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Volumn 8, Issue APR, 2017, Pages

Notch signaling in T helper cell subsets: Instructor or unbiased amplifier?

Author keywords

Allergy; Cytokines; Delta like ligand; Gata3; Jagged; Notch signaling; Th1 immunity; Th2 immunity

Indexed keywords

NOTCH RECEPTOR;

EID: 85018376150     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2017.00419     Document Type: Short Survey
Times cited : (57)

References (134)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol (1986) 136:2348-57
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 2
    • 84959539367 scopus 로고    scopus 로고
    • Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease
    • DuPage M, Bluestone JA. Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease. Nat Rev Immunol (2016) 16:149-63. doi: 10.1038/nri.2015.18
    • (2016) Nat Rev Immunol , vol.16 , pp. 149-163
    • DuPage, M.1    Bluestone, J.A.2
  • 3
    • 84964669956 scopus 로고    scopus 로고
    • CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm
    • Hirahara K, Nakayama T. CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol (2016) 28:163-71. doi:10.1093/intimm/dxw006
    • (2016) Int Immunol , vol.28 , pp. 163-171
    • Hirahara, K.1    Nakayama, T.2
  • 4
    • 84905972007 scopus 로고    scopus 로고
    • Complex interactions of transcription factors in mediating cytokine biology in T cells
    • Li P, Spolski R, Liao W, Leonard WJ. Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 261:141-56. doi:10.1111/imr.12199
    • (2014) Immunol Rev , vol.261 , pp. 141-156
    • Li, P.1    Spolski, R.2    Liao, W.3    Leonard, W.J.4
  • 5
    • 84886790466 scopus 로고    scopus 로고
    • T-bet: a bridge between innate and adaptive immunity
    • Lazarevic V, Glimcher LH, Lord GM. T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 13:777-89. doi:10.1038/nri3536
    • (2013) Nat Rev Immunol , vol.13 , pp. 777-789
    • Lazarevic, V.1    Glimcher, L.H.2    Lord, G.M.3
  • 6
    • 84907316570 scopus 로고    scopus 로고
    • GATA-3 function in innate and adaptive immunity
    • Tindemans I, Serafini N, Di Santo JP, Hendriks RW. GATA-3 function in innate and adaptive immunity. Immunity (2014) 41:191-206. doi:10.1016/j.immuni.2014.06.006
    • (2014) Immunity , vol.41 , pp. 191-206
    • Tindemans, I.1    Serafini, N.2    Di Santo, J.P.3    Hendriks, R.W.4
  • 7
    • 0034653932 scopus 로고    scopus 로고
    • Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile
    • Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Paul WE, Sher A. Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol (2000) 164:3047-55. doi:10.4049/jimmunol.164.6.3047
    • (2000) J Immunol , vol.164 , pp. 3047-3055
    • Jankovic, D.1    Kullberg, M.C.2    Noben-Trauth, N.3    Caspar, P.4    Paul, W.E.5    Sher, A.6
  • 8
    • 0028346887 scopus 로고
    • Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells
    • Schmitz J, Thiel A, Kuhn R, Rajewsky K, Muller W, Assenmacher M, et al. Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J Exp Med (1994) 179:1349-53. doi:10.1084/jem.179.4.1349
    • (1994) J Exp Med , vol.179 , pp. 1349-1353
    • Schmitz, J.1    Thiel, A.2    Kuhn, R.3    Rajewsky, K.4    Muller, W.5    Assenmacher, M.6
  • 9
    • 84949670848 scopus 로고    scopus 로고
    • Notch in T cell differentiation: all things considered
    • Amsen D, Helbig C, Backer RA. Notch in T cell differentiation: all things considered. Trends Immunol (2015) 36:802-14. doi:10.1016/j.it.2015.10.007
    • (2015) Trends Immunol , vol.36 , pp. 802-814
    • Amsen, D.1    Helbig, C.2    Backer, R.A.3
  • 10
    • 2342496710 scopus 로고    scopus 로고
    • Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    • Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 117:515-26. doi:10.1016/S0092-8674(04)00451-9
    • (2004) Cell , vol.117 , pp. 515-526
    • Amsen, D.1    Blander, J.M.2    Lee, G.R.3    Tanigaki, K.4    Honjo, T.5    Flavell, R.A.6
  • 11
    • 84880729295 scopus 로고    scopus 로고
    • Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals
    • Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, et al. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity (2013) 39:148-59. doi:10.1016/j.immuni.2013.07.006
    • (2013) Immunity , vol.39 , pp. 148-159
    • Bailis, W.1    Yashiro-Ohtani, Y.2    Fang, T.C.3    Hatton, R.D.4    Weaver, C.T.5    Artis, D.6
  • 12
    • 84973311475 scopus 로고    scopus 로고
    • Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction
    • Guo B, McMillan BJ, Blacklow SC. Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Curr Opin Struct Biol (2016) 41:38-45. doi:10.1016/j.sbi.2016.05.012
    • (2016) Curr Opin Struct Biol , vol.41 , pp. 38-45
    • Guo, B.1    McMillan, B.J.2    Blacklow, S.C.3
  • 13
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: unfolding the activation mechanism
    • Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 137:216-33. doi:10.1016/j.cell.2009.03.045
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 14
    • 77952316273 scopus 로고    scopus 로고
    • Functions of notch signaling in the immune system: consensus and controversies
    • Yuan JS, Kousis PC, Suliman S, Visan I, Guidos CJ. Functions of notch signaling in the immune system: consensus and controversies. Annu Rev Immunol (2010) 28:343-65. doi:10.1146/annurev.immunol.021908.132719
    • (2010) Annu Rev Immunol , vol.28 , pp. 343-365
    • Yuan, J.S.1    Kousis, P.C.2    Suliman, S.3    Visan, I.4    Guidos, C.J.5
  • 15
    • 0042834334 scopus 로고    scopus 로고
    • Notch signaling augments T cell responsiveness by enhancing CD25 expression
    • Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, et al. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 171:2896-903. doi:10.4049/jimmunol.171.6.2896
    • (2003) J Immunol , vol.171 , pp. 2896-2903
    • Adler, S.H.1    Chiffoleau, E.2    Xu, L.3    Dalton, N.M.4    Burg, J.M.5    Wells, A.D.6
  • 16
    • 84921315205 scopus 로고    scopus 로고
    • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation
    • Laky K, Evans S, Perez-Diez A, Fowlkes BJ. Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation. Immunity (2015) 42:80-94. doi:10.1016/j.immuni.2014.12.027
    • (2015) Immunity , vol.42 , pp. 80-94
    • Laky, K.1    Evans, S.2    Perez-Diez, A.3    Fowlkes, B.J.4
  • 17
    • 84925284022 scopus 로고    scopus 로고
    • Notch controls the survival of memory CD4+ T cells by regulating glucose uptake
    • Maekawa Y, Ishifune C, Tsukumo S, Hozumi K, Yagita H, Yasutomo K. Notch controls the survival of memory CD4+ T cells by regulating glucose uptake. Nat Med (2015) 21:55-61. doi:10.1038/nm.3758
    • (2015) Nat Med , vol.21 , pp. 55-61
    • Maekawa, Y.1    Ishifune, C.2    Tsukumo, S.3    Hozumi, K.4    Yagita, H.5    Yasutomo, K.6
  • 18
    • 0041331708 scopus 로고    scopus 로고
    • TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells
    • Palaga T, Miele L, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol (2003) 171:3019-24. doi:10.4049/jimmunol.171.6.3019
    • (2003) J Immunol , vol.171 , pp. 3019-3024
    • Palaga, T.1    Miele, L.2    Golde, T.E.3    Osborne, B.A.4
