메뉴 건너뛰기




Volumn 185, Issue 10, 2010, Pages 5835-5844

Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; DELTA LIKE LIGAND 4; INTERLEUKIN 2; INTERLEUKIN 4; LIGAND; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

EID: 78650642332     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000175     Document Type: Review
Times cited : (27)

References (75)
  • 1
    • 65449165234 scopus 로고    scopus 로고
    • Evaluation of risk factors and health outcomes among persons with asthma
    • Smith, K., T. Warholak, E. Armstrong, M. Leib, R. Rehfeld, and D. Malone. 2009. Evaluation of risk factors and health outcomes among persons with asthma. J. Asthma 46:234-237.
    • (2009) J. Asthma , vol.46 , pp. 234-237
    • Smith, K.1    Warholak, T.2    Armstrong, E.3    Leib, M.4    Rehfeld, R.5    Malone, D.6
  • 2
    • 67049118969 scopus 로고    scopus 로고
    • The origins of asthma and chronic obstructive pulmonary disease in early life
    • Martinez, F. D. 2009. The origins of asthma and chronic obstructive pulmonary disease in early life. Proc. Am. Thorac. Soc. 6:272-277.
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , pp. 272-277
    • Martinez, F.D.1
  • 3
    • 20344403973 scopus 로고    scopus 로고
    • Is the hygiene hypothesis still a viable explanation for the increased prevalence of asthma?
    • Platts-Mills, T. A., E. Erwin, P. Heymann, and J. Woodfolk. 2005. Is the hygiene hypothesis still a viable explanation for the increased prevalence of asthma? Allergy 60 (Suppl 79):25-31.
    • (2005) Allergy , vol.60 , Issue.79 SUPPL. , pp. 25-31
    • Platts-Mills, T.A.1    Erwin, E.2    Heymann, P.3    Woodfolk, J.4
  • 4
    • 0346216130 scopus 로고    scopus 로고
    • Mechanisms of severe asthma
    • Wenzel, S. 2003. Mechanisms of severe asthma. Clin. Exp. Allergy 33:1622-1628.
    • (2003) Clin. Exp. Allergy , vol.33 , pp. 1622-1628
    • Wenzel, S.1
  • 5
    • 0036964029 scopus 로고    scopus 로고
    • The childhood origins of asthma (COAST) study
    • Lemanske, R. F., Jr. 2002. The childhood origins of asthma (COAST) study. Pediatr. Allergy Immunol. 13 (Suppl 15):38-43.
    • (2002) Pediatr. Allergy Immunol. , vol.13 , Issue.15 SUPPL. , pp. 38-43
    • Lemanske Jr., R.F.1
  • 6
    • 2542486456 scopus 로고    scopus 로고
    • Asthma: Mechanisms of disease persistence and progression
    • Cohn, L., J. A. Elias, and G. L. Chupp. 2004. Asthma: mechanisms of disease persistence and progression. Annu. Rev. Immunol. 22:789-815.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 789-815
    • Cohn, L.1    Elias, J.A.2    Chupp, G.L.3
  • 7
    • 0036020038 scopus 로고    scopus 로고
    • Interleukins-4,-5, and-13: Emerging therapeutic targets in allergic disease
    • Foster, P. S., M. Martinez-Moczygemba, D. P. Huston, and D. B. Corry. 2002. Interleukins-4,-5, and-13: emerging therapeutic targets in allergic disease. Pharmacol. Ther. 94:253-264.
    • (2002) Pharmacol. Ther. , vol.94 , pp. 253-264
    • Foster, P.S.1    Martinez-Moczygemba, M.2    Huston, D.P.3    Corry, D.B.4
  • 8
    • 70049101757 scopus 로고    scopus 로고
    • Biology of lung dendritic cells at the origin of asthma
    • Lambrecht, B. N., and H. Hammad. 2009. Biology of lung dendritic cells at the origin of asthma. Immunity 31:412-424.
    • (2009) Immunity , vol.31 , pp. 412-424
    • Lambrecht, B.N.1    Hammad, H.2
  • 9
    • 17144367365 scopus 로고    scopus 로고
    • In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma
    • van Rijt, L. S., S. Jung, A. Kleinjan, N. Vos, M. Willart, C. Duez, H. C. Hoogsteden, and B. N. Lambrecht. 2005. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201:981-991.
