmore, A.C.5    Hillhouse, A.6
  • 24
    • 84939865663 scopus 로고    scopus 로고
    • c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate
    • Edmunds, L.R., Sharma, L., Kang, A., Lu, J., Vockley, J., Basu, S., et al. c-Myc programs fatty acid metabolism and dictates acetyl-CoA abundance and fate. J. Biol. Chem, 290(33), 2015, 20100.
    • (2015) J. Biol. Chem , vol.290 , Issue.33 , pp. 20100
    • Edmunds, L.R.1    Sharma, L.2    Kang, A.3    Lu, J.4    Vockley, J.5    Basu, S.6
  • 25
    • 78651010566 scopus 로고
    • Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid
    • Farber, S., Diamond, L.K., Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N. Engl. J. Med 238:23 (1948), 787–793.
    • (1948) N. Engl. J. Med , vol.238 , Issue.23 , pp. 787-793
    • Farber, S.1    Diamond, L.K.2
  • 26
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg, A.P., Tycko, B., The history of cancer epigenetics. Nat. Rev. Cancer 4:2 (2004), 143–153.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 27
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg, A.P., Vogelstein, B., Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301:5895 (1983), 89–92.
    • (1983) Nature , vol.301 , Issue.5895 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 28
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa, M.E., Abdel-Wahab, O., Lu, C., Ward, P.S., Patel, J., Shih, A., et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18:6 (2010), 553–567.
    • (2010) Cancer Cell , vol.18 , Issue.6 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 29
    • 0037117501 scopus 로고    scopus 로고
    • A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    • Friso, S., Choi, S.W., Girelli, D., Mason, J.B., Dolnikowski, G.G., Bagley, P.J., et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl. Acad. Sci. U.S.A. 99:8 (2002), 5606–5611.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , Issue.8 , pp. 5606-5611
    • Friso, S.1    Choi, S.W.2    Girelli, D.3    Mason, J.B.4    Dolnikowski, G.G.5    Bagley, P.J.6
  • 31
    • 2942608990 scopus 로고    scopus 로고
    • Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults
    • Gemmati, D., Ongaro, A., Scapoli, G.L., Della Porta, M., Tognazzo, S., Serino, M.L., et al. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol. Biomarkers Prev 13:5 (2004), 787–794.
    • (2004) Cancer Epidemiol. Biomarkers Prev , vol.13 , Issue.5 , pp. 787-794
    • Gemmati, D.1    Ongaro, A.2    Scapoli, G.L.3    Della Porta, M.4    Tognazzo, S.5    Serino, M.L.6
  • 32
    • 84886812954 scopus 로고    scopus 로고
    • The nexus of chromatin regulation and intermediary metabolism
    • Gut, P., Verdin, E., The nexus of chromatin regulation and intermediary metabolism. Nature 502:7472 (2013), 489–498.
    • (2013) Nature , vol.502 , Issue.7472 , pp. 489-498
    • Gut, P.1    Verdin, E.2
  • 33
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., Weinberg, R.A., Hallmarks of cancer: the next generation. Cell 144:5 (2011), 646–674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 34
    • 84921417598 scopus 로고    scopus 로고
    • Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation
    • Henry, R.A., Kuo, Y.M., Bhattacharjee, V., Yen, T.J., Andrews, A.J., Changing the selectivity of p300 by acetyl-CoA modulation of histone acetylation. ACS Chem. Biol 10:1 (2015), 146–156.
    • (2015) ACS Chem. Biol , vol.10 , Issue.1 , pp. 146-156
    • Henry, R.A.1    Kuo, Y.M.2    Bhattacharjee, V.3    Yen, T.J.4    Andrews, A.J.5
  • 35
    • 84958120328 scopus 로고    scopus 로고
    • Metabolic heterogeneity in human lung tumors
    • Hensley, C.T., Faubert, B., Yuan, Q., Lev-Cohain, N., Jin, E., Kim, J., et al. Metabolic heterogeneity in human lung tumors. Cell 164:4 (2016), 681–694.