  • 19
    • 77951080367 scopus 로고    scopus 로고
    • Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival
    • Perumalsamy LR, Nagala M, Sarin A. Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival. Proc Natl Acad Sci U S A (2010) 107:6882-7. doi:10.1073/pnas.0910060107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6882-6887
    • Perumalsamy, L.R.1    Nagala, M.2    Sarin, A.3
  • 20
    • 1642576036 scopus 로고    scopus 로고
    • The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
    • Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J Biol Chem (2004) 279:2937-44. doi:10.1074/jbc.M309924200
    • (2004) J Biol Chem , vol.279 , pp. 2937-2944
    • Sade, H.1    Krishna, S.2    Sarin, A.3
  • 21
    • 85013191577 scopus 로고    scopus 로고
    • PKCtheta links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton
    • Britton GJ, Ambler R, Clark DJ, Hill EV, Tunbridge HM, McNally KE, et al. PKCtheta links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton. Elife (2017) 6. doi:10.7554/eLife.20003
    • (2017) Elife , vol.6
    • Britton, G.J.1    Ambler, R.2    Clark, D.J.3    Hill, E.V.4    Tunbridge, H.M.5    McNally, K.E.6
  • 22
    • 84895509804 scopus 로고    scopus 로고
    • Non-canonical Notch signaling drives activation and differentiation of peripheral CD4(+) T cells
    • Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, et al. Non-canonical Notch signaling drives activation and differentiation of peripheral CD4(+) T cells. Front Immunol (2014) 5:54. doi:10.3389/fimmu.2014.00054
    • (2014) Front Immunol , vol.5 , pp. 54
    • Dongre, A.1    Surampudi, L.2    Lawlor, R.G.3    Fauq, A.H.4    Miele, L.5    Golde, T.E.6
  • 23
    • 84905407019 scopus 로고    scopus 로고
    • NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome
    • Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, et al. NOTCH1 can initiate NF-kappaB activation via cytosolic interactions with components of the T cell signalosome. Front Immunol (2014) 5:249. doi:10.3389/fimmu.2014.00249
    • (2014) Front Immunol , vol.5 , pp. 249
    • Shin, H.M.1    Tilahun, M.E.2    Cho, O.H.3    Chandiran, K.4    Kuksin, C.A.5    Keerthivasan, S.6
  • 24
    • 38449102218 scopus 로고    scopus 로고
    • JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis
    • Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisakk P, Chiba S, et al. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J Immunol (2007) 179:5990-8. doi:10.4049/jimmunol.179.9.5990
    • (2007) J Immunol , vol.179 , pp. 5990-5998
    • Elyaman, W.1    Bradshaw, E.M.2    Wang, Y.3    Oukka, M.4    Kivisakk, P.5    Chiba, S.6
  • 25
    • 84856460586 scopus 로고    scopus 로고
    • Notch-ligand expression by NALT dendritic cells regulates mucosal Th1-and Th2-type responses
    • Fukuyama Y, Tokuhara D, Sekine S, Kataoka K, Markham JD, Irwin AR, et al. Notch-ligand expression by NALT dendritic cells regulates mucosal Th1-and Th2-type responses. Biochem Biophys Res Commun (2012) 418:6-11. doi:10.1016/j.bbrc.2011.12.046
    • (2012) Biochem Biophys Res Commun , vol.418 , pp. 6-11
    • Fukuyama, Y.1    Tokuhara, D.2    Sekine, S.3    Kataoka, K.4    Markham, J.D.5    Irwin, A.R.6
  • 26
    • 84938948753 scopus 로고    scopus 로고
    • Non-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells
    • Gilles S, Beck I, Lange S, Ring J, Behrendt H, Traidl-Hoffmann C. Non-allergenic factors from pollen modulate T helper cell instructing notch ligands on dendritic cells. World Allergy Organ J (2015) 8:2. doi:10.1186/s40413-014-0054-8
    • (2015) World Allergy Organ J , vol.8 , pp. 2
    • Gilles, S.1    Beck, I.2    Lange, S.3    Ring, J.4    Behrendt, H.5    Traidl-Hoffmann, C.6
  • 27
    • 78650642332 scopus 로고    scopus 로고
    • Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity
    • Jang S, Schaller M, Berlin AA, Lukacs NW. Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity. J Immunol (2010) 185:5835-44. doi:10.4049/jimmunol.1000175
    • (2010) J Immunol , vol.185 , pp. 5835-5844
    • Jang, S.1    Schaller, M.2    Berlin, A.A.3    Lukacs, N.W.4
  • 28
    • 84860439165 scopus 로고    scopus 로고
    • Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation
    • Jeong HW, Kim JH, Kim JY, Ha SJ, Kong YY. Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation. PLoS One (2012) 7:e36359. doi:10.1371/journal.pone.0036359
    • (2012) PLoS One , vol.7
    • Jeong, H.W.1    Kim, J.H.2    Kim, J.Y.3    Ha, S.J.4    Kong, Y.Y.5
  • 29
    • 43249111075 scopus 로고    scopus 로고
    • Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma
    • Krishnamoorthy N, Oriss TB, Paglia M, Fei M, Yarlagadda M, Vanhaesebroeck B, et al. Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma. Nat Med (2008) 14:565-73. doi:10.1038/nm1766
    • (2008) Nat Med , vol.14 , pp. 565-573
    • Krishnamoorthy, N.1    Oriss, T.B.2    Paglia, M.3    Fei, M.4    Yarlagadda, M.5    Vanhaesebroeck, B.6
  • 30
    • 70349238800 scopus 로고    scopus 로고
    • Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production
    • Okamoto M, Matsuda H, Joetham A, Lucas JJ, Domenico J, Yasutomo K, et al. Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. J Immunol (2009) 183:2995-3003. doi:10.4049/jimmunol.0900692
    • (2009) J Immunol , vol.183 , pp. 2995-3003
    • Okamoto, M.1    Matsuda, H.2    Joetham, A.3    Lucas, J.J.4    Domenico, J.5    Yasutomo, K.6
  • 31
    • 80052570287 scopus 로고    scopus 로고
    • Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells
    • Okamoto M, Takeda K, Lucas JJ, Joetham A, Yasutomo K, Gelfand EW. Low-dose lipopolysaccharide affects lung allergic responses by regulating Jagged1 expression on antigen-pulsed dendritic cells. Int Arch Allergy Immunol (2012) 157:65-72. doi:10.1159/000324836
    • (2012) Int Arch Allergy Immunol , vol.157 , pp. 65-72
    • Okamoto, M.1    Takeda, K.2    Lucas, J.J.3    Joetham, A.4    Yasutomo, K.5    Gelfand, E.W.6
  • 32
    • 85012888276 scopus 로고    scopus 로고
    • Notch signaling in T cells is essential for allergic airway inflammation, but expression of Notch ligands Jagged1 and Jagged2 on dendritic cells is dispensable
    • Tindemans I, Lukkes M, de Bruijn MJ, Li BW, van Nimwegen M, Amsen D, et al. Notch signaling in T cells is essential for allergic airway inflammation, but expression of Notch ligands Jagged1 and Jagged2 on dendritic cells is dispensable. J Allergy Clin Immunol (2017). doi:10.1016/j.jaci.2016.11.046
    • (2017) J Allergy Clin Immunol
    • Tindemans, I.1    Lukkes, M.2    de Bruijn, M.J.3    Li, B.W.4    van Nimwegen, M.5    Amsen, D.6
  • 33
    • 34248570482 scopus 로고    scopus 로고
    • Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities
    • Wakui M, Nakano K, Matsushita S. Notch ligand mRNA levels of human APCs predict Th1/Th2-promoting activities. Biochem Biophys Res Commun (2007) 358:596-601. doi:10.1016/j.bbrc.2007.04.175
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 596-601
    • Wakui, M.1    Nakano, K.2    Matsushita, S.3
  • 34
    • 50949094678 scopus 로고    scopus 로고
    • Th2 differentiation is unaffected by Jagged2 expression on dendritic cells
