메뉴 건너뛰기




Volumn 25, Issue 11, 2015, Pages 697-707

Ligand-Independent Mechanisms of Notch Activity

Author keywords

Developmental biology; Drosophila; Noncanonical cell signaling; Notch signaling

Indexed keywords

ESCRT PROTEIN; LIGAND; NOTCH RECEPTOR; UBIQUITIN PROTEIN LIGASE E3; PROTEIN BINDING;

EID: 84945580469     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2015.07.010     Document Type: Review
Times cited : (64)

References (89)
  • 1
    • 64249172203 scopus 로고    scopus 로고
    • The canonical notch signaling pathway: unfolding the activation mechanism
    • Kopan R., Ilagan M.X.G. The canonical notch signaling pathway: unfolding the activation mechanism. Cell 2009, 137:216-233.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.G.2
  • 2
    • 0028171718 scopus 로고
    • The suppressor of hairless protein participates in notch receptor signaling
    • Fortini M.E., Artavanis-Tsakonas S. The suppressor of hairless protein participates in notch receptor signaling. Cell 1994, 79:273-282.
    • (1994) Cell , vol.79 , pp. 273-282
    • Fortini, M.E.1    Artavanis-Tsakonas, S.2
  • 3
    • 0028973380 scopus 로고
    • Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
    • Bailey A.M., Posakony J.W. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev. 1995, 9:2609-2622.
    • (1995) Genes Dev. , vol.9 , pp. 2609-2622
    • Bailey, A.M.1    Posakony, J.W.2
  • 4
    • 0028973381 scopus 로고
    • The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling
    • Lecourtois M., Schweisguth F. The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev. 1995, 9:2598-2608.
    • (1995) Genes Dev. , vol.9 , pp. 2598-2608
    • Lecourtois, M.1    Schweisguth, F.2
  • 5
    • 0032417174 scopus 로고    scopus 로고
    • Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
    • Kidd S., et al. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev. 1998, 12:3728-3740.
    • (1998) Genes Dev. , vol.12 , pp. 3728-3740
    • Kidd, S.1
  • 6
    • 84860436944 scopus 로고    scopus 로고
    • Non-canonical notch signaling: emerging role and mechanism
    • Andersen P., et al. Non-canonical notch signaling: emerging role and mechanism. Trends Cell Biol. 2012, 22:257-265.
    • (2012) Trends Cell Biol. , vol.22 , pp. 257-265
    • Andersen, P.1
  • 7
    • 84873152689 scopus 로고    scopus 로고
    • Regulation of ligand-independent Notch signal through intracellular trafficking
    • Hori K., et al. Regulation of ligand-independent Notch signal through intracellular trafficking. Commun. Integr. Biol. 2012, 5:374-376.
    • (2012) Commun. Integr. Biol. , vol.5 , pp. 374-376
    • Hori, K.1
  • 8
    • 84861988042 scopus 로고    scopus 로고
    • Endocytic routes to Notch activation
    • Baron M. Endocytic routes to Notch activation. Semin. Cell Dev. Biol. 2012, 23:437-442.
    • (2012) Semin. Cell Dev. Biol. , vol.23 , pp. 437-442
    • Baron, M.1
  • 9
    • 40849114907 scopus 로고    scopus 로고
    • Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
    • Vaccari T., et al. Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J. Cell Biol. 2008, 180:755-762.
    • (2008) J. Cell Biol. , vol.180 , pp. 755-762
    • Vaccari, T.1
  • 10
    • 84855513161 scopus 로고    scopus 로고
    • Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal
    • Hori K., et al. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J. Cell Biol. 2011, 195:1005-1015.
    • (2011) J. Cell Biol. , vol.195 , pp. 1005-1015
    • Hori, K.1
  • 11
    • 84858118267 scopus 로고    scopus 로고
    • The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4
    • Troost T., et al. The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4. J. Cell Sci. 2012, 125:763-776.
