Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

International Immunology

Volumn 22, Issue 9, 2010, Pages 729-738

  Takeichi, Naoya ^a   Yanagisawa, Satoshi ^a   Kaneyama, Tomoki ^a   Yagita, Hideo ^b   Jin, Young Hee ^c   Kim, Byung S ^c   Koh, Chang Sung ^a  

^a SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; MONOCLONAL ANTIBODY; MPMPCLONAL ANTIBODY DELTA LIKE 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; FEMALE; FLOW CYTOMETRY; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPINAL CORD; TH1 CELL; TH17 CELL;

ANIMALS; ANTIBODIES, BLOCKING; CARDIOVIRUS INFECTIONS; CELL MOVEMENT; CYTOKINES; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKOCYTES, MONONUCLEAR; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MULTIPLE SCLEROSIS; SPINAL CORD; TH1-TH2 BALANCE; THEILOVIRUS;

EID: 77956107505     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq059     Document Type: Article

References (48)

1. Frohman, E. M., Racke, M. K. and Raine, C. S. 2006. Multiple sclerosis-the plaque and its pathogenesis. N. Engl. J. Med. 354:942.
2. Sospedra, M. and Martin, R. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23:683.
3. Kebir, H., Kreymborg, K., Ifergan, I. et al. 2007. Human Th17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13:1173.
4. Yauch, R. L. and Kim, B. S. 1994. A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1(233-244). J. Immunol. 153:4508.
5. Gerety, S. J., Rundell, M. K., Dal Canto, M. C. and Miller, S. D. 1994. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope. J. Immunol. 152:919.
6. Yauch, R. L., Palma, J. P., Yahikozawa, H., Koh, C. S. and Kim, B. S. 1998. Role of individual T-cell epitopes of Theiler's virus in the pathogenesis of demyelination correlates with the ability to induce a Th1 response. J. Virol. 72:6169.
7. Kim, B. S., Lyman, M. A., Kang, B. S. et al. 2001. Pathogenesis of virus-induced immune-mediated demyelination. Immunol. Res. 24:121.
8. Pullen, L. C., Park, S. H., Miller, S. D., Dal Canto, M. C. and Kim, B. S. 1995. Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease. J. Immunol. 155:4497.
9. Palma,J.P.,Park,S.H.andKim,B.S.1996.Treatmentwith lipopolysaccharide enhances the pathogenicity of a low-pathogenic variant of Theiler's murine encephalomyelitis virus. J. Neurosci. Res. 45:776.
10. Maillard, I., Fang, T. and Pear, W. S. 2005. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 23:945.
11. Tsukumo, S. and Yasutomo, K. 2004. Notch governing mature T cell differentiation. J. Immunol. 173:7109.
12. Amsen, D., Blander, J. M., Lee, G. R., Tanigaki, K., Honjo, T. and Flavell, R. A. 2004. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117: 515.
13. Yamaguchi, E., Chiba, S., Kumano, K., Kunisato, A., Takahashi, T. and Hirai, H. 2002. Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice. Immunol. Lett. 81: 59.
14. Kostianovsky, A. M., Maier, L. M., Baecher-Allan, C., Anderson, A. C. and Anderson, D. E. 2007. Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression. J. Immunol. 178:6158.
15. Maekawa, Y., Tsukumo, S., Chiba, S. et al. 2003. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 19:549.
16. Rutz, S., Mordmuller, B., Sakano, S. and Scheffold, A. 2005. Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur. J. Immunol. 35:2443.
17. Skokos, D. and Nussenzweig, M. C. 2007. CD8-DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPS. J. Exp. Med. 204:1525.
18. Jurynczyk, M., Jurewicz, A., Bielecki, B., Raine, C. S. and Selmaj, K. 2008. Overcoming failure to repair demyelination in EAE: gamma-secretase inhibition of Notch signaling. J. Neurol. Sci. 265:5.
19. Jurynczyk, M., Jurewicz, A., Raine, C. S. and Selmaj, K. 2008. Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis. J. Immunol. 180:2634.
20. Elyaman, W., Bradshaw, E. M., Wang, Y. et al. 2007. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J. Immunol. 179:5990.
21. Yamanda, S., Ebihara, S., Asada, M. et al. 2009. Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade. Blood. 113:3631.
