메뉴 건너뛰기




Volumn 76, Issue , 2011, Pages 235-246

Metabolomics in drug target discovery

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; ACETYL COENZYME A; GLUCOSE; GLUTAMINE; N ACETYLASPARTIC ACID; SIALIDASE; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT;

EID: 84867434804     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2011.76.010694     Document Type: Article
Times cited : (81)

References (69)
  • 1
    • 33746606019 scopus 로고    scopus 로고
    • Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography- tandem mass spectrometry
    • Bajad SU, Lu W, Kimball EH, Yuan J, Peterson C, Rabinowitz JD. 2006. Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography- tandem mass spectrometry. J Chromatogr A 1125: 76-8
    • (2006) J Chromatogr A , vol.1125 , pp. 76-78
    • Bajad, S.U.1    Lu, W.2    Kimball, E.H.3    Yuan, J.4    Peterson, C.5    Rabinowitz, J.D.6
  • 3
    • 70149102426 scopus 로고    scopus 로고
    • Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-C(6)]-D-glucose tracer in mice
    • Beger RD, Hansen DK, Schnackenberg LK, Cross BM, Fatollahi JJ, Lagunero FT, Sarnyai Z, Boros LG. 2009. Single valproic acid treatment inhibits glycogen and RNA ribose turnover while disrupting glucose-derived cholesterol synthesis in liver as revealed by the [U-C(6)]-D-glucose tracer in mice. Metabolomics 5: 336-34
    • (2009) Metabolomics , vol.5 , pp. 336-434
    • Beger, R.D.1    Hansen, D.K.2    Schnackenberg, L.K.3    Cross, B.M.4    Fatollahi, J.J.5    Lagunero, F.T.6    Sarnyai, Z.7    Boros, L.G.8
  • 6
    • 64649089947 scopus 로고    scopus 로고
    • Cross-platform comparison of methods for quantitative metabolomics of primary metabolism
    • Buescher JM, Czernik D, Ewald JC, Sauer U, Zamboni N. 2009. Cross-platform comparison of methods for quantitative metabolomics of primary metabolism. Anal Chem 81: 2135-214
    • (2009) Anal Chem , vol.81 , pp. 2135-2214
    • Buescher, J.M.1    Czernik, D.2    Ewald, J.C.3    Sauer, U.4    Zamboni, N.5
  • 7
    • 77952985821 scopus 로고    scopus 로고
    • Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites
    • Buescher JM, Moco S, Sauer U, Zamboni N. 2010. Ultrahigh performance liquid chromatography-tandem mass spectrometry method for fast and robust quantification of anionic and aromatic metabolites. Anal Chem 82: 4403-441
    • (2010) Anal Chem , vol.82 , pp. 4403-4441
    • Buescher, J.M.1    Moco, S.2    Sauer, U.3    Zamboni, N.4
  • 9
    • 75449105003 scopus 로고    scopus 로고
    • Glutamine metabolism is essential for human cytomegalovirus infection
    • Chambers JW, Maguire TG, Alwine JC. 2010. Glutamine metabolism is essential for human cytomegalovirus infection. J Virol 84: 1867-187
    • (2010) J Virol , vol.84 , pp. 1867-2187
    • Chambers, J.W.1    Maguire, T.G.2    Alwine, J.C.3
  • 11
    • 79952844950 scopus 로고    scopus 로고
    • The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection
    • Clippinger AJ, Maguire TG, Alwine JC. 2011. The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol 85: 3930-393
    • (2011) J Virol , vol.85 , pp. 3930-4393
    • Clippinger, A.J.1    Maguire, T.G.2    Alwine, J.C.3
  • 14
    • 2442714139 scopus 로고    scopus 로고
    • Activation of the NF-kB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter
    • DeMeritt IB, Milford LE, Yurochko AD. 2004. Activation of the NF-kB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter. J Virol 78: 4498-450
    • (2004) J Virol , vol.78 , pp. 4498-5450
    • DeMeritt, I.B.1    Milford, L.E.2    Yurochko, A.D.3
  • 16
    • 4544287124 scopus 로고    scopus 로고
    • Cellular stress and signal transduction responses to human cytomegalovirus infection
    • Evers DL, Wang X, Huang ES. 2004. Cellular stress and signal transduction responses to human cytomegalovirus infection. Microbes Infect 6: 1084-109
    • (2004) Microbes Infect , vol.6 , pp. 1084-1109