    • (2016) Cell , vol.164 , Issue.4 , pp. 681-694
    • Hensley, C.T.1    Faubert, B.2    Yuan, Q.3    Lev-Cohain, N.4    Jin, E.5    Kim, J.6
  • 36
    • 0020327457 scopus 로고
    • Methionine dependence in cancer cells – a review
    • Hoffman, R.M., Methionine dependence in cancer cells – a review. In Vitro 18:5 (1982), 421–428.
    • (1982) In Vitro , vol.18 , Issue.5 , pp. 421-428
    • Hoffman, R.M.1
  • 38
    • 84940478601 scopus 로고    scopus 로고
    • Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation
    • Jiang, Y., Qian, X., Shen, J., Wang, Y., Li, X., Liu, R., et al. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat. Cell Biol 17:9 (2015), 1158–1168.
    • (2015) Nat. Cell Biol , vol.17 , Issue.9 , pp. 1158-1168
    • Jiang, Y.1    Qian, X.2    Shen, J.3    Wang, Y.4    Li, X.5    Liu, R.6
  • 40
    • 84904677477 scopus 로고    scopus 로고
    • Sulfur as a signaling nutrient through hydrogen sulfide
    • Kabil, O., Vitvitsky, V., Banerjee, R., Sulfur as a signaling nutrient through hydrogen sulfide. Annu. Rev. Nutr 34 (2014), 171–205.
    • (2014) Annu. Rev. Nutr , vol.34 , pp. 171-205
    • Kabil, O.1    Vitvitsky, V.2    Banerjee, R.3
  • 41
    • 84875755814 scopus 로고    scopus 로고
    • Influence of metabolism on epigenetics and disease
    • Kaelin, W.G. Jr., McKnight, S.L., Influence of metabolism on epigenetics and disease. Cell 153:1 (2013), 56–69.
    • (2013) Cell , vol.153 , Issue.1 , pp. 56-69
    • Kaelin, W.G.1    McKnight, S.L.2
  • 43
    • 84878152241 scopus 로고    scopus 로고
    • Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor
    • Killian, J.K., Kim, S.Y., Miettinen, M., Smith, C., Merino, M., Tsokos, M., et al. Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor. Cancer Discov 3:6 (2013), 648–657.
    • (2013) Cancer Discov , vol.3 , Issue.6 , pp. 648-657
    • Killian, J.K.1    Kim, S.Y.2    Miettinen, M.3    Smith, C.4    Merino, M.5    Tsokos, M.6
  • 44
    • 84886860116 scopus 로고    scopus 로고
    • TET enzymes, TDG and the dynamics of DNA demethylation
    • Kohli, R.M., Zhang, Y., TET enzymes, TDG and the dynamics of DNA demethylation. Nature 502:7472 (2013), 472–479.
    • (2013) Nature , vol.502 , Issue.7472 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 45
    • 84960916279 scopus 로고    scopus 로고
    • MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
    • Kryukov, G.V., Wilson, F.H., Ruth, J.R., Paulk, J., Tsherniak, A., Marlow, S.E., et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science, 351(6278), 2016.
    • (2016) Science , vol.351 , Issue.6278
    • Kryukov, G.V.1    Wilson, F.H.2    Ruth, J.R.3    Paulk, J.4    Tsherniak, A.5    Marlow, S.E.6
  • 46
    • 0037178860 scopus 로고    scopus 로고
    • Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases
    • Langer, M.R., Fry, C.J., Peterson, C.L., Denu, J.M., Modulating acetyl-CoA binding in the GCN5 family of histone acetyltransferases. J. Biol. Chem 277:30 (2002), 27337–27344.
    • (2002) J. Biol. Chem , vol.277 , Issue.30 , pp. 27337-27344
    • Langer, M.R.1    Fry, C.J.2    Peterson, C.L.3    Denu, J.M.4
  • 47
    • 84905816638 scopus 로고    scopus 로고
    • Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
    • Lee, J.V., Carrer, A., Shah, S., Snyder, N.W., Wei, S., Venneti, S., et al. Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation. Cell Metab 20:2 (2014), 306–319.