    • (2005) J. Exp. Med. , vol.201 , pp. 981-991
    • Van Rijt, L.S.1    Jung, S.2    Kleinjan, A.3    Vos, N.4    Willart, M.5    Duez, C.6    Hoogsteden, H.C.7    Lambrecht, B.N.8
  • 11
    • 0036195160 scopus 로고    scopus 로고
    • A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure
    • Julia, V., E. M. Hessel, L. Malherbe, N. Glaichenhaus, A. O'Garra, and R. L. Coffman. 2002. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity 16:271-283.
    • (2002) Immunity , vol.16 , pp. 271-283
    • Julia, V.1    Hessel, E.M.2    Malherbe, L.3    Glaichenhaus, N.4    O'Garra, A.5    Coffman, R.L.6
  • 13
    • 0346849694 scopus 로고    scopus 로고
    • Notch and the immune system
    • Maillard, I., S. H. Adler, and W. S. Pear. 2003. Notch and the immune system. Immunity 19:781-791.
    • (2003) Immunity , vol.19 , pp. 781-791
    • Maillard, I.1    Adler, S.H.2    Pear, W.S.3
  • 14
    • 0033791575 scopus 로고    scopus 로고
    • The CD4/CD8 lineage decision: Integration of signalling pathways
    • Basson, M. A., and R. Zamoyska. 2000. The CD4/CD8 lineage decision: integration of signalling pathways. Immunol. Today 21:509-514.
    • (2000) Immunol. Today , vol.21 , pp. 509-514
    • Basson, M.A.1    Zamoyska, R.2
  • 16
    • 21344433039 scopus 로고    scopus 로고
    • Thymus-derived signals regulate early T-cell development
    • Schmitt, T. M., and J. C. Zúñiga-Pflücker. 2005. Thymus-derived signals regulate early T-cell development. Crit. Rev. Immunol. 25:141-159.
    • (2005) Crit. Rev. Immunol. , vol.25 , pp. 141-159
    • Schmitt, T.M.1    Zúñiga-Pflücker, J.C.2
  • 17
    • 2142656301 scopus 로고    scopus 로고
    • Notch signalling in the peripheral immune system
    • discussion 276-268
    • Dallman, M. J., B. Champion, and J. R. Lamb. 2003. Notch signalling in the peripheral immune system. Novartis Found. Symp. 252:268-276; discussion 276-268.
    • (2003) Novartis Found. Symp. , vol.252 , pp. 268-276
    • Dallman, M.J.1    Champion, B.2    Lamb, J.R.3
  • 18
    • 0035176364 scopus 로고    scopus 로고
    • Notch signalling in the regulation of peripheral immunity
    • Hoyne, G. F., M. J. Dallman, B. R. Champion, and J. R. Lamb. 2001. Notch signalling in the regulation of peripheral immunity. Immunol. Rev. 182:215-227.
    • (2001) Immunol. Rev. , vol.182 , pp. 215-227
    • Hoyne, G.F.1    Dallman, M.J.2    Champion, B.R.3    Lamb, J.R.4
  • 19
    • 2342496710 scopus 로고    scopus 로고
    • Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells
    • Amsen, D., J. M. Blander, G. R. Lee, K. Tanigaki, T. Honjo, and R. A. Flavell. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117:515-526.
    • (2004) Cell. , vol.117 , pp. 515-526
    • Amsen, D.1    Blander, J.M.2    Lee, G.R.3    Tanigaki, K.4    Honjo, T.5    Flavell, R.A.6
  • 25
    • 40749089559 scopus 로고    scopus 로고
    • Suppression of Th2 cell development by Notch ligands Delta1 and Delta4
    • Sun, J., C. J. Krawczyk, and E. J. Pearce. 2008. Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J. Immunol. 180:1655-1661.
    • (2008) J. Immunol. , vol.180 , pp. 1655-1661
    • Sun, J.1    Krawczyk, C.J.2    Pearce, E.J.3
  • 26
    • 36549001590 scopus 로고    scopus 로고
    • Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    • Schaller, M. A., R. Neupane, B. D. Rudd, S. L. Kunkel, L. E. Kallal, P. Lincoln, J. B. Lowe, Y. Man, and N. W. Lukacs. 2007. Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J. Exp. Med. 204:2925-2934.
