Blockade of notch signaling ameliorates murine collagen-induced arthritis via suppressing Th1 and Th17 cell responses

American Journal of Pathology

Volumn 184, Issue 4, 2014, Pages 1085-1093

  Jiao, Zhijun ^a   Wang, Wenhong ^b   Hua, Shenghao ^a   Liu, Meihong ^a   Wang, Hui ^a   Wang, Xuhui ^a   Chen, Yan ^a   Xu, Huaxi ^b   Lu, Liwei ^c  

^a AFFILIATED HOSPITAL OF JIANGSU UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GAMMA SECRETASE INHIBITOR; HYBRID PROTEIN; INTERLEUKIN 17; LIGAND; LIGAND DELTA LIKE 3; N [N (3,5 DIFLUOROPHENACETYL L ALANYL)] S PHENYLGLYCINE T BUTYL ESTER; NOTCH RECEPTOR; UNCLASSIFIED DRUG; DIPEPTIDE; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG TARGETING; IN VIVO STUDY; LYMPH NODE; MALE; MOUSE; MURINAE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SYNOVIUM; TH1 CELL; TH17 CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DBA MOUSE; DRUG EFFECTS; EXPERIMENTAL ARTHRITIS; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARTHRITIS, EXPERIMENTAL; BLOTTING, WESTERN; DIPEPTIDES; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED DBA; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TH1 CELLS; TH17 CELLS;

EID: 84897841109     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.12.010     Document Type: Article

References (26)