    • (2014) Cell Metab , vol.20 , Issue.2 , pp. 306-319
    • Lee, J.V.1    Carrer, A.2    Shah, S.3    Snyder, N.W.4    Wei, S.5    Venneti, S.6
  • 49
    • 84857804808 scopus 로고    scopus 로고
    • The structure and allosteric regulation of mammalian glutamate dehydrogenase
    • Li, M., Li, C., Allen, A., Stanley, C.A., Smith, T.J., The structure and allosteric regulation of mammalian glutamate dehydrogenase. Arch. Biochem. Biophys 519:2 (2012), 69–80.
    • (2012) Arch. Biochem. Biophys , vol.519 , Issue.2 , pp. 69-80
    • Li, M.1    Li, C.2    Allen, A.3    Stanley, C.A.4    Smith, T.J.5
  • 50
    • 84959451365 scopus 로고    scopus 로고
    • The Warburg effect: how does it benefit cancer cells?
    • Liberti, M.V., Locasale, J.W., The Warburg effect: how does it benefit cancer cells?. Trends Biochem. Sci 41:3 (2016), 211–218.
    • (2016) Trends Biochem. Sci , vol.41 , Issue.3 , pp. 211-218
    • Liberti, M.V.1    Locasale, J.W.2
  • 51
    • 84881177291 scopus 로고    scopus 로고
    • Serine, glycine and one-carbon units: cancer metabolism in full circle
    • Locasale, J.W., Serine, glycine and one-carbon units: cancer metabolism in full circle. Nat. Rev. Cancer 13:8 (2013), 572–583.
    • (2013) Nat. Rev. Cancer , vol.13 , Issue.8 , pp. 572-583
    • Locasale, J.W.1
  • 52
    • 84876889621 scopus 로고    scopus 로고
    • What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
    • Losman, J.A., Kaelin, W.G. Jr., What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer. Genes Dev 27:8 (2013), 836–852.
    • (2013) Genes Dev , vol.27 , Issue.8 , pp. 836-852
    • Losman, J.A.1    Kaelin, W.G.2
  • 53
    • 84863534997 scopus 로고    scopus 로고
    • Metabolic regulation of epigenetics
    • Lu, C., Thompson, C.B., Metabolic regulation of epigenetics. Cell Metab 16:1 (2012), 9–17.
    • (2012) Cell Metab , vol.16 , Issue.1 , pp. 9-17
    • Lu, C.1    Thompson, C.B.2
  • 54
    • 84858796262 scopus 로고    scopus 로고
    • IDH mutation impairs histone demethylation and results in a block to cell differentiation
    • Lu, C., Ward, P.S., Kapoor, G.S., Rohle, D., Turcan, S., Abdel-Wahab, O., et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483:7390 (2012), 474–478.
    • (2012) Nature , vol.483 , Issue.7390 , pp. 474-478
    • Lu, C.1    Ward, P.S.2    Kapoor, G.S.3    Rohle, D.4    Turcan, S.5    Abdel-Wahab, O.6
  • 56
    • 84867706295 scopus 로고    scopus 로고
    • S-Adenosylmethionine in liver health, injury, and cancer
    • Lu, S.C., Mato, J.M., S-Adenosylmethionine in liver health, injury, and cancer. Physiol. Rev 92:4 (2012), 1515–1542.
    • (2012) Physiol. Rev , vol.92 , Issue.4 , pp. 1515-1542
    • Lu, S.C.1    Mato, J.M.2
  • 57
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis, E.R., Ding, L., Dooling, D.J., Larson, D.E., McLellan, M.D., Chen, K., et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N. Engl. J. Med 361:11 (2009), 1058–1066.
    • (2009) N. Engl. J. Med , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3    Larson, D.E.4    McLellan, M.D.5    Chen, K.6
  • 59
    • 42249100305 scopus 로고    scopus 로고
    • Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
    • Martinez-Chantar, M.L., Vazquez-Chantada, M., Ariz, U., Martinez, N., Varela, M., Luka, Z., et al. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology 47:4 (2008), 1191–1199.