    • (2007) J. Exp. Med. , vol.204 , pp. 2925-2934
    • Schaller, M.A.1    Neupane, R.2    Rudd, B.D.3    Kunkel, S.L.4    Kallal, L.E.5    Lincoln, P.6    Lowe, J.B.7    Man, Y.8    Lukacs, N.W.9
  • 27
    • 70349238800 scopus 로고    scopus 로고
    • Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production
    • Okamoto, M., H. Matsuda, A. Joetham, J. J. Lucas, J. Domenico, K. Yasutomo, K. Takeda, and E. W. Gelfand. 2009. Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production. J. Immunol. 183:2995-3003.
    • (2009) J. Immunol. , vol.183 , pp. 2995-3003
    • Okamoto, M.1    Matsuda, H.2    Joetham, A.3    Lucas, J.J.4    Domenico, J.5    Yasutomo, K.6    Takeda, K.7    Gelfand, E.W.8
  • 28
    • 65649149442 scopus 로고    scopus 로고
    • Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses
    • Kang, J. H., B. S. Kim, T. G. Uhm, S. H. Lee, G. R. Lee, C. S. Park, and I. Y. Chung. 2009. Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses. Am. J. Respir. Crit. Care Med. 179:875-882.
    • (2009) Am. J. Respir. Crit. Care Med. , vol.179 , pp. 875-882
    • Kang, J.H.1    Kim, B.S.2    Uhm, T.G.3    Lee, S.H.4    Lee, G.R.5    Park, C.S.6    Chung, I.Y.7
  • 30
    • 51849145775 scopus 로고    scopus 로고
    • Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: Regulators of T cell differentiation
    • Ray, P., N. Krishnamoorthy, and A. Ray. 2008. Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiation. Cell Cycle 7:2826-2832.
    • (2008) Cell. Cycle , vol.7 , pp. 2826-2832
    • Ray, P.1    Krishnamoorthy, N.2    Ray, A.3
  • 31
    • 0035284898 scopus 로고    scopus 로고
    • IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent
    • Tekkanat, K. K., H. F. Maassab, D. S. Cho, J. J. Lai, A. John, A. Berlin, M. H. Kaplan, and N. W. Lukacs. 2001. IL-13-induced airway hyperreactivity during respiratory syncytial virus infection is STAT6 dependent. J. Immunol. 166:3542-3548.
    • (2001) J. Immunol. , vol.166 , pp. 3542-3548
    • Tekkanat, K.K.1    Maassab, H.F.2    Cho, D.S.3    Lai, J.J.4    John, A.5    Berlin, A.6    Kaplan, M.H.7    Lukacs, N.W.8
  • 33
    • 0032534685 scopus 로고    scopus 로고
    • Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia
    • Campbell, E. M., S. L. Kunkel, R. M. Strieter, and N. W. Lukacs. 1998. Temporal role of chemokines in a murine model of cockroach allergen-induced airway hyperreactivity and eosinophilia. J. Immunol. 161:7047-7053.
    • (1998) J. Immunol. , vol.161 , pp. 7047-7053
    • Campbell, E.M.1    Kunkel, S.L.2    Strieter, R.M.3    Lukacs, N.W.4
  • 34
    • 65549134481 scopus 로고    scopus 로고
    • T follicular helper cells differentiate from Th2 cells in response to helminth antigens
    • Zaretsky, A. G., J. J. Taylor, I. L. King, F. A. Marshall, M. Mohrs, and E. J. Pearce. 2009. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J. Exp. Med. 206:991-999.
    • (2009) J. Exp. Med. , vol.206 , pp. 991-999
    • Zaretsky, A.G.1    Taylor, J.J.2    King, I.L.3    Marshall, F.A.4    Mohrs, M.5    Pearce, E.J.6
  • 35
    • 24944591093 scopus 로고    scopus 로고
    • Closer to the source: Notch and the nature of thymus-settling cells
    • Zediak, V. P., I. Maillard, and A. Bhandoola. 2005. Closer to the source: notch and the nature of thymus-settling cells. Immunity 23:245-248.
