Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes

Journal of Immunology

Volumn 171, Issue 9, 2003, Pages 4504-4511

  Anastasi, Emanuela ^a   Campese, Antonio F ^a   Bellavia, Diana ^a   Bulotta, Angela ^a   Balestri, Anna ^a   Pascucci, Monica ^a   Checquolo, Saula ^a   Gradini, Roberto ^a   Lendahl, Urban ^b   Frati, Luigi ^a,c   Gulino, Alberto ^a,c   Di Mario, Umberto ^a   Screpanti, Isabella ^a,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

^c IRCCS NEUROMED   (Italy)

^d Pasteur Institute   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; NOTCH RECEPTOR; NOTCH3 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CELL DESTRUCTION; CELL PROTECTION; CYTOTOXIC T LYMPHOCYTE; DIABETES MELLITUS; FLOW CYTOMETRY; IMMUNOLOGICAL TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR AFFINITY; T LYMPHOCYTE ACTIVATION; TARGET CELL; TRANSGENIC MOUSE;

EID: 10744222828     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.9.4504     Document Type: Article

References (34)

1. Yoon, J. W., and H. S. Jun. 2001. Cellular and molecular pathogenetic mechanisms of insulin dependent diabetes mellitus. Ann. NY Acad. Sci. 928:200.
2. Cooke, A., J. M. Phillips, and N. M. Parish. 2001. Tolerogenic strategies to halt or prevent type 1 diabetes. Nat. Immunol. 2:810.
3. Wucherpfennig, K. W., and G. S. Eisenbarth. 2001. Type 1 diabetes. Nat. Immunol. 2:767.
4. Wong, F. S., and C. A. Janeway, Jr. 1999. Insulin-dependent diabetes mellitus and its animal models. Curr. Opin. Immunol. 11:643.
5. Kishimoto, H., and J. Sprent. 2001. A defect in central tolerance in NOD mice. Nat. Immunol. 2:1025.
6. Hanahan, D. 1998. Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. Curr. Opin. Immunol. 10:656.
7. Quinn, A., M. F. McInerney, and E. E. Sercarz. 2001. MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity. J. Immunol. 167:1748.
8. Pugliese, A., D. Brown, D. Garza, D. Murchison, M. Zeller, M. Redondo, J. Diez, G. S. Eisenbarth, D. D. Patel, and C. Ricordi. 2001. Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs. J. Clin. Invest. 107:555.
9. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self tolerance. Cell 101:455.
10. + T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:627.
11. + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317.
12. Saoudi, A., B. Seddon, D. Fowell, and D. Mason. 1996. The thymus contains a high frequency of cells that prevent autoimmune diabetes on transfer into prediabetic recipients. J. Exp. Med. 184:2393.
13. Maloy, K. J., and F. Powne. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816.
14. Seddon, B., and D. Mason. 2000. The third function of the thymus. Immunol. Today 21:95.
15. + subpopulations. J. Immunol. 165:3105.
16. + regulatory T cells induced by an agonist self-peptide. Nat. Immunol. 2:301.
17. Artavanis-Tsakonas, S., M. D. Rand, and R. Lake. 1999. Notch signaling: cell fate control and signal integration in development. Science 284:770.
18. MacDonald, H. R., A. Wilson, and F. Radtke. 2001. Notch1 and T-cell development: insight from conditional knockout mice. Trends Immunol. 22:155.
19. Felli, M. P., M. Maroder, T. A. Mitsiadis, A. F. Campese, D. Bellavia, A. Vacca, R. S. Mann, L. Frati, U. Lendahl, A. Gulino, and I. Screpanti. 1999. Expression pattern of Notch1, 2 and 3 and Jaggedl and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int. Immunol. 11:1017.
20. Bellavia, D., A. F. Campese, E. Alesse, A. Vacca, M. P. Felli, A. Balestri, A. Stoppacciaro, C. Tiveron, L. Tatangelo, M. Giovarelli, et al. 2000. Constitutive activation of NF-κB and T cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J. 19:3337.
21. Chambers, C. A., M. S. Kuhns, J. G. Egen, and J. P. Allison. 2001. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19:565.
22. Rabinovitch, A. 1998. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab. Rev. 14:129.
23. + regulatory T cell-mediated immunosuppression. Cytokine Growth Factor Rev. 14:85.
24. Burkart, V., Z. Q. Wang, J. Radons, B. Heller, Z. Herceg, L. Stingl, E. F. Wagner, and H. Kolb. 1999. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic β-cell destruction and diabetes development induced by streptozotocin. Nat. Med. 5:314.
25. Like, A. A., and A. A. Rossini. 1976. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193:415.
26. Reddy, S., and S. Sandler. 1995. Age-dependent sensitivity to streptozotocin of pancreatic islets isolated from female NOD mice. Autoimmunity 22:121.
27. + suppressor T cells. J. Exp. Med. 193:F41.
28. + T cells: IL-4 and IFN-γ have opposing effects, while TGF-β positively regulates its own production. J. Immunol. 160:5719.
29. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389:737.
30. + T cells. Int. Immunol. 12:177.
31. Hoyne, G. F., M. J. Dallman, B. R. Champion, and J. R. Lamb. 2001. Notch signalling in the regulation of peripheral immunity. Immunol. Rev. 182:215.
32. + cells: a naturally occurring population of regulatory T cells. Blood 98:2736.
33. + regulatory cells in autoimmunity and allergy. Curr. Opin. Immunol. 14:771.
34. + T cells: a common basis between tumor immunity and autoimmunity. J. Immunol. 163:5211.