    • Krawczyk CM, Sun J, Pearce EJ. Th2 differentiation is unaffected by Jagged2 expression on dendritic cells. J Immunol (2008) 180:7931-7. doi:10.4049/jimmunol.180.12.7931
    • (2008) J Immunol , vol.180 , pp. 7931-7937
    • Krawczyk, C.M.1    Sun, J.2    Pearce, E.J.3
  • 35
    • 34247567868 scopus 로고    scopus 로고
    • MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection
    • Rudd BD, Schaller MA, Smit JJ, Kunkel SL, Neupane R, Kelley L, et al. MyD88-mediated instructive signals in dendritic cells regulate pulmonary immune responses during respiratory virus infection. J Immunol (2007) 178:5820-7. doi:10.4049/jimmunol.178.9.5820
    • (2007) J Immunol , vol.178 , pp. 5820-5827
    • Rudd, B.D.1    Schaller, M.A.2    Smit, J.J.3    Kunkel, S.L.4    Neupane, R.5    Kelley, L.6
  • 36
    • 36549001590 scopus 로고    scopus 로고
    • Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    • Schaller MA, Neupane R, Rudd BD, Kunkel SL, Kallal LE, Lincoln P, et al. Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J Exp Med (2007) 204:2925-34. doi:10.1084/jem.20070661
    • (2007) J Exp Med , vol.204 , pp. 2925-2934
    • Schaller, M.A.1    Neupane, R.2    Rudd, B.D.3    Kunkel, S.L.4    Kallal, L.E.5    Lincoln, P.6
  • 37
    • 34447254518 scopus 로고    scopus 로고
    • CD8-DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS
    • Skokos D, Nussenzweig MC. CD8-DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J Exp Med (2007) 204:1525-31. doi:10.1084/jem.20062305
    • (2007) J Exp Med , vol.204 , pp. 1525-1531
    • Skokos, D.1    Nussenzweig, M.C.2
  • 38
    • 40749089559 scopus 로고    scopus 로고
    • Suppression of Th2 cell development by Notch ligands Delta1 and Delta4
    • Sun J, Krawczyk CJ, Pearce EJ. Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J Immunol (2008) 180:1655-61. doi:10.4049/jimmunol.180.3.1655
    • (2008) J Immunol , vol.180 , pp. 1655-1661
    • Sun, J.1    Krawczyk, C.J.2    Pearce, E.J.3
  • 39
    • 0037121946 scopus 로고    scopus 로고
    • Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
    • Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med (2002) 196:1645-51. doi:10.1084/jem.20021340
    • (2002) J Exp Med , vol.196 , pp. 1645-1651
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 40
    • 0036312668 scopus 로고    scopus 로고
    • Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation
    • Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S. Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation. Int Immunol (2002) 14:695-700. doi:10.1093/intimm/dxf039
    • (2002) Int Immunol , vol.14 , pp. 695-700
    • Kaisho, T.1    Hoshino, K.2    Iwabe, T.3    Takeuchi, O.4    Yasui, T.5    Akira, S.6
  • 42
    • 84877796487 scopus 로고    scopus 로고
    • Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production
    • Huang HM, Hsiao G, Fan CK, Lin CL, Leu SJ, Chiang BL, et al. Notch ligand delta-like 4-pretreated dendritic cells alleviate allergic airway responses by enhancing IL-10 production. PLoS One (2013) 8:e63613. doi:10.1371/journal.pone.0063613
    • (2013) PLoS One , vol.8
    • Huang, H.M.1    Hsiao, G.2    Fan, C.K.3    Lin, C.L.4    Leu, S.J.5    Chiang, B.L.6
  • 43
    • 84994806254 scopus 로고    scopus 로고
    • The effect of Dermatophagoides pteronyssinus group 7 allergen (Der p 7) on dendritic cells and its role in T cell polarization
    • Tsai JJ, Wang HC, Chiu CL, Liao EC. The effect of Dermatophagoides pteronyssinus group 7 allergen (Der p 7) on dendritic cells and its role in T cell polarization. Immunobiology (2016) 221(11):1319-28. doi:10.1016/j.imbio.2016.04.002
    • (2016) Immunobiology , vol.221 , Issue.11 , pp. 1319-1328
    • Tsai, J.J.1    Wang, H.C.2    Chiu, C.L.3    Liao, E.C.4
  • 44
    • 41449093693 scopus 로고    scopus 로고
    • Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    • Liotta F, Frosali F, Querci V, Mantei A, Fili L, Maggi L, et al. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J Allergy Clin Immunol (2008) 121:1000.e-5.e. doi:10.1016/j.jaci.2008.01.004
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1000.e-1005.e
    • Liotta, F.1    Frosali, F.2    Querci, V.3    Mantei, A.4    Fili, L.5    Maggi, L.6
  • 45
    • 78650634881 scopus 로고    scopus 로고
    • Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin
    • Bleck B, Tse DB, Gordon T, Ahsan MR, Reibman J. Diesel exhaust particle-treated human bronchial epithelial cells upregulate Jagged-1 and OX40 ligand in myeloid dendritic cells via thymic stromal lymphopoietin. J Immunol (2010) 185:6636-45. doi:10.4049/jimmunol.1000719
    • (2010) J Immunol , vol.185 , pp. 6636-6645
    • Bleck, B.1    Tse, D.B.2    Gordon, T.3    Ahsan, M.R.4    Reibman, J.5
  • 46
    • 0142157141 scopus 로고    scopus 로고
    • Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells
    • Maekawa Y, Tsukumo S, Chiba S, Hirai H, Hayashi Y, Okada H, et al. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity (2003) 19:549-59. doi:10.1016/S1074-7613(03)00270-X
    • (2003) Immunity , vol.19 , pp. 549-559
    • Maekawa, Y.1    Tsukumo, S.2    Chiba, S.3    Hirai, H.4    Hayashi, Y.5    Okada, H.6
  • 47
    • 77956107505 scopus 로고    scopus 로고
    • Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease
    • Takeichi N, Yanagisawa S, Kaneyama T, Yagita H, Jin YH, Kim BS, et al. Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int Immunol (2010) 22:729-38. doi:10.1093/intimm/dxq059
    • (2010) Int Immunol , vol.22 , pp. 729-738
    • Takeichi, N.1    Yanagisawa, S.2    Kaneyama, T.3    Yagita, H.4    Jin, Y.H.5    Kim, B.S.6
  • 48
    • 79952520029 scopus 로고    scopus 로고
    • Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)-and Th17-type expansion involving Notch3 and Delta-like1
    • Jiao Z, Wang W, Xu H, Wang S, Guo M, Chen Y, et al. Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)-and Th17-type expansion involving Notch3 and Delta-like1. Clin Exp Immunol (2011) 164:66-71. doi:10.1111/j.1365-2249.2010.04310.x
    • (2011) Clin Exp Immunol , vol.164 , pp. 66-71
    • Jiao, Z.1    Wang, W.2    Xu, H.3    Wang, S.4    Guo, M.5    Chen, Y.6
  • 49
    • 80052685578 scopus 로고    scopus 로고
    • Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development
    • Bassil R, Zhu B, Lahoud Y, Riella LV, Yagita H, Elyaman W, et al. Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development. J Immunol (2011) 187:2322-8. doi:10.4049/jimmunol.1100725
    • (2011) J Immunol , vol.187 , pp. 2322-2328
    • Bassil, R.1    Zhu, B.2    Lahoud, Y.3    Riella, L.V.4    Yagita, H.5    Elyaman, W.6
  • 50
    • 84876420699 scopus 로고    scopus 로고
    • Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis
    • Eixarch H, Mansilla MJ, Costa C, Kunkel SL, Montalban X, Godessart N, et al. Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis. Neurosci Lett (2013) 541:161-6. doi:10.1016/j.neulet.2013.02.038
    • (2013) Neurosci Lett , vol.541 , pp. 161-166
    • Eixarch, H.1    Mansilla, M.J.2    Costa, C.3    Kunkel, S.L.4    Montalban, X.5    Godessart, N.6
  • 51
    • 84918840039 scopus 로고    scopus 로고
    • Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-beta signalling pathway
