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Volumn 138, Issue 3, 2016, Pages 801-811.e9

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function

Author keywords

Anaphylaxis; food allergy; group 2 innate lymphoid cells; IL 13; IL 33; IL 4; innate lymphoid cells; mast cells; nuocytes; oral tolerance; regulatory T cells

Indexed keywords

FOOD ALLERGEN; INTERLEUKIN 13; INTERLEUKIN 33; INTERLEUKIN 4;

EID: 84975127155     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.02.030     Document Type: Article
Times cited : (194)

References (61)
  • 2
    • 84895060304 scopus 로고    scopus 로고
    • Food allergy: epidemiology, pathogenesis, diagnosis, and treatment
    • 2 Sicherer, S.H., Sampson, H.A., Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol 133 (2014), 291–295.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 291-295
    • Sicherer, S.H.1    Sampson, H.A.2
  • 3
    • 84925038493 scopus 로고    scopus 로고
    • Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy
    • 3 Noval Rivas, M., Burton, O.T., Wise, P., Charbonnier, L.-M., Georgiev, P., Oettgen, H.C., et al. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity 42 (2015), 512–523.
    • (2015) Immunity , vol.42 , pp. 512-523
    • Noval Rivas, M.1    Burton, O.T.2    Wise, P.3    Charbonnier, L.-M.4    Georgiev, P.5    Oettgen, H.C.6
  • 4
    • 84904428409 scopus 로고    scopus 로고
    • Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells
    • 4 Burton, O.T., Noval Rivas, M., Zhou, J.S., Logsdon, S.L., Darling, A.R., Koleoglou, K.J., et al. Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity 41 (2014), 141–151.
    • (2014) Immunity , vol.41 , pp. 141-151
    • Burton, O.T.1    Noval Rivas, M.2    Zhou, J.S.3    Logsdon, S.L.4    Darling, A.R.5    Koleoglou, K.J.6
  • 5
    • 84882778526 scopus 로고    scopus 로고
    • Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production
    • 5 Doherty, T.A., Khorram, N., Lund, S., Mehta, A.K., Croft, M., Broide, D.H., Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol 132 (2013), 205–213.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 205-213
    • Doherty, T.A.1    Khorram, N.2    Lund, S.3    Mehta, A.K.4    Croft, M.5    Broide, D.H.6
  • 6
    • 84455169459 scopus 로고    scopus 로고
    • Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity
    • e1-6
    • 6 Kim, H.Y., Chang, Y.-J., Subramanian, S., Lee, H.-H., Albacker, L.A., Matangkasombut, P., et al. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol 129 (2012), 216–227 e1-6.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 216-227
    • Kim, H.Y.1    Chang, Y.-J.2    Subramanian, S.3    Lee, H.-H.4    Albacker, L.A.5    Matangkasombut, P.6
  • 7
    • 79959380307 scopus 로고    scopus 로고
    • Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity
    • 7 Chang, Y.-J., Kim, H.Y., Albacker, L.A., Baumgarth, N., McKenzie, A.N.J., Smith, D.E., et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol 12 (2011), 631–638.
    • (2011) Nat Immunol , vol.12 , pp. 631-638
    • Chang, Y.-J.1    Kim, H.Y.2    Albacker, L.A.3    Baumgarth, N.4    McKenzie, A.N.J.5    Smith, D.E.6
  • 8
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
    • 8 Mjösberg, J., Bernink, J., Golebski, K., Karrich, J.J., Peters, C.P., Blom, B., et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 37 (2012), 649–659.
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjösberg, J.1    Bernink, J.2    Golebski, K.3    Karrich, J.J.4    Peters, C.P.5    Blom, B.6
  • 9
    • 84882625503 scopus 로고    scopus 로고
    • IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps
    • 9 Shaw, J.L., Fakhri, S., Citardi, M.J., Porter, P.C., Corry, D.B., Kheradmand, F., et al. IL-33-responsive innate lymphoid cells are an important source of IL-13 in chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 188 (2013), 432–439.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 432-439
    • Shaw, J.L.1    Fakhri, S.2    Citardi, M.J.3    Porter, P.C.4    Corry, D.B.5    Kheradmand, F.6
  • 10
    • 84878257969 scopus 로고    scopus 로고
    • Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells
    • 10 Roediger, B., Kyle, R., Yip, K.H., Sumaria, N., Guy, T.V., Kim, B.S., et al. Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells. Nat Immunol 14 (2013), 564–573.