    • Evers, D.L.1    Wang, X.2    Huang, E.S.3
  • 17
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotoperesolved metabolomics (SIRM)
    • Fan TW, Lane AN, Higashi RM, Farag MA, Gao H, Bousamra M, Miller DM. 2009. Altered regulation of metabolic pathways in human lung cancer discerned by 13C stable isotoperesolved metabolomics (SIRM). Mol Cancer 8: 4
    • (2009) Mol Cancer , vol.8 , pp. 4
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3    Farag, M.A.4    Gao, H.5    Bousamra, M.6    Miller, D.M.7
  • 18
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics-The link between genotypes and phenotypes
    • Fiehn O. 2002. Metabolomics-The link between genotypes and phenotypes. Plant Mol Biol 48: 155-17
    • (2002) Plant Mol Biol , vol.48 , pp. 155-217
    • Fiehn, O.1
  • 22
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • Ibarra RU, Edwards JS, Palsson BO. 2002. Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature 420: 186-18
    • (2002) Nature , vol.420 , pp. 186-218
    • Ibarra, R.U.1    Edwards, J.S.2    Palsson, B.O.3
  • 23
    • 77955517340 scopus 로고    scopus 로고
    • Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours
    • 12-18; discussion
    • Jentzmik F, Stephan C, Miller K, Schrader M, Erbersdobler A, Kristiansen G, Lein M, Jung K. 2010. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 58: 12-18; discussion 20-2
    • (2010) Eur Urol , vol.58 , pp. 20-22
    • Jentzmik, F.1    Stephan, C.2    Miller, K.3    Schrader, M.4    Erbersdobler, A.5    Kristiansen, G.6    Lein, M.7    Jung, K.8
  • 24
    • 33748339379 scopus 로고    scopus 로고
    • Metabolic profiling of patients with schizophrenia
    • Kaddurah-Daouk R. 2006. Metabolic profiling of patients with schizophrenia. PLoS Med 3: e36
    • (2006) PLoS Med , vol.3
    • Kaddurah-Daouk, R.1
  • 25
    • 33644867564 scopus 로고    scopus 로고
    • MZmine. Toolbox for processing and visualization of mass spectrometry based molecular profile data
    • Katajamaa M, Miettinen J, Oresic M. 2006. MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data. Bioinformatics 22: 634-63
    • (2006) Bioinformatics , vol.22 , pp. 634-663
    • Katajamaa, M.1    Miettinen, J.2    Oresic, M.3
  • 26
    • 1642462823 scopus 로고    scopus 로고
    • A new technique (COMSPARI) to facilitate the identification of minor compounds in complex mixtures by GC/MS and LC/MS, Tools for the visualization of matched datasets
    • Katz JE, Dumlao DS, Clarke S, Hau J. 2004. A new technique (COMSPARI) to facilitate the identification of minor compounds in complex mixtures by GC/MS and LC/MS: Tools for the visualization of matched datasets. J Am Soc Mass Spectrom 15: 580-58
    • (2004) J Am Soc Mass Spectrom , vol.15 , pp. 580-658
    • Katz, J.E.1    Dumlao, D.S.2    Clarke, S.3    Hau, J.4
  • 27
    • 33646754900 scopus 로고    scopus 로고
    • Metabolomic database annotations via query of elemental compositions, Mass accuracy is insufficient even at less than 1 ppm
    • Kind T, Fiehn O. 2006. Metabolomic database annotations via query of elemental compositions: Mass accuracy is insufficient even at less than 1 ppm. BMC Bioinformatics 7: 23
    • (2006) BMC Bioinformatics , vol.7 , pp. 23
    • Kind, T.1    Fiehn, O.2
  • 28
    • 34247163207 scopus 로고    scopus 로고
    • Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry
    • Kind T, Fiehn O. 2007. Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics 8: 10
    • (2007) BMC Bioinformatics , vol.8 , pp. 10
    • Kind, T.1    Fiehn, O.2
  • 29
    • 4644252994 scopus 로고    scopus 로고
    • Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
    • Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. 2004. Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. J Virol 78: 11030-1103
    • (2004) J Virol , vol.78 , pp. 11030-11103
    • Kudchodkar, S.B.1    Yu, Y.2    Maguire, T.G.3    Alwine, J.C.4