    • (2012) J. Cell Sci. , vol.125 , pp. 763-776
    • Troost, T.1
  • 12
    • 28544440935 scopus 로고    scopus 로고
    • Regulation of Notch signalling by non-visual beta-arrestin
    • Mukherjee A., et al. Regulation of Notch signalling by non-visual beta-arrestin. Nat. Cell Biol. 2005, 7:1191-1201.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 1191-1201
    • Mukherjee, A.1
  • 13
    • 77949567362 scopus 로고    scopus 로고
    • VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo
    • Ren X., Hurley J.H. VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo. EMBO J. 2010, 29:1045-1054.
    • (2010) EMBO J. , vol.29 , pp. 1045-1054
    • Ren, X.1    Hurley, J.H.2
  • 14
    • 63649086486 scopus 로고    scopus 로고
    • The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    • Raiborg C., Stenmark H. The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 2009, 458:445-452.
    • (2009) Nature , vol.458 , pp. 445-452
    • Raiborg, C.1    Stenmark, H.2
  • 15
    • 84929050106 scopus 로고    scopus 로고
    • Basal body proteins regulate Notch signaling via endosomal trafficking
    • Leitch C.C., et al. Basal body proteins regulate Notch signaling via endosomal trafficking. J. Cell Sci. 2014, 127:2407-2419.
    • (2014) J. Cell Sci. , vol.127 , pp. 2407-2419
    • Leitch, C.C.1
  • 16
    • 79955134314 scopus 로고    scopus 로고
    • RalGTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation
    • Cho B., Fischer J.A. RalGTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. Development 2011, 138:1349-1359.
    • (2011) Development , vol.138 , pp. 1349-1359
    • Cho, B.1    Fischer, J.A.2
  • 17
    • 84863787773 scopus 로고    scopus 로고
    • Ral inhibits ligand-independent Notch signaling in Drosophila
    • Cho B., Fischer J.A. Ral inhibits ligand-independent Notch signaling in Drosophila. Small GTPases 2012, 3:186-191.
    • (2012) Small GTPases , vol.3 , pp. 186-191
    • Cho, B.1    Fischer, J.A.2
  • 18
    • 0033832942 scopus 로고    scopus 로고
    • RLIP76, an effector of the GTPaseRal, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis
    • Jullien-Flores V., et al. RLIP76, an effector of the GTPaseRal, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. J. Cell Sci. 2000, 113:2837-2844.
    • (2000) J. Cell Sci. , vol.113 , pp. 2837-2844
    • Jullien-Flores, V.1
  • 19
    • 0036141393 scopus 로고    scopus 로고
    • The exocyst is a Ral effector complex
    • Moskalenko S., et al. The exocyst is a Ral effector complex. Nat. Cell Biol. 2002, 4:66-72.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 66-72
    • Moskalenko, S.1
  • 20
    • 34250012834 scopus 로고    scopus 로고
    • A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis
    • Nachury M.V., et al. A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. Cell 2007, 129:1201-1213.
    • (2007) Cell , vol.129 , pp. 1201-1213
    • Nachury, M.V.1
  • 21
    • 79952597165 scopus 로고    scopus 로고
    • Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome
    • Westlake C.J., et al. Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:2759-2764.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 2759-2764
    • Westlake, C.J.1
  • 22
    • 79957933050 scopus 로고    scopus 로고
    • Interaction between Notch and Hif-α in development and survival of Drosophila blood cells
    • Mukherjee T., et al. Interaction between Notch and Hif-α in development and survival of Drosophila blood cells. Science 2011, 332:1210-1213.
    • (2011) Science , vol.332 , pp. 1210-1213
    • Mukherjee, T.1
  • 23
    • 0025087027 scopus 로고
    • Deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster
    • Xu T., Artavanis-Tsakonas S. deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics 1990, 126:665-677.