    • (2013) Nat Immunol , vol.14 , pp. 564-573
    • Roediger, B.1    Kyle, R.2    Yip, K.H.3    Sumaria, N.4    Guy, T.V.5    Kim, B.S.6
  • 11
    • 84874055169 scopus 로고    scopus 로고
    • TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation
    • 11 Kim, B.S., Siracusa, M.C., Saenz, S.A., Noti, M., Monticelli, L.A., Sonnenberg, G.F., et al. TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation. Sci Transl Med, 5, 2013, 170ra16.
    • (2013) Sci Transl Med , vol.5 , pp. 170ra16
    • Kim, B.S.1    Siracusa, M.C.2    Saenz, S.A.3    Noti, M.4    Monticelli, L.A.5    Sonnenberg, G.F.6
  • 12
  • 13
    • 84859384082 scopus 로고    scopus 로고
    • Innate lymphoid cells: emerging insights in development, lineage relationships, and function
    • 13 Spits, H., Cupedo, T., Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 30 (2012), 647–675.
    • (2012) Annu Rev Immunol , vol.30 , pp. 647-675
    • Spits, H.1    Cupedo, T.2
  • 14
    • 78650310810 scopus 로고    scopus 로고
    • The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling
    • 14 Spits, H., Di Santo, J.P., The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nat Immunol 12 (2011), 21–27.
    • (2011) Nat Immunol , vol.12 , pp. 21-27
    • Spits, H.1    Di Santo, J.P.2
  • 15
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • 15 Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463 (2010), 540–544.
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3    Takeuchi, T.4    Ikawa, T.5    Kawamoto, H.6
  • 16
    • 84866519013 scopus 로고    scopus 로고
    • Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation
    • 16 Halim, T.Y.F., MacLaren, A., Romanish, M.T., Gold, M.J., McNagny, K.M., Takei, F., Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity 37 (2012), 463–474.
    • (2012) Immunity , vol.37 , pp. 463-474
    • Halim, T.Y.F.1    MacLaren, A.2    Romanish, M.T.3    Gold, M.J.4    McNagny, K.M.5    Takei, F.6
  • 17
  • 18
    • 84867769688 scopus 로고    scopus 로고
    • The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
    • 18 Hoyler, T., Klose, C.S.N., Souabni, A., Turqueti-Neves, A., Pfeifer, D., Rawlins, E.L., et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity 37 (2012), 634–648.
    • (2012) Immunity , vol.37 , pp. 634-648
    • Hoyler, T.1    Klose, C.S.N.2    Souabni, A.3    Turqueti-Neves, A.4    Pfeifer, D.5    Rawlins, E.L.6
  • 19
    • 84886630206 scopus 로고    scopus 로고
    • IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells
    • 19 Saenz, S.A., Siracusa, M.C., Monticelli, L.A., Ziegler, C.G.K., Kim, B.S., Brestoff, J.R., et al. IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. J Exp Med 210 (2013), 1823–1837.
    • (2013) J Exp Med , vol.210 , pp. 1823-1837
    • Saenz, S.A.1    Siracusa, M.C.2    Monticelli, L.A.3    Ziegler, C.G.K.4    Kim, B.S.5    Brestoff, J.R.6
  • 20
    • 84890825282 scopus 로고    scopus 로고
    • A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis
    • 20 Salimi, M., Barlow, J.L., Saunders, S.P., Xue, L., Gutowska-Owsiak, D., Wang, X., et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med 210 (2013), 2939–2950.
    • (2013) J Exp Med , vol.210 , pp. 2939-2950
    • Salimi, M.1    Barlow, J.L.2    Saunders, S.P.3    Xue, L.4    Gutowska-Owsiak, D.5    Wang, X.6
  • 21
    • 84896343916 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation
    • 21 Halim, T.Y.F., Steer, C.A., Mathä, L., Gold, M.J., Martinez-Gonzalez, I., McNagny, K.M., et al. Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation. Immunity 40 (2014), 425–435.
