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Volumn 5, Issue MAY, 2014, Pages

NOTCH1 can initiate NF-κB activation via cytosolic interactions with components of the T cell signalosome

(12)  Shin, Hyun Mu a,g   Tilahun, Mulualem E a,h   Cho, Ok Hyun a,g   Chandiran, Karthik a   Kuksin, Christina Arieta a   Keerthivasan, Shilpa b,i   Fauq, Abdul H c,j   Golde, Todd E d   Miele, Lucio e,k   Thome, Margot f   Osborne, Barbara A a   Minter, Lisa M a  


Author keywords

CARMA1; Cytosolic; NF b; Non canonical; NOTCH1; PKC ; Signal transduction; T cell subject category: immunology

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH1 RECEPTOR; PROTEIN BCL 10; REGULATOR PROTEIN; T LYMPHOCYTE RECEPTOR;

EID: 84905407019     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00249     Document Type: Article
Times cited : (46)

References (52)
  • 1
    • 28844499919 scopus 로고    scopus 로고
    • Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-kappaB activation
    • doi: 10.1016/j.immuni.2005.10.007
    • Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, et al. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-kappaB activation. Immunity (2005) 5:575-85. doi: 10.1016/j.immuni.2005.10.007
    • (2005) Immunity , vol.5 , pp. 575-585
    • Matsumoto, R.1    Wang, D.2    Blonska, M.3    Li, H.4    Kobayashi, M.5    Pappu, B.6
  • 2
    • 0346993668 scopus 로고    scopus 로고
    • CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1
    • doi:10.1128/MCB.24.1.164-171.2003
    • Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen S, et al. CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol (2004) 24:164-71. doi:10.1128/MCB.24.1.164-171.2003
    • (2004) Mol Cell Biol , vol.24 , pp. 164-171
    • Wang, D.1    Matsumoto, R.2    You, Y.3    Che, T.4    Lin, X.Y.5    Gaffen, S.6
  • 4
    • 58549094896 scopus 로고    scopus 로고
    • The kinase PDK1 integrates T cell antigen receptor and CD28 co-receptor signaling to induce NF-kappaB and activate T cells
    • doi:10.1038/ni.1687
    • Park SG, Schulze-Leuhrman J, Hayden MS, Hashimoto N, Ogawa W, Kasuga M, et al. The kinase PDK1 integrates T cell antigen receptor and CD28 co-receptor signaling to induce NF-kappaB and activate T cells. Nat Immunol (2009) 10:158-66. doi:10.1038/ni.1687
    • (2009) Nat Immunol , vol.10 , pp. 158-166
    • Park, S.G.1    Schulze-Leuhrman, J.2    Hayden, M.S.3    Hashimoto, N.4    Ogawa, W.5    Kasuga, M.6
  • 5
    • 15944410614 scopus 로고    scopus 로고
    • PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation
    • doi:10.1126/science.1107107
    • Lee KY, D'Azcuisto F, Hayden MS, Shim JH, Ghosh S. PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science (2005) 308:114-8. doi:10.1126/science.1107107
    • (2005) Science , vol.308 , pp. 114-118
    • Lee, K.Y.1    D'Azcuisto, F.2    Hayden, M.S.3    Shim, J.H.4    Ghosh, S.5
  • 6
    • 18844473151 scopus 로고    scopus 로고
    • PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    • doi:10.1038/35006090
    • Sun Z, Arendt CW, Ellimer W, Schaeffer EM, Sunshine MJ, Ghandi L, et al. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (2000) 404:402-7. doi:10.1038/35006090
    • (2000) Nature , vol.404 , pp. 402-407
    • Sun, Z.1    Arendt, C.W.2    Ellimer, W.3    Schaeffer, E.M.4    Sunshine, M.J.5    Ghandi, L.6
  • 7
    • 80054953932 scopus 로고    scopus 로고
    • The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinsase PKC-Θ in T cells
    • doi:10.1038/ni.2121
    • Chuang H-C, Lan J-L, Chen D-Y, Yang C-Y, Chen Y-M, Li J-P, et al. The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinsase PKC-Θ in T cells. Nat Immunol (2011) 12:1113-8. doi:10.1038/ni.2121
    • (2011) Nat Immunol , vol.12 , pp. 1113-1118
    • Chuang, H.-C.1    Lan, J.-L.2    Chen, D.-Y.3    Yang, C.-Y.4    Chen, Y.-M.5    Li, J.-P.6
  • 8
    • 0038375851 scopus 로고    scopus 로고
    • Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation
    • doi:10.1016/S0960-9822(03)00491-3
    • Egawa T, Albrecht B, Favier B, Sunshine MJ, Mirchandani K, O'Brien W, et al. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Curr Biol (2003) 13:1252-8. doi:10.1016/S0960-9822(03)00491-3