    • (1990) Genetics , vol.126 , pp. 665-677
    • Xu, T.1    Artavanis-Tsakonas, S.2
  • 24
    • 0026633973 scopus 로고
    • A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster
    • Gorman M.J., Girton J.R. A genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 1992, 131:99-112.
    • (1992) Genetics , vol.131 , pp. 99-112
    • Gorman, M.J.1    Girton, J.R.2
  • 25
    • 0028293148 scopus 로고
    • Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway
    • Diederich R.J., et al. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development 1994, 120:473-481.
    • (1994) Development , vol.120 , pp. 473-481
    • Diederich, R.J.1
  • 26
    • 0029047609 scopus 로고
    • Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
    • Matsuno K., et al. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 1995, 121:2633-2644.
    • (1995) Development , vol.121 , pp. 2633-2644
    • Matsuno, K.1
  • 27
    • 10344263367 scopus 로고    scopus 로고
    • Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling
    • Hori K., et al. Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development 2004, 131:5527-5537.
    • (2004) Development , vol.131 , pp. 5527-5537
    • Hori, K.1
  • 28
    • 55349128573 scopus 로고    scopus 로고
    • Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of Notch in the endosomal trafficking pathway
    • Wilkin M., et al. Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of Notch in the endosomal trafficking pathway. Dev. Cell 2008, 15:762-772.
    • (2008) Dev. Cell , vol.15 , pp. 762-772
    • Wilkin, M.1
  • 29
    • 84873359868 scopus 로고    scopus 로고
    • Notch signaling from the endosome requires a conserved dileucine motif
    • Zheng L., et al. Notch signaling from the endosome requires a conserved dileucine motif. Mol. Biol. Cell 2013, 24:297-307.
    • (2013) Mol. Biol. Cell , vol.24 , pp. 297-307
    • Zheng, L.1
  • 30
    • 0031788431 scopus 로고    scopus 로고
    • Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of Notch signaling
    • Fostier M., et al. Genetic characterization of the Drosophila melanogaster suppressor of deltex gene: a regulator of Notch signaling. Genetics 1998, 150:1477-1485.
    • (1998) Genetics , vol.150 , pp. 1477-1485
    • Fostier, M.1
  • 31
    • 0033051919 scopus 로고    scopus 로고
    • The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
    • Cornell M., et al. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Genetics 1999, 152:567-576.
    • (1999) Genetics , vol.152 , pp. 567-576
    • Cornell, M.1
  • 32
    • 0037443973 scopus 로고    scopus 로고
    • Down-regulation of notch target gene expression by suppressor of deltex
    • Mazaleyrat S.L., et al. Down-regulation of notch target gene expression by suppressor of deltex. Dev. Biol. 2003, 255:363-372.
    • (2003) Dev. Biol. , vol.255 , pp. 363-372
    • Mazaleyrat, S.L.1
  • 33
    • 11144350287 scopus 로고    scopus 로고
    • Drosophila Nedd4 regulates endocytosis of Notch and suppresses its ligand-independent activation
    • Sakata T., et al. Drosophila Nedd4 regulates endocytosis of Notch and suppresses its ligand-independent activation. Curr. Biol. 2004, 14:2228-2236.
    • (2004) Curr. Biol. , vol.14 , pp. 2228-2236
    • Sakata, T.1
  • 34
    • 19944389530 scopus 로고    scopus 로고
    • Regulation of Notch endosomal sorting and signaling by Drosophila Nedd4 family proteins
    • Wilkin M.B., et al. Regulation of Notch endosomal sorting and signaling by Drosophila Nedd4 family proteins. Curr. Biol. 2004, 14:2237-2244.
    • (2004) Curr. Biol. , vol.14 , pp. 2237-2244
    • Wilkin, M.B.1
  • 35
    • 84901295370 scopus 로고    scopus 로고
    • Compensatory flux changes within an endocytic trafficking network maintain thermal robustness of Notch signaling
    • Shimizu H., et al. Compensatory flux changes within an endocytic trafficking network maintain thermal robustness of Notch signaling. Cell 2014, 157:1160-1174.
