Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

PLoS ONE

Volumn 3, Issue 7, 2008, Pages

  Ong, Chin Tong ^a,b   Sedy, John R ^a,c   Murphy, Kenneth M ^a   Kopan, Raphael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA SECRETASE; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 4; JAGGED1; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PRESENILIN;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL FATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TH1 CELL; TH2 CELL; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL LINEAGE; CHO CELL; CRICETULUS; HAMSTER; METABOLISM;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; CHO CELLS; CRICETINAE; CRICETULUS; CYTOKINES; INTERLEUKIN-12; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; PRESENILINS; RECEPTORS, NOTCH; TH1 CELLS; TH2 CELLS;

EID: 50949091487     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002823     Document Type: Article

References (95)

1. Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
2. Abbas AK, Murphy KM, Sher A (1996) Functional diversity of helper T lymphocytes. Nature 383: 787-793.
3. Reinhardt RJ, Kang SJ, Liang HE, Locksley RM (2006) T helper cell effector fates-who, how and where? Curr Opin Immunol 18: 271-277.
4. Weaver CT, Harrington LE, Mangan PR, Gavrieli M, Murphy KM (2006) Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24: 677-688.
5. O'Garra A, Robinson D (2004) Development and function of T helper 1 cells. Adv Immunol 83: 133-162.
6. O'Garra A, Vicira P (2004) Regulatory T cells and mechanisms of immune system control. Nat Med 10: 801-805.
7. Jankovic D, Steinfelder S, Kullberg MC, Sher A (2006) Mechanisms underlying helminth- induced Th2 polarization: default, negative or positive pathways? Chem Immunol Allergy 90: 65-81.
8. O'Garra A, Murphy K (1994) Role of cytokines in determining T-lymphocyte function. Curr Opin Immunol 6: 458-466.
9. O'Shea JJ, Paul WE (2002) Regulation of T(H)1 differentiation-controlling the controllers. Nat Immunol 3: 506-508.
10. Murphy KM, Reiner SL (2002) The lineage decisions of helper T cells. Nat Rev Immunol 2: 933-944.
11. Zhu J, Yamane H, Cote-Sierra J, Guo L, Paul WE (2006) GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res 16: 3-10.
12. Agnello D, Lankford CS, Bream J, Morinobu A, Gadina M, et al. (2003) Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol 23: 147-161.
13. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, et al. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669.
14. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, et al. (2002) Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295: 33B-342.
15. Glimcher LH (2007) Trawling for treasure: tales of T-bet. Nat Immunol 8: 448-450.
16. Zheng W, Flavell RA (1997) The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596.
17. Farrar JD, Ouyang W, Lohning M, Assenmacher M, Radbruch A, et al. (2001) An instructive component in T helper cell type 2 (M) development mediated by GATA-3. J Exp Med 193: 643-650.
18. Ouyang W, Lohning M, Gao Z, Assemnacher M, Ranganath S, et al. (2000) Stat6-independent GATA-3 autoactivation directs IL,4-independent Th2 development and commitment. Immunity 12: 27-37.
19. Ouyang W, Ranganath SH, Weindel Ir, Bhattacharya D, Murphy TL, et al. (1998) Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9: 745-755.
20. Ranganath S, Ouyang W, Bhattarcharya D, Sha WC, Grupe A, et al. (1998) GATA-3-dependent enhancer activity in IL-4 gene regulation. J Immunol 161: 3822-3826.
21. Ivanov II, McKenzie BS, Zhou L, Tadokoro CE, Lepelley A, et al. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133.
22. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH (2003) Molecular mechanism regulating Th1 immune responses. Annu Rev Immunol 21: 713-758.
23. Mowen KA, Glimcher LH (2004) Signaling pathways in Th2 development. Immunol Rev 202: 203-222.
24. Glimcher LH, Townsend MJ, Sullivan BM, Lord GM (2004) Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 4: 900-911.
25. Santana MA, Rosenstein Y (2003) What it takes to become an effector T cell: the process, the cells involved, and the mechanisms. J Cell Physiol 195: 392-401.
26. Constant SL, Bottomly K (1997) Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches. Annu Rev Immunol 15: 297-322.
27. Dong C, Nurieva RI, Prasad DV (2003) Immune regulation by novel costimulatory molecules. Immunol Res 28: 39-48.
28. Ansel KM, Djuretic I, Tanasa B, Rao A (2006) Regulation of Th2 differentiation and I14 locus accessibility. Annu Rev Immunol 24: 607-656.