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1191-1199
    • Martinez-Chantar, M.L.1    Vazquez-Chantada, M.2    Ariz, U.3    Martinez, N.4    Varela, M.5    Luka, Z.6
  • 60
    • 84919903877 scopus 로고    scopus 로고
    • Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
    • Mashimo, T., Pichumani, K., Vemireddy, V., Hatanpaa, K.J., Singh, D.K., Sirasanagandla, S., et al. Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 159:7 (2014), 1603–1614.
    • (2014) Cell , vol.159 , Issue.7 , pp. 1603-1614
    • Mashimo, T.1    Pichumani, K.2    Vemireddy, V.3    Hatanpaa, K.J.4    Singh, D.K.5    Sirasanagandla, S.6
  • 61
    • 0035874520 scopus 로고    scopus 로고
    • Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma
    • Matsuo, K., Suzuki, R., Hamajima, N., Ogura, M., Kagami, Y., Taji, H., et al. Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma. Blood 97:10 (2001), 3205–3209.
    • (2001) Blood , vol.97 , Issue.10 , pp. 3205-3209
    • Matsuo, K.1    Suzuki, R.2    Hamajima, N.3    Ogura, M.4    Kagami, Y.5    Taji, H.6
  • 62
    • 84960885579 scopus 로고    scopus 로고
    • Disordered methionine metabolism in MTAP/CDKN2A deleted cancers leads to dependence on PRMT5
    • Mavrakis, K.J., McDonald, E.R. 3rd, Schlabach, M.R., Billy, E., Hoffman, G.R., deWeck, A., et al. Disordered methionine metabolism in MTAP/CDKN2A deleted cancers leads to dependence on PRMT5. Science 351:6278 (2016), 1208–1213.
    • (2016) Science , vol.351 , Issue.6278 , pp. 1208-1213
    • Mavrakis, K.J.1    McDonald, E.R.2    Schlabach, M.R.3    Billy, E.4    Hoffman, G.R.5    deWeck, A.6
  • 64
    • 84912139448 scopus 로고    scopus 로고
    • Characterization of the usage of the serine metabolic network in human cancer
    • Mehrmohamadi, M., Liu, X., Shestov, A.A., Locasale, J.W., Characterization of the usage of the serine metabolic network in human cancer. Cell Rep 9:4 (2014), 1507–1519.
    • (2014) Cell Rep , vol.9 , Issue.4 , pp. 1507-1519
    • Mehrmohamadi, M.1    Liu, X.2    Shestov, A.A.3    Locasale, J.W.4
  • 65
    • 84949655663 scopus 로고    scopus 로고
    • One-carbon metabolism and epigenetics: understanding the specificity
    • Mentch, S.J., Locasale, J.W., One-carbon metabolism and epigenetics: understanding the specificity. Ann. N. Y. Acad. Sci 1363 (2015), 91–98.
    • (2015) Ann. N. Y. Acad. Sci , vol.1363 , pp. 91-98
    • Mentch, S.J.1    Locasale, J.W.2
  • 66
    • 84948412126 scopus 로고    scopus 로고
    • Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism
    • Mentch, S.J., Mehrmohamadi, M., Huang, L., Liu, X., Gupta, D., Mattocks, D., et al. Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism. Cell Metab 22:5 (2015), 861–873.
    • (2015) Cell Metab , vol.22 , Issue.5 , pp. 861-873
    • Mentch, S.J.1    Mehrmohamadi, M.2    Huang, L.3    Liu, X.4    Gupta, D.5    Mattocks, D.6
  • 67
    • 84905096743 scopus 로고    scopus 로고
    • Caloric restriction and cancer: molecular mechanisms and clinical implications
    • Meynet, O., Ricci, J.E., Caloric restriction and cancer: molecular mechanisms and clinical implications. Trends Mol. Med 20:8 (2014), 419–427.