    • (2014) Cell , vol.157 , pp. 1160-1174
    • Shimizu, H.1
  • 36
    • 79251523519 scopus 로고    scopus 로고
    • Mechanism and significance of cis-inhibition in Notch signalling
    • del Álamo D., et al. Mechanism and significance of cis-inhibition in Notch signalling. Curr. Biol. 2011, 21:R40-R47.
    • (2011) Curr. Biol. , vol.21 , pp. R40-R47
    • del Álamo, D.1
  • 37
    • 84932604043 scopus 로고    scopus 로고
    • Cis-interactions between Notch and its ligands block ligand-independent Notch activity
    • Palmer W.H., et al. Cis-interactions between Notch and its ligands block ligand-independent Notch activity. Elife 2014, 3:e04415.
    • (2014) Elife , vol.3
    • Palmer, W.H.1
  • 38
    • 84875974377 scopus 로고    scopus 로고
    • An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling
    • Fleming R.J., et al. An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling. Development 2013, 140:2039-2049. 10.1242/dev.087916.
    • (2013) Development , vol.140 , pp. 2039-2049
    • Fleming, R.J.1
  • 39
    • 77952092577 scopus 로고    scopus 로고
    • Cis-interactions between Notch and Delta generate mutually exclusive signalling states
    • Sprinzak D., et al. Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature 2010, 465:86-90.
    • (2010) Nature , vol.465 , pp. 86-90
    • Sprinzak, D.1
  • 41
    • 33750940206 scopus 로고    scopus 로고
    • Lethal giant discs, a novel C2-domain protein, restricts Notch activation during endocytosis
    • Childress J.L., et al. Lethal giant discs, a novel C2-domain protein, restricts Notch activation during endocytosis. Curr. Biol. 2006, 16:2228-2233.
    • (2006) Curr. Biol. , vol.16 , pp. 2228-2233
    • Childress, J.L.1
  • 42
    • 33750433236 scopus 로고    scopus 로고
    • The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking
    • Jaekel R., Klein T. The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. Dev. Cell 2006, 11:655-669.
    • (2006) Dev. Cell , vol.11 , pp. 655-669
    • Jaekel, R.1    Klein, T.2
  • 43
    • 84876080154 scopus 로고    scopus 로고
    • Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome
    • Schneider M., et al. Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome. J. Cell Sci. 2013, 126:645-656.
    • (2013) J. Cell Sci. , vol.126 , pp. 645-656
    • Schneider, M.1
  • 44
    • 27644568520 scopus 로고    scopus 로고
    • The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking
    • Vaccari T., Bilder D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev. Cell 2005, 9:687-698.
    • (2005) Dev. Cell , vol.9 , pp. 687-698
    • Vaccari, T.1    Bilder, D.2
  • 45
    • 27644498439 scopus 로고    scopus 로고
    • Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila
    • Thompson B.J., et al. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 2005, 9:711-720.
    • (2005) Dev. Cell , vol.9 , pp. 711-720
    • Thompson, B.J.1
  • 46
    • 27644593284 scopus 로고    scopus 로고
    • Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth
    • Moberg K.H., et al. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev. Cell 2005, 9:699-710.
    • (2005) Dev. Cell , vol.9 , pp. 699-710
    • Moberg, K.H.1
  • 47
    • 33745066393 scopus 로고    scopus 로고
    • Vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis
    • Herz H-M., et al. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development 2006, 133:1871-1880.
    • (2006) Development , vol.133 , pp. 1871-1880
    • Herz, H.-M.1
  • 48
    • 69649094146 scopus 로고    scopus 로고
    • Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants
    • Vaccari T., et al. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J. Cell Sci. 2009, 122:2413-2423.