    • (2014) Immunity , vol.40 , pp. 425-435
    • Halim, T.Y.F.1    Steer, C.A.2    Mathä, L.3    Gold, M.J.4    Martinez-Gonzalez, I.5    McNagny, K.M.6
  • 22
    • 84890852091 scopus 로고    scopus 로고
    • IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation
    • 22 Turner, J.-E., Morrison, P.J., Wilhelm, C., Wilson, M., Ahlfors, H., Renauld, J.-C., et al. IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation. J Exp Med 210 (2013), 2951–2965.
    • (2013) J Exp Med , vol.210 , pp. 2951-2965
    • Turner, J.-E.1    Morrison, P.J.2    Wilhelm, C.3    Wilson, M.4    Ahlfors, H.5    Renauld, J.-C.6
  • 23
    • 84871719326 scopus 로고    scopus 로고
    • IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization
    • e1-8
    • 23 Chu, D.K., Llop-Guevara, A., Walker, T.D., Flader, K., Goncharova, S., Boudreau, J.E., et al. IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization. J Allergy Clin Immunol 131 (2013), 187–200 e1-8.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 187-200
    • Chu, D.K.1    Llop-Guevara, A.2    Walker, T.D.3    Flader, K.4    Goncharova, S.5    Boudreau, J.E.6
  • 24
    • 84963963441 scopus 로고    scopus 로고
    • IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy
    • 24 Lee, J.-B., Chen, C.-Y., Liu, B., Mugge, L., Angkasekwinai, P., Facchinetti, V., et al. IL-25 and CD4(+) TH2 cells enhance type 2 innate lymphoid cell-derived IL-13 production, which promotes IgE-mediated experimental food allergy. J Allergy Clin Immunol 137 (2016), 1216–1225.e5.
    • (2016) J Allergy Clin Immunol , vol.137 , pp. 1216-1225.e5
    • Lee, J.-B.1    Chen, C.-Y.2    Liu, B.3    Mugge, L.4    Angkasekwinai, P.5    Facchinetti, V.6
  • 25
    • 77951667264 scopus 로고    scopus 로고
    • In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif
    • 25 Tachdjian, R., Khatib Al, S., Schwinglshackl, A., Kim, H.S., Chen, A., Blasioli, J., et al. In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol 125 (2010), 1128–1136.e8.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1128-1136.e8
    • Tachdjian, R.1    Khatib Al, S.2    Schwinglshackl, A.3    Kim, H.S.4    Chen, A.5    Blasioli, J.6
  • 26
    • 84871722246 scopus 로고    scopus 로고
    • A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
    • 26 Noval Rivas, M., Burton, O.T., Wise, P., Zhang, Y.-Q., Hobson, S.A., Garcia Lloret, M., et al. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol 131 (2013), 201–212.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 201-212
    • Noval Rivas, M.1    Burton, O.T.2    Wise, P.3    Zhang, Y.-Q.4    Hobson, S.A.5    Garcia Lloret, M.6
  • 27
    • 84860557017 scopus 로고    scopus 로고
    • MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice
    • 27 Noval Rivas, M., Koh, Y.T., Chen, A., Nguyen, A., Lee, Y.H., Lawson, G., et al. MyD88 is critically involved in immune tolerance breakdown at environmental interfaces of Foxp3-deficient mice. J Clin Invest 122 (2012), 1933–1947.
    • (2012) J Clin Invest , vol.122 , pp. 1933-1947
    • Noval Rivas, M.1    Koh, Y.T.2    Chen, A.3    Nguyen, A.4    Lee, Y.H.5    Lawson, G.6
  • 28
    • 79952310804 scopus 로고    scopus 로고
    • IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling
    • e1-6
    • 28 Mathias, C.B., Hobson, S.A., Garcia Lloret, M., Lawson, G., Poddighe, D., Freyschmidt, E.-J., et al. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol 127 (2011), 795–805 e1-6.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 795-805
    • Mathias, C.B.1    Hobson, S.A.2    Garcia Lloret, M.3    Lawson, G.4    Poddighe, D.5    Freyschmidt, E.-J.6
  • 29
    • 84858775590 scopus 로고    scopus 로고
    • Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation
    • 29 Halim, T.Y.F., Krauss, R.H., Sun, A.C., Takei, F., Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity 36 (2012), 451–463.