    • (2003) Curr Biol , vol.13 , pp. 1252-1258
    • Egawa, T.1    Albrecht, B.2    Favier, B.3    Sunshine, M.J.4    Mirchandani, K.5    O'Brien, W.6
  • 9
    • 17744386318 scopus 로고    scopus 로고
    • Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure
    • doi:10.1016/S0092-8674(01)00189-1
    • Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 104:33-42. doi:10.1016/S0092-8674(01)00189-1
    • (2001) Cell , vol.104 , pp. 33-42
    • Ruland, J.1    Duncan, G.S.2    Elia, A.3    del Barco Barrantes, I.4    Nguyen, L.5    Plyte, S.6
  • 10
    • 0345358541 scopus 로고    scopus 로고
    • Differential requirement for Malt1 in T and B cell antigen receptor signaling
    • doi:10.1016/S1074-7613(03)00293-0
    • Ruland J, Duncan GS, Wakeham A, Mak TW. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity (2003) 19:749-58. doi:10.1016/S1074-7613(03)00293-0
    • (2003) Immunity , vol.19 , pp. 749-758
    • Ruland, J.1    Duncan, G.S.2    Wakeham, A.3    Mak, T.W.4
  • 12
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • doi:10.1146/annurev.immunol.021908.132641
    • Vallabhapurapu S, Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annu Rev Immunol (2009) 27:693-733. doi:10.1146/annurev.immunol.021908.132641
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 13
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-kB activation pathways and their role in innate and adaptive immunity
    • doi:10.1016/j.it.2004.03.008
    • Bonizzi G, Karin M. The two NF-kB activation pathways and their role in innate and adaptive immunity. Trends Immunol (2004) 25:280-8. doi:10.1016/j.it.2004.03.008
    • (2004) Trends Immunol , vol.25 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 14
    • 0034031401 scopus 로고    scopus 로고
    • Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta
    • doi:10.1128/MCB.20.8.2933-2940.2000
    • Lin X, O'Mahony A, Mu Y, Geleziunas R, Greene WC. Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta. Mol Cell Biol (2000) 20:2933-40. doi:10.1128/MCB.20.8.2933-2940.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 2933-2940
    • Lin, X.1    O'Mahony, A.2    Mu, Y.3    Geleziunas, R.4    Greene, W.C.5
  • 15
    • 33845894709 scopus 로고    scopus 로고
    • Notch signaling during peripheral T-cell activation and differentiation
    • doi:10.1038/nri1998
    • Osborne BA, Minter LM. Notch signaling during peripheral T-cell activation and differentiation. Nat Rev Immunol (2007) 7:64-75. doi:10.1038/nri1998
    • (2007) Nat Rev Immunol , vol.7 , pp. 64-75
    • Osborne, B.A.1    Minter, L.M.2
  • 16
    • 0042834334 scopus 로고    scopus 로고
    • Notch signaling augments T cell responsiveness by enhancing CD25 expression
    • doi:10.4049/jimmunol.171.6.2896
    • Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, et al. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 171:2896-903. doi:10.4049/jimmunol.171.6.2896
    • (2003) J Immunol , vol.171 , pp. 2896-2903
    • Adler, S.H.1    Chiffoleau, E.2    Xu, L.3    Dalton, N.M.4    Burg, J.M.5    Wells, A.D.6
  • 17
    • 0041331708 scopus 로고    scopus 로고
    • TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells
    • doi:10.4049/jimmunol.171.6.3019
    • Palaga T, Miele L, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J Immunol (2003) 171:3019-24. doi:10.4049/jimmunol.171.6.3019
    • (2003) J Immunol , vol.171 , pp. 3019-3024
    • Palaga, T.1    Miele, L.2    Golde, T.E.3    Osborne, B.A.4
  • 18
    • 84895509804 scopus 로고    scopus 로고
    • Non-canonical Notch signaling drives activation and differentiation of peripheral CD4+ T cells
    • doi:10.3389/fimmu.2014.00054
    • Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, et al. Non-canonical Notch signaling drives activation and differentiation of peripheral CD4+ T cells. Front Immunol (2014). doi:10.3389/fimmu.2014.00054
    • (2014) Front Immunol
    • Dongre, A.1    Surampudi, L.2    Lawlor, R.G.3    Fauq, A.H.4    Miele, L.5    Golde, T.E.6
  • 19
    • 30444450802 scopus 로고    scopus 로고