    • (2009) J. Cell Sci. , vol.122 , pp. 2413-2423
    • Vaccari, T.1
  • 49
    • 84877898714 scopus 로고    scopus 로고
    • Loss- and gain-of-function analyses of vacuolar protein sorting 2 in Notch signaling of Drosophila melanogaster
    • Aoyama N., et al. Loss- and gain-of-function analyses of vacuolar protein sorting 2 in Notch signaling of Drosophila melanogaster. Genes Genet. Syst. 2013, 88:45-57.
    • (2013) Genes Genet. Syst. , vol.88 , pp. 45-57
    • Aoyama, N.1
  • 50
  • 51
    • 84907322903 scopus 로고    scopus 로고
    • Endocytic pathways downregulate the L1-type cell adhesion molecule neuroglian to promote dendrite pruning in Drosophila
    • Zhang H., et al. Endocytic pathways downregulate the L1-type cell adhesion molecule neuroglian to promote dendrite pruning in Drosophila. Dev. Cell 2014, 30:463-478.
    • (2014) Dev. Cell , vol.30 , pp. 463-478
    • Zhang, H.1
  • 52
    • 58349086568 scopus 로고    scopus 로고
    • Common and distinct genetic properties of ESCRT-II components in Drosophila
    • Herz H-M., et al. Common and distinct genetic properties of ESCRT-II components in Drosophila. PLoS ONE 2009, 4:e4165.
    • (2009) PLoS ONE , vol.4 , pp. e4165
    • Herz, H.-M.1
  • 53
    • 0347093486 scopus 로고    scopus 로고
    • Hrs mediates downregulation of multiple signalling receptors in Drosophila
    • Jékely G., Rørth P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep. 2003, 4:1163-1168.
    • (2003) EMBO Rep. , vol.4 , pp. 1163-1168
    • Jékely, G.1    Rørth, P.2
  • 54
    • 84899555601 scopus 로고    scopus 로고
    • ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila
    • Tognon E., et al. ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila. PLoS ONE 2014, 9:e93987.
    • (2014) PLoS ONE , vol.9
    • Tognon, E.1
  • 55
    • 2642553077 scopus 로고    scopus 로고
    • Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes
    • Katoh Y., et al. Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. J. Biol. Chem. 2004, 279:24435-24443.
    • (2004) J. Biol. Chem. , vol.279 , pp. 24435-24443
    • Katoh, Y.1
  • 56
    • 58549084391 scopus 로고    scopus 로고
    • Dictyostelium Tom1 participates to an ancestral ESCRT-0 complex
    • Blanc C., et al. Dictyostelium Tom1 participates to an ancestral ESCRT-0 complex. Traffic 2009, 10:161-171.
    • (2009) Traffic , vol.10 , pp. 161-171
    • Blanc, C.1
  • 57
    • 79951868953 scopus 로고    scopus 로고
    • Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation
    • Yamada K., et al. Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation. Genes Cells 2011, 16:261-272.
    • (2011) Genes Cells , vol.16 , pp. 261-272
    • Yamada, K.1
  • 58
    • 0030877659 scopus 로고    scopus 로고
    • Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane
    • Blaumueller C.M., et al. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell 1997, 90:281-291.
    • (1997) Cell , vol.90 , pp. 281-291
    • Blaumueller, C.M.1
  • 59
    • 69249209928 scopus 로고    scopus 로고
    • In vivo analysis of the Notch receptor S1 cleavage
    • Lake R.J., et al. In vivo analysis of the Notch receptor S1 cleavage. PLoS ONE 2009, 4:e6728.
    • (2009) PLoS ONE , vol.4 , pp. e6728
    • Lake, R.J.1
  • 60
    • 0033535504 scopus 로고    scopus 로고
    • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    • De Strooper B., et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999, 398:518-522.
    • (1999) Nature , vol.398 , pp. 518-522
    • De Strooper, B.1
  • 61
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G., Greenwald I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 1999, 398:522-525.
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 62
    • 0343196671 scopus 로고    scopus 로고
    • Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis
    • Pan D., Rubin G.M. Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997, 90:271-280.