    • (2005) Immunity , vol.23 , pp. 245-248
    • Zediak, V.P.1    Maillard, I.2    Bhandoola, A.3
  • 37
    • 0032968707 scopus 로고    scopus 로고
    • Regulation of T cell fate by Notch
    • Robey, E. 1999. Regulation of T cell fate by Notch. Annu. Rev. Immunol. 17:283-295.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 283-295
    • Robey, E.1
  • 38
    • 50949091487 scopus 로고    scopus 로고
    • Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
    • Ong, C. T., J. R. Sedy, K. M. Murphy, and R. Kopan. 2008. Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS ONE 3: e2823.
    • (2008) PLoS ONE , vol.3
    • Ong, C.T.1    Sedy, J.R.2    Murphy, K.M.3    Kopan, R.4
  • 39
    • 23844549973 scopus 로고    scopus 로고
    • Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells
    • Rutz, S., B. Mordmüller, S. Sakano, and A. Scheffold. 2005. Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur. J. Immunol. 35:2443-2451.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 2443-2451
    • Rutz, S.1    Mordmüller, B.2    Sakano, S.3    Scheffold, A.4
  • 40
    • 38449102218 scopus 로고    scopus 로고
    • JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis
    • Elyaman, W., E. M. Bradshaw, Y. Wang, M. Oukka, P. Kivisäkk, S. Chiba, H. Yagita, and S. J. Khoury. 2007. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179:5990-5998.
    • (2007) J. Immunol. , vol.179 , pp. 5990-5998
    • Elyaman, W.1    Bradshaw, E.M.2    Wang, Y.3    Oukka, M.4    Kivisäkk, P.5    Chiba, S.6    Yagita, H.7    Khoury, S.J.8
  • 41
  • 42
    • 67849129018 scopus 로고    scopus 로고
    • The Notch ligands Jagged2, Delta1, and Delta4 induce differentiation and expansion of functional human NK cells from CD34 (+) cord blood hematopoietic progenitor cells
    • Beck, R. C., M. Padival, D. Yeh, J. Ralston, K. R. Cooke, and J. B. Lowe. 2009. The Notch ligands Jagged2, Delta1, and Delta4 induce differentiation and expansion of functional human NK cells from CD34 (+) cord blood hematopoietic progenitor cells. Biol. Blood Marrow Transplant. 15:1026-1037.
    • (2009) Biol. Blood Marrow Transplant , vol.15 , pp. 1026-1037
    • Beck, R.C.1    Padival, M.2    Yeh, D.3    Ralston, J.4    Cooke, K.R.5    Lowe, J.B.6
  • 43
    • 12944255642 scopus 로고    scopus 로고
    • Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
    • Yang, L. T., J. T. Nichols, C. Yao, J. O. Manilay, E. A. Robey, and G. Weinmaster. 2005. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol. Biol. Cell 16:927-942.
    • (2005) Mol. Biol. Cell. , vol.16 , pp. 927-942
    • Yang, L.T.1    Nichols, J.T.2    Yao, C.3    Manilay, J.O.4    Robey, E.A.5    Weinmaster, G.6
  • 44
    • 0343774150 scopus 로고    scopus 로고
    • Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: A role for the Notch ligand, Jagged1
    • Jiménez, E., A. Vicente, R. Sacedón, J. J. Muñoz, G. Weinmaster, A. G. Zapata, and A. Varas. 2001. Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1. J. Immunol. 166:5898-5908.
    • (2001) J. Immunol. , vol.166 , pp. 5898-5908
    • Jiménez, E.1    Vicente, A.2    Sacedón, R.3    Muñoz, J.J.4    Weinmaster, G.5    Zapata, A.G.6    Varas, A.7
  • 45
    • 25144476332 scopus 로고    scopus 로고
    • Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment
    • Yamane, H., J. Zhu, and W. E. Paul. 2005. Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment. J. Exp. Med. 202:793-804.
    • (2005) J. Exp. Med. , vol.202 , pp. 793-804
    • Yamane, H.1    Zhu, J.2    Paul, W.E.3
  • 47
    • 0344064893 scopus 로고    scopus 로고
    • Stat5 activation plays a critical role in Th2 differentiation
    • Zhu, J., J. Cote-Sierra, L. Guo, and W. E. Paul. 2003. Stat5 activation plays a critical role in Th2 differentiation. Immunity 19:739-748.