    • (2014) Trends Mol. Med , vol.20 , Issue.8 , pp. 419-427
    • Meynet, O.1    Ricci, J.E.2
  • 69
    • 77953644347 scopus 로고    scopus 로고
    • Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases
    • Mosammaparast, N., Shi, Y., Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases. Annu. Rev. Biochem 79 (2010), 155–179.
    • (2010) Annu. Rev. Biochem , vol.79 , pp. 155-179
    • Mosammaparast, N.1    Shi, Y.2
  • 70
    • 84897414311 scopus 로고    scopus 로고
    • Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
    • Nilsson, R., Jain, M., Madhusudhan, N., Sheppard, N.G., Strittmatter, L., Kampf, C., et al. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat. Commun, 5, 2014, 3128.
    • (2014) Nat. Commun , vol.5 , pp. 3128
    • Nilsson, R.1    Jain, M.2    Madhusudhan, N.3    Sheppard, N.G.4    Strittmatter, L.5    Kampf, C.6
  • 71
    • 84924370236 scopus 로고    scopus 로고
    • DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway
    • Nishikawa, K., Iwamoto, Y., Kobayashi, Y., Katsuoka, F., Kawaguchi, S., Tsujita, T., et al. DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway. Nat. Med 21:3 (2015), 281–287.
    • (2015) Nat. Med , vol.21 , Issue.3 , pp. 281-287
    • Nishikawa, K.1    Iwamoto, Y.2    Kobayashi, Y.3    Katsuoka, F.4    Kawaguchi, S.5    Tsujita, T.6
  • 72
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr, H., Weisenberger, D.J., Diefes, K., Phillips, H.S., Pujara, K., Berman, B.P., et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17:5 (2010), 510–522.
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3    Phillips, H.S.4    Pujara, K.5    Berman, B.P.6
  • 73
    • 84955326448 scopus 로고    scopus 로고
    • The emerging hallmarks of cancer metabolism
    • Pavlova, N.N., Thompson, C.B., The emerging hallmarks of cancer metabolism. Cell Metab 23:1 (2016), 27–47.
    • (2016) Cell Metab , vol.23 , Issue.1 , pp. 27-47
    • Pavlova, N.N.1    Thompson, C.B.2
  • 74
    • 84886099830 scopus 로고    scopus 로고
    • Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
    • Plass, C., Pfister, S.M., Lindroth, A.M., Bogatyrova, O., Claus, R., Lichter, P., Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nat. Rev. Genet 14:11 (2013), 765–780.
    • (2013) Nat. Rev. Genet , vol.14 , Issue.11 , pp. 765-780
    • Plass, C.1    Pfister, S.M.2    Lindroth, A.M.3    Bogatyrova, O.4    Claus, R.5    Lichter, P.6
  • 75
    • 26444570010 scopus 로고    scopus 로고
    • Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations
    • Pollard, P.J., Briere, J.J., Alam, N.A., Barwell, J., Barclay, E., Wortham, N.C., et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum. Mol. Genet 14:15 (2005), 2231–2239.
    • (2005) Hum. Mol. Genet , vol.14 , Issue.15 , pp. 2231-2239
    • Pollard, P.J.1    Briere, J.J.2    Alam, N.A.3    Barwell, J.4    Barclay, E.5    Wortham, N.C.6
  • 76
    • 84866479450 scopus 로고    scopus 로고
    • IDH mutations in acute myeloid leukemia
    • Rakheja, D., Konoplev, S., Medeiros, L.J., Chen, W., IDH mutations in acute myeloid leukemia. Hum. Pathol 43:10 (2012), 1541–1551.
    • (2012) Hum. Pathol , vol.43 , Issue.10 , pp. 1541-1551
    • Rakheja, D.1    Konoplev, S.2    Medeiros, L.J.3    Chen, W.4
  • 77
    • 84876838620 scopus 로고    scopus 로고
    • The B55alpha subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation
    • Reid, M.A., Wang, W.I., Rosales, K.R., Welliver, M.X., Pan, M., Kong, M., The B55alpha subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation. Mol. Cell 50:2 (2013), 200–211.