    • Notch1 augments NF-kappaB activity by facilitating its nuclear retention
    • doi:10.1038/sj.emboj.7600902
    • Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, et al. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. EMBO J (2006) 25:129-38. doi:10.1038/sj.emboj.7600902
    • (2006) EMBO J , vol.25 , pp. 129-138
    • Shin, H.M.1    Minter, L.M.2    Cho, O.H.3    Gottipati, S.4    Fauq, A.H.5    Golde, T.E.6
  • 20
    • 67349086051 scopus 로고    scopus 로고
    • A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells
    • doi:10.1038/cdd.2009.20
    • Perumalsamy LR, Nagala M, Banerjee P, Sarin A. A hierarchical cascade activated by non-canonical Notch signaling and the mTOR-Rictor complex regulates neglect-induced death in mammalian cells. Cell Death Differ (2009) 16:879-89. doi:10.1038/cdd.2009.20
    • (2009) Cell Death Differ , vol.16 , pp. 879-889
    • Perumalsamy, L.R.1    Nagala, M.2    Banerjee, P.3    Sarin, A.4
  • 21
    • 77951080367 scopus 로고    scopus 로고
    • Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival
    • doi:10.1073/pnas.0910060107
    • Perumalsamy LR, Nagala M, Sarin A. Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival. Proc Natl Acad Sci U S A (2010) 107:6882-7. doi:10.1073/pnas.0910060107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6882-6887
    • Perumalsamy, L.R.1    Nagala, M.2    Sarin, A.3
  • 22
    • 84864401500 scopus 로고    scopus 로고
    • Distinct spatial and molecular features of Notch pathway assembly in regulatory T cells
    • doi:10.1126/scisignal.2002859
    • Perumalsamy LR, Marcel N, Kulkarni S, Radtke F, Sarin A. Distinct spatial and molecular features of Notch pathway assembly in regulatory T cells. Sci Signal (2012) 5:1-11. doi:10.1126/scisignal.2002859
    • (2012) Sci Signal , vol.5 , pp. 1-11
    • Perumalsamy, L.R.1    Marcel, N.2    Kulkarni, S.3    Radtke, F.4    Sarin, A.5
  • 23
    • 84880848750 scopus 로고    scopus 로고
    • Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia
    • doi:10.1084/jem.20112615
    • Roderick JE, Gonzalez-Perez G, Kuksin CA, Dongre A, Roberts ER, Srinivasan J, et al. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. J Exp Med (2013) 210:1311-29. doi:10.1084/jem.20112615
    • (2013) J Exp Med , vol.210 , pp. 1311-1329
    • Roderick, J.E.1    Gonzalez-Perez, G.2    Kuksin, C.A.3    Dongre, A.4    Roberts, E.R.5    Srinivasan, J.6
  • 24
    • 20044395661 scopus 로고    scopus 로고
    • Quantitative assessment of mouse skin transplant rejection using digital photography
    • doi:10.1258/0023677053739792
    • Schwoebel F, Barsig J, Wendel A, Hamacher J. Quantitative assessment of mouse skin transplant rejection using digital photography. Lab Anim (2005) 39:209-14. doi:10.1258/0023677053739792
    • (2005) Lab Anim , vol.39 , pp. 209-214
    • Schwoebel, F.1    Barsig, J.2    Wendel, A.3    Hamacher, J.4
  • 25
    • 0034024625 scopus 로고    scopus 로고
    • Neoplastic transformation by Notch requires nuclear localization
    • doi:10.1128/MCB.20.11.3928-3941.2000
    • Jeffries S, Capobianco AJ. Neoplastic transformation by Notch requires nuclear localization. Mol Cell Biol (2000) 20:3928-41. doi:10.1128/MCB.20.11.3928-3941.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 3928-3941
    • Jeffries, S.1    Capobianco, A.J.2
  • 26
    • 0036707522 scopus 로고    scopus 로고
    • CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation
    • doi:10.1038/ni830
    • Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, et al. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation. Nat Immunol (2002) 3:836-43. doi:10.1038/ni830
    • (2002) Nat Immunol , vol.3 , pp. 836-843
    • Gaide, O.1    Favier, B.2    Legler, D.F.3    Bonnet, D.4    Brissoni, B.5    Valitutti, S.6
  • 27
    • 0037296110 scopus 로고    scopus 로고
    • Impaired NF-κB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts
    • doi:10.1034/j.1600-6143.2003.00033.x
    • Zhou P, Woo KH, Paluki DA, Gou Z, Boothby M, Newell KA, et al. Impaired NF-κB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts. Am J Transplant (2003) 3:139-47. doi:10.1034/j.1600-6143.2003.00033.x