    • (2003) Immunity , vol.19 , pp. 739-748
    • Zhu, J.1    Cote-Sierra, J.2    Guo, L.3    Paul, W.E.4
  • 48
    • 33846548750 scopus 로고    scopus 로고
    • Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells
    • Sun, J., and E. J. Pearce. 2007. Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells. J. Immunol. 178:1635-1644.
    • (2007) J. Immunol. , vol.178 , pp. 1635-1644
    • Sun, J.1    Pearce, E.J.2
  • 50
    • 50849144847 scopus 로고    scopus 로고
    • Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination
    • Rothenberg, E. V., and D. D. Scripture-Adams. 2008. Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination. Semin. Immunol. 20:236-246.
    • (2008) Semin. Immunol. , vol.20 , pp. 236-246
    • Rothenberg, E.V.1    Scripture-Adams, D.D.2
  • 54
    • 67649216137 scopus 로고    scopus 로고
    • Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    • Mukherjee, S., M. A. Schaller, R. Neupane, S. L. Kunkel, and N. W. Lukacs. 2009. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J. Immunol. 182:7381-7388.
    • (2009) J. Immunol. , vol.182 , pp. 7381-7388
    • Mukherjee, S.1    Schaller, M.A.2    Neupane, R.3    Kunkel, S.L.4    Lukacs, N.W.5
  • 56
    • 33645506145 scopus 로고    scopus 로고
    • Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta
    • Ostroukhova, M., Z. Qi, T. B. Oriss, B. Dixon-McCarthy, P. Ray, and A. Ray. 2006. Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. J. Clin. Invest. 116:996-1004.
    • (2006) J. Clin. Invest. , vol.116 , pp. 996-1004
    • Ostroukhova, M.1    Qi, Z.2    Oriss, T.B.3    Dixon-McCarthy, B.4    Ray, P.5    Ray, A.6
  • 57
    • 33846250032 scopus 로고    scopus 로고
    • Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling
    • Kared, H., H. Adle-Biassette, E. Foïs, A. Masson, J. F. Bach, L. Chatenoud, E. Schneider, and F. Zavala. 2006. Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. Immunity 25:823-834.
    • (2006) Immunity , vol.25 , pp. 823-834
    • Kared, H.1    Adle-Biassette, H.2    Foïs, E.3    Masson, A.4    Bach, J.F.5    Chatenoud, L.6    Schneider, E.7    Zavala, F.8
  • 58
    • 61749095416 scopus 로고    scopus 로고
    • TLR9 regulates the mycobacteriaelicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4
    • Ito, T., M. Schaller, C. M. Hogaboam, T. J. Standiford, M. Sandor, N. W. Lukacs, S. W. Chensue, and S. L. Kunkel. 2009. TLR9 regulates the mycobacteriaelicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J. Clin. Invest. 119:33-46.
    • (2009) J. Clin. Invest. , vol.119 , pp. 33-46
    • Ito, T.1    Schaller, M.2    Hogaboam, C.M.3    Standiford, T.J.4    Sandor, M.5    Lukacs, N.W.6    Chensue, S.W.7    Kunkel, S.L.8
  • 59
    • 34447254518 scopus 로고    scopus 로고
    • CD8-DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS
    • Skokos, D., and M. C. Nussenzweig. 2007. CD8-DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J. Exp. Med. 204:1525-1531.
    • (2007) J. Exp. Med. , vol.204 , pp. 1525-1531
    • Skokos, D.1    Nussenzweig, M.C.2
  • 60
    • 70349238802 scopus 로고    scopus 로고
    • A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice
    • Page, K., J. R. Ledford, P. Zhou, and M. Wills-Karp. 2009. A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice. J. Immunol. 183:3400-3408.
    • (2009) J. Immunol. , vol.183 , pp. 3400-3408
    • Page, K.1    Ledford, J.R.2    Zhou, P.3    Wills-Karp, M.4
  • 61
    • 44449101242 scopus 로고    scopus 로고
    • TLR2-mediated activation of neutrophils in response to German cockroach frass
    • Page, K., K. M. Lierl, V. S. Hughes, P. Zhou, J. R. Ledford, and M. Wills-Karp. 2008. TLR2-mediated activation of neutrophils in response to German cockroach frass. J. Immunol. 180:6317-6324.