    • (2013) Mol. Cell , vol.50 , Issue.2 , pp. 200-211
    • Reid, M.A.1    Wang, W.I.2    Rosales, K.R.3    Welliver, M.X.4    Pan, M.5    Kong, M.6
  • 78
    • 25144515912 scopus 로고    scopus 로고
    • Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer
    • Roessler, M., Rollinger, W., Palme, S., Hagmann, M.L., Berndt, P., Engel, A.M., et al. Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin. Cancer Res 11:18 (2005), 6550–6557.
    • (2005) Clin. Cancer Res , vol.11 , Issue.18 , pp. 6550-6557
    • Roessler, M.1    Rollinger, W.2    Palme, S.3    Hagmann, M.L.4    Berndt, P.5    Engel, A.M.6
  • 79
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
    • Rohle, D., Popovici-Muller, J., Palaskas, N., Turcan, S., Grommes, C., Campos, C., et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340:6132 (2013), 626–630.
    • (2013) Science , vol.340 , Issue.6132 , pp. 626-630
    • Rohle, D.1    Popovici-Muller, J.2    Palaskas, N.3    Turcan, S.4    Grommes, C.5    Campos, C.6
  • 80
    • 84887069903 scopus 로고    scopus 로고
    • Nutritional control of epigenetic processes in yeast and human cells
    • Sadhu, M.J., Guan, Q., Li, F., Sales-Lee, J., Iavarone, A.T., Hammond, M.C., et al. Nutritional control of epigenetic processes in yeast and human cells. Genetics 195:3 (2013), 831–844.
    • (2013) Genetics , vol.195 , Issue.3 , pp. 831-844
    • Sadhu, M.J.1    Guan, Q.2    Li, F.3    Sales-Lee, J.4    Iavarone, A.T.5    Hammond, M.C.6
  • 81
    • 84947648620 scopus 로고    scopus 로고
    • Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
    • Schug, Z.T., Peck, B., Jones, D.T., Zhang, Q., Grosskurth, S., Alam, I.S., et al. Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 27:1 (2015), 57–71.
    • (2015) Cancer Cell , vol.27 , Issue.1 , pp. 57-71
    • Schug, Z.T.1    Peck, B.2    Jones, D.T.3    Zhang, Q.4    Grosskurth, S.5    Alam, I.S.6
  • 83
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen, H., Laird, P.W., Interplay between the cancer genome and epigenome. Cell 153:1 (2013), 38–55.
    • (2013) Cell , vol.153 , Issue.1 , pp. 38-55
    • Shen, H.1    Laird, P.W.2
  • 84
    • 84872166360 scopus 로고    scopus 로고
    • Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor
    • Shimazu, T., Hirschey, M.D., Newman, J., He, W., Shirakawa, K., Le Moan, N., et al. Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science 339:6116 (2013), 211–214.
    • (2013) Science , vol.339 , Issue.6116 , pp. 211-214
    • Shimazu, T.1    Hirschey, M.D.2    Newman, J.3    He, W.4    Shirakawa, K.5    Le Moan, N.6
  • 85
    • 84900332195 scopus 로고    scopus 로고
    • Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells
    • Shiraki, N., Shiraki, Y., Tsuyama, T., Obata, F., Miura, M., Nagae, G., et al. Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells. Cell Metab 19:5 (2014), 780–794.
    • (2014) Cell Metab , vol.19 , Issue.5 , pp. 780-794
    • Shiraki, N.1    Shiraki, Y.2    Tsuyama, T.3    Obata, F.4    Miura, M.5    Nagae, G.6
  • 86
    • 84872160110 scopus 로고    scopus 로고
    • Influence of threonine metabolism on S-adenosylmethionine and histone methylation
    • Shyh-Chang, N., Locasale, J.W., Lyssiotis, C.A., Zheng, Y., Teo, R.Y., Ratanasirintrawoot, S., et al. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science 339:6116 (2013), 222–226.