    • Li Y, Wu S, Pu J, Huang X, Zhang P. Dengue virus up-regulates expression of notch ligands Dll1 and Dll4 through interferon-beta signalling pathway. Immunology (2015) 144:127-38. doi:10.1111/imm.12357
    • (2015) Immunology , vol.144 , pp. 127-138
    • Li, Y.1    Wu, S.2    Pu, J.3    Huang, X.4    Zhang, P.5
  • 52
    • 84957656074 scopus 로고    scopus 로고
    • The Notch ligand DLL4 defines a capability of human dendritic cells in regulating Th1 and Th17 differentiation
    • Meng L, Bai Z, He S, Mochizuki K, Liu Y, Purushe J, et al. The Notch ligand DLL4 defines a capability of human dendritic cells in regulating Th1 and Th17 differentiation. J Immunol (2016) 196:1070-80. doi:10.4049/jimmunol.1501310
    • (2016) J Immunol , vol.196 , pp. 1070-1080
    • Meng, L.1    Bai, Z.2    He, S.3    Mochizuki, K.4    Liu, Y.5    Purushe, J.6
  • 53
    • 34447634411 scopus 로고    scopus 로고
    • Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    • Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 27:89-99. doi:10.1016/j.immuni.2007.05.021
    • (2007) Immunity , vol.27 , pp. 89-99
    • Amsen, D.1    Antov, A.2    Jankovic, D.3    Sher, A.4    Radtke, F.5    Souabni, A.6
  • 55
    • 33745081482 scopus 로고    scopus 로고
    • The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells
    • Tanaka S, Tsukada J, Suzuki W, Hayashi K, Tanigaki K, Tsuji M, et al. The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells. Immunity (2006) 24:689-701. doi:10.1016/j.immuni.2006.04.009
    • (2006) Immunity , vol.24 , pp. 689-701
    • Tanaka, S.1    Tsukada, J.2    Suzuki, W.3    Hayashi, K.4    Tanigaki, K.5    Tsuji, M.6
  • 56
    • 26844538164 scopus 로고    scopus 로고
    • Notch signaling is an important regulator of type 2 immunity
    • Tu L, Fang TC, Artis D, Shestova O, Pross SE, Maillard I, et al. Notch signaling is an important regulator of type 2 immunity. J Exp Med (2005) 202:1037-42. doi:10.1084/jem.20050923
    • (2005) J Exp Med , vol.202 , pp. 1037-1042
    • Tu, L.1    Fang, T.C.2    Artis, D.3    Shestova, O.4    Pross, S.E.5    Maillard, I.6
  • 57
    • 85006414607 scopus 로고    scopus 로고
    • Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice
    • Jiang S, Han S, Chen J, Li X, Che H. Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice. Ann Allergy Asthma Immunol (2017) 118:94-102. doi:10.1016/j.anai.2016.10.024
    • (2017) Ann Allergy Asthma Immunol , vol.118 , pp. 94-102
    • Jiang, S.1    Han, S.2    Chen, J.3    Li, X.4    Che, H.5
  • 58
    • 65649149442 scopus 로고    scopus 로고
    • Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses
    • Kang JH, Kim BS, Uhm TG, Lee SH, Lee GR, Park CS, et al. Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses. Am J Respir Crit Care Med (2009) 179:875-82. doi:10.1164/rccm.200806-893OC
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 875-882
    • Kang, J.H.1    Kim, B.S.2    Uhm, T.G.3    Lee, S.H.4    Lee, G.R.5    Park, C.S.6
  • 59
    • 84939963673 scopus 로고    scopus 로고
    • Blockade of Notch signalling by gamma-secretase inhibitor in lung t cells of asthmatic mice affects T cell differentiation and pulmonary inflammation
    • Zhou M, Cui ZL, Guo XJ, Ren LP, Yang M, Fan ZW, et al. Blockade of Notch signalling by gamma-secretase inhibitor in lung t cells of asthmatic mice affects T cell differentiation and pulmonary inflammation. Inflammation (2015) 38:1281-8. doi:10.1007/s10753-014-0098-5
    • (2015) Inflammation , vol.38 , pp. 1281-1288
    • Zhou, M.1    Cui, Z.L.2    Guo, X.J.3    Ren, L.P.4    Yang, M.5    Fan, Z.W.6
  • 60
    • 84893349932 scopus 로고    scopus 로고
    • STAT5-induced lunatic fringe during Th2 development alters delta-like 4-mediated Th2 cytokine production in respiratory syncytial virus-exacerbated airway allergic disease
    • Mukherjee S, Rasky AJ, Lundy PA, Kittan NA, Kunkel SL, Maillard IP, et al. STAT5-induced lunatic fringe during Th2 development alters delta-like 4-mediated Th2 cytokine production in respiratory syncytial virus-exacerbated airway allergic disease. J Immunol (2014) 192:996-1003. doi:10.4049/jimmunol.1301991
    • (2014) J Immunol , vol.192 , pp. 996-1003
    • Mukherjee, S.1    Rasky, A.J.2    Lundy, P.A.3    Kittan, N.A.4    Kunkel, S.L.5    Maillard, I.P.6
  • 61
    • 22144492615 scopus 로고    scopus 로고
    • Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
    • Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, et al. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol (2005) 6:680-8. doi:10.1038/ni1209
    • (2005) Nat Immunol , vol.6 , pp. 680-688
    • Minter, L.M.1    Turley, D.M.2    Das, P.3    Shin, H.M.4    Joshi, I.5    Lawlor, R.G.6
  • 62
    • 84863598267 scopus 로고    scopus 로고
    • Redundant Notch1 and Notch2 signaling is necessary for IFNgamma secretion by T helper 1 cells during infection with Leishmania major
    • Auderset F, Schuster S, Coutaz M, Koch U, Desgranges F, Merck E, et al. Redundant Notch1 and Notch2 signaling is necessary for IFNgamma secretion by T helper 1 cells during infection with Leishmania major. PLoS Pathog (2012) 8:e1002560. doi:10.1371/journal.ppat.1002560
    • (2012) PLoS Pathog , vol.8
    • Auderset, F.1    Schuster, S.2    Coutaz, M.3    Koch, U.4    Desgranges, F.5    Merck, E.6
  • 63
    • 43049163813 scopus 로고    scopus 로고
    • Substrate specificity of gamma-secretase and other intramembrane proteases
    • Beel AJ, Sanders CR. Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 65:1311-34. doi:10.1007/s00018-008-7462-2
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1311-1334
    • Beel, A.J.1    Sanders, C.R.2
  • 64
    • 80555149831 scopus 로고    scopus 로고
    • Blockade of Notch ligand delta1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation
    • Riella LV, Ueno T, Batal I, De Serres SA, Bassil R, Elyaman W, et al. Blockade of Notch ligand delta1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation. J Immunol (2011) 187:4629-38. doi:10.4049/jimmunol.1004076
    • (2011) J Immunol , vol.187 , pp. 4629-4638
    • Riella, L.V.1    Ueno, T.2    Batal, I.3    De Serres, S.A.4    Bassil, R.5    Elyaman, W.6
  • 65
    • 84859997488 scopus 로고    scopus 로고
    • Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
    • Elyaman W, Bassil R, Bradshaw EM, Orent W, Lahoud Y, Zhu B, et al. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity (2012) 36:623-34. doi:10.1016/j.immuni.2012.01.020
    • (2012) Immunity , vol.36 , pp. 623-634
    • Elyaman, W.1    Bassil, R.2    Bradshaw, E.M.3    Orent, W.4    Lahoud, Y.5    Zhu, B.6
  • 66
    • 85006257573 scopus 로고    scopus 로고
    • Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner
    • Coutaz M, Hurrell BP, Auderset F, Wang H, Siegert S, Eberl G, et al. Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner. Sci Rep (2016) 6:39117. doi:10.1038/srep39117
    • (2016) Sci Rep , vol.6 , pp. 39117
    • Coutaz, M.1    Hurrell, B.P.2    Auderset, F.3    Wang, H.4    Siegert, S.5    Eberl, G.6
  • 67
  • 68
    • 84992502293 scopus 로고    scopus 로고
    • RBPJ controls development of pathogenic Th17 cells by regulating IL-23 receptor expression
