Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable

Journal of Allergy and Clinical Immunology

Volumn 140, Issue 4, 2017, Pages 1079-1089

  Tindemans, Irma ^a   Lukkes, Melanie ^a   de Bruijn, Marjolein J W ^a   Li, Bobby W S ^a   van Nimwegen, Menno ^a   Amsen, Derk ^b   KleinJan, Alex ^a   Hendriks, Rudi W ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b CENTRAL LABORATORY   (Netherlands)

Author keywords

Allergic asthma; cytokines; Gata 3; house dust mite; Jagged; Notch signaling; recombination signal binding protein for immunoglobulin J region; TH1 immunity; TH2 immunity

Indexed keywords

CRE RECOMBINASE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; NOTCH RECEPTOR; PROTEIN JAGGED 1; PROTEIN JAGGED 2; HOUSE DUST ALLERGEN;

ALLERGIC AIRWAY INFLAMMATION; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL POLARITY; CELL SPECIFICITY; CYTOKINE PRODUCTION; DENDRITIC CELL; DERMATOPHAGOIDES; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF QUANTITATION; MACROPHAGE; NOTCH SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENSITIZATION; T LYMPHOCYTE; TH1 CELL; TH2 CELL; UPREGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; FEMALE; GENETICS; HUMAN; HYPERSENSITIVITY; IMMUNOLOGY; KNOCKOUT MOUSE; MALE; METABOLISM; MOUSE; PYROGLYPHIDAE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, DERMATOPHAGOIDES; CELLS, CULTURED; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERSENSITIVITY; JAGGED-1 PROTEIN; JAGGED-2 PROTEIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PYROGLYPHIDAE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TH2 CELLS;

EID: 85012888276     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2016.11.046     Document Type: Article

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