29. Osborne BA, Minter LM (2007) Notch signalling during peripheral T-cell activation and differentiation. Nat Rev Immunol 7: 64-75.
30. Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, et al. (2004) Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515-526.
31. Maekawa Y, Tsukumo S, Chiba S, Hirai H, Hayashi Y, et al. (2003) Deltal-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 19: 549-559.
32. Tanigaki K, Honjo T (2007) Regulation of lymphocyte development by Notch signaling. Nat Immunol 8: 451-456.
33. Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689.
34. Rothenberg EV, Taghon T (2005) Molecular genetics of T cell development. Annu Rev Immunol 23: 601-649.
35. Thomas MD, Srivastava B, Allman D (2006) Regulation of peripheral B cell maturation. Cell Immunol 239: 92-102.
36. Ye M, Graf T (2007) Early decisions in lymphoid development. Curr Opin Immunol 19: 123-128.
37. Minato Y, Yasutomo K (2005) Regulation of acquired immune system by notch signaling. Int J Hematol 82: 302-306.
38. Maillard I, Fang T, Pear WS (2005) Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol 23: 945-974.
39. Hayday AC, Pennington DJ (2007) Key factors in the organized chaos of early T cell development. Nat Immunol 8: 137-144.
40. de La Coste A, Freitas AA (2006) Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation. Immunol Lett 102: 1-9.
41. Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, et al. (2007) Structural basis for autoinhibition of Notch. Nat Struct Mol Biol.
42. Nichols JT, Miyamoto A, Olsen SL, D'Souza B, Yao C, et al. (2007) DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol 176: 445-458.
43. Brou C, Logeat F, Gupta N, Bessia C, LeBail O, et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE, Mol Cell 5: 207-216.
44. Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian X, et al. (2000) A ligand-induced extrucellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell 5: 197-206.
45. Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, et al. (2005) Nicastrin functions as a gamma-secretase-substrate receptor. Cell 122: 435-447.
46. De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, et al. (1999) A presenilin- 1 -dependent gamma-secretase-like protease mediates release of Notch intraccellular domain. Nature 398: 518-522.
47. Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced protcolytic release of intracellular domain. Nature 393: 382-386.
48. Struhl G, Adachi A (1998) Nuclear access and action of notch in vivo. Cell 93: 649-660.
49. Ilagan MX, Kopan R (2007) SnapShot: Notch Signaling Pathway. Cell 128: 1246.
50. Wu L, Sun T, Kobayashi K, Gao P, Griffin JD (2002) Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol 22: 7688-7700.
51. Nam Y, Sliz P, Song L, Aster JC, Blacklow SC (2006) Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell 124: 973-983.
52. Wilson JJ, Kovall RA (2006) Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA. Cell 124: 985-996.
53. Fryer CJ, White JB, Jones KA (2004) Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 16: 509-520.
54. Kurooka H, Honjo T (2000) Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem 275: 17211-17220.
55. Oswald F, Tauber B, Dobner T, Bourteele S, Kostezka U, et al. (2001) p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol 21: 7761-7774.
56. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, et al. (2007) Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity 27: 89-99.
57. Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, et al. (2007) Notch directly regulates Gata3 expression during T helper 2 Cell differentiation. Immunity 27: 100-110.
58. Palaga T, Miele L, Golde TE, Osborne BA (2003) TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol 171: 3019-3024.
59. Adler SH, Chiffobleau E, Xu I, Dalton NM, Burg JM, et al. (2003) Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol 171: 2896-2903.
60. Rutz S, Mordmuller B, Sakano S, Scheffold A (2005) Notch ligands Delta-like 1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur J Immunol 35: 24-43-2451.
61. Lee PP, Fitzpatrick DR, Beard C, Jessup HK, Lehar S, et al. (2001) A critical role for Drunt1 and DNA methylation in T Cell development, function, and survival. Immunity 15: 763-774.
62. Yu H, Saura CA, Choi SY, Sun LD, Yang X, et al. (2001) APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron 31: 713-726.
63. Han H, Tanigaki K, Yamamoto N, Kuroda K, Yomshimoto M, et al. (2002) Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol 14: 637-645.
64. Murphy KM, Heimberger AB, Loh DY (1990) Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. Science 250: 1720-1723.