    • (2003) Am J Transplant , vol.3 , pp. 139-147
    • Zhou, P.1    Woo, K.H.2    Paluki, D.A.3    Gou, Z.4    Boothby, M.5    Newell, K.A.6
  • 28
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: a simple pathway becomes complex
    • doi:10.1038/nrm2009
    • Bray S. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 7:678-89. doi:10.1038/nrm2009
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.1
  • 29
    • 0035374476 scopus 로고    scopus 로고
    • Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation
    • doi:10.1038/88765
    • Bi K, Tanaka Y, Coudronniere N, Sugie K, Hong S, van Stipdonk MJ, et al. Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol (2001) 2:556-63. doi:10.1038/88765
    • (2001) Nat Immunol , vol.2 , pp. 556-563
    • Bi, K.1    Tanaka, Y.2    Coudronniere, N.3    Sugie, K.4    Hong, S.5    van Stipdonk, M.J.6
  • 30
    • 16344378618 scopus 로고    scopus 로고
    • Kinasing and clipping down the NF-kappaB trail
    • doi:10.1126/science.1110902
    • van Oers NS, Chen ZJ. Kinasing and clipping down the NF-kappaB trail. Science (2005) 308:65-6. doi:10.1126/science.1110902
    • (2005) Science , vol.308 , pp. 65-66
    • van Oers, N.S.1    Chen, Z.J.2
  • 31
    • 1642576036 scopus 로고    scopus 로고
    • The anti-apoptotic effect of Notch-1 requires p56lck-dependent. AKT/PKB-mediated signaling in T cells
    • doi:10.1074/jbc.M309924200
    • Sade H, Krishna S, Sarin A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, AKT/PKB-mediated signaling in T cells. J Biol Chem (2004) 279:2937-44. doi:10.1074/jbc.M309924200
    • (2004) J Biol Chem , vol.279 , pp. 2937-2944
    • Sade, H.1    Krishna, S.2    Sarin, A.3
  • 32
    • 0015950912 scopus 로고
    • Cholera toxin: interaction of subunits with ganglioside GM1
    • doi:10.1126/science.183.4125.656
    • Heyningen SV. Cholera toxin: interaction of subunits with ganglioside GM1. Science (1974) 183:656-7. doi:10.1126/science.183.4125.656
    • (1974) Science , vol.183 , pp. 656-657
    • Heyningen, S.V.1
  • 33
    • 0034846540 scopus 로고    scopus 로고
    • Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy
    • doi:10.1006/meth.2001.1189
    • Kenworthy AK. Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy. Methods (2001) 24:289-96. doi:10.1006/meth.2001.1189
    • (2001) Methods , vol.24 , pp. 289-296
    • Kenworthy, A.K.1
  • 34
    • 4344656346 scopus 로고    scopus 로고
    • Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
    • doi:10.1073/pnas.0404041101
    • Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A (2004) 101:12288-93. doi:10.1073/pnas.0404041101
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 12288-12293
    • Luker, K.E.1    Smith, M.C.2    Luker, G.D.3    Gammon, S.T.4    Piwnica-Worms, H.5    Piwnica-Worms, D.6
  • 35
    • 0036241055 scopus 로고    scopus 로고
    • Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation
    • doi:10.1016/S1097-2765(02)00496-3
    • Hu CD, Chinenov Y, Kerppola TK. Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation. Mol Cell (2002) 9:789-98. doi:10.1016/S1097-2765(02)00496-3
    • (2002) Mol Cell , vol.9 , pp. 789-798
    • Hu, C.D.1    Chinenov, Y.2    Kerppola, T.K.3
  • 36
    • 48249132926 scopus 로고    scopus 로고
    • Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells
    • doi:10.1146/annurev.biophys.37.032807.125842
    • Kerppola TK. Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells. Annu Rev Biophys (2008) 37:465-87. doi:10.1146/annurev.biophys.37.032807.125842
    • (2008) Annu Rev Biophys , vol.37 , pp. 465-487
    • Kerppola, T.K.1
  • 37
    • 0037154292 scopus 로고    scopus 로고
    • Protein degradation: four E3s for the notch pathway
    • doi:10.1016/S0960-9822(01)00679-0
    • Lai EC. Protein degradation: four E3s for the notch pathway. Curr Biol (2002) 12:R74-8. doi:10.1016/S0960-9822(01)00679-0
    • (2002) Curr Biol , vol.12
    • Lai, E.C.1
  • 38
    • 0029047609 scopus 로고
    • Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
    • Matsuno K, Diederich RJ, Go MJ, Blaumeuller CM, Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development (1995) 121:2633-44.