    • (2012) Immunity , vol.36 , pp. 451-463
    • Halim, T.Y.F.1    Krauss, R.H.2    Sun, A.C.3    Takei, F.4
  • 30
    • 84884905739 scopus 로고    scopus 로고
    • IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction
    • 30 Barlow, J.L., Peel, S., Fox, J., Panova, V., Hardman, C.S., Camelo, A., et al. IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. J Allergy Clin Immunol 132 (2013), 933–941.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 933-941
    • Barlow, J.L.1    Peel, S.2    Fox, J.3    Panova, V.4    Hardman, C.S.5    Camelo, A.6
  • 31
    • 84941181442 scopus 로고    scopus 로고
    • Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells
    • 31 Oczypok, E.A., Milutinovic, P.S., Alcorn, J.F., Khare, A., Crum, L.T., Manni, M.L., et al. Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells. J Allergy Clin Immunol 136 (2015), 747–756.e4.
    • (2015) J Allergy Clin Immunol , vol.136 , pp. 747-756.e4
    • Oczypok, E.A.1    Milutinovic, P.S.2    Alcorn, J.F.3    Khare, A.4    Crum, L.T.5    Manni, M.L.6
  • 32
    • 84892928571 scopus 로고    scopus 로고
    • Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity
    • 32 Spencer, S.P., Wilhelm, C., Yang, Q., Hall, J.A., Bouladoux, N., Boyd, A., et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 343 (2014), 432–437.
    • (2014) Science , vol.343 , pp. 432-437
    • Spencer, S.P.1    Wilhelm, C.2    Yang, Q.3    Hall, J.A.4    Bouladoux, N.5    Boyd, A.6
  • 33
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • 33 Neill, D.R., Wong, S.H., Bellosi, A., Flynn, R.J., Daly, M., Langford, T.K.A., et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464 (2010), 1367–1370.
    • (2010) Nature , vol.464 , pp. 1367-1370
    • Neill, D.R.1    Wong, S.H.2    Bellosi, A.3    Flynn, R.J.4    Daly, M.5    Langford, T.K.A.6
  • 34
    • 80054889051 scopus 로고    scopus 로고
    • Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    • 34 Mjösberg, J.M., Trifari, S., Crellin, N.K., Peters, C.P., van Drunen, C.M., Piet, B., et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol 12 (2011), 1055–1062.
    • (2011) Nat Immunol , vol.12 , pp. 1055-1062
    • Mjösberg, J.M.1    Trifari, S.2    Crellin, N.K.3    Peters, C.P.4    van Drunen, C.M.5    Piet, B.6
  • 35
    • 0034877815 scopus 로고    scopus 로고
    • Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter
    • 35 Mohrs, M., Shinkai, K., Mohrs, K., Locksley, R.M., Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15 (2001), 303–311.
    • (2001) Immunity , vol.15 , pp. 303-311
    • Mohrs, M.1    Shinkai, K.2    Mohrs, K.3    Locksley, R.M.4
  • 36
    • 3042594506 scopus 로고    scopus 로고
    • Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    • 36 Karlsson, M.R., Rugtveit, J., Brandtzaeg, P., Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med 199 (2004), 1679–1688.
    • (2004) J Exp Med , vol.199 , pp. 1679-1688
    • Karlsson, M.R.1    Rugtveit, J.2    Brandtzaeg, P.3
  • 37
    • 84893405498 scopus 로고    scopus 로고
    • Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
    • 37 Syed, A., Garcia, M.A., Lyu, S.-C., Bucayu, R., Kohli, A., Ishida, S., et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 133 (2014), 500–510.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 500-510
    • Syed, A.1    Garcia, M.A.2    Lyu, S.-C.3    Bucayu, R.4    Kohli, A.5    Ishida, S.6
  • 39
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • 39 Chatila, T.A., Blaeser, F., Ho, N., Lederman, H.M., Voulgaropoulos, C., Helms, C., et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 106 (2000), R75–R81.