    • Meyer Zu Horste G, Wu C, Wang C, Cong L, Pawlak M, Lee Y, et al. RBPJ controls development of pathogenic Th17 cells by regulating IL-23 receptor expression. Cell Rep (2016) 16:392-404. doi:10.1016/j.celrep.2016.05.088
    • (2016) Cell Rep , vol.16 , pp. 392-404
    • Meyer Zu Horste, G.1    Wu, C.2    Wang, C.3    Cong, L.4    Pawlak, M.5    Lee, Y.6
  • 69
    • 67649216137 scopus 로고    scopus 로고
    • Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    • Mukherjee S, Schaller MA, Neupane R, Kunkel SL, Lukacs NW. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J Immunol (2009) 182:7381-8. doi:10.4049/jimmunol.0804322
    • (2009) J Immunol , vol.182 , pp. 7381-7388
    • Mukherjee, S.1    Schaller, M.A.2    Neupane, R.3    Kunkel, S.L.4    Lukacs, N.W.5
  • 70
    • 84939625833 scopus 로고    scopus 로고
    • gamma-Secretase inhibitor alleviates acute airway inflammation of allergic asthma in mice by downregulating Th17 cell differentiation
    • Zhang W, Zhang X, Sheng A, Weng C, Zhu T, Zhao W, et al. gamma-Secretase inhibitor alleviates acute airway inflammation of allergic asthma in mice by downregulating Th17 cell differentiation. Mediators Inflamm (2015) 2015:258168. doi:10.1155/2015/258168
    • (2015) Mediators Inflamm , vol.2015
    • Zhang, W.1    Zhang, X.2    Sheng, A.3    Weng, C.4    Zhu, T.5    Zhao, W.6
  • 71
    • 84949730012 scopus 로고    scopus 로고
    • Dll4 in the DCs isolated from OVA-sensitized mice is involved in Th17 differentiation inhibition by 1,25-dihydroxyvitamin D3 in vitro
    • Jiang Y, Zhao S, Yang X, Liu Y, Wang C. Dll4 in the DCs isolated from OVA-sensitized mice is involved in Th17 differentiation inhibition by 1,25-dihydroxyvitamin D3 in vitro. J Asthma (2015) 52:989-95. doi:10.3109/02770903.2015.1056349
    • (2015) J Asthma , vol.52 , pp. 989-995
    • Jiang, Y.1    Zhao, S.2    Yang, X.3    Liu, Y.4    Wang, C.5
  • 72
    • 77954544155 scopus 로고    scopus 로고
    • Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells
    • Higashi T, Hashimoto K, Takagi R, Mizuno Y, Okazaki Y, Tanaka Y, et al. Curdlan induces DC-mediated Th17 polarization via Jagged1 activation in human dendritic cells. Allergol Int (2010) 59:161-6. doi:10.2332/allergolint.09-OA-0103
    • (2010) Allergol Int , vol.59 , pp. 161-166
    • Higashi, T.1    Hashimoto, K.2    Takagi, R.3    Mizuno, Y.4    Okazaki, Y.5    Tanaka, Y.6
  • 73
    • 84949636448 scopus 로고    scopus 로고
    • Jagged-1 signaling suppresses the IL-6 and TGF-beta treatment-induced Th17 cell differentiation via the reduction of RORgammat/IL-17A/IL-17F/IL-23a/IL-12rb1
    • Wang Y, Xing F, Ye S, Xiao J, Di J, Zeng S, et al. Jagged-1 signaling suppresses the IL-6 and TGF-beta treatment-induced Th17 cell differentiation via the reduction of RORgammat/IL-17A/IL-17F/IL-23a/IL-12rb1. Sci Rep (2015) 5:8234. doi:10.1038/srep08234
    • (2015) Sci Rep , vol.5 , pp. 8234
    • Wang, Y.1    Xing, F.2    Ye, S.3    Xiao, J.4    Di, J.5    Zeng, S.6
  • 74
    • 84878780079 scopus 로고    scopus 로고
    • Jagged-1-HES-1 signaling inhibits the differentiation of TH17 cells via ROR gammat
    • You P, Xing F, Mao C, Chen Z, Zhang H, Wang Y, et al. Jagged-1-HES-1 signaling inhibits the differentiation of TH17 cells via ROR gammat. J Biol Regul Homeost Agents (2013) 27:79-93
    • (2013) J Biol Regul Homeost Agents , vol.27 , pp. 79-93
    • You, P.1    Xing, F.2    Mao, C.3    Chen, Z.4    Zhang, H.5    Wang, Y.6
  • 75
    • 84897841109 scopus 로고    scopus 로고
    • Blockade of Notch signaling ameliorates murine collagen-induced arthritis via suppressing Th1 and Th17 cell responses
    • Jiao Z, Wang W, Hua S, Liu M, Wang H, Wang X, et al. Blockade of Notch signaling ameliorates murine collagen-induced arthritis via suppressing Th1 and Th17 cell responses. Am J Pathol (2014) 184:1085-93. doi:10.1016/j.ajpath.2013.12.010
    • (2014) Am J Pathol , vol.184 , pp. 1085-1093
    • Jiao, Z.1    Wang, W.2    Hua, S.3    Liu, M.4    Wang, H.5    Wang, X.6
  • 76
    • 24944501849 scopus 로고    scopus 로고
    • The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
    • Ladi E, Nichols JT, Ge W, Miyamoto A, Yao C, Yang LT, et al. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol (2005) 170:983-92. doi:10.1083/jcb.200503113
    • (2005) J Cell Biol , vol.170 , pp. 983-992
    • Ladi, E.1    Nichols, J.T.2    Ge, W.3    Miyamoto, A.4    Yao, C.5    Yang, L.T.6
  • 77
    • 10744222828 scopus 로고    scopus 로고
    • Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes
    • Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, Pascucci M, et al. Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol (2003) 171:4504-11. doi:10.4049/jimmunol.171.9.4504
    • (2003) J Immunol , vol.171 , pp. 4504-4511
    • Anastasi, E.1    Campese, A.F.2    Bellavia, D.3    Bulotta, A.4    Balestri, A.5    Pascucci, M.6
  • 78
    • 79958058411 scopus 로고    scopus 로고
    • Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription
    • Barbarulo A, Grazioli P, Campese AF, Bellavia D, Di Mario G, Pelullo M, et al. Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription. J Immunol (2011) 186:6199-206. doi:10.4049/jimmunol.1002136
    • (2011) J Immunol , vol.186 , pp. 6199-6206
    • Barbarulo, A.1    Grazioli, P.2    Campese, A.F.3    Bellavia, D.4    Di Mario, G.5    Pelullo, M.6
  • 79
    • 78751580511 scopus 로고    scopus 로고
    • Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated Treg function in RBP-J deficient mice
    • Fu T, Zhang P, Feng L, Ji G, Wang XH, Zheng MH, et al. Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated Treg function in RBP-J deficient mice. Mol Immunol (2011) 48:751-9. doi:10.1016/j.molimm.2010.11.016
    • (2011) Mol Immunol , vol.48 , pp. 751-759
    • Fu, T.1    Zhang, P.2    Feng, L.3    Ji, G.4    Wang, X.H.5    Zheng, M.H.6
  • 80
    • 52649179291 scopus 로고    scopus 로고
    • Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells
    • Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, et al. Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood (2008) 112:1813-21. doi:10.1182/blood-2008-03-144980
    • (2008) Blood , vol.112 , pp. 1813-1821
    • Samon, J.B.1    Champhekar, A.2    Minter, L.M.3    Telfer, J.C.4    Miele, L.5    Fauq, A.6
  • 81
    • 84928538044 scopus 로고    scopus 로고
    • Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells
    • Cahill EF, Tobin LM, Carty F, Mahon BP, English K. Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells. Stem Cell Res Ther (2015) 6:19. doi:10.1186/s13287-015-0021-5
    • (2015) Stem Cell Res Ther , vol.6 , pp. 19
    • Cahill, E.F.1    Tobin, L.M.2    Carty, F.3    Mahon, B.P.4    English, K.5
  • 82
    • 84878029055 scopus 로고    scopus 로고
    • OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells
    • Gopisetty A, Bhattacharya P, Haddad C, Bruno JC Jr, Vasu C, Miele L, et al. OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells. J Immunol (2013) 190:5516-25. doi:10.4049/jimmunol.1202298
    • (2013) J Immunol , vol.190 , pp. 5516-5525
    • Gopisetty, A.1    Bhattacharya, P.2    Haddad, C.3    Bruno, J.C.4    Vasu, C.5    Miele, L.6
  • 83