  • 30
    • 33749040235 scopus 로고    scopus 로고
    • Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes
    • Kudchodkar SB, Yu Y, Maguire TG, Alwine JC. 2006. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proc Natl Acad Sci 103: 14182-1418
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 14182-21418
    • Kudchodkar, S.B.1    Yu, Y.2    Maguire, T.G.3    Alwine, J.C.4
  • 34
    • 77951072181 scopus 로고    scopus 로고
    • Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer
    • Lu W, Clasquin MF, Melamud E, Amador-Noguez D, Caudy AA, Rabinowitz JD. 2010. Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Anal Chem 82: 3212-322
    • (2010) Anal Chem , vol.82 , pp. 3212-3322
    • Lu, W.1    Clasquin, M.F.2    Melamud, E.3    Amador-Noguez, D.4    Caudy, A.A.5    Rabinowitz, J.D.6
  • 35
    • 33947503169 scopus 로고    scopus 로고
    • Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry
    • Luo B, Groenke K, Takors R, Wandrey C, Oldiges M. 2007. Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry. J Chromatogr A 1147: 153-16
    • (2007) J Chromatogr A , vol.1147 , pp. 153-216
    • Luo, B.1    Groenke, K.2    Takors, R.3    Wandrey, C.4    Oldiges, M.5
  • 37
    • 77953105101 scopus 로고    scopus 로고
    • Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection
    • Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt S. 2010. Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. Proc Natl Acad Sci 107: 9819-982
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 9819-9982
    • Marrero, J.1    Rhee, K.Y.2    Schnappinger, D.3    Pethe, K.4    Ehrt, S.5
  • 39
    • 78650660123 scopus 로고    scopus 로고
    • Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirusinduced glycolytic activation and severely attenuates production of viral progeny
    • McArdle J, Schafer XL, Munger J. 2011. Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirusinduced glycolytic activation and severely attenuates production of viral progeny. J Virol 85: 705-71
    • (2011) J Virol , vol.85 , pp. 705-771
    • McArdle, J.1    Schafer, X.L.2    Munger, J.3
  • 40
    • 78649695759 scopus 로고    scopus 로고
    • Metabolomic analysis and visualization engine for LC-MS data
    • Melamud E, Vastag L, Rabinowitz JD. 2010. Metabolomic analysis and visualization engine for LC-MS data. Anal Chem 82: 9818-982
    • (2010) Anal Chem , vol.82 , pp. 9818-9982
    • Melamud, E.1    Vastag, L.2    Rabinowitz, J.D.3
  • 41
    • 41849101685 scopus 로고    scopus 로고
    • Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex
    • Moorman NJ, Cristea IM, Terhune SS, Rout MP, Chait BT, Shenk T. 2008. Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe 3: 253-26
    • (2008) Cell Host Microbe , vol.3 , pp. 253-326
    • Moorman, N.J.1    Cristea, I.M.2    Terhune, S.S.3    Rout, M.P.4    Chait, B.T.5    Shenk, T.6
  • 45
    • 73149109062 scopus 로고    scopus 로고
    • Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    • Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. 2010. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140: 49-6
    • (2010) Cell , vol.140 , pp. 49-56
    • Nomura, D.K.1    Long, J.Z.2    Niessen, S.3    Hoover, H.S.4    Ng, S.W.5    Cravatt, B.F.6
  • 50
    • 70149093062 scopus 로고    scopus 로고
    • Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase
    • Pesek JJ, Matyska MT, Loo JA, Fischer SM, Sana TR. 2009. Analysis of hydrophilic metabolites in physiological fluids by HPLC-MS using a silica hydride-based stationary phase. J Sep Sci 32: 2200-220
    • (2009) J Sep Sci , vol.32 , pp. 2200-2220
    • Pesek, J.J.1    Matyska, M.T.2    Loo, J.A.3    Fischer, S.M.4    Sana, T.R.5
  • 52
    • 33846061120 scopus 로고    scopus 로고
    • Metabolic networks in motion, 13C-based flux analysis
    • Sauer U. 2006. Metabolic networks in motion: 13C-based flux analysis. Mol Syst Biol 2: 6
