Blockade of Notch Signalling by γ-Secretase Inhibitor in Lung T Cells of Asthmatic Mice Affects T Cell Differentiation and Pulmonary Inflammation

Inflammation

Volumn 38, Issue 3, 2015, Pages 1281-1288

  Zhou, Min ^a,b   Cui, Zhi lei ^a   Guo, Xue jun ^a   Ren, Lian pin ^a   Yang, Min ^a   Fan, Zhi wen ^b   Han, Rui chao ^a   Xu, Wei guo ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Surgery   (China)

Author keywords

asthma; inflammation; Notch signal; T lymphocyte; secretase inhibitor

Indexed keywords

GAMMA INTERFERON; GATA3 PROTEIN, MOUSE; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; MW167; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; OVALBUMIN; PEPTIDE; SECRETASE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; TRANSCRIPTION FACTOR GATA 3;

ANIMAL; ANTAGONISTS AND INHIBITORS; ASTHMA; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; FEMALE; IMMUNOLOGY; LUNG; MALE; METABOLISM; MOUSE; PNEUMONIA; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH1 TH2 BALANCE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIFFERENTIATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; GATA3 TRANSCRIPTION FACTOR; IMMUNOGLOBULIN E; INTERFERON-GAMMA; INTERLEUKIN-4; INTERLEUKIN-5; LUNG; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; PEPTIDES; PNEUMONIA; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES; TH1-TH2 BALANCE;

EID: 84939963673     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-014-0098-5     Document Type: Article

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