    • (2013) Science , vol.339 , Issue.6116 , pp. 222-226
    • Shyh-Chang, N.1    Locasale, J.W.2    Lyssiotis, C.A.3    Zheng, Y.4    Teo, R.Y.5    Ratanasirintrawoot, S.6
  • 87
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern, L.L., Mason, J.B., Selhub, J., Choi, S.W., Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol. Biomarkers Prev 9:8 (2000), 849–853.
    • (2000) Cancer Epidemiol. Biomarkers Prev , vol.9 , Issue.8 , pp. 849-853
    • Stern, L.L.1    Mason, J.B.2    Selhub, J.3    Choi, S.W.4
  • 88
    • 84875537133 scopus 로고    scopus 로고
    • Epigenetic reprogramming in cancer
    • Suva, M.L., Riggi, N., Bernstein, B.E., Epigenetic reprogramming in cancer. Science 339:6127 (2013), 1567–1570.
    • (2013) Science , vol.339 , Issue.6127 , pp. 1567-1570
    • Suva, M.L.1    Riggi, N.2    Bernstein, B.E.3
  • 89
    • 33745557847 scopus 로고    scopus 로고
    • Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription
    • Takahashi, H., McCaffery, J.M., Irizarry, R.A., Boeke, J.D., Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol. Cell 23:2 (2006), 207–217.
    • (2006) Mol. Cell , vol.23 , Issue.2 , pp. 207-217
    • Takahashi, H.1    McCaffery, J.M.2    Irizarry, R.A.3    Boeke, J.D.4
  • 90
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan, M., Luo, H., Lee, S., Jin, F., Yang, J.S., Montellier, E., et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146:6 (2011), 1016–1028.
    • (2011) Cell , vol.146 , Issue.6 , pp. 1016-1028
    • Tan, M.1    Luo, H.2    Lee, S.3    Jin, F.4    Yang, J.S.5    Montellier, E.6
  • 91
    • 0141798673 scopus 로고    scopus 로고
    • Polyamine metabolism and cancer
    • Thomas, T., Thomas, T.J., Polyamine metabolism and cancer. J. Cell. Mol. Med 7:2 (2003), 113–126.
    • (2003) J. Cell. Mol. Med , vol.7 , Issue.2 , pp. 113-126
    • Thomas, T.1    Thomas, T.J.2
  • 92
    • 84865687580 scopus 로고    scopus 로고
    • Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery
    • Towbin, B.D., Gonzalez-Aguilera, C., Sack, R., Gaidatzis, D., Kalck, V., Meister, P., et al. Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery. Cell 150:5 (2012), 934–947.
    • (2012) Cell , vol.150 , Issue.5 , pp. 934-947
    • Towbin, B.D.1    Gonzalez-Aguilera, C.2    Sack, R.3    Gaidatzis, D.4    Kalck, V.5    Meister, P.6
  • 93
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan, S., Rohle, D., Goenka, A., Walsh, L.A., Fang, F., Yilmaz, E., et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483:7390 (2012), 479–483.
    • (2012) Nature , vol.483 , Issue.7390 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3    Walsh, L.A.4    Fang, F.5    Yilmaz, E.6
  • 94
    • 84879083630 scopus 로고    scopus 로고
    • NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink
    • Ulanovskaya, O.A., Zuhl, A.M., Cravatt, B.F., NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat. Chem. Biol 9:5 (2013), 300–306.
    • (2013) Nat. Chem. Biol , vol.9 , Issue.5 , pp. 300-306
    • Ulanovskaya, O.A.1    Zuhl, A.M.2    Cravatt, B.F.3
  • 95
    • 84885155285 scopus 로고    scopus 로고
    • Widespread and enzyme-independent Nepsilon-acetylation and Nepsilon-succinylation of proteins in the chemical conditions of the mitochondrial matrix
    • Wagner, G.R., Payne, R.M., Widespread and enzyme-independent Nepsilon-acetylation and Nepsilon-succinylation of proteins in the chemical conditions of the mitochondrial matrix. J. Biol. Chem 288:40 (2013), 29036–29045.