65. Minoguchi S, Taniguchi Y, Kato H, Okazaki T, Strohl, LJ, et al. (1997) RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol 17: 2679-2687.
66. Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, et al. (2000) Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol 20: 6913-6922.
67. Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, et al. (1998) Helper T Cell differentiation is controlled by the Cell cycle. Immunity 9: 229-237.
68. Ben-Sasson SZ, Gerstel R, Hu-Li J, Paul WE (2001) Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4. J Immunol 166: 112-120.
69. Laouar Y, Crispe IN (2000) Functional flexibility in T cells: independent regulation of CD4+ T Cell proliferation and effector function in vivo. Immunity 13: 291-301.
70. Richter A, Lohning M, Radbruch A (1999) Instruction for cytokine expression in T helper lymphocytes in relation to proliferation and cell cycle progression. J Exp Med 190: 1439-1450.
71. Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, et al. (2000) Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol 2: 515-520.
72. Visan I, Yuan JS, Tan JB, Cretegny K, Guidos CJ (2006) Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions. Immunol Rev 209: 76-94.
73. Visan I, Tan JB, Yuan JS, Harper JA, Koch U, et al. (2006) Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol 7: 634-643.
74. Laky K, Fowlkes BJ (2007) Presenilins regulate alphabeta T Cell development by modulating TCR signaling. J Exp Med 204: 2115-2129.
75. Tanigaki K, Tsuji M, Yamamoto N, Han H, Tsukada J, et al. (2004) Regulation of alphabeta/gammadelta T Cell lineage commitment and peripheral T Cell responses by Notch/RBP-J signaling. Immunity 20: 611-622.
76. Anastasi E, Campese AF, Bellavia D, Bulotta A, Balestri A, et al. (2003) Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J Immunol 171: 4504-4511.
77. Minter LM, Turley DM, Das P, Shin HM, Joshi I, et al. (2005) Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat Immunol 6: 680-688.
78. Tu L, Fang TC, Artis D, Shestova O, Pross SE, et al. (2005) Notch signaling is an important regulator of type 2 immunity. J Exp Med 202: 1037-1042.
79. Lubman OY, Korolev SV, Kopan R (2004) Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol Cell 13: 619-626.
80. Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, et al. (2002) Notch-RBP-J signaling is involved in Cell fate determination of marginal zone B cells. Nat Immunol 3: 443-450.
81. Witt CM, Won WJ, Hurez V, Klug CA (2003) Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J Immunol 171: 2783-2788.
82. Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, et al. (2003) Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 18: 675-685.
83. Ciofani M, Zuniga-Pflucker JC (2005) Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 6: 881-888.
84. Hadland BK, Manley NR, Su D, Longmore GD, Moore CL, et al. (2001) Gamma -secretase inhibitors repress thymocyte development. Proc Natl Acad Sci U S A 98: 7487-7491.
85. Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, et al. (1999) Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11: 299-308.
86. Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, et al. (1999) Deficient T Cell fate specification in mice with an induced inactivation of Notch1. Immunity 10: 547-558.
87. Schmitt TM, Ciofani M, Petrie HT, Zuniga-Pflucker JC (2004) Maintenance of T Cell specification and differentiation requires recurrent notch receptor-ligand interactions. J Exp Med 200: 469-479.
88. Tan JB, Visan I, Y uan JS, Guidos CJ (2005) Requirement for Notch1 signals at sequential early stages of intrathymic T Cell development. Nat Immunol 6: 671-679.
89. Tsuji M, Shinkura R, Kuroda K, Yabe D, Honjo T (2007) Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Proc Natl Acad Sci U S A 104: 1610-1615.
90. Wilson A, MacDonald HR, Radtke F (2001) Notch 1-deficient common lymphoid precursors adopt a B Cell fate in the thymus. J Exp Med 194: 1003-1012.
91. Ge C, Stanley P (2008) The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T Cell development. Proc Natl Acad Sci U S A 105: 1539-1544.
92. Gridley T (2007) Notch signaling in vascular development and physiology. Development.
93. Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, et al. (2005) Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell 16: 927-942.
94. Huppert SS, Ilagan MX, De Strooper B, Kopan R (2005) Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Dev Cell 8: 677-688.
95. Khandelwal A, Chandu D, Roe CM, Kopan R, Quatrano RS (2007) Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved. Proc Natl Acad Sci U S A 104: 13337-13342.