    • (1997) Cell , vol.90 , pp. 271-280
    • Pan, D.1    Rubin, G.M.2
  • 63
    • 0033868818 scopus 로고    scopus 로고
    • A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE
    • Brou C., et al. A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol. Cell 2000, 5:207-216.
    • (2000) Mol. Cell , vol.5 , pp. 207-216
    • Brou, C.1
  • 64
    • 0037080699 scopus 로고    scopus 로고
    • Kuzbanian-mediated cleavage of Drosophila Notch
    • Lieber T., et al. kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev. 2002, 16:209-221.
    • (2002) Genes Dev. , vol.16 , pp. 209-221
    • Lieber, T.1
  • 65
    • 6344251643 scopus 로고    scopus 로고
    • Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats
    • Sanchez-Irizarry C., et al. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol. Cell. Biol. 2004, 24:9265-9273.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9265-9273
    • Sanchez-Irizarry, C.1
  • 66
    • 0034051852 scopus 로고    scopus 로고
    • Ligand endocytosis drives receptor dissociation and activation in the Notch pathway
    • Parks A.L., et al. Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 2000, 127:1373-1385.
    • (2000) Development , vol.127 , pp. 1373-1385
    • Parks, A.L.1
  • 67
    • 55449135598 scopus 로고    scopus 로고
    • The molecular logic of Notch signaling: a structural and biochemical perspective
    • Gordon W.R., et al. The molecular logic of Notch signaling: a structural and biochemical perspective. J. Cell Sci. 2008, 121:3109-3119.
    • (2008) J. Cell Sci. , vol.121 , pp. 3109-3119
    • Gordon, W.R.1
  • 68
    • 84867381846 scopus 로고    scopus 로고
    • Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region
    • Stephenson N.L., Avis J.M. Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E2757-E2765.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E2757-E2765
    • Stephenson, N.L.1    Avis, J.M.2
  • 69
    • 70350536784 scopus 로고    scopus 로고
    • Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling
    • Bozkulak E.C., Weinmaster G. Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol. Cell. Biol. 2009, 29:5679-5695.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 5679-5695
    • Bozkulak, E.C.1    Weinmaster, G.2
  • 70
    • 84930638722 scopus 로고    scopus 로고
    • Human NOTCH2 is resistant to ligand independent activation by metalloprotease Adam17
    • Habets R.A., et al. Human NOTCH2 is resistant to ligand independent activation by metalloprotease Adam17. J. Biol. Chem. 2015, 290:14705-14716.
    • (2015) J. Biol. Chem. , vol.290 , pp. 14705-14716
    • Habets, R.A.1
  • 71
    • 47749118343 scopus 로고    scopus 로고
    • Kuz and TACE can activate Notch independent of ligand
    • Delwig A., Rand M.D. Kuz and TACE can activate Notch independent of ligand. Cell. Mol. Life Sci. 2008, 65:2232-2243.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 2232-2243
    • Delwig, A.1    Rand, M.D.2
  • 72
    • 71449113533 scopus 로고    scopus 로고
    • Metalloprotease ADAM10 is required for Notch1 site 2 cleavage
    • van Tetering G., et al. Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J. Biol. Chem. 2009, 284:31018-31027.
    • (2009) J. Biol. Chem. , vol.284 , pp. 31018-31027
    • van Tetering, G.1
  • 73
    • 33846968807 scopus 로고    scopus 로고
    • DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur
    • Nichols J.T., et al. DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J. Cell Biol. 2007, 176:445-458.
    • (2007) J. Cell Biol. , vol.176 , pp. 445-458
    • Nichols, J.T.1
  • 74
    • 0033974972 scopus 로고    scopus 로고
    • Calcium depletion dissociates and activates heterodimeric notch receptors
    • Rand M.D., et al. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol. Cell. Biol. 2000, 20:1825-1835.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1825-1835
    • Rand, M.D.1
  • 75
    • 78651415502 scopus 로고    scopus 로고
    • Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH
    • Scott C.C., Gruenberg J. Ion flux and the function of endosomes and lysosomes: pH is just the start: the flux of ions across endosomal membranes influences endosome function not only through regulation of the luminal pH. Bioessays 2011, 33:103-110.