    • 33846250032 scopus 로고    scopus 로고
    • Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
    • Kared H, Adle-Biassette H, Fois E, Masson A, Bach JF, Chatenoud L, et al. Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity (2006) 25:823-34. doi:10.1016/j.immuni.2006.09.008
    • (2006) Immunity , vol.25 , pp. 823-834
    • Kared, H.1    Adle-Biassette, H.2    Fois, E.3    Masson, A.4    Bach, J.F.5    Chatenoud, L.6
  • 84
    • 84916877038 scopus 로고    scopus 로고
    • Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells
    • Mota C, Nunes-Silva V, Pires AR, Matoso P, Victorino RM, Sousa AE, et al. Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells. J Immunol (2014) 193:5854-62. doi:10.4049/jimmunol.1400198
    • (2014) J Immunol , vol.193 , pp. 5854-5862
    • Mota, C.1    Nunes-Silva, V.2    Pires, A.R.3    Matoso, P.4    Victorino, R.M.5    Sousa, A.E.6
  • 86
    • 23844549973 scopus 로고    scopus 로고
    • Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells
    • Rutz S, Mordmuller B, Sakano S, Scheffold A. Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur J Immunol (2005) 35:2443-51. doi:10.1002/eji.200526294
    • (2005) Eur J Immunol , vol.35 , pp. 2443-2451
    • Rutz, S.1    Mordmuller, B.2    Sakano, S.3    Scheffold, A.4
  • 87
    • 0141566334 scopus 로고    scopus 로고
    • Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes
    • Vigouroux S, Yvon E, Wagner HJ, Biagi E, Dotti G, Sili U, et al. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol (2003) 77:10872-80. doi:10.1128/JVI.77.20.10872-10880.2003
    • (2003) J Virol , vol.77 , pp. 10872-10880
    • Vigouroux, S.1    Yvon, E.2    Wagner, H.J.3    Biagi, E.4    Dotti, G.5    Sili, U.6
  • 88
    • 0242493801 scopus 로고    scopus 로고
    • Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells
    • Yvon ES, Vigouroux S, Rousseau RF, Biagi E, Amrolia P, Dotti G, et al. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood (2003) 102:3815-21. doi:10.1182/blood-2002-12-3826
    • (2003) Blood , vol.102 , pp. 3815-3821
    • Yvon, E.S.1    Vigouroux, S.2    Rousseau, R.F.3    Biagi, E.4    Amrolia, P.5    Dotti, G.6
  • 89
    • 58049180417 scopus 로고    scopus 로고
    • Notch signaling regulates the FOXP3 promoter through RBP-J-and Hes1-dependent mechanisms
    • Ou-Yang HF, Zhang HW, Wu CG, Zhang P, Zhang J, Li JC, et al. Notch signaling regulates the FOXP3 promoter through RBP-J-and Hes1-dependent mechanisms. Mol Cell Biochem (2009) 320:109-14. doi:10.1007/s11010-008-9912-4
    • (2009) Mol Cell Biochem , vol.320 , pp. 109-114
    • Ou-Yang, H.F.1    Zhang, H.W.2    Wu, C.G.3    Zhang, P.4    Zhang, J.5    Li, J.C.6
  • 90
    • 84863794078 scopus 로고    scopus 로고
    • Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice
    • Billiard F, Lobry C, Darrasse-Jeze G, Waite J, Liu X, Mouquet H, et al. Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice. J Exp Med (2012) 209:1011-28. doi:10.1084/jem.20111615
    • (2012) J Exp Med , vol.209 , pp. 1011-1028
    • Billiard, F.1    Lobry, C.2    Darrasse-Jeze, G.3    Waite, J.4    Liu, X.5    Mouquet, H.6
  • 91
    • 84945473719 scopus 로고    scopus 로고
    • Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling
    • Charbonnier LM, Wang S, Georgiev P, Sefik E, Chatila TA. Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling. Nat Immunol (2015) 16:1162-73. doi:10.1038/ni.3288
    • (2015) Nat Immunol , vol.16 , pp. 1162-1173
    • Charbonnier, L.M.1    Wang, S.2    Georgiev, P.3    Sefik, E.4    Chatila, T.A.5
  • 92
    • 84888374898 scopus 로고    scopus 로고
    • Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells
    • Burghardt S, Erhardt A, Claass B, Huber S, Adler G, Jacobs T, et al. Hepatocytes contribute to immune regulation in the liver by activation of the Notch signaling pathway in T cells. J Immunol (2013) 191:5574-82. doi:10.4049/jimmunol.1300826
    • (2013) J Immunol , vol.191 , pp. 5574-5582
    • Burghardt, S.1    Erhardt, A.2    Claass, B.3    Huber, S.4    Adler, G.5    Jacobs, T.6
  • 93
    • 76249101454 scopus 로고    scopus 로고
    • Cutting edge: plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis
    • Kassner N, Krueger M, Yagita H, Dzionek A, Hutloff A, Kroczek R, et al. Cutting edge: plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol (2010) 184:550-4. doi:10.4049/jimmunol.0903152
    • (2010) J Immunol , vol.184 , pp. 550-554
    • Kassner, N.1    Krueger, M.2    Yagita, H.3    Dzionek, A.4    Hutloff, A.5    Kroczek, R.6
  • 94
    • 84883396890 scopus 로고    scopus 로고
    • Notch signaling regulates follicular helper T cell differentiation
    • Auderset F, Schuster S, Fasnacht N, Coutaz M, Charmoy M, Koch U, et al. Notch signaling regulates follicular helper T cell differentiation. J Immunol (2013) 191:2344-50. doi:10.4049/jimmunol.1300643
    • (2013) J Immunol , vol.191 , pp. 2344-2350
    • Auderset, F.1    Schuster, S.2    Fasnacht, N.3    Coutaz, M.4    Charmoy, M.5    Koch, U.6
  • 95
    • 84908226945 scopus 로고    scopus 로고
    • Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses
    • Fasnacht N, Huang HY, Koch U, Favre S, Auderset F, Chai Q, et al. Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med (2014) 211:2265-79. doi:10.1084/jem.20132528
    • (2014) J Exp Med , vol.211 , pp. 2265-2279
    • Fasnacht, N.1    Huang, H.Y.2    Koch, U.3    Favre, S.4    Auderset, F.5    Chai, Q.6
  • 96
    • 58849099058 scopus 로고    scopus 로고
    • The different faces of Notch in T-helper-cell differentiation
    • Amsen D, Antov A, Flavell RA. The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol (2009) 9:116-24. doi:10.1038/nri2488
    • (2009) Nat Rev Immunol , vol.9 , pp. 116-124
    • Amsen, D.1    Antov, A.2    Flavell, R.A.3
  • 97
    • 0141995063 scopus 로고    scopus 로고
    • Glycosylation regulates Notch signalling
    • Haines N, Irvine KD. Glycosylation regulates Notch signalling. Nat Rev Mol Cell Biol (2003) 4:786-97. doi:10.1038/nrm1228
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 786-797
    • Haines, N.1    Irvine, K.D.2
  • 98
    • 84867341618 scopus 로고    scopus 로고
    • Fringe controls naive CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models
    • Gu W, Xu W, Ding T, Guo X. Fringe controls naive CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models. PLoS One (2012) 7:e47288. doi:10.1371/journal.pone.0047288
    • (2012) PLoS One , vol.7
    • Gu, W.1    Xu, W.2    Ding, T.3    Guo, X.4
  • 99
    • 84857444873 scopus 로고    scopus 로고
    • Expression of Notch receptors and ligands on immature and mature T cells
    • Koyanagi A, Sekine C, Yagita H. Expression of Notch receptors and ligands on immature and mature T cells. Biochem Biophys Res Commun (2012) 418:799-805. doi:10.1016/j.bbrc.2012.01.106
    • (2012) Biochem Biophys Res Commun , vol.418 , pp. 799-805
    • Koyanagi, A.1    Sekine, C.2    Yagita, H.3
  • 100
    • 52549130987 scopus 로고    scopus 로고
    • Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
    • Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, et al. Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol (2008) 9:1140-7. doi:10.1038/ni.1649
