Jagged-1 signaling suppresses the IL-6 and TGF-β treatment-induced Th17 cell differentiation via the reduction of RORγt/IL-17A/IL-17F/IL-23a/IL-12rb1

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Wang, Yuan ^a   Xing, Feiyue ^a   Ye, Siqi ^a   Xiao, Jia ^a   Di, Jingfang ^a   Zeng, Shan ^a   Liu, Jing ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM BINDING PROTEIN; CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 6; MEMBRANE PROTEIN; NOTCH RECEPTOR; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SERRATE PROTEINS; SIGNAL PEPTIDE;

ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TH17 CELL;

ANIMALS; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CYTOKINES; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-17; INTERLEUKIN-6; MEMBRANE PROTEINS; MICE; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; TH17 CELLS;

EID: 84949636448     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep08234     Document Type: Article

References (44)

1. Harrington, L. E. et al. Interleukin 17-producing CD41 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6, 1123-1132 (2005).
2. Park, H. et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6, 1133-1141 (2005).
3. Veldhoen, M. et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24, 179-189 (2006).
4. Li, M. O. et al. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 24, 99-146 (2006).
5. Bettelli, E. et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441, 235-238 (2006).
6. Ivanov, II et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-171 T helper cells. Cell 126, 1121-1133 (2006).
7. Zhou, L. et al. TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature 453, 236-240 (2008).
8. Zhou, L. A. et al. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8, 967-974 (2007).
9. Han, H. et al. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol 14, 637-645 (2002).
10. Radtke, F. et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity 10, 547-558 (1999).
11. Radtke, F., Wilson, A. & MacDonald, H. R. Notch signaling in T-and B-cell development. Curr Opin Immunol 16, 174-179 (2004).
12. Tanigaki, K. & Honjo, T. Regulation of lymphocyte development by Notch signaling. Nat Immunol 8, 451-456 (2007).
13. Nyfeler, Y. et al. Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J 24, 3504-3515 (2005).
14. Amsen, D. et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117, 515-526 (2004).
15. Mukherjee, S. et al. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J Immunol 182, 7381-7388 (2009).
16. Ito, T. et al. TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4. J Clin Invest 119, 33-46 (2009).
17. Jurynczyk, M. et al. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. J Immunol 180, 2634-2640 (2008).
18. You, P. et al. Jagged-1-HES-1 signaling inhibits the differentiation of TH17 cells via ROR gammat. J Biol Regul Homeost Ag 27, 79-93 (2013).
19. Alam, C. et al. Inflammatory tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change. Diabetes 59, 2237-2246 (2010).
20. Broberg, E. K. et al. Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice. J Interf Cytok Res 22, 641-651 (2002).
21. Diefenbach A, S. H. et al. Requirement for type 2 NO synthase for IL-12 signaling in innate immunity. Science 284, 951-955 (1999).
22. Yang, X. X. O. et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity 28, 29-39 (2008).
23. Choi, J. W. et al. Characterization of the transcriptional expression of Notch-1 signaling pathwaymembers, Deltex and HES-1, in developing mouse thymocytes. Dev Comp Immunol 26, 575-588 (2002).
24. Hoyne, G. F. et al. Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(1) T cells. Int Immunol 12, 177-185 (2000).
25. Kuroda, K. et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 18, 301-312 (2003).
26. Singh, N. et al. Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis. Exp Hematol 28, 527-534 (2000).
27. Lindsell C. E., S. C., Boulter, J. &Weinmaster, G. Jagged: a mammalian ligand that activates Notch1. Cell 80, 909-917 (1995).
28. Tsukumo, S. & Yasutomo, K. Notch governing mature T cell differentiation. J Immunol 173, 7109-7113 (2004).
29. Maekawa, Y. et al. Delta1-Notch3 interactions bias the functional differentiation of activated CD4(1) T cells. Immunity 19, 549-559 (2003).
30. Vigouroux, S. et al. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol 77, 10872-10880 (2003).
31. Yvon, E. S. et al. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood 102, 3815-3821 (2003).
32. Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 (2000).
33. Cua, D. J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
34. McKenzie, B. S., Kastelein, R. A. & Cua, D. J. Understanding the IL-23-IL-17 immune pathway. Trends Immunol 27, 17-23 (2006).
35. Langrish, C. L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med 201, 233-240 (2005).
36. Elson, C. O. et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cellmediated model in mice. Gastroenterol 132, 2359-2370 (2007).
37. Mangan, P. R. et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 441, 231-234 (2006).
38. Aggarwal, S. et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 278, 1910-1914 (2003).
39. Parham C, C. M. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 168, 5699-5708 (2002).
40. Mathur, A. N. et al. Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol 178, 4901-4907 (2007).
41. Yang, X. O. et al. Watowich, and C. Dong. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem 282, 9358-9363 (2007).
42. Elyaman, W. et al. Jagged1 and Delta1 differentially regulate the outcome of Experimental Autoimmune Encephalomyelitis. J Immunol 179, 5990-5998 (2007).
43. Keerthivasan, S. et al. Notch signaling regulates mouse and human Th17 differentiation. J Immunol 187, 692-701 (2011).
44. Bailis, W. et al. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity 39, 148-159 (2013).