Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity

Nature Medicine

Volumn 9, Issue 5, 2003, Pages 582-588

  Akbari, Omid ^a   Stock, Philippe ^a   Meyer, Everett ^a   Kronenberg, Mitchell ^b   Sidobre, Stephane ^b   Nakayama, Toshinori ^c   Taniguchi, Masaru ^c   Grusby, Michael J ^d   DeKruyff, Rosemarie H ^a   Umetsu, Dale T ^a  

^a STANFORD UNIVERSITY   (United States)

^b LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^c CHIBA UNIVERSITY   (Japan)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CD1D ANTIGEN; INTERLEUKIN 13; INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 13; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNITY; IMMUNIZATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ADOPTIVE TRANSFER; ALLERGENS; ANIMALS; ANTIGENS, CD1; BRONCHIAL HYPERREACTIVITY; INTERLEUKIN-13; INTERLEUKIN-4; KILLER CELLS, NATURAL; MICE; MICE, INBRED BALB C;

ANIMALIA; BRONCHUS;

EID: 0037911660     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm851     Document Type: Article

References (46)

1. Forecasted state-specific estimates of self-reported asthma prevalence - United States, 1998. Morb. Mortal. Wkly. Rep. 47, 1022-1025 (1998).
2. Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17, 255-281 (1999).
3. Martinez, F.D. et al. Asthma and wheezing in the first six years of life. N. Engl. J. Med. 332, 133-138 (1995).
4. Burrows, B., Martinez, F.D., Halonen, M., Barbee, R.A. & Cline, M.G. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 320, 271-277 (1989).
5. Illi, S. et al. The pattern of atopic sensitization is associated with the development of asthma in childhood. J. Allergy Clin. Immunol. 108, 709-714 (2001).
6. Van Eerdewegh, P. et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 418, 426-430 (2002).
7. Holgate, S. et al. Epithelial-mesenchymal interactions in the pathogenesis of asthma. J. Allergy Clin. Immunol. 105, 193-204 (2000).
8. Bendelac, A., Rivera, M.N., Park, S.H. & Roark, J.H. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu. Rev. Immunol. 15, 535-562 (1997).
9. Kronenberg, M. & Gapin, L. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2, 557-568 (2002).
10. Brossay, L. et al. CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J. Exp. Med. 188, 1521-1528 (1998).
11. Kawano, T. et al. CD1 d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278, 1626-1629 (1997).
12. Spada, F., Koezuka, Y. & Porcelli, 5. CD1d-restricted recognition of synthetic glycolipid antigens by human natural killer T cells. J. Exp. Med. 188, 1529-1534 (1998).
13. + T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285-1295 (1994).
14. Carnaud, C. et al. Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163, 4647-4650 (1999).
15. Cui, J. et al. Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Vα14 natural killer T cells. J. Exp. Med. 190, 783-792 (1999).
16. Wilson, S.B. et al. Extreme Th1 bias of invariant Vα24jαQ T cells in type 1 diabetes. Nature 391, 177-181 (1998).
17. Lee, P. et al. Testing the NKT cell hypothesis of human IDDM pathogenesis. J. Clin. Invest 110, 793-800 (2002).
18. +-like thymocytes in the NOD mouse. Eur J. Immunol 26, 2989-2989 (1996).
19. - T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46, 572-582 (1997).
20. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187, 1047-1056 (1998).
21. Lehuen, A. et al. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188, 1831-1839 (1998).
22. Miyamoto, K., Miyake, S. & Yamamura, T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413, 531-534 (2001).
23. Korsgren, M. et al. Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice. J. Exp. Med. 189, 553-62 (1999).
24. Zhang, Y., Rogers, K.H. & Lewis, D.B. β2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J. Exp. Med. 184, 1507-1512 (1996).
25. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184, 1295-304 (1996).
26. Smiley, S.T., Kaplan, M.H. & Grusby, M.J. Immunoglobulin E production in the absence of interleukin-4-secreting CD1-dependent cells. Science 275, 977-979 (1997).
27. Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science 282, 2258-2261 (1998).
28. Walter, D. et al. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. J. Immunol. 167, 4668-4675 (2001).
29. Corry, D.B. et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183, 109-117 (1996).
30. Leckie, M. et al. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 356, 2144-2148 (2000).
31. Nieuwenhuis, E.E. et al. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat. Med. 8, 588-593 (2002).
32. Matsuda, J. et al. Homeostasis of Vα14i NKT cells. Nat. Immunol. 3, 966-974 (2002).
33. Wang, B., Geng, Y. & Wang, C. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194, 313-320 (2001).
34. Hong, S. et al. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7, 1052-1056 (2001).
35. Sharif, S. et al. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat. Med. 7, 1057-1062 (2001).
36. Cui, J. et al. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors. Science 278, 1623-1626 (1997).
37. + T cells are positively selected in the thymus by agonist self-peptides. Immunity 16, 355-364 (2002).
38. Terabe, M. et al. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 1, 515-520 (2000).
39. Heller, F., Fuss, I., Nieuwenhuis, E., Blumberg, R. & Strober, W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity 17, 629-638 (2002).
40. McKenzie, G.J., Fallon, P.G., Emson, C.L., Grencis, R.K. & McKenzie, A.N. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189, 1565-1572 (1999).
41. Hansen, G., Berry, G., DeKruyff, R.H. & Umetsu, D.T. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J. Clin. Invest. 103, 175-183 (1999).
42. Matsuda, J. et al. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192, 741-754 (2000).
43. Haczku, A. et al. Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice. Am J. Respir. Cell. Mol. Biol. 25, 45-50 (2001).
44. Martin, T.R., Gerard, N.P., Galli, S.J. & Drazen, J.M. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64, 2318-2323 (1988).
45. Assenmacher, M., Schmitz, J. & Radbruch, A. Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-γ and in interleukin-4-expressing cells. Eur. J. Immunol. 24, 1097-1101 (1994).
46. + cells indicates memory type responsiveness. Scand. J. Immunol. 33, 287-296 (1991).