Strength of TCR Signal Determines the Costimulatory Requirements for Th1 and Th2 CD4+ T Cell Differentiation

Journal of Immunology

Volumn 159, Issue 12, 1997, Pages 5956-5963

  Tao, Xiang ^b   Constant, Stephanie ^b   Jorritsma, Patricia ^b   Bottomly, Kim ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ANTIBODY CONJUGATE; B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CD86 PROTEIN, HUMAN; CD86 PROTEIN, MOUSE; CYTOCHROME C; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOLOGICAL ADJUVANT; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PEPTIDE FRAGMENT;

A J MOUSE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; ARTICLE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; GENETICS; HUMAN; IMMUNIZATION; IMMUNOLOGY; INTERPHASE; LEPIDOPTERA; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; PROTEIN BINDING; SECRETION; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; TRANSGENIC MOUSE;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOCHROME C GROUP; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; IMMUNIZATION, SECONDARY; IMMUNOCONJUGATES; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON TYPE II; INTERLEUKIN-4; INTERPHASE; LYMPHOCYTE ACTIVATION; MANDUCA; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED A; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

EID: 0031573660     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Janeway, C. A., Jr., and K. Bottomly. 1994. Signals and signs of lymphocyte responses. Cell 76:275.
2. Schwartz, R. H. 1992. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065.
3. Sperling, A. I., and J. A. Bluestone. 1996. The complexities of T-cell costimulation: CD28 and beyond. Immunol. Rev. 153:155.
4. Lenschow, D. J., T. L Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
5. Kuchroo, V. J., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. W. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 cosimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
6. Lenschow, D. J., C. H. Stephen, H. Sattar, L. Rhee, G. Gray, N. Nabavi, K. C. Herold, and J. Bluestone. 1995. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the non-obese diabetic mouse. J. Exp. Med. 181:1145.
7. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kundig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261:609.
8. Cory, D. B., S. L. Reiner, P. S. Linsley, and R. M. Locksley. 1994. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J. Immunol. 153:4142.
9. Seder, R. A., R. N. Germain, P. S. Linsley, and W. E. Paul. 1994. CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J. Exp. Med. 179:299.
10. Ronchese, F., B. Hausmann, S. Hubele, and P. Lane. 1994. Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J. Exp. Med. 179:809.
11. Lu, P., X. di Zhou, S.-J. Chen, M. Moorman, S. C. Morris, F. D. Finkelman, P. S. Linsley, J. F. Urban, and W. C. Gause. 1994. CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite. J. Exp. Med. 180:693.
12. Rulifson, I. C., A. I. Sperling, P. E. Fields, F. W. Fitch, and J. A. Bluestone. 1997. CD28 costimulation promotes the production of the Th2 cytokines. J. Immunol. 158:658.
13. Lanier, L. L., S. O'Fallon, C. Somoza, J. H. Philips, P. S. Linsley, K. Okumura, D. Ito, and M. Azuma. 1995. CD80 (B7) and CD86 (B70) provide similar co-stimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:97.
14. Natesan, M., Z. Razi-Wolf, and H. Reiser. 1996. Costimulation of IL-4 production by murine B7-1 and B7-2 molecules. J. Immunol. 156:2783.
15. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104.
16. Kundig, T. M., A. Shahinian, K. Kawai, H. W. Mittrucker, E. Sebzda, M. F. Bachmann, T. W. Mak, and P. S. Ohashi. 1996. Duration of TCR stimulation determines costimulatory requirement of T cells. Immunity 5:41.
17. Pfeiffer, C., J. Murray, J. Madri, and K. Bottomly. 1991. Selective activation of Th1 and Th2 like cells in vivo: response to human collagen IV. Immunol. Rev. 123:65.
18. Pfeiffer, C., J. Stein, S. Southwood, H. Ketelaar, A. Sette, and K. Bottomly. 1995. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. J. Exp. Med. 181:1569.
19. Constant, S. L., C. Pfeiffer, T. Pasqualini, and K. Bottomly. 1995. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J. Exp. Med 182:1591.
20. + T cells by antigenic peptides altered for TCR binding. J. Immunol. 158:4237.
21. Constant, S. L., and K. Bottomly. 1997. Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu. Rev. Immunol. 15:297.
22. Kaye, J., M. L. Hsu, M. E. Sauron, S. C. Jameson, N. R. J. Gascoigne, and S. M. Hedrick. 1989. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341:746.
23. Linsley, P. S., W. Brady, M. Urnes, L. S. Grosmaire, N. K. Damle, and J. A. Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174:561.
24. Jones, B. 1983. Evidence that the Thy-1 molecule is the target for T cell mitogenic antibody against brain-associated antigens. Eur. J. Immunol. 13:678.
25. Landais, D., C. Waltzinger, B. M. Beck, A. Staub, D. J. McKean, C. Benoist, and D. Mathis. 1986. Functional sites on Ia molecules: a molecular dissection of A α immunogenicity. Cell 47:172.
26. Levin, D., S. Constant, T. Pasqualini, R. Flavell, and K. Bottomly. 1993. The role of dendritic cells in the priming of CD4+ T lymphocytes in vivo. J. Immunol. 151:6742.
27. Seder, R., and W. E. Paul. 1994. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu. Rev. Immunol. 12:635.
28. Secrist, H., R. H. DeKruyff, and D. T. Umetsu. 1995. Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen-presenting cell type. J. Exp. Med. 181:1081.
29. Hosken, N. A., K. Shibuya, A. W. Heath, K. M. Murphy, and A. O'Garra. 1995. The effect of antigen dose on CD4 T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Immunol. 182:1579.
30. Thompson, C. B. 1995. Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 81:979.
31. Evavold, B. D., and P. Allen. 1991. Separation of IL4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252:1308.
32. Racioppi, L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. J. Exp. Med. 177:1047.
33. Gause, W. C., M. J. Halvorson, P. Lu, R. Greenwald, P. Linsley, J. F. Urban, and F. D. Finkelman. 1997. The function of costimulatory molecules and the development of IL-4-producing T cells. Immunol. Today 18:115.
34. Brown, D. R., J. M. Green, N. H. Moskowitz, M. Davis, C. B. Thompson, and S. L. Reiner. 1996. Limited role of CD28-mediated signals in T subset differentiation. J. Exp. Med. 184:803.
35. Miller, S. D., C. L. Vanderlugt, D. J. Lenschow, J. G. Pope, N. J. Karandikar, M. C. Dal Canto, and J. A. Bluestone. 1995. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity 3:739.