    • (2008) J. Immunol. , vol.180 , pp. 6317-6324
    • Page, K.1    Lierl, K.M.2    Hughes, V.S.3    Zhou, P.4    Ledford, J.R.5    Wills-Karp, M.6
  • 64
    • 70449729967 scopus 로고    scopus 로고
    • Regulatory T cells negatively regulate neovasculature of airway remodeling via DLL4-Notch signaling
    • Huang, M. T., Y. S. Dai, Y. B. Chou, Y. H. Juan, C. C. Wang, and B. L. Chiang. 2009. Regulatory T cells negatively regulate neovasculature of airway remodeling via DLL4-Notch signaling. J. Immunol. 183:4745-4754.
    • (2009) J. Immunol. , vol.183 , pp. 4745-4754
    • Huang, M.T.1    Dai, Y.S.2    Chou, Y.B.3    Juan, Y.H.4    Wang, C.C.5    Chiang, B.L.6
  • 65
    • 42049103185 scopus 로고    scopus 로고
    • Notch signaling in leukemias and lymphomas
    • Jundt, F., R. Schwarzer, and B. Dörken. 2008. Notch signaling in leukemias and lymphomas. Curr. Mol. Med. 8:51-59.
    • (2008) Curr. Mol. Med. , vol.8 , pp. 51-59
    • Jundt, F.1    Schwarzer, R.2    Dörken, B.3
  • 66
    • 33745698041 scopus 로고    scopus 로고
    • A survival guide to early T cell development
    • Ciofani, M., and J. C. Zúñiga-Pflücker. 2006. A survival guide to early T cell development. Immunol. Res. 34:117-132.
    • (2006) Immunol. Res. , vol.34 , pp. 117-132
    • Ciofani, M.1    Zúñiga-Pflücker, J.C.2
  • 67
    • 0348047540 scopus 로고    scopus 로고
    • Notch signaling in the immune system
    • Hoyne, G. F. 2003. Notch signaling in the immune system. J. Leukoc. Biol. 74:971-981.
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 971-981
    • Hoyne, G.F.1
  • 68
    • 0037382518 scopus 로고    scopus 로고
    • Notch signaling in lymphopoiesis
    • Pear, W. S., and F. Radtke. 2003. Notch signaling in lymphopoiesis. Semin. Immunol. 15:69-79.
    • (2003) Semin. Immunol. , vol.15 , pp. 69-79
    • Pear, W.S.1    Radtke, F.2
  • 69
    • 0033545688 scopus 로고    scopus 로고
    • T-cell development: What does Notch do for T cells?
    • von Boehmer, H. 1999. T-cell development: what does Notch do for T cells? Curr. Biol. 9: R186-R188.
    • (1999) Curr. Biol. , vol.9
    • Von Boehmer, H.1
  • 70
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: Unfolding the activation mechanism
    • Kopan, R., and M. X. Ilagan. 2009. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137:216-233.
    • (2009) Cell. , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 71
    • 34248217573 scopus 로고    scopus 로고
    • Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression
    • Kostianovsky, A. M., L. M. Maier, C. Baecher-Allan, A. C. Anderson, and D. E. Anderson. 2007. Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. J. Immunol. 178:6158-6163.
    • (2007) J. Immunol. , vol.178 , pp. 6158-6163
    • Kostianovsky, A.M.1    Maier, L.M.2    Baecher-Allan, C.3    Anderson, A.C.4    Anderson, D.E.5
  • 72
    • 68249147994 scopus 로고    scopus 로고
    • Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy
    • Hsiao, H. W., W. H. Liu, C. J. Wang, Y. H. Lo, Y. H. Wu, S. T. Jiang, and M. Z. Lai. 2009. Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy. Immunity 31:72-83.
    • (2009) Immunity , vol.31 , pp. 72-83
    • Hsiao, H.W.1    Liu, W.H.2    Wang, C.J.3    Lo, Y.H.4    Wu, Y.H.5    Jiang, S.T.6    Lai, M.Z.7
  • 73
    • 4644285392 scopus 로고    scopus 로고
    • E3 ubiquitin ligases as T cell anergy factors
    • Mueller, D. L. 2004. E3 ubiquitin ligases as T cell anergy factors. Nat. Immunol. 5:883-890.
    • (2004) Nat. Immunol. , vol.5 , pp. 883-890
    • Mueller, D.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.