    • (2011) Bioessays , vol.33 , pp. 103-110
    • Scott, C.C.1    Gruenberg, J.2
  • 76
    • 84926382243 scopus 로고    scopus 로고
    • A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis
    • Tian X., et al. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015, 13:e1002103.
    • (2015) PLoS Biol. , vol.13 , pp. e1002103
    • Tian, X.1
  • 77
    • 34247189534 scopus 로고    scopus 로고
    • Structural basis for autoinhibition of Notch
    • Gordon W.R., et al. Structural basis for autoinhibition of Notch. Nat. Struct. Mol. Biol. 2007, 14:295-300.
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 295-300
    • Gordon, W.R.1
  • 78
    • 66149151737 scopus 로고    scopus 로고
    • Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL
    • Gordon W.R., et al. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood 2009, 113:4381-4390.
    • (2009) Blood , vol.113 , pp. 4381-4390
    • Gordon, W.R.1
  • 79
    • 77952184721 scopus 로고    scopus 로고
    • The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor
    • Vaccari T., et al. The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development 2010, 137:1825-1832.
    • (2010) Development , vol.137 , pp. 1825-1832
    • Vaccari, T.1
  • 80
    • 69949137273 scopus 로고    scopus 로고
    • The vacuolar proton pump, V-ATPase, is required for Notch signaling and endosomal trafficking in Drosophila
    • Yan Y., et al. The vacuolar proton pump, V-ATPase, is required for Notch signaling and endosomal trafficking in Drosophila. Dev. Cell 2009, 17:387-402.
    • (2009) Dev. Cell , vol.17 , pp. 387-402
    • Yan, Y.1
  • 81
    • 0037698096 scopus 로고    scopus 로고
    • Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane
    • Pasternak S.H., et al. Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. J. Biol. Chem. 2003, 278:26687-26694.
    • (2003) J. Biol. Chem. , vol.278 , pp. 26687-26694
    • Pasternak, S.H.1
  • 82
    • 0029788321 scopus 로고    scopus 로고
    • KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
    • Rooke J., et al. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 1996, 273:1227-1231.
    • (1996) Science , vol.273 , pp. 1227-1231
    • Rooke, J.1
  • 83
    • 0037444109 scopus 로고    scopus 로고
    • The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development
    • Klein T. The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev. Biol. 2003, 255:313-333.
    • (2003) Dev. Biol. , vol.255 , pp. 313-333
    • Klein, T.1
  • 84
    • 33750479395 scopus 로고    scopus 로고
    • The conserved C2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila
    • Gallagher C.M., Knoblich J.A. The conserved C2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. Dev. Cell 2006, 11:641-653.
    • (2006) Dev. Cell , vol.11 , pp. 641-653
    • Gallagher, C.M.1    Knoblich, J.A.2
  • 85
    • 84896914323 scopus 로고    scopus 로고
    • Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation
    • Ma J., et al. Noncanonical activation of Notch1 protein by membrane type 1 matrix metalloproteinase (MT1-MMP) controls melanoma cell proliferation. J. Biol. Chem. 2014, 289:8442-8449.
    • (2014) J. Biol. Chem. , vol.289 , pp. 8442-8449
    • Ma, J.1
  • 86
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng A.P., et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004, 306:269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 87
    • 33745045658 scopus 로고    scopus 로고
    • Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
    • Malecki M.J., et al. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol. Cell. Biol. 2006, 26:4642-4651.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 4642-4651
    • Malecki, M.J.1
  • 88
    • 84923283486 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation
    • Hirata N., et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat. Commun. 2014, 5:4806.
    • (2014) Nat. Commun. , vol.5 , pp. 4806
    • Hirata, N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.