22. Benveniste, E. N. 1997. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 75:165.
23. Lipton, H. L., Kratochvil, J., Sethi, P. and Dal Canto, M. C. 1984. Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection. Neurology. 34:1117.
24. Clatch, R. J., Miller, S. D., Metzner, R., Dal Canto, M. C. and Lipton, H. L. 1990. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology. 176:244.
25. Clatch, R. J., Lipton, H. L. and Miller, S. D. 1986. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs. J. Immunol. 136:920.
26. Pullen, L. C., Miller, S. D., Dal Canto, M. C., Van der Meide, P. H. and Kim, B. S. 1994. Alteration in the level of interferon-gamma results in acceleration of Theiler's virus-induced demyelinating disease. J. Neuroimmunol. 55:143.
27. Inoue, A., Koh, C. S., Yahikozawa, H. et al. 1996. The level of tumor necrosis factor-alpha producing cells in the spinal cord correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int. Immunol. 8:1001.
28. Hou, W., Kang, H. S. and Kim, B. S. 2009. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J. Exp. Med. 206:313.
29. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133.
30. Zanoni, I., Foti, M., Ricciardi-Castagnoli, P. and Granucci, F. 2005. TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells. J. Immunol. 175:286.
31. Xu, D., Liu, H. and Komai-Koma, M. 2004. Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell. Mol. Immunol. 1:239.
32. Dabbagh, K. and Lewis, D. B. 2003. Toll-like receptors and T-helper-1/T-helper-2 responses. Curr. Opin. Infect. Dis. 16: 199.
33. Dallman, M. J., Smith, E., Benson, R. A. and Lamb, J. R. 2005. Notch: control of lymphocyte differentiation in the periphery. Curr. Opin. Immunol. 17:259.
34. Raymond, T., Schaller, M., Hogaboam, C. M., Lukacs, N. W., Rochford, R. and Kunkel, S. L. 2007. Toll-like receptors, Notch ligands, and cytokines drive the chronicity of lung inflammation. Proc. Am. Thorac. Soc. 4:635.
35. Schaller, M. A., Neupane, R., Rudd, B. D. et al. 2007. Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J. Exp. Med. 204:2925.
36. Mukherjee, S., Schaller, M. A., Neupane, R., Kunkel, S. L. and Lukacs, N. W. 2009. Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation. J. Immunol. 182:7381.
37. So, E. Y., Kang, M. H. and Kim, B. S. 2006. Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3. Glia. 53:858.
38. So, E. Y. and Kim, B. S. 2009. Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. Glia. 57:1216.
39. Myoung, J., Bahk, Y. Y., Kang, H. S., Dal Canto, M. C. and Kim, B. S. 2008. Anticapsid immunity level, not viral persistence level, correlates with the progression of Theiler's virus-induced demyelinating disease in viral P1-transgenic mice. J. Virol. 82: 5606.
40. Jin, Y. H., Kang, B. and Kim, B. S. 2009. Theiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J mice. J. Virol. 83:10981.
41. Minter, L. M., Turley, D. M., Das, P. et al. 2005. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 6:680.
42. Tzartos, J. S., Friese, M. A., Craner, M. J. et al. 2008. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172:146.
43. Iso, T., Hamamori, Y. and Kedes, L. 2003. Notch signaling in vascular development. Arterioscler. Thromb. Vasc. Biol. 23: 543.
44. Harman, B. C., Jenkinson, E. J. and Anderson, G. 2003. Microenvironmental regulation of Notch signalling in T cell development. Semin. Immunol. 15:91.
45. Jenkinson, E. J., Jenkinson, W. E., Rossi, S. W. and Anderson, G. 2006. The thymus and T-cell commitment: the right niche for Notch? Nat. Rev. Immunol. 6:551.
46. Basson, M. A. and Zamoyska, R. 2000. The CD4/CD8 lineage decision: integration of signalling pathways. Immunol. Today. 21:509.
47. Koch, U., Fiorini, E., Benedito, R. et al. 2008. Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J. Exp. Med. 205:2515.
48. Hozumi, K., Mailhos, C., Negishi, N. et al. 2008. Delta-like 4 is indispensable in thymic environment specific for T cell development. J. Exp. Med. 205:2507.