    • (2000) J Clin Invest , vol.106 , pp. R75-R81
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3    Lederman, H.M.4    Voulgaropoulos, C.5    Helms, C.6
  • 41
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • 41 Haribhai, D., Williams, J.B., Jia, S., Nickerson, D., Schmitt, E.G., Edwards, B., et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 35 (2011), 109–122.
    • (2011) Immunity , vol.35 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3    Nickerson, D.4    Schmitt, E.G.5    Edwards, B.6
  • 43
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • 43 Veldhoen, M., Uyttenhove, C., Van Snick, J., Helmby, H., Westendorf, A., Buer, J., et al. Transforming growth factor-beta “reprograms” the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 9 (2008), 1341–1346.
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    Van Snick, J.3    Helmby, H.4    Westendorf, A.5    Buer, J.6
  • 44
    • 84879332763 scopus 로고    scopus 로고
    • Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy
    • 44 Burton, O.T., Darling, A.R., Zhou, J.S., Noval-Rivas, M., Jones, T.G., Gurish, M.F., et al. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol 6 (2013), 740–750.
    • (2013) Mucosal Immunol , vol.6 , pp. 740-750
    • Burton, O.T.1    Darling, A.R.2    Zhou, J.S.3    Noval-Rivas, M.4    Jones, T.G.5    Gurish, M.F.6
  • 46
    • 79958086613 scopus 로고    scopus 로고
    • Interleukin-33 biology with potential insights into human diseases
    • 46 Palmer, G., Gabay, C., Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol 7 (2011), 321–329.
    • (2011) Nat Rev Rheumatol , vol.7 , pp. 321-329
    • Palmer, G.1    Gabay, C.2
  • 47
    • 79952986650 scopus 로고    scopus 로고
    • RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    • 47 Sawa, S., Lochner, M., Satoh-Takayama, N., Dulauroy, S., Bérard, M., Kleinschek, M., et al. RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat Immunol 12 (2011), 320–326.
    • (2011) Nat Immunol , vol.12 , pp. 320-326
    • Sawa, S.1    Lochner, M.2    Satoh-Takayama, N.3    Dulauroy, S.4    Bérard, M.5    Kleinschek, M.6
  • 49
    • 84873410596 scopus 로고    scopus 로고
    • Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice
    • 49 Li, J., Wang, Y., Tang, L., de Villiers, W.J.S., Cohen, D., Woodward, J., et al. Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice. J Allergy Clin Immunol 131 (2013), 442–450.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 442-450
    • Li, J.1    Wang, Y.2    Tang, L.3    de Villiers, W.J.S.4    Cohen, D.5    Woodward, J.6
  • 50
    • 84908541933 scopus 로고    scopus 로고
    • Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells
    • 50 Lefrançais, E., Duval, A., Mirey, E., Roga, S., Espinosa, E., Cayrol, C., et al. Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells. Proc Natl Acad Sci U S A 111 (2014), 15502–15507.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 15502-15507
    • Lefrançais, E.1    Duval, A.2    Mirey, E.3    Roga, S.4    Espinosa, E.5    Cayrol, C.6
  • 51
    • 77957787918 scopus 로고    scopus 로고
    • IL-33 is produced by mast cells and regulates IgE-dependent inflammation
    • 51 Hsu, C.-L., Neilsen, C.V., Bryce, P.J., IL-33 is produced by mast cells and regulates IgE-dependent inflammation. PLoS One, 5, 2010, e11944.
    • (2010) PLoS One , vol.5 , pp. e11944
    • Hsu, C.-L.1    Neilsen, C.V.2    Bryce, P.J.3
  • 52
    • 84893373218 scopus 로고    scopus 로고
    • State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous
    • 52 Jones, S.M., Burks, A.W., Dupont, C., State of the art on food allergen immunotherapy: oral, sublingual, and epicutaneous. J Allergy Clin Immunol 133 (2014), 318–323.
