Target selectivity of vertebrate notch proteins: Collaboration between discrete domains and CSL-binding site architecture determines activation probability

Journal of Biological Chemistry

Volumn 281, Issue 8, 2006, Pages 5106-5119

  Ong, Chin Tong ^a   Cheng, Hui Teng ^a   Chang, Li Wei ^a   Ohtsuka, Toshiyuki ^b   Kageyama, Ryoichiro ^b   Stormo, Gary D ^a   Kopan, Raphael ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELL CULTURE; CELLS; CONCENTRATION (PROCESS); DNA; PROBABILITY;

METANEPHROI CULTURES; SYNTHETIC NOTCH PROTEIN; TARGET SELECTIVITY; VERTEBRATE NOTCH PROTEINS;

PROTEINS;

ANKYRIN; DNA BINDING PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; PROTEIN HES5; RBP J KAPPA ASSOCIATED MOLECULE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; DNA; GREEN FLUORESCENT PROTEIN; HES1 PROTEIN, HUMAN; HES1 PROTEIN, MOUSE; HES5 PROTEIN, HUMAN; HES5 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; LUCIFERASE; REPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; EMBRYO; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; TRANSACTIVATION; VERTEBRATE; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN 3T3; CHEMISTRY; DOSE RESPONSE; GENE DELETION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELA CELL; IMMUNOHISTOCHEMISTRY; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; ORGAN CULTURE TECHNIQUE; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; STATISTICAL MODEL; TIME; TUMOR CELL LINE; WESTERN BLOTTING;

MAMMALIA; VERTEBRATA;

ANIMALS; BASE SEQUENCE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE DELETION; GREEN FLUORESCENT PROTEINS; HELA CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; KINETICS; LUCIFERASES; MALE; MICE; MODELS, BIOLOGICAL; MODELS, GENETIC; MODELS, STATISTICAL; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; ORGAN CULTURE TECHNIQUES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; REPRESSOR PROTEINS; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33646203458     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M506108200     Document Type: Article

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