Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

Nature

Volumn 528, Issue 7580, 2015, Pages 127-131

  Lafkas, Daniel ^a   Shelton, Amy ^a   Chiu, Cecilia ^a   De Leon Boenig, Gladys ^a   Chen, Yongmei ^a   Stawicki, Scott S ^a   Siltanen, Christian ^a,b   Reichelt, Mike ^a   Zhou, Meijuan ^a   Wu, Xiumin ^a   Eastham Anderson, Jeffrey ^a   Moore, Heather ^a   Roose Girma, Meron ^a   Chinn, Yvonne ^a   Hang, Julie Q ^a   Warming, Søren ^a   Egen, Jackson ^a,c   Lee, Wyne P ^a   Austin, Cary ^a   Wu, Yan ^a   Payandeh, Jian ^a   Lowe, John B ^a   Siebel, Christian W ^a   more..

^a GENENTECH INC   (United States)

^b University of California   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCKING ANTIBODY; JAG1 BLOCKING ANTIBODY 70; JAG2 BLOCKING ANTIBODY 33; JAGGED1; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; UNCLASSIFIED DRUG; ANTIBODY; CALCIUM BINDING PROTEIN; JAG2 PROTEIN, HUMAN; JAG2 PROTEIN, MOUSE; LIGAND; MEMBRANE PROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE;

ADULT; ANTIBODY; APOPTOSIS; CELLS AND CELL COMPONENTS; HOMEOSTASIS; LIGAND; MUCUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIBODY STRUCTURE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BINDING AFFINITY; BRONCHUS MUCOSA; CELL COMMUNICATION; CELL DEATH; CELL DIVISION; CELL FATE; CELL PROLIFERATION; CELL TRANSDIFFERENTIATION; CILIATED EPITHELIUM CELL; CLUB CELL; CONTROLLED STUDY; CROSS REACTION; DRUG MECHANISM; DRUG SELECTIVITY; FEMALE; GOBLET CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; MALE; METAPLASIA; MOUSE; MUCOCILIARY CLEARANCE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY CELL; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; C57BL MOUSE; CELL LINEAGE; CELL TRACKING; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; EUKARYOTIC FLAGELLUM; HOMEOSTASIS; IMMUNOLOGY; LUNG; METABOLISM; PATHOLOGY;

MAMMALIA;

ANIMALS; ANTIBODIES; ASTHMA; CALCIUM-BINDING PROTEINS; CELL DEATH; CELL DIVISION; CELL LINEAGE; CELL TRACKING; CELL TRANSDIFFERENTIATION; CILIA; DISEASE MODELS, ANIMAL; FEMALE; GOBLET CELLS; HOMEOSTASIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LUNG; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84949224539     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15715     Document Type: Article

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