    • (2014) J Allergy Clin Immunol , vol.133 , pp. 318-323
    • Jones, S.M.1    Burks, A.W.2    Dupont, C.3
  • 53
    • 84925038493 scopus 로고    scopus 로고
    • Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy
    • Noval Rivas, M., Burton, O.T., Wise, P., Charbonnier, L.-M., Georgiev, P., Oettgen, H.C., et al. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity 42 (2015), 512–523.
    • (2015) Immunity , vol.42 , pp. 512-523
    • Noval Rivas, M.1    Burton, O.T.2    Wise, P.3    Charbonnier, L.-M.4    Georgiev, P.5    Oettgen, H.C.6
  • 54
    • 84904428409 scopus 로고    scopus 로고
    • Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells
    • Burton, O.T., Noval Rivas, M., Zhou, J.S., Logsdon, S.L., Darling, A.R., Koleoglou, K.J., et al. Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity 41 (2014), 141–151.
    • (2014) Immunity , vol.41 , pp. 141-151
    • Burton, O.T.1    Noval Rivas, M.2    Zhou, J.S.3    Logsdon, S.L.4    Darling, A.R.5    Koleoglou, K.J.6
  • 55
    • 77951667264 scopus 로고    scopus 로고
    • In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif
    • Tachdjian, R., Khatib Al, S., Schwinglshackl, A., Kim, H.S., Chen, A., Blasioli, J., et al. In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol 125 (2010), 1128–1136.e8.
    • (2010) J Allergy Clin Immunol , vol.125 , pp. 1128-1136.e8
    • Tachdjian, R.1    Khatib Al, S.2    Schwinglshackl, A.3    Kim, H.S.4    Chen, A.5    Blasioli, J.6
  • 56
    • 79952310804 scopus 로고    scopus 로고
    • IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling
    • e1-6
    • Mathias, C.B., Hobson, S.A., Garcia Lloret, M., Lawson, G., Poddighe, D., Freyschmidt, E.-J., et al. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol 127 (2011), 795–805 e1-6.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 795-805
    • Mathias, C.B.1    Hobson, S.A.2    Garcia Lloret, M.3    Lawson, G.4    Poddighe, D.5    Freyschmidt, E.-J.6
  • 57
    • 84871722246 scopus 로고    scopus 로고
    • A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis
    • Noval Rivas, M., Mazmanian, S., Burton, O.T., Wise, P., Talal, C., A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol 131 (2013), 201–212.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 201-212
    • Noval Rivas, M.1    Mazmanian, S.2    Burton, O.T.3    Wise, P.4    Talal, C.5
  • 58
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • Haribhai, D., Williams, J.B., Jia, S., Nickerson, D., Schmitt, E.G., Edwards, B., et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity 35 (2011), 109–122.
    • (2011) Immunity , vol.35 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3    Nickerson, D.4    Schmitt, E.G.5    Edwards, B.6
  • 59
    • 65449136307 scopus 로고    scopus 로고
    • A central role for induced regulatory T cells in tolerance induction in experimental colitis
    • Haribhai, D., Lin, W., Edwards, B., Ziegelbauer, J., Salzman, N.H., Carlson, M.R., et al. A central role for induced regulatory T cells in tolerance induction in experimental colitis. J Immunol 182 (2009), 3461–3468.
    • (2009) J Immunol , vol.182 , pp. 3461-3468
    • Haribhai, D.1    Lin, W.2    Edwards, B.3    Ziegelbauer, J.4    Salzman, N.H.5    Carlson, M.R.6
  • 60
    • 0026581936 scopus 로고
    • RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
    • Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., et al. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68 (1992), 855–867.
    • (1992) Cell , vol.68 , pp. 855-867
    • Shinkai, Y.1    Rathbun, G.2    Lam, K.P.3    Oltz, E.M.4    Stewart, V.5    Mendelsohn, M.6
  • 61
    • 0034689033 scopus 로고    scopus 로고
    • T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
    • Townsend, M.J., Fallon, P.G., Matthews, D.J., Jolin, H.E., McKenzie, A.N., T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med 191 (2000), 1069–1076.
    • (2000) J Exp Med , vol.191 , pp. 1069-1076
    • Townsend, M.J.1    Fallon, P.G.2    Matthews, D.J.3    Jolin, H.E.4    McKenzie, A.N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.