    • (2013) J. Biol. Chem , vol.288 , Issue.40 , pp. 29036-29045
    • Wagner, G.R.1    Payne, R.M.2
  • 96
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang, F., Travins, J., DeLaBarre, B., Penard-Lacronique, V., Schalm, S., Hansen, E., et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 340:6132 (2013), 622–626.
    • (2013) Science , vol.340 , Issue.6132 , pp. 622-626
    • Wang, F.1    Travins, J.2    DeLaBarre, B.3    Penard-Lacronique, V.4    Schalm, S.5    Hansen, E.6
  • 97
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
    • Ward, P.S., Thompson, C.B., Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21:3 (2012), 297–308.
    • (2012) Cancer Cell , vol.21 , Issue.3 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 98
    • 0035986095 scopus 로고    scopus 로고
    • Dynamics of histone acetylation in vivo. A function for acetylation turnover?
    • Waterborg, J.H., Dynamics of histone acetylation in vivo. A function for acetylation turnover?. Biochem. Cell Biol 80:3 (2002), 363–378.
    • (2002) Biochem. Cell Biol , vol.80 , Issue.3 , pp. 363-378
    • Waterborg, J.H.1
  • 99
    • 84858796367 scopus 로고    scopus 로고
    • A two-way street: reciprocal regulation of metabolism and signalling
    • Wellen, K.E., Thompson, C.B., A two-way street: reciprocal regulation of metabolism and signalling. Nat. Rev. Mol. Cell Biol 13:4 (2012), 270–276.
    • (2012) Nat. Rev. Mol. Cell Biol , vol.13 , Issue.4 , pp. 270-276
    • Wellen, K.E.1    Thompson, C.B.2
  • 101
    • 84892763878 scopus 로고    scopus 로고
    • Reversing DNA methylation: mechanisms, genomics, and biological functions
    • Wu, H., Zhang, Y., Reversing DNA methylation: mechanisms, genomics, and biological functions. Cell 156:1–2 (2014), 45–68.
    • (2014) Cell , vol.156 , Issue.1-2 , pp. 45-68
    • Wu, H.1    Zhang, Y.2
  • 102
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., et al. Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev 26:12 (2012), 1326–1338.
    • (2012) Genes Dev , vol.26 , Issue.12 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6
  • 103
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
    • Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.H., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell 19:1 (2011), 17–30.
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6
  • 105
    • 84875353168 scopus 로고    scopus 로고
    • Interactions between epigenetics and metabolism in cancers
    • Yun, J., Johnson, J.L., Hanigan, C.L., Locasale, J.W., Interactions between epigenetics and metabolism in cancers. Front. Oncol, 2, 2012, 163.
    • (2012) Front. Oncol , vol.2 , pp. 163
    • Yun, J.1    Johnson, J.L.2    Hanigan, C.L.3    Locasale, J.W.4
  • 106
    • 84874687850 scopus 로고    scopus 로고
    • Hydrogen sulfide, the next potent preventive and therapeutic agent in aging and age-associated diseases
    • Zhang, Y., Tang, Z.H., Ren, Z., Qu, S.L., Liu, M.H., Liu, L.S., et al. Hydrogen sulfide, the next potent preventive and therapeutic agent in aging and age-associated diseases. Mol. Cell. Biol 33:6 (2013), 1104–1113.
    • (2013) Mol. Cell. Biol , vol.33 , Issue.6 , pp. 1104-1113
    • Zhang, Y.1    Tang, Z.H.2    Ren, Z.3    Qu, S.L.4    Liu, M.H.5    Liu, L.S.6
  • 107
    • 84881179223 scopus 로고    scopus 로고
    • Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites
    • Zheng, Y., Thomas, P.M., Kelleher, N.L., Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Nat. Commun, 4, 2013, 2203.
    • (2013) Nat. Commun , vol.4 , pp. 2203
    • Zheng, Y.1    Thomas, P.M.2    Kelleher, N.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.