    • (1995) Development , vol.121 , pp. 2633-2644
    • Matsuno, K.1    Diederich, R.J.2    Go, M.J.3    Blaumeuller, C.M.4    Artavanis-Tsakonas, S.5
  • 39
    • 0037663379 scopus 로고    scopus 로고
    • Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    • doi:10.1074/jbc.M302827200
    • McGill MA, McGlade CJ. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem (2003) 278:23196-203. doi:10.1074/jbc.M302827200
    • (2003) J Biol Chem , vol.278 , pp. 23196-23203
    • McGill, M.A.1    McGlade, C.J.2
  • 40
    • 84868304869 scopus 로고    scopus 로고
    • Canonical and non-canonical Notch signaling in CD4+ T cells
    • doi:10.1007/82_2012_233
    • Minter LM, Osborne BA. Canonical and non-canonical Notch signaling in CD4+ T cells. Curr Top Microbiol Immunol (2012) 360:99-114. doi:10.1007/82_2012_233
    • (2012) Curr Top Microbiol Immunol , vol.360 , pp. 99-114
    • Minter, L.M.1    Osborne, B.A.2
  • 41
    • 0036790507 scopus 로고    scopus 로고
    • CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex
    • doi:10.1093/emboj/cdf505
    • Pomerantz JL, Denny EM, Baltimore D. CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J (2002) 21:5184-94. doi:10.1093/emboj/cdf505
    • (2002) EMBO J , vol.21 , pp. 5184-5194
    • Pomerantz, J.L.1    Denny, E.M.2    Baltimore, D.3
  • 42
    • 0033230122 scopus 로고    scopus 로고
    • Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family
    • doi:10.1002/(SICI)1521-1878(199911)21:11<912::AID-BIES3>3.0.CO;2-Z
    • Dimitratos SD, Woods DF, Stathakis DG, Bryant PJ. Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family. Bioessays (1999) 21:912-21. doi:10.1002/(SICI)1521-1878(199911)21:11<912::AID-BIES3>3.0.CO;2-Z
    • (1999) Bioessays , vol.21 , pp. 912-921
    • Dimitratos, S.D.1    Woods, D.F.2    Stathakis, D.G.3    Bryant, P.J.4
  • 43
    • 58149083028 scopus 로고    scopus 로고
    • Scaffold proteins and immune-cell signaling
    • doi:10.1038/nri2473
    • Shaw AS, Filbert EL. Scaffold proteins and immune-cell signaling. Nat Rev Immunol (2009) 9:47-56. doi:10.1038/nri2473
    • (2009) Nat Rev Immunol , vol.9 , pp. 47-56
    • Shaw, A.S.1    Filbert, E.L.2
  • 44
    • 84872395016 scopus 로고    scopus 로고
    • PKCΘ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes
    • doi:10.1371/journal.pone.0053709
    • Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, et al. PKCΘ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. PLoS One (2013) 8(1):e53709. doi:10.1371/journal.pone.0053709
    • (2013) PLoS One , vol.8 , Issue.1
    • Thuille, N.1    Wachowicz, K.2    Hermann-Kleiter, N.3    Kaminski, S.4    Fresser, F.5    Lutz-Nicoladoni, C.6
  • 45
    • 13944266008 scopus 로고    scopus 로고
    • PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia
    • doi:10.1038/sj.onc.1208302
    • Felli MP, Vacca A, Calce A, Bellavia D, Campese AF, Grillo R, et al. PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene (2005) 24:992-1000. doi:10.1038/sj.onc.1208302
    • (2005) Oncogene , vol.24 , pp. 992-1000
    • Felli, M.P.1    Vacca, A.2    Calce, A.3    Bellavia, D.4    Campese, A.F.5    Grillo, R.6
  • 46
    • 78650901943 scopus 로고    scopus 로고
    • NF-κF signaling pathways regulated by CARMA family of scaffold proteins