    • (2006) Mol Syst Biol , vol.2 , pp. 6
    • Sauer, U.1
  • 53
    • 33947418741 scopus 로고    scopus 로고
    • Human cytomegalovirus pUL37 × 1 induces the release of endoplasmic reticulum calcium stores
    • Sharon-Friling R, Goodhouse J, Colberg-Poley AM, Shenk T. 2006. Human cytomegalovirus pUL37 × 1 induces the release of endoplasmic reticulum calcium stores. Proc Natl Acad Sci 103: 19117-1912
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 19117-21912
    • Sharon-Friling, R.1    Goodhouse, J.2    Colberg-Poley, A.M.3    Shenk, T.4
  • 54
    • 32444446805 scopus 로고    scopus 로고
    • XCMS, Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
    • Smith CA, Want EJ, O'Maille G, Abagyan R, Siuzdak G. 2006. XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal Chem 78: 779-78
    • (2006) Anal Chem , vol.78 , pp. 779-878
    • Smith, C.A.1    Want, E.J.2    O'Maille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 55
    • 79958108811 scopus 로고    scopus 로고
    • Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication
    • Spencer CM, Schafer XL, Moorman NJ, Munger J. 2011. Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. J Virol 85: 5814-582
    • (2011) J Virol , vol.85 , pp. 5814-6582
    • Spencer, C.M.1    Schafer, X.L.2    Moorman, N.J.3    Munger, J.4
  • 57
    • 79960958455 scopus 로고    scopus 로고
    • Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism
    • Vastag L, Koyuncu E, Grady SL, Shenk TE, Rabinowitz JD. 2011. Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog 7: e100212
    • (2011) PLoS Pathog , vol.7
    • Vastag, L.1    Koyuncu, E.2    Grady, S.L.3    Shenk, T.E.4    Rabinowitz, J.D.5
  • 60
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, Ito S, Yang C, Xiao MT, Liu LX, et al. 2011. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell 19: 17-3
    • (2011) Cancer Cell , vol.19 , pp. 17-23
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.H.6    Ito, S.7    Yang, C.8    Xiao, M.T.9    Liu, L.X.10
  • 63
    • 77954197778 scopus 로고    scopus 로고
    • Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model
    • Yizhak K, Benyamini T, Liebermeister W, Ruppin E, Shlomi T. 2010. Integrating quantitative proteomics and metabolomics with a genome-scale metabolic network model. Bioinformatics 26: i255-i26
    • (2010) Bioinformatics , vol.26
    • Yizhak, K.1    Benyamini, T.2    Liebermeister, W.3    Ruppin, E.4    Shlomi, T.5
  • 64
    • 34547662951 scopus 로고    scopus 로고
    • Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition
    • Yuan J, Rabinowitz JD. 2007. Differentiating metabolites formed from de novo synthesis versus macromolecule decomposition. J Am Chem Soc 129: 9294-929
    • (2007) J Am Chem Soc , vol.129 , pp. 9294-9929
    • Yuan, J.1    Rabinowitz, J.D.2
  • 65
  • 66
    • 50349092706 scopus 로고    scopus 로고
    • Kinetic flux profiling for quantitation of cellular metabolic fluxes
    • Yuan J, Bennett BD, Rabinowitz JD. 2008. Kinetic flux profiling for quantitation of cellular metabolic fluxes. Nat Protoc 3: 1328-134
    • (2008) Nat Protoc , vol.3 , pp. 1328-2134
    • Yuan, J.1    Bennett, B.D.2    Rabinowitz, J.D.3
  • 68
    • 48849114064 scopus 로고    scopus 로고
    • Human cytomegalovirus modulation of signal transduction
    • Yurochko AD. 2008. Human cytomegalovirus modulation of signal transduction. Curr Top Microbiol Immunol 325: 205-22
    • (2008) Curr Top Microbiol Immunol , vol.325 , pp. 205-222
    • Yurochko, A.D.1
  • 69
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1a
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y, et al. 2009. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1a. Science 324: 261-26
    • (2009) Science , vol.324 , pp. 261-326
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5    Wang, P.6    Yu, W.7    Li, Z.8    Gong, L.9    Peng, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.