    • (2008) Nat Immunol , vol.9 , pp. 1140-1147
    • Maekawa, Y.1    Minato, Y.2    Ishifune, C.3    Kurihara, T.4    Kitamura, A.5    Kojima, H.6
  • 101
    • 33646203458 scopus 로고    scopus 로고
    • Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability
    • Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, et al. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2006) 281:5106-19. doi:10.1074/jbc.M506108200
    • (2006) J Biol Chem , vol.281 , pp. 5106-5119
    • Ong, C.T.1    Cheng, H.T.2    Chang, L.W.3    Ohtsuka, T.4    Kageyama, R.5    Stormo, G.D.6
  • 102
    • 78549289477 scopus 로고    scopus 로고
    • Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes
    • Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, et al. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol (2010) 17:1312-7. doi:10.1038/nsmb.1938
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 1312-1317
    • Arnett, K.L.1    Hass, M.2    McArthur, D.G.3    Ilagan, M.X.4    Aster, J.C.5    Kopan, R.6
  • 103
    • 73349133349 scopus 로고    scopus 로고
    • Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies
    • Fiorini E, Merck E, Wilson A, Ferrero I, Jiang W, Koch U, et al. Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. J Immunol (2009) 183:7212-22. doi:10.4049/jimmunol.0902432
    • (2009) J Immunol , vol.183 , pp. 7212-7222
    • Fiorini, E.1    Merck, E.2    Wilson, A.3    Ferrero, I.4    Jiang, W.5    Koch, U.6
  • 104
    • 84938750482 scopus 로고    scopus 로고
    • Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade
    • Xia M, Viera-Hutchins L, Garcia-Lloret M, Noval Rivas M, Wise P, McGhee SA, et al. Vehicular exhaust particles promote allergic airway inflammation through an aryl hydrocarbon receptor-notch signaling cascade. J Allergy Clin Immunol (2015) 136:441-53. doi:10.1016/j.jaci.2015.02.014
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 441-453
    • Xia, M.1    Viera-Hutchins, L.2    Garcia-Lloret, M.3    Noval Rivas, M.4    Wise, P.5    McGhee, S.A.6
  • 105
    • 50949091487 scopus 로고    scopus 로고
    • Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
    • Ong CT, Sedy JR, Murphy KM, Kopan R. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 3:e2823. doi:10.1371/journal.pone.0002823
    • (2008) PLoS One , vol.3
    • Ong, C.T.1    Sedy, J.R.2    Murphy, K.M.3    Kopan, R.4
  • 106
    • 84861893409 scopus 로고    scopus 로고
    • Notch controls the magnitude of T helper cell responses by promoting cellular longevity
    • Helbig C, Gentek R, Backer RA, de Souza Y, Derks IA, Eldering E, et al. Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci U S A (2012) 109:9041-6. doi:10.1073/pnas.1206044109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 9041-9046
    • Helbig, C.1    Gentek, R.2    Backer, R.A.3    de Souza, Y.4    Derks, I.A.5    Eldering, E.6
  • 107
    • 84937542228 scopus 로고    scopus 로고
    • GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells
    • Helft J, Bottcher J, Chakravarty P, Zelenay S, Huotari J, Schraml BU, et al. GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c(+)MHCII(+) macrophages and dendritic cells. Immunity (2015) 42:1197-211. doi:10.1016/j.immuni.2015.05.018
    • (2015) Immunity , vol.42 , pp. 1197-1211
    • Helft, J.1    Bottcher, J.2    Chakravarty, P.3    Zelenay, S.4    Huotari, J.5    Schraml, B.U.6
  • 108
    • 0033950375 scopus 로고    scopus 로고
    • Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells
    • Hoyne GF, Le Roux I, Corsin-Jimenez M, Tan K, Dunne J, Forsyth LM, et al. Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int Immunol (2000) 12:177-85. doi:10.1093/intimm/12.2.177
    • (2000) Int Immunol , vol.12 , pp. 177-185
    • Hoyne, G.F.1    Le Roux, I.2    Corsin-Jimenez, M.3    Tan, K.4    Dunne, J.5    Forsyth, L.M.6
  • 110
    • 0025125920 scopus 로고
    • Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta
    • Cabrera CV. Lateral inhibition and cell fate during neurogenesis in Drosophila: the interactions between scute, Notch and Delta. Development (1990) 110:733-42
    • (1990) Development , vol.110 , pp. 733-742
    • Cabrera, C.V.1
  • 111
    • 84945580469 scopus 로고    scopus 로고
    • Ligand-independent mechanisms of Notch activity
    • Palmer WH, Deng WM. Ligand-independent mechanisms of Notch activity. Trends Cell Biol (2015) 25:697-707. doi:10.1016/j.tcb.2015.07.010
    • (2015) Trends Cell Biol , vol.25 , pp. 697-707
    • Palmer, W.H.1    Deng, W.M.2
  • 112
    • 77950441537 scopus 로고    scopus 로고
    • Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells
    • Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, et al. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A (2010) 107:5012-7. doi:10.1073/pnas.1000896107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 5012-5017
    • Mazzone, M.1    Selfors, L.M.2    Albeck, J.3    Overholtzer, M.4    Sale, S.5    Carroll, D.L.6
  • 113
    • 84878663215 scopus 로고    scopus 로고
    • Specific Notch receptor-ligand interactions control human TCR-alphabeta/gammadelta development by inducing differential Notch signal strength
    • Van de Walle I, Waegemans E, De Medts J, De Smet G, De Smedt M, Snauwaert S, et al. Specific Notch receptor-ligand interactions control human TCR-alphabeta/gammadelta development by inducing differential Notch signal strength. J Exp Med (2013) 210:683-97. doi:10.1084/jem.20121798
    • (2013) J Exp Med , vol.210 , pp. 683-697
    • Van de Walle, I.1    Waegemans, E.2    De Medts, J.3    De Smet, G.4    De Smedt, M.5    Snauwaert, S.6
  • 114
    • 0028799945 scopus 로고
    • Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells
    • Constant S, Pfeiffer C, Woodard A, Pasqualini T, Bottomly K. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med (1995) 182:1591-6. doi:10.1084/jem.182.5.1591
    • (1995) J Exp Med , vol.182 , pp. 1591-1596
    • Constant, S.1    Pfeiffer, C.2    Woodard, A.3    Pasqualini, T.4    Bottomly, K.5
  • 115
    • 0031573660 scopus 로고    scopus 로고
    • Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation
    • Tao X, Constant S, Jorritsma P, Bottomly K. Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol (1997) 159:5956-63
    • (1997) J Immunol , vol.159 , pp. 5956-5963
    • Tao, X.1    Constant, S.2    Jorritsma, P.3    Bottomly, K.4
  • 116
    • 84958121940 scopus 로고    scopus 로고
    • T follicular helper cell plasticity shapes pathogenic T helper 2 cell-mediated immunity to inhaled house dust mite
    • Ballesteros-Tato A, Randall TD, Lund FE, Spolski R, Leonard WJ, Leon B. T follicular helper cell plasticity shapes pathogenic T helper 2 cell-mediated immunity to inhaled house dust mite. Immunity (2016) 44:259-73. doi:10.1016/j.immuni.2015.11.017
    • (2016) Immunity , vol.44 , pp. 259-273
    • Ballesteros-Tato, A.1    Randall, T.D.2    Lund, F.E.3    Spolski, R.4    Leonard, W.J.5    Leon, B.6
  • 117
    • 84940996934 scopus 로고    scopus 로고
    • Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites
    • Coquet JM, Schuijs MJ, Smyth MJ, Deswarte K, Beyaert R, Braun H, et al. Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites. Immunity (2015) 43:318-30. doi:10.1016/j.immuni.2015.07.015