    • doi:10.1038/cr.2010.182
    • Blonska M, Lin X. NF-κF signaling pathways regulated by CARMA family of scaffold proteins. Cell Res (2011) 21:55-70. doi:10.1038/cr.2010.182
    • (2011) Cell Res , vol.21 , pp. 55-70
    • Blonska, M.1    Lin, X.2
  • 47
    • 15844366269 scopus 로고    scopus 로고
    • Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production
    • doi:10.1002/eji.200425562
    • Benson RA, Adamson K, Corsin-Jiminez M, Marley JV, Wahl KA, Lab JR, et al. Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production. Eur J Immunol (2005) 35:859-69. doi:10.1002/eji.200425562
    • (2005) Eur J Immunol , vol.35 , pp. 859-869
    • Benson, R.A.1    Adamson, K.2    Corsin-Jiminez, M.3    Marley, J.V.4    Wahl, K.A.5    Lab, J.R.6
  • 48
    • 8644283766 scopus 로고    scopus 로고
    • The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse
    • doi:10.1084/jem.20032246
    • Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, et al. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med (2004) 200:1167-77. doi:10.1084/jem.20032246
    • (2004) J Exp Med , vol.200 , pp. 1167-1177
    • Hara, H.1    Bakal, C.2    Wada, T.3    Bouchard, D.4    Rottapel, R.5    Saito, T.6
  • 49
    • 0030945447 scopus 로고    scopus 로고
    • Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
    • doi:10.1074/jbc.272.17.11336
    • Aster JC, Roberstons ES, Hasserjian RP, Turner JR, Kieff E, Sklar J. Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription. J Biol Chem (1997) 272:11336-43. doi:10.1074/jbc.272.17.11336
    • (1997) J Biol Chem , vol.272 , pp. 11336-11343
    • Aster, J.C.1    Roberstons, E.S.2    Hasserjian, R.P.3    Turner, J.R.4    Kieff, E.5    Sklar, J.6
  • 50
    • 0027991383 scopus 로고
    • The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
    • Kopan R, Nye JS, Weintraub H. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development (1994) 120:2385-96.
    • (1994) Development , vol.120 , pp. 2385-2396
    • Kopan, R.1    Nye, J.S.2    Weintraub, H.3
  • 51
    • 26444435322 scopus 로고    scopus 로고
    • Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit JNK signaling pathway
    • doi:10.1073/pnas.0501600102
    • Kim JW, Kim MJ, Kim KJ, Yun HJ, Chae JS, Hwang SG, et al. Notch interferes with the scaffold function of JNK-interacting protein 1 to inhibit JNK signaling pathway. Proc Natl Acad Sci U S A (2005) 102:14308-13. doi:10.1073/pnas.0501600102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14308-14313
    • Kim, J.W.1    Kim, M.J.2    Kim, K.J.3    Yun, H.J.4    Chae, J.S.5    Hwang, S.G.6
  • 52
    • 84876863453 scopus 로고    scopus 로고
    • Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-regulating kinase 1
    • doi:10.1073/pnas.12090781
    • Mo J-S, Yoon J-H, Ann E-J, Ahn J-S, Baek H-J, Lee H-J, et al. Notch1 modulates oxidative stress induced cell death through suppression of apoptosis signal-regulating kinase 1. Proc Natl Acad Sci U S A (2013) 110:6865-70. doi:10.1073/pnas.12090781
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6865-6870
    • Mo, J.-S.1    Yoon, J.-H.2    Ann, E.-J.3    Ahn, J.-S.4    Baek, H.-J.5    Lee, H.-J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.