1. N.M. Kofler, C.J. Shawber, T. Kangsamaksin, H.O. Reed, J. Galatioto, and J. Kitajewski Notch signaling in developmental and tumor angiogenesis Genes Cancer 2 2011 1106 1116
2. A. Garcia, and J.J. Kandel Notch: a key regulator of tumor angiogenesis and metastasis Histol Histopathol 27 2012 151 156
3. H. Nagase, C.S. Koh, and K. Nakayama γ-Secretase-regulated signaling pathways, such as Notch signaling, mediate the differentiation of hematopoietic stem cells, development of the immune system, and peripheral immune responses Curr Stem Cell Res Ther 6 2011 131 141
4. F. Radtke, N. Fasnacht, and H.R. Macdonald Notch signaling in the immune system Immunity 32 2010 14 27
5. D.L. Scott, F. Wolfe, and T.W. Huizinga Rheumatoid arthritis Lancet 376 2010 1094 1108
6. H. Ishii, M. Nakazawa, S. Yoshino, H. Nakamura, K. Nishioka, and T. Nakajima Expression of Notch homologues in the synovium of rheumatoid arthritis and osteoarthritis patients Rheumatol Int 21 2001 10 14
7. Z. Jiao, W. Wang, M. Guo, T. Zhang, L. Chen, Y. Wang, H. You, and J. Li Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis Scand J Rheumatol 39 2010 26 32
8. H. Mizugaki, J. Sakakibara-Konishi, Y. Ikezawa, J. Kikuchi, E. Kikuchi, S. Oizumi, T.P. Dang, and M. Nishimura gamma-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer Br J Cancer 106 2012 1953 1959
9. C.E. Augelli-Szafran, H.X. Wei, D. Lu, J. Zhang, Y. Gu, T. Yang, P. Osenkowski, W. Ye, and M.S. Wolfe Discovery of Notch-sparing gamma-secretase inhibitors Curr Alzheimer Res 7 2010 207 209
10. S. Keerthivasan, R. Suleiman, R. Lawlor, J. Roderick, T. Bates, L. Minter, J. Anguita, I. Juncadella, B.J. Nickoloff, I.C. Le Poole, L. Miele, and B.A. Osborne Notch signaling regulates mouse and human Th17 differentiation J Immunol 187 2011 692 701
11. J. Deng, Y. Liu, M. Yang, S. Wang, M. Zhang, X. Wang, K.H. Ko, Z. Hua, L. Sun, X. Cao, and L. Lu Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response Arthritis Rheum 64 2012 3564 3573
12. L.Q. Lai Kwan, K.O. King Hung, B.J. Zheng, and L. Lu Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis Proc Natl Acad Sci U S A 105 2008 14993 14998
13. H. Xu, J. Zhu, S. Smith, J. Foldi, B. Zhao, A.Y. Chung, H. Outtz, J. Kitajewski, C. Shi, S. Weber, P. Saftig, Y. Li, K. Ozato, C.P. Blobel, L.B. Ivashkiv, and X. Hu Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization Nat Immunol 13 2012 642 650
14. M. Kijima, A. Iwata, Y. Maekawa, H. Uehara, K. Izumi, A. Kitamura, H. Yagita, S. Chiba, H. Shiota, and K. Yasutomo Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells J Immunol 182 2009 3566 3572
15. Z. Jiao, W. Wang, H. Xu, S. Wang, M. Guo, Y. Chen, and J. Gao Engagement of activated Notch signalling in collagen II-specific T helper type 1 (Th1)- and Th17-type expansion involving Notch3 and Delta-like1 Clin Exp Immunol 164 2011 66 71
16. G.J. Martinez, R.I. Nurieva, X.O. Yang, and C. Dong Regulation and function of proinflammatory TH17 cells Ann N Y Acad Sci 1143 2008 188 211
17. J.P. van Hamburg, P.S. Asmawidjaja, N. Davelaar, A.M. Mus, E.M. Colin, J.M. Hazes, R.J. Dolhain, and E. Lubberts Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production Arthritis Rheum 63 2011 73 83
18. N. Kavian, A. Servettaz, C. Mongaret, A. Wang, C. Nicco, C. Chereau, P. Grange, V. Vuiblet, P. Birembaut, M.D. Diebold, B. Weill, N. Dupin, and F. Batteux Targeting ADAM-17/Notch signaling abrogates the development of systemic sclerosis in a murine model [Erratum appeared in Arthritis Rheum 2013, 65:1231] Arthritis Rheum 62 2010 3477 3487
19. M. Juryńczyk, and K. Selmaj Notch: a new player in MS mechanisms J Neuroimmunol 218 2010 3 11
20. D.T. Teachey, A.E. Seif, V.I. Brown, M. Bruno, R.M. Bunte, Y.J. Chang, J.K. Choi, J.D. Fish, J. Hall, G.S. Reid, T. Ryan, C. Sheen, P. Zweidler-McKay, and S.A. Grupp Targeting Notch signaling in autoimmune and lymphoproliferative disease Blood 111 2008 705 714
21. S.L. Wagner, R.E. Tanzi, W.C. Mobley, and D. Galasko Potential use of γ-secretase modulators in the treatment of Alzheimer disease Arch Neurol 69 2012 1255 1258
22. G. Tong, J.S. Wang, O. Sverdlov, S.P. Huang, R. Slemmon, R. Croop, L. Castaneda, H. Gu, O. Wong, H. Li, R.M. Berman, C. Smith, C.F. Albright, and R.C. Dockens Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile, pharmacokinetic parameters, and pharmacodynamic markers Clin Ther 34 2012 654 667
23. M.S. Maddur, P. Miossec, S.V. Kaveri, and J. Bayry Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies Am J Pathol 181 2012 8 18
24. M.J. Dallman, E. Smith, R.A. Benson, and J.R. Lamb Notch: control of lymphocyte differentiation in the periphery Curr Opin Immunol 17 2005 259 266
25. H. Kared, H. Adle-Biassette, E. Foïs, A. Masson, J.F. Bach, L. Chatenoud, E. Schneider, and F. Zavala Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through Notch signaling Immunity 25 2006 823 834
26. L.M. Minter, D.M. Turley, P. Das, H.M. Shin, I. Joshi, R.G. Lawlor, O.H. Cho, T. Palaga, S. Gottipati, J.C. Telfer, L. Kostura, A.H. Fauq, K. Simpson, K.A. Such, L. Miele, T.E. Golde, S.D. Miller, and B.A. Osborne Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 Nat Immunol 6 2005 680 688