    • (2015) Immunity , vol.43 , pp. 318-330
    • Coquet, J.M.1    Schuijs, M.J.2    Smyth, M.J.3    Deswarte, K.4    Beyaert, R.5    Braun, H.6
  • 118
    • 84949224539 scopus 로고    scopus 로고
    • Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
    • Lafkas D, Shelton A, Chiu C, de Leon Boenig G, Chen Y, Stawicki SS, et al. Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung. Nature (2015) 528:127-31. doi:10.1038/nature15715
    • (2015) Nature , vol.528 , pp. 127-131
    • Lafkas, D.1    Shelton, A.2    Chiu, C.3    de Leon Boenig, G.4    Chen, Y.5    Stawicki, S.S.6
  • 120
    • 84875837518 scopus 로고    scopus 로고
    • Blockade of individual Notch ligands and receptors controls graft-versus-host disease
    • Tran IT, Sandy AR, Carulli AJ, Ebens C, Chung J, Shan GT, et al. Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest (2013) 123:1590-604. doi:10.1172/JCI65477
    • (2013) J Clin Invest , vol.123 , pp. 1590-1604
    • Tran, I.T.1    Sandy, A.R.2    Carulli, A.J.3    Ebens, C.4    Chung, J.5    Shan, G.T.6
  • 121
    • 77949395629 scopus 로고    scopus 로고
    • Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors
    • Aste-Amezaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, et al. Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One (2010) 5:e9094. doi:10.1371/journal.pone.0009094
    • (2010) PLoS One , vol.5
    • Aste-Amezaga, M.1    Zhang, N.2    Lineberger, J.E.3    Arnold, B.A.4    Toner, T.J.5    Gu, M.6
  • 122
    • 43149113910 scopus 로고    scopus 로고
    • Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3
    • Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, et al. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem (2008) 283:8046-54. doi:10.1074/jbc.M800170200
    • (2008) J Biol Chem , vol.283 , pp. 8046-8054
    • Li, K.1    Li, Y.2    Wu, W.3    Gordon, W.R.4    Chang, D.W.5    Lu, M.6
  • 123
    • 77951139188 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of individual Notch receptors
    • Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, et al. Therapeutic antibody targeting of individual Notch receptors. Nature (2010) 464:1052-7. doi:10.1038/nature08878
    • (2010) Nature , vol.464 , pp. 1052-1057
    • Wu, Y.1    Cain-Hom, C.2    Choy, L.3    Hagenbeek, T.J.4    de Leon, G.P.5    Chen, Y.6
  • 124
    • 67849124654 scopus 로고    scopus 로고
    • DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency
    • Hoey T, Yen WC, Axelrod F, Basi J, Donigian L, Dylla S, et al. DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell (2009) 5:168-77. doi:10.1016/j.stem.2009.05.019
    • (2009) Cell Stem Cell , vol.5 , pp. 168-177
    • Hoey, T.1    Yen, W.C.2    Axelrod, F.3    Basi, J.4    Donigian, L.5    Dylla, S.6
  • 125
    • 84861968011 scopus 로고    scopus 로고
    • Therapeutic approaches to modulating Notch signaling: current challenges and future prospects
    • Groth C, Fortini ME. Therapeutic approaches to modulating Notch signaling: current challenges and future prospects. Semin Cell Dev Biol (2012) 23:465-72. doi:10.1016/j.semcdb.2012.01.016
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 465-472
    • Groth, C.1    Fortini, M.E.2
  • 126
    • 0037911660 scopus 로고    scopus 로고
    • Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    • Akbari O, Stock P, Meyer E, Kronenberg M, Sidobre S, Nakayama T, et al. Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med (2003) 9:582-8. doi:10.1038/nm851
    • (2003) Nat Med , vol.9 , pp. 582-588
    • Akbari, O.1    Stock, P.2    Meyer, E.3    Kronenberg, M.4    Sidobre, S.5    Nakayama, T.6
  • 127
    • 4344647601 scopus 로고    scopus 로고
    • Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    • Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES, et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med (2004) 200:507-17. doi:10.1084/jem.20040590
    • (2004) J Exp Med , vol.200 , pp. 507-517
    • Min, B.1    Prout, M.2    Hu-Li, J.3    Zhu, J.4    Jankovic, D.5    Morgan, E.S.6
  • 128
    • 84975127155 scopus 로고    scopus 로고
    • IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function
    • Noval Rivas M, Burton OT, Oettgen HC, Chatila T. IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J Allergy Clin Immunol (2016) 138:801.e-11.e. doi:10.1016/j.jaci.2016.02.030
    • (2016) J Allergy Clin Immunol , vol.138 , pp. 801.e-811.e
    • Noval Rivas, M.1    Burton, O.T.2    Oettgen, H.C.3    Chatila, T.4
  • 129
    • 84991608456 scopus 로고    scopus 로고
    • IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection
    • Pelly VS, Kannan Y, Coomes SM, Entwistle LJ, Ruckerl D, Seddon B, et al. IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection. Mucosal Immunol (2016) 9:1407-17. doi:10.1038/mi.2016.4
    • (2016) Mucosal Immunol , vol.9 , pp. 1407-1417
    • Pelly, V.S.1    Kannan, Y.2    Coomes, S.M.3    Entwistle, L.J.4    Ruckerl, D.5    Seddon, B.6
  • 130
    • 0025753325 scopus 로고
    • Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils
    • Seder RA, Paul WE, Dvorak AM, Sharkis SJ, Kagey-Sobotka A, Niv Y, et al. Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A (1991) 88:2835-9. doi:10.1073/pnas.88.7.2835
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2835-2839
    • Seder, R.A.1    Paul, W.E.2    Dvorak, A.M.3    Sharkis, S.J.4    Kagey-Sobotka, A.5    Niv, Y.6
  • 131
    • 0028177589 scopus 로고
    • CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • Yoshimoto T, Paul WE. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 179:1285-95. doi:10.1084/jem.179.4.1285
    • (1994) J Exp Med , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 132
    • 0029959243 scopus 로고    scopus 로고
    • Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses
    • Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, et al. Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses. J Exp Med (1996) 184:1295-304. doi:10.1084/jem.184.4.1295
    • (1996) J Exp Med , vol.184 , pp. 1295-1304
    • Brown, D.R.1    Fowell, D.J.2    Corry, D.B.3    Wynn, T.A.4    Moskowitz, N.H.5    Cheever, A.W.6
  • 133
    • 85006412427 scopus 로고    scopus 로고
    • Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses
    • De Grove KC, Provoost S, Hendriks RW, McKenzie AN, Seys LJ, Kumar S, et al. Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses. J Allergy Clin Immunol (2017) 139:246-57. doi:10.1016/j.jaci.2016.03.044
    • (2017) J Allergy Clin Immunol , vol.139 , pp. 246-257
    • De Grove, K.C.1    Provoost, S.2    Hendriks, R.W.3    McKenzie, A.N.4    Seys, L.J.5    Kumar, S.6
  • 134
    • 77957745031 scopus 로고    scopus 로고
    • Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
    • Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M, et al. Inflammatory dendritic cells-not basophils-are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med (2010) 207:2097-111. doi:10.1084/jem.20101563
    • (2010) J Exp Med , vol.207 , pp. 2097-2111
    • Hammad, H.1    Plantinga, M.2    Deswarte, K.3    Pouliot, P.4    Willart, M.A.5    Kool, M.6


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